[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:health":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,43,73,98,139,161,193,215,247,280,313,340,361,385,417,440],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100493169","nutrition-for-precision-health-powered-by-the-all-of-us-100493169",false,"NCT05701657","Nutrition for Precision Health, Powered by the All of Us","Nutrition for Precision Health, Powered by the All of Us Research Program","Inclusion Criteria:\n\n* Overall Inclusion -- Participants 18 years of age or older who have completed the primary All of Us consent process, Electronic Health Record consent process, have provided at least one All of Us biospecimen suitable for DNA sequencing, and have completed All of Us Participant Provided Information (PPI) Modules 1-3 (Basics, Overall Health, and Lifestyle); Speak English or Spanish; Able and willing to comply with study requirements and consent to participate.\n* Module 1 -- Must be willing and able to comply with Module 1 protocol; Must provide informed consent for Module 1.\n* Module 2 -- Must have completed Module 1; Must provide informed consent for Module 2; Must agree to comply with protocol over a period of approximately 10 to 12 weeks and up to six months. This includes consuming only the foods provided during periods of controlled feeding. Module 2 has three controlled feeding periods each lasting approximately two weeks with at least two weeks between feeding periods, and up to 6 months allowed for completion of the Module.\n* Module 3 -- Must have completed Module 1; Must provide informed consent for Module 3; Must agree to comply with protocol over a period of approximately 10 to 12 weeks and up to 6 months. This includes being domiciled three times, for two weeks each, and consuming only the foods provided during the domiciled periods. There is at least two weeks between domiciled periods, and up to 6 months allowed for completion of the Module.\n\nExclusion Criteria:\n\n* Module 1\n\n  1. Any change to the participant's status from the time of All of Us enrollment that would render them ineligible for All of Us (e.g., being incarcerated, no longer living in the United States, or withdrawn from that study).\n  2. Inability to provide informed consent and engage in informed consent procedures\n  3. Participants who suffer from allergic reactions to, or are unwilling to consume, any components of the liquid mixed meal (e.g., milk products, soy products)\n  4. Barriers to safe insertion of peripheral IV canula:\n\n     1. Contraindications to peripheral IV canula insertion such as local skin infection, inflammation, trauma or burns if all the upper extremities were involved and there is no unaffected extremity available for IV placement; or\n     2. A need for long-term IV access (e.g., ESRD); or\n     3. Lymphedema or deep vein thrombosis (DVT) in the extremity of the IV (in the case where another extremity is not available); or\n     4. Coagulopathy requiring blood thinning products; or\n     5. Arteriovenous (AV) graft or fistula in the extremity of the IV (in the case where another extremity is not available)\n  5. Pregnancy-related conditions:\n\n     1. Gestational age precluding completion of the Module by 36 weeks. A pregnant participant should complete visit 1 by gestational age 34 weeks, 0 days and complete Module 1 by week 36.\n     2. Severe morning sickness limiting mixed meal tolerance test (MMTT) consumption\n  6. Certain types of disease states:\n\n     1. Dumping syndrome or inability to consume the volume of the MMTT liquid\n     2. Severe malabsorption such as history of short gut syndrome or need for parenteral or enteral nutrition\n     3. Less than 12-months post-metabolic or bariatric surgery\n     4. History of chronic pancreatitis (e.g., Cystic fibrosis) complicated by inability to tolerate the volume of the MMTT liquid\n     5. Health conditions requiring chronic blood transfusions or iron infusions\n     6. Hemoglobin \\\u003C9.5 g\u002FdL at screening\n  7. Serious illness and in hospice or palliative care for terminal disease\n  8. Swallowing issues:\n\n     1. Self-reported difficulty tolerating solids or liquids\n     2. Aspiration risks that require change in thickness of liquid or dietary modifications\n  9. Short term antibiotic use. For example, active antibiotics use for an ongoing acute infection\n  10. Blood donation in the last 3 months\n  11. GLP-1 agonist medication (e.g. Semaglutide) instability as defined by less than 3 months of continuous use\n  12. Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator's and\u002For team's opinion jeopardizes the safety of the participant or others or would interfere with adherence to the protocol.\n* Module 2\n\n  1. Any change to the participant's status from the time of All of Us enrollment that would render them ineligible for All of Us (e.g., being incarcerated, no longer living in the United States, or withdrawn from that study)\n  2. All the above mentioned exclusion criteria for Module 1 (except inability to consume components of the liquid mixed meal)\n  3. Inability to provide informed consent and engage in informed consent procedures\n  4. Inability or failure to complete all critical elements from Module 1 (dietary, physical activity and sleep assessments, continuous glucose monitoring, MMTT)\n  5. Participants who are already enrolled in Module 3\n  6. Participants who are unlikely to be able to adhere to the protocol, based on structured adherence assessment by a study registered dietitian or other trained staff. This includes participants who have known allergic reactions to, or unwillingness to consume, study foods in Module 2 (e.g., gluten, meat, fish, nuts, dairy products) that cannot be reasonably accommodated by the metabolic kitchen within allowable criteria for the test diets.\n  7. Participants who plan to relocate to an area not served by NPH or travel plans that do not permit completion of the Module over a period of up to 6 months.\n  8. Pregnancy-related conditions:\n\n     1. Gestational age precluding completion of the Module by week 36. A pregnant participant must be able to begin the first diet by gestational age 26 weeks, 0 days and complete the Module by week 36.\n     2. High risk pregnancy defined as fetal anomaly, gestational hypertension (SBP \\>140 mmHg and DBP \\>90 mmHg), pre-eclampsia, or gestational diabetes mellitus\n  9. Possible ethanol (alcohol) use disorder defined by Alcohol Use Disorders Identification Test (AUDIT) score of \\>15\n  10. History of surgery for the treatment of obesity and:\n\n      1. Self-reported dumping syndrome; or\n      2. Following a special diet prescribed by their practitioner\n  11. Uncontrolled disease states:\n\n      1. Hypertension \\>160\u002F100mmHg\n      2. Exacerbation of underlying gastrointestinal disease, including inflammatory bowel disease or other malabsorptive disorders\n      3. Decompensated cirrhosis\n      4. Previously diagnosed diabetes Mellitus with HbA1c \\>12% at screening\n      5. Newly diagnosed diabetes within the past three months, or HbA1c \\>6.5% at screening in a person not previously diagnosed with diabetes.