[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healing-wound\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healing-wound":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100537323","influence-of-timing-of-implant-placement-on-early-healing-molecular-events-100537323",false,"NCT06276335","Influence of Timing of Implant Placement on Early Healing Molecular Events","Influence of Timing of Implant Placement on Early Healing Molecular Events: A Two-centre, Parallel Group, Pilot Study","Inclusion Criteria:\n\n* Age ≥25 years old\n* Good\u002Fcontrolled medical and psychological health\n* Good oral hygiene (FMPS≤20%)\n* Presence of a tooth in the aesthetic region (from incisor to second premolar) in need of extraction and further oral rehabilitation with a single dental implant.\n* For the IP group, the extraction socket should fulfil the following parameters, as described by the 5th ITI consensus \\[46\\]: intact socket wall; facial bone wall ≥1mm in thickness; no acute infection at the site; availability of bone apical and palatal to the socket to provide primary stability.\n* At least one neighbouring natural tooth.\n* A functional occlusion with a minimum of four occlusal units (i.e., pairs of occluding posterior teeth).\n* Willingness to read and sign a copy of the Informed Consent Form (ICF) after reading the Patient Information Sheet (PIS), and after the nature of the study has been fully explained and potential questions fully answered.\n\nExclusion Criteria:\n\n* Any known systemic disease severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis or diabetes type I and uncontrolled diabetes type II).\n* Self-reported HIV or viral hepatitis.\n* Self-reported alcoholism or chronic drug abuse.\n* Smokers (including current smokers or former smokers who had quit for \\\u003C 3 months); patients reporting use of vape\u002Fe-cigarettes will also be excluded.\n* Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results).\n* Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status or bone metabolism (e.g., bisphosphonates, hormone replacement therapy, immunosuppressants) within 1 month before baseline visit.\n* Chronic treatment with anticoagulants (including Aspirin), corticosteroids, immunosuppressants or other medications that may influence blood coagulation\u002Fcount.\n* Antibiotic or anti-inflammatory therapy during the month preceding the baseline exam.\n* Untreated caries lesions and untreated\u002Funcontrolled periodontal disease; If patients require periodontal treatment (non-surgical and\u002For surgical), this will be arranged outside the study protocol and completed prior to enrolment;\n* Inadequate keratinized tissue width (\\\u003C2 mm) in the mid-buccal aspect of the area to be treated in the study.\n* Physical handicaps that would interfere with the ability to perform adequate oral hygiene in the area of implant placement.\n* Patients requiring maxillary sinus lift surgery before implant placement.\n* Self-reported bruxism.\n* Patients not willing to receive animal-derived biomaterials for GBR.\n* Patients suffering from a known psychological disorder or with limited mental capacity or language skills such that study information could not be understood, informed consent could not be obtained, or simple instructions could not be followed.\n* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial.","ALL","25 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","Dental implants have been on the market for several years and they are routinely used to replace single\u002Fmultiple missing teeth with a high success rate. However, there is still a limited number of studies comparing the influence of timing of implant placement on wound healing. In addition, there is no data available on the signaling pathways and the expression of healing biomarkers involved in the early stages of osseointegration after immediate implant placement (IP) or delayed implant placement (DP).\n\nThe primary objective of this study is to describe changes in the expression of inflammatory, angiogenesis and osseous biomarkers of saliva at 1, 3, 7, 15 and 30 days and of PICF at 3, 7, 15 and 30 days after immediate implant placement (IP) compared with delayed placement (DP).",[26,27,28,29],"Dental Implant","Healing Wound","Biomarkers","Saliva",[31],"Implant placement protocol","RECRUITING","2025-11-17",{"date":35,"type":36},"2025-11-19","ACTUAL",{"date":38,"type":36},"2024-09-26",{"date":40,"type":20},"2026-12-31",{"name":42,"class":43},"Queen Mary University of London","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":44},"100517411","ultrasound-for-socket-healing-evaluation-100517411","NCT06017193","Ultrasound for Socket Healing Evaluation","Ultrasonic Imaging of Bone Graft Healing in Extraction Sockets for Precise and Personalized Implant Therapy (HUM00226516)","Inclusion Criteria:\n\n* Patients at least 18 years of age and have at least a tooth that is considered hopeless, planned for an extraction and a bone grafting procedure for subsequent dental implant surgery.\n\nExclusion Criteria:\n\n* Patients not willing or not able to have an extraction, bone graft and subsequent implant surgery due to health, finance, or any other reasons.",true,"18 Years",{"count":55,"type":20},140,"OBSERVATIONAL","The design is a single blinded, dual comparative study of ultrasound versus micro-CT\u002FLASCA in one study group. Up to a total of 140 subjects registered will be recruited. Subjects who are treatment planned for extraction of a hopeless tooth and socket augmentation with bone graft and are planned for a dental implant surgery. The socket will be evaluated before the extraction and multi-time points during healing until an implant is placed with various evaluation tools, including ultrasound.",[27,59,60,61,62],"Alveolar; Wound","Alveolar Bone Loss","Image","Dent Disease","2025-10-30",{"date":65,"type":36},"2025-10-31",{"date":67,"type":36},"2024-07-25",{"date":69,"type":20},"2027-07-01",{"name":71,"class":43},"University of Michigan",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":79,"minAge":4,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100484714","phase-4-hyaluronic-acid-for-the-treatment-of-damaged-nipples-in-breastfeeding-women-100484714","NCT05591651","Hyaluronic Acid for the Treatment of Damaged Nipples in Breastfeeding Women","The Effectiveness of Hyaluronic Acid for the Treatment of Damaged Nipples in Breastfeeding Women: a Double-blind Randomised, Controlled Trial","Inclusion Criteria:\n\n* for mothers: a breastfeeding mother, living or residing in Osijek, with nipple skin damage (NTS 1, 2, 3, 4, or 5).\n* for babies: newborns from a singleton pregnancy, of gestational age from 37 to 42 weeks, with a birth weight of 2,500 to 4,500 grams.\n\nExclusion Criteria:\n\n* for mothers: mothers who do not breastfeed, mothers not living or residing in Osijek, mothers without nipple skin damage and mothers using other preparations for healing sore nipples (shells, pads).\n* for children: visible anomalies in the newborn which may affect the breastfeeding process, newborns that required admission to the neonatal unit","FEMALE",{"count":81,"type":20},160,[83],"PHASE4","Previous studies have shown that application of hyaluronic acid preparations to wounds of the skin and mucosa have a beneficial effect.\n\nThere is a lack of studies showing the effect of applying hyaluronic acid preparations to treat damaged nipple skin in breastfeeding mothers.\n\nThis study aims to determine the effect of applying a hyaluronic acid preparation to damaged nipple skin in breastfeeding women.",[86,87,27],"Cracked Nipple","Breastfeeding",[89,90,91],"hyaluronic acid","cracked nipple","breastfeeding","2024-07-30",{"date":94,"type":36},"2024-07-31",{"date":96,"type":36},"2023-01-09",{"date":98,"type":20},"2026-02",{"name":100,"class":43},"Specijalisticka Pedijatrijska Ordinacija prim.mr.sc. Maja Stimac, Specijalist Pedijatrije Sspecijalnosti Neonatologije"]