[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-ageing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-ageing":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,52,94,125,167,212],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100637926","mitigating-mitochondrial-rna-release-during-aging-to-control-inflammation-and-senescence-100637926",false,"NCT07596615","Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence","Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence, Preserving Organ Function and Enhancing Healthspan","MIRACLE","Inclusion Criteria:\n\n* Male and female\n* Age between 18 and 90 years (stratified in three groups: young, middle-aged, elderly)\n* Written informed consent\n\nExclusion Criteria:\n\n* Inability to understand the potential risk and benefits of the study\n* Legal incapacity\n* Subjects who have taken antibiotics, anti-inflammatory drugs, or antihistamines within the past 7 days\n* Diagnosis of diabetes mellitus\n* Use of anticoagulant medications\n* Any subject with a contraindication to the mini-invasive biopsy procedure",true,"ALL","18 Years","90 Years",{"count":22,"type":23},90,"ESTIMATED","INTERVENTIONAL",[26],"NA","The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups. Skin-derived fibroblasts and peripheral blood mononuclear cells (PBMCs) will be isolated from skin biopsy and blood samples to characterize age-related cellular and molecular changes and to test experimental therapeutic strategies identified in preclinical studies. Serum, plasma, and whole-blood RNA will be used for protocol-defined analyses of circulating inflammatory mediators and systemic transcriptional signatures related to inflammation, type I interferon activation, mitochondrial stress response, immune aging, and senescence-associated pathways.",[29,30,31],"Aging","Inflammation","Healthy Ageing",[33,34,35,36,37,38],"mitochondrial dysfunction","skin-derived fibroblasts","mtRNA","PBMCs","senescence","inflammaging","NOT_YET_RECRUITING","2026-05-12",{"date":42,"type":43},"2026-05-19","ACTUAL",{"date":45,"type":23},"2026-09",{"date":47,"type":23},"2031-09",{"name":49,"class":50},"Mario Negri Institute for Pharmacological Research","OTHER",2,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":72,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":93},"100633575","the-effects-of-peptistrong-and-whey-on-muscle-function-in-older-adults-100633575","NCT07528469","The Effects of PeptiStrong and Whey on Muscle Function In Older Adults","The Effects of PeptiStrong and Low Dose Whey Protein Versus High Dose Whey Protein Alone on Muscle Function In Older Adults","Inclusion Criteria:\n\n* Men and women aged 60 to 85 years at the time of enrolment\n* Community-dwelling (living independently or with minimal assistance)\n* Able to walk independently (with or without a walking aid) and complete simple physical function tests (such as standing up from a chair and walking short distances)\n* Willing and able to attend two study visits at the research facility (baseline and end of study)\n* Willing and able to consume a protein drink containing whey protein (derived from milk) once daily for 30 days\n* Able to understand the study information and provide written informed consent\n\nExclusion Criteria:\n\n* Any known food allergy or intolerance to fava bean protein or milk protein\n* Diagnosed kidney disease or any medical condition where increased protein intake is contraindicated\n* Yes to any of the answers on the \"Older Adult Functional Assessment Screening Questionnaire\"\n* Individuals with implanted electronic devices\n* Current or recent (within the past 3 months) participation in another clinical research study involving a nutritional or exercise intervention\n* Conditions that significantly impair mobility or balance such that safe completion of the physical function tests is not possible","60 Years","85 Years",{"count":62,"type":23},80,[26],"Examining the effects of PeptiStrong and protein on muscle function in older adults",[31,66,67,68,69,70,71],"Protein Supplementation","Muscle Health","Muscle Function","Hand Grip Strength","Longevity","Peptides",[73,74,75,76,70,77,78,79,80,81],"Healthy Aging","Protein supplementation","Muscle function","Physical performance","Bioactive peptides","Hand grip strength","Short performance physical battery","Nuritas","Liverpool John Moore University","RECRUITING","2026-04-30",{"date":85,"type":43},"2026-05-06",{"date":87,"type":43},"2026-04-06",{"date":89,"type":23},"2026-10-30",{"name":91,"class":92},"Nuritas Ltd","INDUSTRY",1,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":24,"phases":103,"briefSummary":104,"conditions":105,"keywords":109,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":93},"100629660","optimizing-intrinsic-capacity-for-functional-independence-and-to-impede-frailty-in-older-adults-adaptation-of-the-who-icope-for-healthy-ageing-in-singapore-100629660","NCT07477561","Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore","INFINITY-ICOPE","Inclusion Criteria: (in Phases 1, 2 and 3):\n\n* Any Singaporean or Permanent Resident (PR) aged 60 years and above\n* Able to provide informed consent (or legally acceptable representative available)\n\nExclusion Criteria (in Phases 1, 2 and 3):\n\n* Non-Singaporeans or non-PRs under 60 years of age\n* Residents of sheltered or nursing homes",{"count":102,"type":23},600,[26],"The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early identification and targeted interventions can improve health outcomes and support healthy ageing. The main questions it aims to answer are:\n\n* Can combined frailty and intrinsic capacity screening with targeted interventions prevent or reduce functional decline in older adults, as measured by changes in life space mobility?\n* Will at least 80% of screened older adults adhere to recommended care pathways and interventions?\n* Can this screening and intervention programme demonstrate sustainability through continued community participation and recruitment of new partner organizations beyond the initial implementation phase? The investigators will compare an intervention group (receiving immediate assessment and clinical referrals based on identified needs) to a wait-list control group (receiving the same interventions 12 months later) to see if early intervention leads to better health outcomes and quality of life.\n\nParticipants will:\n\n* Attend 4 study visits over 2 years (at 6-monthly intervals in the first year, with final assessment at end of year 2), each lasting up to 2 hours.