\n  12. Participants with a history of end-stage renal disease (ESRD) on hemodialysis\n  13. Active infectious diseases (e.g., active tuberculosis \\\u003C 3 months from symptom onset or positive test, COVID \\\u003C 1 month from symptom onset or positive test)\n  14. Malignancy (e.g., cancer) actively receiving cytotoxic chemotherapy (oral or infusions) treatment except for nonmelanoma skin cancers during the study period\n  15. Participants who require dietary restrictions due to a medical condition or are on a prescribed diet for underlying chronic diseases\n  16. Participants with type 1 or type 2 diabetes on insulin\n  17. Participants aged ≥ 75 years with type 2 diabetes taking prescribed medications that can cause hypoglycemia (e.g. sulfonylureas, glinides), or on a prescribed diet\n  18. Hospitalization for a chronic disease (e.g., congestive heart failure, stroke) within the past three months\n  19. Requiring transfusions\u002Fapheresis during study period\n  20. Participants with a current diagnosis of, or who have received treatment for, bulimia or anorexia nervosa within the past 3 years\n  21. Participants with major psychiatric disorders, including major depression, schizophrenia, or psychosis, who have been hospitalized in the past six (6) months or are currently enrolled in treatment programs\n  22. Hemoglobin \\\u003C9.5 g\u002FdL at screening\n  23. Myocardial infarction, invasive cardiac procedure, participation in a cardiac or acute rehabilitation programs, transient ischemic attacks, or unstable arrhythmias within the past 3 months\n  24. Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator's opinion, might jeopardize the safety of the participant or others, or be expected to interfere with adherence to the protocol.\n* Module 3\n\n  1. All the above mentioned exclusion criteria for Modules 1 and 2\n  2. Participants who are already enrolled in Module 2\n  3. Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator's opinion, might jeopardize the safety of the participant or others, or would interfere with adherence to the protocol\n  4. Inability to abstain from tobacco or nicotine use, vaping, alcohol, illicit drug use, or recreational drug use for two (2) consecutive weeks while domiciled in the clinical unit. Nicotine gum, pouch, or patch are permitted.\n  5. Any condition requiring in-person treatments or visits during the study period. This will not be accommodated by the domiciling protocol; however, tele-health visits with the participants regular doctor are permitted.\n  6. Lactation or other infant care needs that cannot be accommodated while domiciled in the clinical unit\n  7. Depression as assessed by:\n\n     1. Patient Health Questionnaire (PHQ-9) score ≥ 15; or\n     2. Affirmative answer to PHQ-9 suicidality question: \"Thoughts that you would be better off dead or of hurting yourself in some way\"\n  8. Unable to engage in daily self-care activities (e.g., bathing, transferring, toileting, feeding, dressing)\n  9. Uncontrolled endocrine disorders (such as Cushing's disease, pituitary disorders, diabetes)\n  10. Uncontrolled pain requiring frequent or daily treatment, or adjustment of medication requiring weekly or bi-weekly visits. Pain medications used on an as-needed basis (PRN), such as acetaminophen or NSAIDs, are not excluded.\n  11. Chronic prescription medications that would pose logistical and safety issues for participation",true,"ALL","18 Years",{"count":20,"type":21},8000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence\u002FMachine Learning (AI\u002FML) algorithms that predict individual responses to diet patterns using rich multimodal data streams collected across multiple domains (e.g., behavior, social, environmental, clinical and molecular biomarkers). NPH includes a large phenotyping cohort (Module 1, N=8000) and two separate follow-up groups drawn from a subset of Module 1participants. One group (Module 2, N=1200) receives three distinct diets in a 14-day crossover sequence, with at least a 14-day washout period between diets, while living in their own homes. A second group (Module 3, N=150) receives the same three diets under full-time supervision in a residential research setting. We will train and test AI\u002FML models to predict 0-4 hour postprandial response curves for glucose, insulin, triglycerides, and GLP-1, to the standardized diet-specific meal test (DSMT) collected after each of the three different diets delivered in Module 2. Each diet functions as a controlled stimulus to reveal biological features (such as individual variables, patterns, or clusters of measurements) that best predict a person's response.\n\nThe Module 2 DSMT response curves are the primary outcomes (dependent variables) for AI\u002FML algorithms that predict individual responses to diet patterns.\n\nAs a secondary objective, NPH will evaluate the validity and acceptability of technology-based dietary assessment tools. The Automated Self-Administered 24-hour recall (ASA24), Automatic Ingestion Monitor-2 (AIM-2), and the mobile food record (mFR) will be evaluated in Modules 2 and 3, and the ASA24 food record and the image-assisted ASA24 recall will be evaluated only in Module 3. Total energy intake, macronutrient and dietary fiber intake data are the main outcomes for validity testing compared against measures of actual intake. Acceptability will be determined from feedback surveys.",[27,28,29],"Nutrition","Health","Dietary Habits","RECRUITING","2026-06-01",{"date":33,"type":34},"2026-06-03","ACTUAL",{"date":36,"type":34},"2023-04-14",{"date":38,"type":21},"2027-01-31",{"name":40,"class":41},"RTI International","OTHER",14,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100489978","influence-of-resentment-and-forgivingness-on-quality-of-life-in-people-living-with-hiv-100489978","NCT05660148","Influence of Resentment and Forgivingness on Quality of Life in People Living With HIV","FORGHIV","Inclusion Criteria:\n\n* Belonging to the PLHIV followed at the Amiens University Hospital, not likely to move within the year\n* Possibility of follow-up in teleconsultation (usual support of the service)\n* Benefiting from a social security scheme\n* Consent to participate in the research\n\nExclusion Criteria:\n\n* Erratic follow-up (non-compliance, predictable move) or moribund patient\n* Illiterate or not speaking french",{"count":51,"type":21},206,"OBSERVATIONAL","Life stress is strongly associated with poor mental and physical health and its effects explain significant morbidity and mortality. Forgiveness is one of the factors that can influence the effects of stress on health. By definition, forgiveness is the release of negative feelings, emotions, and behaviors - and possibly the release of positive feelings - toward an offender. Numerous studies have shown that forgiveness is associated with several mental and physical health benefits. The literature argues that high levels of propensity to