[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-adult-volunteer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-adult-volunteer":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100637952","the-role-of-fatigue-associated-with-strength-training-in-exercise-induced-hypoalgesia-100637952",false,"NCT07577622","The Role of Fatigue Associated With Strength Training in Exercise-induced Hypoalgesia","The Role of Fatigue Associated With Different Protocols of Strength Training in Exercise-induced Hypoalgesia: A Randomized Crossover Trial","FATIGUEIH","Inclusion Criteria:\n\n* Healthy, asymptomatic subjects\n* Being physically active\n\nExclusion Criteria:\n\n* Experiencing episodes of acute pain in any part of the body.\n* Having chronic pain or a recent history of chronic pain conditions considered resolved within the last 6 months.\n* Having a serious illness or inability to perform moderate or intense physical activity.\n* Having taken pain relievers, fever reducers, anti-inflammatory drugs (NSAIDs), steroids, opioids, or similar medications in the 24 hours before a session.\n* Having consumed alcohol or other psychoactive substances, caffeine, or other stimulants in the 24 hours before a session.\n* Having performed tiring physical activity or strength exercise in the 24 hours before a session.",true,"ALL","18 Years","45 Years",{"count":22,"type":23},27,"ESTIMATED","INTERVENTIONAL",[26],"NA","Strength exercise is an active and dynamic activity that involves applying force against a resistance. This produces fatigue, seen as a reduced ability to apply force during and after the exercise, and perceived effort, which is a person's subjective feeling of how hard they are working.\n\nStrength exercise can also be used for therapy, as it has many benefits for different parts of the body. One of these is changing how the individual feels pain. It has been shown that doing strength exercises can reduce pain perception, a phenomenon called exercise-induced hypoalgesia (EIH), although the exact physical reasons and the amount of exercise needed to cause this effect are not yet known.\n\nOne of the most studied exercises in this area is the leg extension machine. This is a specific exercise where the legs move freely (open kinetic chain) and the machine guides the movement, which helps keep things stable and limits the effect of other factors. It is usually used to strengthen and grow the muscles in the front of the thigh, especially the quadriceps, but it can also be used to study the effects on EIH.\n\nThe main goal of this study is to see if fatigue and perceived effort during strength exercise are important for EIH to happen in healthy people. Participants will complete 3 sessions, at least 7 days apart. These will include a control session and 2 sessions designed to show different levels of fatigue. Before, during, and after the sessions, the investigators will measure pain sensitivity, isometric strength, and perceived effort. Also, there will be a test to find the maximum weight for 10 repetitions and several questionnaires to collect basic info (sex, age, height...), weekly physical activity, experience with strength training, and other factors like sleep quality, stress, and mood. All this information will be completely anonymous when the study results are shared.",[29,30],"Exercise Induced Hypoalgesia","Healthy Adult Volunteer",[32,33,34,35,36,37],"Fatigue","Exercise","Hypoalgesia","Strength training","Healthy adult","leg extension","NOT_YET_RECRUITING","2026-05-05",{"date":41,"type":42},"2026-05-11","ACTUAL",{"date":44,"type":23},"2026-05-15",{"date":46,"type":23},"2027-06-30",{"name":48,"class":49},"Universidad Miguel Hernandez de Elche","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":50},"100620994","phase-1-a-phase-1-clinical-trial-to-evaluate-the-safety-and-pharmacokinetics-of-dw4421-t1-and-dw4421s-t1-in-healthy-adult-volunteers-100620994","NCT07364851","A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetics of DW4421-T1 and DW4421S-T1 in Healthy Adult Volunteers","A Randomized, Open-label, Single-dose, 2-sequence, Two-period, Crossover Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics After Administration of DW4421-T1 and DW4421S-T1 in Healthy Adult Volunteers","Inclusion Criteria:\n\n* Healthy adult aged 19 to 50 (inclusive) years\n* Subjects weighing between 50 kg and 90 kg with BMI between 18 and 27 kg\u002Fm2 (inclusive)\n\nExclusion Criteria:\n\n* clinical significant liver, kidney, nervous system, respiratory, endocrine, hematology and oncology, cardiovascular, urinary, and mental diseases or past history","19 Years","50 Years",{"count":61,"type":23},38,[63],"PHASE1","Safety and pharmacokinetic characteristics evaluation of DW4421-T1 and DW4421S-T1",[30],"2026-01-18",{"date":68,"type":42},"2026-01-23",{"date":70,"type":23},"2026-03-06",{"date":72,"type":23},"2026-08-30",{"name":74,"class":75},"Daewon Pharmaceutical Co., Ltd.","INDUSTRY",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":24,"phases":85,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100606972","phase-2-the-effect-of-bifidobacterium-probiotics-on-gut-microbiota-changes-in-healthy-adults-during-short-term-travel-along-the-silk-road-100606972","NCT07182500","The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road","Inclusion Criteria:\n\n* Generally healthy adults\n* Scheduled to undertake a short-term round trip (less than 7 days) to abroad\n* Able to complete study procedures\n* Willing to take intervention products\n\nExclusion Criteria:\n\n* Use of antibiotics, probiotics, hormones, immunosuppressants, biologics or JAK inhibitors within four weeks prior to study\n* Chronic or severe systemic diseases (including cardiovascular, hepatic, renal, malignant or psychiatric disorders)\n* Uncontrolled parasitic infections\n* Long-term use of corticosteroids, growth hormone, vitamin B12, lysine or inositol\n* Major surgery within one month\n* Allergy to probiotic components\n* Other conditions deemed inappropriate by investigators","65 Years",{"count":84,"type":23},75,[86],"PHASE2","Journeying along the historic Silk Road exposes travelers to dramatic dietary shifts, unfamiliar microbial environments, and the physical stresses of long-distance travel-all known to disrupt gut health and cause gastrointestinal complaints, including traveler's diarrhea and sleep disturbances. Such disruptions may also elevate the risk of acquiring antibiotic-resistant organisms.\n\nThis randomized, double-blind, placebo-controlled trial evaluated whether probiotic supplementation can help maintain gut microbial balance and support traveler well-being during trips to Silk Road regions. In addition to monitoring changes in gut microbiota composition, the study assessed gastrointestinal symptoms, sleep quality, anxiety levels, overall well-being, gut immune markers, functional profiles of the microbiome, and the presence of antibiotic resistance genes.",[30],[90,91,92],"probiotc","travel","Silk Road","RECRUITING","2025-12-02",{"date":96,"type":42},"2025-12-10",{"date":98,"type":42},"2025-10-16",{"date":100,"type":23},"2025-12-31",{"name":102,"class":49},"Universiti Sains Malaysia",2]