[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100617904","evaluation-of-irisin-levels-in-adult-forearm-fracture-surgery-under-infraclavicular-block-and-general-anesthesia-100617904",false,"NCT07324681","Evaluation of Irisin Levels in Adult Forearm Fracture Surgery Under Infraclavicular Block and General Anesthesia","Evaluation of Irisin Levels in Adult Patients With Forearm Fractures Undergoing Surgery With Infraclavicular Block and General Anesthesia","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n\nScheduled for elective forearm fracture surgery\n\nPlanned to receive either general anesthesia or infraclavicular brachial plexus block\n\nAmerican Society of Anesthesiologists (ASA) physical status I-III\n\nAble to provide written and verbal informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>65 years\n\nEmergency surgery\n\nRefusal or inability to provide informed consent\n\nASA physical status IV or V\n\nKnown bone diseases or metabolic bone disorders\n\nMultiple trauma or associated organ injury\n\nInability to mobilize\n\nMorbid obesity (BMI \\>40 kg\u002Fm²)\n\nRenal failure\n\nHepatic failure\n\nNeurological deficits or sequelae\n\nContraindication or allergy to any anesthetic agents used in the study","ALL","18 Years","65 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized prospective study evaluates the effect of general anesthesia versus infraclavicular nerve block on perioperative serum irisin levels in adults undergoing forearm fracture surgery. Irisin levels will be measured preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively. The association between irisin changes and fracture healing will be explored as a secondary outcome.",[27,28,29],"Inflamation","Healing","Angiogenesis",[31,32,33],"irisin","infraclavicular block","forearm fracture","NOT_YET_RECRUITING","2026-01-07",{"date":37,"type":38},"2026-01-09","ACTUAL",{"date":40,"type":21},"2026-01-25",{"date":42,"type":21},"2026-05-05",{"name":44,"class":45},"Ankara City Hospital Bilkent","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100608358","effect-of-probiotics-after-neurosurgery-100608358","NCT07200518","Effect of Probiotics After Neurosurgery","The Multistrain Probiotic OMNi-BiOTiC® Hetox for Treatment After Neurosurgery (ProSURG)","ProSURG","Inclusion Criteria:\n\n* adults with MRI-confirmed disc herniation, stenosis, or instability of the lumbar or cervical spine.\n* Able to provide written informed consent\n* Willing to comply with study procedures and follow-up assessments\n* No contraindications to probiotic administration\n\nExclusion Criteria:\n\n* symptoms of acute infection (vomiting, fever above 38°C, diarrhea, respiratory symptoms),\n* chronic diseases,\n* use of probiotics one month before inclusion.",true,{"count":56,"type":21},110,[24],"The goal of this randomised controlled trial is to determine the effect of consuming a multistrain probiotic OMNi-BiOTiC® Hetox on improving the healing, pain management, and postsurgical complications after neurosurgery.\n\nThe main question it aims to answer is:\n\n• Is the multistrain probiotic OMNi-BiOTiC® Hetox effective in in improving patient-reported disability after neurosurgery?\n\nResearchers will compare the probiotic group and the placebo group to determine if the healing is significantly different between the groups.",[28],[61,62,63],"neurosurgery","probiotics","Omni-Biotic Hetox","RECRUITING","2025-11-21",{"date":67,"type":38},"2025-11-28",{"date":69,"type":38},"2025-11-03",{"date":71,"type":21},"2027-06-01",{"name":73,"class":45},"University Maribor",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100588451","effect-of-solutions-used-in-burn-wound-irrigation-on-healing-pain-fear-and-anxiety-randomized-controlled-study-100588451","NCT06941571","Effect of Solutions Used in Burn Wound Irrigation on Healing, Pain, Fear and Anxiety: Randomized Controlled Study","Inclusion Criteria: The child must be between the ages of 5-10, be followed up in the burn clinic of the pediatric surgery service, be conscious, alert, and open to communication, be a child with 10% or 2nd degree superficial and deep burns who are being followed up as an outpatient, have burns on the arms, legs, and torso, have hot water (boiling water, etc.) burns, and the parent and child must agree to participate in the study.\n\nExclusion Criteria: The child must be younger than 5 years old or older than 10 years old, have a general condition disorder due to burns, have a change in consciousness, have genital area and facial burns, have a 10% or more second and third degree burn, have a burn that is an indication for hospitalization, the parent uses topical agents for burn healing at home, and the parent and child do not accept to participate in the study.","5 Years","10 Years",{"count":84,"type":21},69,[24],"Burn, skin and\u002For subcutaneous tissues; It is an acute injury that causes traumatic lesions by exposure to thermal, chemical, mechanical or electrical agents. Among all traumatic injuries, burns are the most common type of injury and affect the entire body system. The World Health Organization reports that approximately 180,00 deaths per year are due to burns, making it the fifth most common type of childhood injury. It is also stated that 80% of burned children have hot water burns. Treatment is in two ways: surgical and non-surgical. The type of burn, its size, depth and the individual characteristics of the child affect the type of treatment.\n\nNon-surgical treatment is always the first choice in burn treatment. The primary method of this method is burn dressings. Before dressing, the burn surface must be cleaned\u002Firrigated with an appropriate antiseptic solution to remove metabolic wastes and tissue exudate. The aim here is to prepare a suitable environment for the burn wound to heal and to accelerate the healing process. In the literature, it is recommended to use various antiseptic solutions such as 0.9% NaCl, 0.5% chlorhexidine and hypochlorous acid for irrigation of burn wounds. Applying these solutions involves physical contact with the wound, and this contact may cause pain in the child. Additionally, the temperature and pH of the solution may cause discomfort. The pain that occurs during the irrigation process can further intensify anxiety and fear. However, it is not known which burn solutions used cause more pain, anxiety and fear. In this project, the effects of irrigation solutions used in the care of pediatric burn wounds on pain, fear, anxiety, infection development and healing will be examined. Child patients aged 5-10 years old with limb burns who present with hot water burns and do not have an indication for hospitalization will be included in the project. Children coming to burn dressing will be divided into three groups by simple randomization method. The burn wound of children in the first group will be irrigated with 0.09% NaCl, the children in the second group will be irrigated with 0.5% chlorhexidine, and the burn wound of children in the third group will be irrigated with hypochlorous acid solution. During irrigation of the burn wound, the child's anxiety, fear and pain status will be evaluated. At the same time, the effectiveness of the irrigation solutions used on the development of infection on the wound and its effectiveness on healing will be examined. For this reason, the burn wound will be monitored every three days. For this reason, children will be called to the burn clinic for dressing every three days. Before each dressing, a wound swab sample will be taken to determine the infection status in the burn wound. The Bates-Jensen wound assessment tool will be used to determine the healing status of the burn wound, and this tool will be evaluated by the burn nurse and two pediatric surgeons. In total, children will be monitored for 12 days. At the end of the project, the effect of the solutions used in burn irrigation on infection and healing will be determined. At the same time, the effects of the solutions on anxiety, fear and pain in children will be evaluated. It is thought that the data obtained as a result of the project will contribute to the development of a burn wound care protocol.",[88,89,28,90,91,92],"Burn","Burn Wound","Pain","Anxiety","Fear","2025-07-24",{"date":95,"type":38},"2025-07-28",{"date":97,"type":21},"2025-09-30",{"date":99,"type":21},"2026-04-30",{"name":101,"class":45},"Nurdan AKCAY DİDİSEN"]