forgive (trait) predispose that person to experience forgiveness (state) more often. In other words, a stronger forgiving disposition is believed to increase the experience of forgiveness, which, in turn, mitigates the negative effects of stress. Forgiveness is therefore a coping style that can play a beneficial role in the stress-health relationship. Patients living with HIV (PLHIV) are patients particularly exposed to stress, not only because of their chronic pathology but also because of the stigma attached to this disease. Very few studies have studied the impact of forgiveness (state or trait) on the physical health of PLHIV and even fewer the impact of an intervention promoting the disposition to forgive. The objective of this prospective observational monocentric study is to show in a very secular country that forgiveness has an effect on well-being as well as on other health parameters.",[55,56,57,58,28],"Forgiveness","Hiv","Stress","Stigma",[55,60,56,57,61,62],"forgivingness","stigma","health","2026-05-27",{"date":65,"type":34},"2026-05-28",{"date":67,"type":34},"2024-05-06",{"date":69,"type":21},"2026-11-06",{"name":71,"class":41},"Centre Hospitalier Universitaire, Amiens",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":72},"100219340","optical-coherence-tomography-and-nephropathy-the-octane-study-100219340","NCT02132741","Optical Coherence Tomography And NEphropathy: The OCTANE Study","Assessment of Retinal Vasculature Using Optical Coherence Tomography in Health, Hypertension & Chronic Kidney Disease.","Inclusion Criteria:\n\n* Male or female\n* Age 18-80\n* Body mass index ≤35\n* For those with hypertension: BP ≥140\u002F90 or on treatment for hypertension\n* For those with CKD: CKD as defined by the Kidney Diseases Quality Initiative guidelines\n\nExclusion Criteria:\n\n* Subject is below the age of legal consent, or is mentally or legally incapacitated\n* The subject has donated blood (450 ml) within the last 4 weeks\n* Past or present drug or alcohol abuse including intravenous drug abuse at any time\n* Participation in another clinical trial within 1 month\n* Considered to be at high risk of HIV or hepatitis B\n* Patients with known eye disease, or previous eye surgery, or refractive error greater than +\u002F- 6 dioptres.","80 Years",{"count":82,"type":21},150,"Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes. Part of this risk is due to changes in the structure and function of the blood vessels throughout the body. It is thought that reducing high blood pressure and treating chronic kidney disease improves the structure and function of blood vessels but information on this is limited. Optical coherence tomography (OCT) is a method of looking at the blood vessels at the back of the eye. It is a simple, quick and non-invasive test that you may have previously had during a visit to the optician. The purpose of the study is to ascertain whether OCT is able to detect changes in the eye's blood vessels in patients with hypertension and chronic kidney disease compared to healthy individuals and also to see if any differences seen improve with treatment.",[28,85,86],"Hypertension","Chronic Kidney Disease",[88],"OCT; hypertension; CKD","2026-05-08",{"date":91,"type":34},"2026-05-13",{"date":93,"type":34},"2014-05-16",{"date":95,"type":21},"2028-09",{"name":97,"class":41},"University of Edinburgh",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":16,"sex":17,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":72},"100636297","an-open-label-direct-to-consumer-study-assessing-the-impact-of-health-and-wellness-products-on-gi-health-and-related-health-outcomes-100636297","NCT07563855","An Open Label Direct-to-Consumer Study Assessing the Impact of Health and Wellness Products on GI Health and Related Health Outcomes","Inclusion Criteria:\n\n* Adults, at least 21-75 years of age at the time of electronic consent, inclusive of all ethnicities, races, and gender identities.\n* Assigned sex at birth will determine sex-specific recruitment and surveys (male vs female) employed, when needed\n* Resides in the United States\n* Has the opportunity for at least 30% improvement in their primary health outcome\n* One of the following:\n* Currently taking a GLP-1 for at least 3 months with no plans to stop or switch current GLP-1\n* Expressing the interest to lose weight, but not currently taking a GLP-1 in the last 6 months and with no plans to start taking a GLP-1\n* Must be willing to complete a biomarker collection (stool and blood) at 2 timepoints during the study (baseline and end of study)\n* Expresses a willingness to take the study product everyday for 4 weeks\n\nExclusion Criteria:\n\n* Report being pregnant, trying to become pregnant, or breastfeeding\n* Unable to provide a valid US shipping address and mobile phone number\n* Reports current enrollment in another clinical trial\n* Reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages per day)\n* Unable to read and understand English at a 7th grade level\n* Reports enrollment, current or within in the past 30 days, in another clinical trial\n* Reports a current and\u002For recent (up to 3 months ago) major illness and\u002For surgery that poses a known, significant safety risk.\n* Reports a diagnosis of cardiac dysfunction, liver or kidney disease that presents a known contraindication and\u002For a significant safety risk with any of the study product ingredients.\n* NYHA Class III or IV congestive heart failure, atrial fibrillation, uncontrolled arrhythmias, cirrhosis, end-stage liver disease, stage 3b or 4 chronic kidney disease, or kidney failure\n* Reports taking medications that have a well-established moderate or severe interaction, posing a substantial safety risk with any of the study product ingredients.\n* Anticoagulants, antihypertensives, anxiolytics, antidepressants, chemotherapy, immunotherapy, sedative hypnotics, seizure medications, medications that warn against grapefruit consumption, corticosteroids at doses greater than 5 mg per day, Diabetic medications to treat Type 1 or Type 2 diabetes , oral anti-infectives (antibiotics, antifungals, antivirals) to treat an acute infection, antipsychotics, MAOIs, or thyroid products\n* Reports current use, or use within the past 30 days, of whey protein and\u002For similar product(s) to the study product that may limit the effects of the study products and\u002For pose a safety risk\n* Reports taking an antibiotic or probiotic in the last 4 weeks\n* Lack of reliable daily access to the internet","21 Years","75 Years",{"count":107,"type":21},133,[24],"The purpose of this study is to:\n\n1. Understand the participant experience using a health and wellness product and effects of the study product on GLP-1 users and those trying to lose weight\n2. Understand how participants may use and accept a health and wellness product\n3. Understand the side effects of a health and wellness product\n4. Evaluate the quality and effects of a health and wellness product on participant health through self-reported measures (electronic surveys) and