[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthcare-associated-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthcare-associated-infection":118},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100528052","transmission-and-acquisition-of-nontuberculous-mycobacteria-outbreak-investigation-transmit-100528052",false,"NCT06155747","Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)","TrANsMIt","Inclusion Criteria:\n\n* Male or female participant of any age who has a history of NTM or a first positive NTM culture collected as part of routine clinical care from expectorated sputum, induced sputum and\u002For bronchoalveolar lavage.\n\nExclusion Criteria:\n\n* No NTM respiratory culture","ALL","1 Month","99 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to support U.S. healthcare centers in determining if they may have an NTM outbreak among patients receiving care at the healthcare center. The study applies a standardized, reproducible outbreak investigation approach across diverse healthcare settings. This study focuses on patients with NTM isolates suspected to be part of an outbreak, receiving care at a specific U.S. healthcare center.\n\nThe main questions it aims to answer are:\n\nCan application of a standardized epidemiologic investigation framework support evaluation of whether clustered NTM infections may be consistent with healthcare-associated exposure? Are respiratory NTM isolates genetically related to environmental NTM isolates identified within healthcare settings or shared home water sources?\n\nResearchers will compare clinical, epidemiologic, molecular, and infection prevention data from suspected NTM isolates to determine whether patterns are consistent with healthcare-associated transmission or acquisition.\n\nParticipants (healthcare centers and selected patients) will:\n\n* Implement a standardized epidemiologic investigation using the Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria (HALT-NTM) toolkit\n* Submit available respiratory and environmental NTM isolates for molecular comparison, when applicable\n* Optionally collect dust and water biofilm samples within the healthcare setting\n* Complete a survey to provide home address history for watershed mapping, when clustered infections are identified",[25,26,27,28],"Nontuberculous Mycobacterial Pulmonary Infection","Outbreak Investigation","Healthcare Associated Infection","Mycobacterium Infections",[30,25,31,27,32,33],"Epidemiology","Outbreak investigation","Infection transmission","Infection acquisition","RECRUITING","2026-05-20",{"date":37,"type":38},"2026-05-26","ACTUAL",{"date":40,"type":38},"2023-03-01",{"date":42,"type":21},"2036-12-28",{"name":44,"class":45},"University of North Carolina, Chapel Hill","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100548433","surgical-handwashing-drying-with-one-or-two-surgical-towels-100548433","NCT06420934","Surgical Handwashing: Drying With One or Two Surgical Towels","Comparison of the Breach of the Aseptic Barrier After Surgical Handwashing: Drying With One or Two Surgical Towels","Inclusion Criteria:\n\n* Workers and students who have a current affiliation with the institutions where the study will be executed.\n* Workers and students whose practice or work involves performing surgical handwashing at least once a week for invasive procedures.\n\nExclusion Criteria:\n\n* Workers and students who do not wish to participate in the study.\n* Workers and students whose work activities do not allow them time to participate in the study.\n* Workers and students who are allergic to the fluorescent cream\n* Workers and students whose nails exceed a length of 0.5 cm from the fingertip edge.\n* Workers and students whose nails are painted with polish.\n* Workers and students who refuse to remove jewelry and accessories from wrists and hands.\n* Workers and students with recent wounds on hands or forearms, including tattoos done in the last month.\n* Workers and students who do not adhere to the handwashing and drying technique taught prior to the study's implementation.",true,"18 Years",{"count":57,"type":21},72,"INTERVENTIONAL",[60],"NA","This study aims to determine whether the use of two sterile towels for drying after surgical handwashing results in fewer contamination events compared to the use of only one towel among healthcare personnel. This randomized, multicenter, superiority-controlled trial will enroll up to 72 healthcare workers and surgical residents from three hospitals in Bogotá, Colombia. A fluorescent product will simulate bacteria, and contamination will be assessed by evaluating the presence of fluorescent cream after hand drying technique with either two or one surgical sterile towel. Data will be collected through REDCap and deidentified. Differences in the proportion of contamination between the two groups will be assessed using an exact Fischer test, and confounding variables will be included in the analysis through logistic multivariate regression, with a significance level set a priori at 0.05. Results will be submitted for publication in a peer-reviewed journal.",[63,64,27,65],"Hand Hygiene","Surgical Wound Infection","Medical Errors",[67,68,69,27,63],"Surgical Scrubbing","Handwashing","Disinfection","2024-10-01",{"date":72,"type":38},"2024-10-02",{"date":74,"type":38},"2024-04-26",{"date":76,"type":21},"2025-06-30",{"name":78,"class":45},"Instituto de Ortopedia Infantil Roosevelt",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":58,"phases":89,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100514518","phase-4-early-impact-therapy-with-ceftazidime-avibactam-via-rapid-diagnostics-100514518","NCT05979545","EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics","EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics Versus Standard of Care Antibiotics and Diagnostics in Patients With Bloodstream Infection, Hospital-acquired Pneumonia or Ventilator-associated Pneumonia Due to Pseudomonas Aeruginosa or Carbapenemase Producing Enterobacterales (RAPID)","RAPID","Inclusion Criteria:\n\n1. patient developed clinical symptoms compatible with bloodstream infection, hospital-acquired or ventilator-associated pneumonia (hospital-acquired and ventilator-associated pneumonia should fulfil US CDC NHSN criteria) AND,\n2. an appropriate specimen has been received by the participating laboratory - that is, a blood culture bottle showing Gram negative bacilli or a respiratory sample collected for clinical purposes showing Gram negative bacilli on Gram stain;\n\nExclusion Criteria:\n\n1. Refractory shock or comorbid condition such that patient not expected to survive more than 48 hours; OR,\n2. where the bloodstream infection is thought to be related to a vascular catheter and the catheter is unable to be removed; OR,\n3. treatment is not with the intent to cure the infection; OR,\n4. patient is incarcerated in a correctional facility; OR,\n5. patients previously randomised in this trial within the last 60 days.",{"count":88,"type":21},1900,[90],"PHASE4","The goal of this clinical trial is to propose a seamless intervention linking rapid bacterial isolate identification and antibiotic resistance gene detection and targeted antibiotic prescription to minimise time between infection onset and appropriate treatment in patients with Pseudomonas aeruginosa or carbapenemase producing Enterobacterales infections. This is an investigator initiated trial.\n\nThe primary hypothesis is that these interventions will lead to improved clinical outcomes amongst patients with hospital-acquired bloodstream infection, hospital-acquired pneumonia or ventilator-associated pneumonia due to carbapenem non-susceptible Pseudomonas aeruginosa or Enterobacterales, compared to standard antibiotic susceptibility testing.\n\nPatients will be randomised to either a control or intervention arm. Patients randomised to the intervention arm will have relevant specimens analysed by rapid microbiological diagnostics and will have early availability of ceftazidime-avibactam if appropriate. Patients randomised to the control arm, will have samples analysed by clinical microbiology laboratories using standard of care diagnostics. Antibiotics will be available to these patients as per usual institutional practice.",[93,94,27,95,96],"Blood Stream Infections","Ventilator Associated Pneumonia","Carbapenem-Resistant Enterobacteriaceae Infection","Hospital-acquired Pneumonia",[98,99,100,101,102,103,104,105,106,107],"rapid diagnostics","ceftazidime-avibactam","carbapenemase producing Enterobacterales","hospital-acquired","MDR","AMR","ASP","CRE","BCID2","PN Plus","2024-03-03",{"date":110,"type":38},"2024-03-06",{"date":112,"type":38},"2023-12-12",{"date":114,"type":21},"2026-12-31",{"name":116,"class":45},"National University of Singapore",4,"Healthcare-associated Infection"]