biomarker collections.",[28,111,112],"Wellness","Quality of Life",[114,115,116,117,118,119,120,121,122,123,124,125,126,127,128],"product","beverage","protein","fiber","electrolytes","hydration","satiety","digestion","gastrointestinal","constipation","belly pain","GLP-1","weight","attitudes","behaviors","2026-04-29",{"date":131,"type":34},"2026-05-04",{"date":133,"type":21},"2026-04",{"date":135,"type":21},"2026-08",{"name":137,"class":138},"PepsiCo Global R&D","INDUSTRY",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":72},"100636700","research-plan-for-early-disease-screening-biomarkers-in-healthy-individuals-100636700","NCT07569094","Research Plan for Early Disease Screening Biomarkers in Healthy Individuals","Inclusion Criteria:\n\n1. Age: 18 - 65 years old, gender not restricted;\n2. No clear history of chronic diseases (hypertension, diabetes, cardiovascular and cerebrovascular diseases, chronic liver and kidney diseases, tumors, etc.);\n3. No infection history in the past 3 months (fever, cough, sore throat, etc.);\n4. No use of antibiotics, hormones, immunosuppressants, etc. within the past 1 month;\n5. Voluntarily sign the informed consent form and cooperate to complete the follow-up.\n\nExclusion Criteria:\n\n1. Abnormal laboratory indicators (ALT\u002FAST \\> 2 times the upper limit of normal value, Cr \\> upper limit of normal value, main indicators of blood routine test are abnormal and have clinical significance);\n2. Pregnant or lactating women;\n3. Recent (within 3 months) history of surgery, trauma or blood transfusion;\n4. Mental illness or cognitive impairment that makes it impossible to cooperate with the research.","65 Years",{"count":147,"type":21},300,"The establishment of reference intervals for biomarkers in healthy populations relies on large-scale, standardized cohort data. However, current baseline data for hematology, liver and kidney function, and multi-omics (genomics, transcriptomics, proteomics, and metabolomics) in Chinese healthy populations are constrained by significant regional disparities and insufficient sample sizes, limiting the development of early disease screening markers. To address these challenges, this study aims to: (1) establish a comprehensive database for hematology and liver\u002Fkidney function indicators; (2) construct a multi-omics database using blood and sputum samples; and (3) explore the correlations among multi-omics indicators and their associations with demographic characteristics.",[28],[62],"NOT_YET_RECRUITING","2026-04-28",{"date":154,"type":34},"2026-05-06",{"date":156,"type":21},"2026-05",{"date":158,"type":21},"2027-12",{"name":160,"class":41},"Zhonghao Fang",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":170,"conditions":171,"keywords":180,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100632068","elderly-care-in-transition---perspectives-of-the-elderly-and-the-staff-100632068","NCT07508878","Elderly Care in Transition - Perspectives of the Elderly and the Staff","Elderly Care in Transition - The Elderlys' and the Staffs' Perspective on Person-centered Care, Environment, Health and Well-being","Inclusion Criteria - Older people:\n\n* Living in nursing homes - academic or standard\n* Able to complete a questionnaire independently or with reading assistance\n\nInclusion Criteria - Staff:\n\n* Employed at an Academic nursing home or a regular nursing home (comparison unit)\n* Belonging to care, nursing, or rehabilitation staff, including registered nurses, occupational therapists, and physiotherapists\n* Able to complete a questionnaire\n\nExclusion Criteria - Older people:\n\n* Individuals receiving only safety alarm services and\u002For meal delivery (no ongoing care contact)\n* Individuals unable to provide informed consent\n* Individuals unable to complete a questionnaire, even with reading assistance\n* Individuals with acute medical conditions that make participation inappropriate (as judged by care staff)\n* Individuals with severe cognitive impairment preventing meaningful participation in surveys.",{"count":169,"type":21},600,"Elderly care in Sweden faces several significant challenges. The number of older people is increasing at the same time as there are fewer of working age. Elderly care staff, such as nurses, care assistants and nurses, have on average more sick days than many other professional groups and often experience high work-related stress. In some municipalities, there are also problems with high staff turnover and a lack of formal competence. At the same time, research shows that many employees experience work in elderly care as meaningful and valuable. Taking advantage of and strengthening these positive aspects is central to creating good conditions for the health and well-being of staff and for the quality of care and care for older people. An important area of development in elderly care is person-centred care, which means that care is based on the individual person's needs, wishes, life history and resources. Person-centred practice emphasises the relationship between the older person, the staff and, if the person so wishes, relatives. Although person-centered care is often seen as an obvious part of good care, research shows that it is not fully implemented in practice and that the introduction of person-centered working methods can be complex and demanding.\n\nThis study is being carried out in collaboration between municipalities and the University of Gävle and is linked to the establishment of nursing homes for the elderly that will function as academic nursing homes. In these nursing homes, person-centered care will be a pronounced focus area. Through recurring measurements, the activities will be monitored and developed in close collaboration between practice and research. The overall aim of the study is to investigate older people's experience of academic nursing homes with a focus on person-centered care and nursing, outdoor environment, health and well-being, and to investigate the staff's experience of person-centered working methods, learning, structural conditions and work-related well-being. The study also aims to analyze the relationship between older people's experiences of person-centered care, outdoor environment, health and well-being, both among older people living in academic nursing homes and among older people living in their own homes. The study has a longitudinal design and data will be collected at several points in time using questionnaires and interviews, which enables both statistical analyses and an in-depth understanding of the participants' experiences over time. By highlighting the perspectives of both older people and staff, the study can contribute new knowledge about how person-centered care can be developed and maintained in practice. In the long term, the results can contribute to a more health-promoting, sustainable and attractive elderly care for both older people and staff.",[172,173,28,174,175,176,177,178,179],"Person-Centred Care","Well Being","Environment","Work-related Well-being","Structural Conditions","Learning Development","Older People","Staff Working in Nursing Homes",[181,182,183,62],"person-centered care","elderly care","work-related well-being","2026-03-30",{"date":186,"type":34},"2026-04-02",{"date":188,"type":21},"2026-04-01",{"date":190,"type":21},"2028-12-31",{"name":192,"class":41},"University of Gavle",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":16,"sex":200,"minAge":18,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":72},"100590224","the-ku-ola-project-enhancing-health-promotion-among-native-hawaiian-men-100590224","NCT06964633","The Ku Ola Project: Enhancing Health Promotion Among Native Hawaiian Men.","The Ku Ola Project","* Inclusion Criteria Self-identified as male At least 18 years of age Hawaii residency Able to read and understand English\n* Exclusion Criteria Under 18 years of age Not proficient in English Any medical condition or situation that, in the investigator's judgment, would make continued participation not in the participant's best interest","MALE",{"count":169,"type":21},[24],"The Ku Ola Project: The goal of this study is to determine if community-based discussion groups and small educational sessions enhance health awareness and behaviors among Native Hawaiian men. The study will examine if these interventions improve participants' health knowledge, attitudes, and self-efficacy while fostering local networks to support ongoing health promotion. Participants will engage in group discussions and educational sessions designed to build capacity and encourage healthy lifestyle choices.",[205,28],"Health Promotion","2026-03-29",{"date":208,"type":34},"2026-03-31",{"date":210,"type":21},"2026-05-01",{"date":212,"type":21},"2028-05-31",{"name":214,"class":41},"University of Hawaii",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":16,"sex":17,"minAge":223,"maxAge":105,"enrollmentInfo":224,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":226,"conditions":227,"keywords":231,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":246},"100569556","food-typologies-and-multidimensional-phenotyping-of-elderly-in-auvergne-rhne-alpes-partage-100569556","NCT06695780","Food Typologies and Multidimensional Phenotyping of Elderly in Auvergne-Rhône-Alpes (Part'AGE)","Exploration Des Typologies Alimentaires et caractérisation Par un phénotypage Multidimensionnel d'Une Population de Personnes âgées de la région Auvergne-Rhône Alpes","Part'AGE","Inclusion Criteria:\n\n* Male or female (balanced sex ratio or at least 40% male to 60% female) in complete autonomy at home.\n* 55 to 75 years old, including the limits\n* 20 ≤ BMI ≤35 kg\u002Fm2\n* Available to carry out the entire protocol, including self-sampling (not sensitive to the sight of one's own blood for example) and agreeing to stop taking food supplements during the study.\n* Having a scale available: at home, pharmacy, family, etc.\n* Having internet access and a device with a screen and camera (PC, tablet, smartphone, etc.) at home or able to go to a project partner (CCAS, Point France Service, Community, Association, etc.) that can provide this access\n* Subject agreeing to give written consent (by phone or videoconferencing), and registration in the national file of volunteers who participate in research\n* Person declaring to be subject to a social security scheme.\n\nExclusion Criteria:\n\n* Weight loss ≥ 5% in 1 month or ≥ 10% in 6 months or ≥ 10% compared to usual weight\n* Treated diabetes\n* Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days prior to inclusion.\n* Hepatocellular insufficiency,\n* Heart failure with decompensation,\n* Renal insufficiency (clearance \\\u003C30 ml\u002Fmin)\n* Chronic anti-inflammatory treatment, long-term corticosteroid therapy \\> 1 month, infiltration\n* Progressive pathology at the time of inclusion (cancer, etc.)\n* Gastrointestinal pathology deemed incompatible with the protocol\n* Unstable thyroid diseases\n* Recent change in eating habits in the last 30 days (weight loss diet, veganism, intermittent fasting, ketogenic diet, etc.)\n* Intense physical activity (activity causing shortness of breath and sweating) \\> 10 hours per week\n* Person in a period of exclusion from the National File of Healthy Volunteers\n* Subject under guardianship, curator-ship, deprived of liberty or under judicial protection","55 Years",{"count":225,"type":21},1000,"To better understand how diet influences health during aging, the French National Research Institute for Agriculture, Food and the Environment (INRAE) is working with the Gérontopôle Auvergne-Rhône-Alpes on a project called Part'AGE. Part'AGE is a participatory research project where researchers want to recruit 1,000 people aged between 55 and 75 years, men and women, living in Auvergne-Rhône-Alpes in urban or rural areas. The goal is to study eating habits and state of health. To do this, researchers will examine many factors that can influence them, such as physical activity, overall health, consumption patterns or territories. Researchers will collect detailed information to classify participants into different groups (food typologies) based on their eating habits and state of health. With this distribution, the goal is to be able to give each group personalized nutritional advice to age in better health.\n\nTo participate in the study, the participants will need to collect a few drops of blood from the end of the finger, a urine sample, and do some tests (mobility, oral health). It will also be necessary to fill out questionnaires on eating habits, physical activity, and other aspects that may influence health. The benefices for to participants will be to contribute to nutrition research and to receive personalized feedback and advices on eating habits.",[228,229,28,230],"Nutritional Assessment","Physical Activity","Oral Health",[232,233,62,234,235,236],"eating behaviors","elderly","phenotyping","food typologies","prevention","2026-03-24",{"date":239,"type":34},"2026-03-27",{"date":241,"type":34},"2025-02-03",{"date":243,"type":21},"2028-02",{"name":245,"class":41},"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement",2,{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":254,"targetDuration":256,"studyType":52,"phases":4,"briefSummary":257,"conditions":258,"keywords":261,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":276,"leadSponsor":278,"locationsCount":72},"100629279","obesity-medicine-bank-of-the-quebec-heart-and-lung-institute---laval-university-iucpq-ulaval-100629279","NCT07472608","Obesity Medicine Bank of the Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval)","Database and Biological Material Bank in Obesity Medicine of the Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval)","To be included in the registry (database + biobank), a person must first be referred to the Bariatric Medicine Clinic at the IUCPQ-ULaval and meet several criteria:\n\n1. Be over 18 years of age\n2. Meet at least one of the following five criteria:\n\n   1. Body mass index ≥30 kg\u002Fm2 with or without comorbidities (preclinical or clinical obesity);\n   2. Require weight loss related to a transplant, bariatric surgery, or another type of surgery (e.g., hernia repair, orthopedic surgery, neurosurgery, etc.);\n   3. History of bariatric surgery resulting in weight regain of at least 15% of the total weight lost;\n   4. History of bariatric surgery resulting in weight loss deemed insufficient by the treating medical team;\n   5. Having undergone bariatric surgery with complications related to it (i.e., flushing syndrome or hypoglycemia, nephrolithiasis, return of comorbidities in remission, abnormalities in phosphocalcic balance and vitamin deficiencies).",{"count":255,"type":21},25000,"25 Years","Obesity medicine, or bariatric medicine, focuses not only on the biological and behavioral aspects, but also on the environmental and social factors that contribute to the development of obesity. Many diseases are associated with obesity, such as type 2 diabetes, hypertension, cardiovascular diseases, numerous cancers, gynecological disorders, etc. Focusing on obesity medicine is crucial for improving patients' quality of life, reducing healthcare costs, and developing effective prevention strategies. The Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval) maintains a clinical database and biological material bank for studying the multidisciplinary management of obesity and its complications.\n\nA biobank is a collection of information, clinical or biochemical data (including radiological, cardiac, and genetic data), and blood samples concerning donors. The information that can be collected includes, for example, age, sex, diagnosis, progression or treatment of a medical condition, medications, DNA, etc. DNA is a molecule present in all cells and contains all the information necessary for the development and functioning of our body.\n\nThis bank aims to better characterize patients' profile receiving follow-up care in obesity medicine, identify predictive factors of success or failure of interventions and adapt management strategies according to specific needs. The collected data and blood samples will be used in several research projects with the following objectives:\n\n1. To document the socioeconomic, demographic, clinical, radiological, genetic, and biochemical characteristics of patients living with obesity and requiring medical follow-up at the bariatric medicine clinic at the IUCPQ-ULaval\n2. To explore the effects or associations of genetic and biochemical determinants on health in the context of obesity\n3. To gain a better understanding of the pathophysiology and genes involved in obesity and associated metabolic abnormalities\n4. To evaluate the clinical utility of non-invasive biomarkers in the screening of preclinical obesity and its comorbidities and\u002For\n5. To evaluate the effectiveness of medications, health behavior changes, and bariatric surgery in order to develop optimal interventions aimed at improving the health and medical management of people with obesity.",[259,260,28],"Obesity","Metabolic Abnormalities",[262,263,264,265,266,267,268,269,270,28,271],"Biobank","Clinical data","Radiological data","Genetic data","Biochemical data","Cardiac data","Blood samples","Prospective patient registry","Bariatric medicine","Obesity medicine","2026-03-11",{"date":274,"type":34},"2026-03-16",{"date":31,"type":21},{"date":277,"type":21},"2051-06",{"name":279,"class":41},"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":22,"phases":289,"briefSummary":290,"conditions":291,"keywords":295,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":246},"100456503","national-sponsorship-program-for-transitioning-service-members-100456503","NCT05224440","National Sponsorship Program for Transitioning Service Members","Partnered Implementation Evaluation of a National Sponsorship Program for Transitioning Service Members ( PEC 20-170)","Inclusion Criteria:\n\n* TSMVs must be 18-years of age or older,\n* be approximately 6 months from military discharge and\n* be planning to transition to one of the target cities included in the evaluation during an active enrollment window for the respective city.\n\nExclusion Criteria:\n\nN\u002FA",{"count":288,"type":21},630,[24],"Background:\n\nThe United States is undergoing a suicide epidemic for its youngest Veterans (18-to-34-years-old) as their suicide rate has almost doubled since 2001. Veterans are at the highest risk during their first-year post-discharge, thus creating a \"deadly gap\" for them. In response, the nation has developed strategies that emphasize a preventive, universal and public health approach and embrace the value of community interventions. The three-step theory of suicide suggests that community interventions that reduce pain from reintegration difficulties and promote connectedness for Veterans as they transition to civilian life have the greatest likelihood of success. Recent research shows that the effectiveness of community interventions can be enhanced when augmented by volunteer and certified sponsors (1-on-1) who actively engage with Veterans, as part of the Veterans Affairs' Transitioning Servicemember\u002FVeteran (TSMV) Sponsorship Initiative.\n\nMethod\u002FDesign:\n\nThe purpose of this trial is to determine how to implement the Veteran Sponsorship Initiative in six cities in Texas in collaboration with the US Department of Defense, VA, Texas government, and local stakeholders. Texas is an optimal location for this large-scale implementation as it has the second largest population of Veterans aged 18-to-34-years-old and is home to the largest US military installation, Fort Hood. The first aim is to further determine the effectiveness of the Sponsorship Initiative, as evidenced by measures of proximal variables (reintegration difficulties, health\u002Fpsychological distress, VA healthcare utilization and connectedness) and distal variables (suicidal ideation and behaviors). The second aim is to determine how best to implement the Veteran Sponsorship Initiative in Texas with the intent of future expansion in more states. TSMVs (n=630) will be recruited from military installations six months prior to discharge and prior to moving to target cities. The evaluators are utilizing implementation strategies, such as building community partnerships and external facilitation. Evaluation will be conducted through interviews with TSMVs and periodic reflections with key stakeholders to identify barriers, facilitators, and adaptations. Outcome evaluations will be conducted with TSMVs completing surveys and data collection from working with stakeholders.\n\nDiscussion:\n\nThis evaluation will have important implications for the national implementation of community interventions that address the epidemic of TSMV suicide. Aligned with the Evidence Act, it is the first large-scale implementation of an evidence-based practice that conducts a thorough assessment of TSMVs during the \"deadly gap\".",[292,28,293,294],"Reintegration Difficulties","Suicidal Ideation and Behaviors","Connectedness",[296,297,298,294,299,300,301,302],"Reintegration difficulties","Transitioning Servicemember\u002FVeteran","Veteran Sponsorship Initiative","Suicide prevention","VA Utilization","Community intervention","Stepped Wedge","2026-01-13",{"date":305,"type":34},"2026-01-14",{"date":307,"type":34},"2022-02-04",{"date":309,"type":21},"2026-09-30",{"name":311,"class":312},"VA Office of Research and Development","FED",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":325,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":72},"100620351","expanding-veteran-sponsorship-initiative-to-support-high-risk-transitioning-servicemembers-and-veterans-a-precision-medicine-approach-100620351","NCT07356492","Expanding Veteran Sponsorship Initiative+ to Support High-Risk Transitioning Servicemembers and Veterans: A Precision Medicine Approach","Expanding Veteran Sponsorship Initiative+ to Support High-Risk Transitioning Servicemembers and Veterans: A Precision Medicine Approach (PEC 24-113)","Inclusion Criteria:\n\n* TSMVs must be 18-years of age or older\n* Enroll prior to military discharge\n* Be planning to transition from one of the target military installations' included in the evaluation during an active enrollment window\n\nExclusion Criteria:\n\n* The participants Army STARRS score cannot identify the TSMV as low risk nor as acute high risk for suicide",{"count":321,"type":21},2700,[24],"Background Young Veterans in the U.S. face a heightened risk of suicide, particularly during the first year after leaving military service-a period often referred to as the \"deadly gap.\" Suicide rates among Veterans aged 18 to 34 have nearly doubled since 2001, and research shows that reintegration challenges during this transition are closely linked to increased suicide risk.\n\nThe Veteran Sponsorship Initiative (VSI) was developed to address this critical period by connecting Transitioning Servicemembers and Veterans (TSMVs) with trained, VA-certified peer sponsors. These sponsors help TSMVs navigate civilian life and access VA care. Early evaluations show that TSMVs matched with sponsors are more likely to report lower levels of reintegration difficulties, higher levels of social support, engage in VA services and report lower rates of depression and suicide risk.\n\nThis project enhances VSI by integrating predictive analytics-developed in partnership with Harvard Medical School and the DoW STARRS-LS team-to identify high-risk TSMVs before they leave the military. Those identified receive not only a sponsor but also targeted VA mental and health care services. This hybrid effectiveness-implementation study will evaluate the impact of this enhanced model (VSI+) on mental health outcomes and VA engagement among 2,700 high-risk TSMVs.\n\nMethod\u002FDesign\n\nThe purpose of this PEI proposal is to evaluate VSI expansion into VSI+ with enrollment occurring on four US Army installations (FY2026-2027). The study employs a pragmatic cluster-randomized trial with embedded mixed-method implementation evaluation to compare three arms:\n\n1. Transition as Usual (TAU)\n2. VSI Base= peer sponsorship and community support\n3. VSI+= VSI Base plus VA stepped care services\n\nThe evaluation is guided by the RE-AIM framework to assess:\n\n* Reach (enrollment rates)\n* Effectiveness (reintegration difficulties, depression, anxiety, suicidal ideation\u002Fbehavior, and VA utilization outcomes)\n* Adoption (site and staff uptake)\n* Implementation (fidelity and feasibility)\n* Maintenance (sustainability)\n\nStudy Aims\n\n1. Effectiveness: Evaluate the impact of VSI Base and VSI+ on reintegration difficulties, depression, anxiety, suicidal ideation\u002Fbehavior, and VA utilization outcomes.\n2. Implementation: Assess the feasibility and fidelity of implementing VSI Base and VSI+ across multiple sites using a bundled strategy.\n3. Economic Impact: Estimate the budget impact of VSI Base and VSI+ on healthcare costs, including inpatient, emergency, and outpatient care.",[292,293,28,294],[326,327,328,297,329,300,330,331],"Suicide","Reintegration","Social Determinants of Health","Suicide Prevention","Community Intervention","Suicidal Behavior","2026-01-12",{"date":334,"type":34},"2026-01-21",{"date":336,"type":34},"2026-01-01",{"date":338,"type":21},"2027-09-30",{"name":311,"class":312},{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":16,"sex":17,"minAge":223,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":72},"100601199","temporal-investigation-of-multimodal-elements-100601199","NCT07107386","Temporal Investigation of Multimodal Elements","An Observational, Longitudinal Study to Characterize the Dynamic Structure of Molecular and Digital Health Data in Healthy Older Adults","TIME","Inclusion Criteria:\n\n* Healthy adults aged 55 years or older.\n* Own a smartphone capable of running study-specific apps.\n* Willing and able to attend in-person visits at the Buck Institute in Novato, CA.\n* Reside in the Pacific or Mountain Time Zones.\n* Able to speak, read, and write English.\n* Willing to wear study devices continuously and allow researchers access to all data.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Hospitalization within the last 3 months.\n* Needing assistance with daily living activities.\n* Working night or irregular shifts.\n* Certain musculoskeletal, pulmonary, or cardiovascular conditions.\n* Uncontrolled high blood pressure (BP \\> 180\u002F100 mmHg).\n* Bleeding disorders, anemia requiring treatment, or recent blood donation.\n* Poor vein access.\n* Unstable health conditions.\n* Chronic antibiotic use.\n* Certain psychiatric disorders.\n* Use of excluded medications, supplements, or products, including certain antibiotics or frequent sleep aids.",{"count":349,"type":21},120,"The TIME Study is a research project aiming to understand the body's natural rhythms. The goal is to see how daily and weekly changes in our bodies-from what's happening at a molecular level to data from wearable devices-are connected.\n\nWhat is the study about? This study is trying to create a detailed map of how a person's body changes over time. By looking at information from blood, urine, and other samples, as well as data from smartwatches and other devices, researchers want to learn how our bodies' natural cycles work in healthy older adults. The long-term goal is to use this knowledge to help develop more personalized healthcare in the future.\n\nWho can participate? The study is looking for healthy adults, age 55 or older, who have a smartphone and are able to travel to the Buck Institute in Novato, California, for study visits.\n\nParticipants will be asked to:\n\nAttend weekly visits over 11 weeks to provide blood and other samples.\n\nWear health-tracking devices like a smart ring and watch.\n\nUse a smartphone app to answer questions about their daily routines.\n\nComplete two \"challenge\" tests, including drinking a glucose solution and exercising on a stationary bicycle.\n\nReturn for follow-up visits after 6 and 12 months.\n\nAre there any risks or benefits? Benefits: There are no direct health benefits for participants. However, the information gained will help scientists create better diagnostic tools and treatments for future generations.\n\nRisks: The main risks are minor discomfort from things like blood draws or skin irritation from the wearable devices. All personal information and data are kept private and secure.",[28],"2025-08-12",{"date":354,"type":34},"2025-08-15",{"date":356,"type":34},"2025-06-15",{"date":358,"type":21},"2028-06",{"name":360,"class":41},"Buck Institute for Research on Aging",{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":16,"sex":17,"minAge":368,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":384},"100601817","effectiveness-of-school-based-oral-health-intervention-for-children-100601817","NCT07115433","Effectiveness of School-based Oral Health Intervention for Children","Effectiveness of a School-Based Oral Health Promotion Program on Oral Health Practices, Behaviour, Self-Efficacy, and Clinical Outcomes Among Primary School Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 6-8 years enrolled in selected schools\n* Written informed consent from parents\u002Fguardians and assent from children\n\nExclusion Criteria:\n\n* Children with systemic conditions affecting oral health\n* Those currently in other oral health interventions","6 Years","8 Years",{"count":169,"type":21},[24],"Schools provide an ideal setting for early interventions. Evidence suggests that educational programs incorporating behavioural change theories can improve oral hygiene practices and clinical outcomes.\n\nA School-Based Oral Health Promotion Program on Oral Health Practices, Behaviour, Self-Efficacy, and Clinical Outcomes Among Primary School Children for six months, while the control group will receive no intervention, only routine care.",[374,28],"Oral","2025-08-03",{"date":377,"type":34},"2025-08-11",{"date":379,"type":21},"2025-08-05",{"date":381,"type":21},"2026-02-10",{"name":383,"class":41},"Universiti Putra Malaysia",3,{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":16,"sex":393,"minAge":104,"maxAge":394,"enrollmentInfo":395,"targetDuration":4,"studyType":22,"phases":397,"briefSummary":398,"conditions":399,"keywords":406,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":72},"100569196","how-a-single-workout-affects-gut-bugs-in-women-with-different-fitness-levels-and-body-types-100569196","NCT06691100","How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types","The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes","FITGut-W","Inclusion Criteria:\n\n* Biological sex: female\n* BMI 19 to 24.99 kg\u002Fm2 or BMI 30-40 kg\u002Fm2\n* Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)\n* Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).\n\nExclusion Criteria:\n\n* Biological sex: male\n* BMI \\\u003C 19 kg\u002Fm2 or \\> 40 kg\u002Fm2\n* Currently pregnant, \\\u003C 2 years postpartum, lactating\n* Currently taking any herbal, fiber, or prebiotic supplement\n* Current or 1-month before the study, taking oral or vaginal antibiotics\n* Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.","FEMALE","40 Years",{"count":396,"type":21},40,[24],"This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w\u002Fo obesity). The specific aims are as follows:\n\n* Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity.\n* Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.",[400,259,401,402,403,404,28,405],"Weight Management","Exercise","Women","Gut Microbiome","Metabolome","Gut Microbiota",[405,407,401,400,259],"Womens Health","2025-07-22",{"date":410,"type":34},"2025-07-24",{"date":412,"type":34},"2024-10-16",{"date":414,"type":21},"2027-10-16",{"name":416,"class":41},"George Washington University",{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":16,"sex":17,"minAge":424,"maxAge":425,"enrollmentInfo":426,"targetDuration":427,"studyType":52,"phases":4,"briefSummary":428,"conditions":429,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":72},"100528175","characteristics-of-intestinal-bacteria-and-their-effects-on-growth-and-immune-function-in-children-at-high-altitude-100528175","NCT06157346","Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude","Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude in Diqing Tibetan Autonomous Prefecture, Yunnan Province","Inclusion Criteria:\n\n* Children aged 1-3 years old\n* Both men and women;\n* The child's legal guardian signed the informed consent to participate in the study.\n* The legal guardian of the child commits to follow the study procedures and cooperate with the entire study process\n\nExclusion Criteria:\n\n* Probiotics or antibiotics within 1 month\n* Associated with clinically significant abnormalities in liver and kidney function, nervous system, respiratory system, and coagulation function as determined by the investigator\n* Unstable vital signs;\n* Have other underlying medical conditions\n* Individuals deemed unsuitable for this clinical trial.","1 Year","3 Years",{"count":147,"type":21},"7 Days","Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora. Therefore, the development and maturation process of children's intestinal flora in plateau areas was discovered, and its relationship with children's immunity, metabolism, and growth was understood. The mechanism of action of children's intestinal flora on immunity, growth and development was further analyzed by comparing it with people in low-altitude areas, to provide a scientific basis for improving children's health in plateau areas.",[28,430,405],"Children, Only","2025-04-03",{"date":433,"type":34},"2025-04-04",{"date":435,"type":34},"2023-10-16",{"date":437,"type":21},"2026-08-31",{"name":439,"class":41},"Ruijin Hospital",{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":446,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":448,"conditions":449,"keywords":451,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":72},"100567060","acute-effects-of-meteorological-factors-and-air-pollution-on-cardiovascular-health-100567060","NCT06663267","Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health","Inclusion Criteria:\n\n·Relevant records in the physical examination database shall be ≥3 times\n\n·≥18 years old\n\nExclusion Criteria:\n\n* Relevant records in the physical examination database shall be ≥３times\n* Serious heart and lung diseases\n* Malignant tumors\n* Serious mental illness in the past",{"count":447,"type":21},350000,"The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:\n\n1. How do meteorological factors and air pollution affect cardiovascular system?\n2. What is the interaction between meteorological factors and air pollution on cardiovascular system?\n\nParticipants will:\n\n1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound.\n2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.",[450,28],"Cardiovascular System",[450,452,453,454],"Air Pollution Exposure","Acute effect","Weather","2024-10-26",{"date":457,"type":34},"2024-10-29",{"date":459,"type":21},"2024-11",{"date":461,"type":21},"2028-05",{"name":463,"class":41},"The Affiliated Hospital of Hangzhou Normal University"]