\n* Undergo comprehensive screening assessments including mobility, cognition, mental health, hearing, vision, and nutritional status.\n* Receive 2 follow-up phone calls at 3-month and 9-month intervals to monitor progress.\n* If in the intervention group: receive personalized referrals for further care (which may include comprehensive geriatric assessment, primary care reviews, rehabilitation, or dietitian consultations) and guidance on using a mobile health monitoring application.\n* If in the wait-list control group: receive the same interventions after their 3rd study visit (12 months later).",[106,107,108,31],"Frailty in Older Adults","Intrinsic Capacity","Age-related Functional Decline",[110,111,112,113,114,115],"Frailty","Intrinsic capacity decline","Community-dwelling older adults","Age-related functional decline","Healthy ageing","Early identification and management of frailty and functional decline","2026-04-14",{"date":118,"type":43},"2026-04-17",{"date":120,"type":43},"2023-07-17",{"date":122,"type":23},"2028-01-15",{"name":124,"class":50},"Sengkang General Hospital",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":17,"sex":18,"minAge":132,"maxAge":60,"enrollmentInfo":133,"targetDuration":4,"studyType":24,"phases":135,"briefSummary":136,"conditions":137,"keywords":145,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":93},"100628795","l-serine-and-strength-training-in-the-elderly-100628795","NCT07466290","L-serine and Strength Training in the Elderly","AAAging","Inclusion Criteria:\n\n* Men and women between the ages of 65 and 85\n* Mini-Mental-State \\>23\n* Independently mobile, without aids (walker, cane, etc.)\n\nExclusion Criteria:\n\n* Chronic diseases that contraindicate medical training therapy\n* Regular strength training (\\>1x\u002Fweek) in the last 6 months before confinement\n* Frailty Index ≥ 3\n* Lack of written consent to test physical performance\n* Regular use of Cortison-containing medications or Antibiotika\n* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body\n* Non-compliance with the study protocol: \\\u003C70% of the planned L-serine administration, \\\u003C70% of the strength training","65 Years",{"count":134,"type":23},126,[26],"This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.\n\nHealthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.\n\nCognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.",[138,70,139,140,31,141,142,143,144],"Brain Health","Cognitive Performance","Strength Training Effects","Ageing","Cognition","Memory","Muscle Strength",[31,146,147,148,149,150,151,143,152,153,154,155,156,157],"Brain ageing","Older adults","L-serine supplementation","Resistance training","Cognitive function","Cognitive ageing","Hippocampus","Magnetic resonance imaging","Electroencephalography","Brain connectivity","Muscle strength","Synaptic plasticity","2026-03-06",{"date":160,"type":43},"2026-03-12",{"date":162,"type":23},"2026-03",{"date":164,"type":23},"2028-12",{"name":166,"class":50},"University of Vienna",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":18,"minAge":59,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":24,"phases":177,"briefSummary":178,"conditions":179,"keywords":189,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":93},"100520408","the-effect-of-motor-image-training-on-balance-performance-in-geriatric-individuals-100520408","NCT06056180","The Effect of Motor Image Training on Balance Performance in Geriatric Individuals","Investigation of the Effects of Motor Imagery Training Given With Action Observation on Balance Performance in Geriatric Individuals","Inclusion Criteria:\n\n1. To be between 60-80 years old\n2. Having the ability to speak, read, understand and write Turkish\n3. To have the cognitive skills to understand and apply the trainings to be applied in the study (with ≥ 24 points from the Mini Mental State Test)\n4. Being able to do activities of daily living independently\n5. Being able to walk independently (without using a walking aid and at least 10 meters)\n6. Having a body mass index of \\\u003C35 kg\u002Fm2 (not being severely obese or morbidly obese)\n\nExclusion Criteria:\n\n1. Having visual, hearing and sensory impairment\n2. To have had a trauma, lesion or surgery that may affect balance and musculoskeletal system in the last 6 months\n3. Having a history of 2 ≥ falls in the last 6 months\n4. Having any chronic lower extremity pain\n5. Having an acute or chronic illness that may cause problems with balance and falling\n6. Being diagnosed with sensory, vestibular and cerebellar ataxia\n7. Being on any medication that may cause problems with balance, focus, attention and falling.\n8. Exercising regularly, which may affect performance results\n9. To stop participating in the study for any reason","80 Years",{"count":176,"type":23},46,[26],"The goal of this study \\[type of study: clinical trial\\] is to was planned to investigate the effect of motor imagery training given to geriatric individuals with action observation on their balance performance and to compare these two methods.\n\nThe main questions it aims to answer are:\n\n1. Is virtual reality-based balance training given together with action observation and motor imagery for six weeks in geriatric individuals more effective in improving static balance than virtual reality-based balance training given alone?\n2. Is virtual reality-based balance training given together with action observation and motor imagery for six weeks in geriatric individuals more effective in improving dynamic balance than virtual reality-based balance training given alone?\n3. Is virtual reality-based balance training given together with motor imagery for six weeks in geriatric individuals more effective in increasing balance confidence than virtual reality-based balance training given alone?\n\n46 geriatric individuals will be randomized into 2 groups. Along with action observation, motor imagery training and virtual reality-based balance training will be given to the study group. On the other hand, only virtual reality-based balance training will be given to the control group. All assessments will be repeated before and after the trainings. The trainings will be applied 2 days a week for 6 weeks. Each training session; 25 minutes for the control group and 45 minutes for the study group.",[180,181,182,183,184,185,186,187,31,73,188],"Imagery (Psychotherapy)","Postural Control","Postural Balance","Virtual Reality Therapy","Surface Electromyography","Geriatric Assessment","Physical Therapy Techniques","Physical Therapy","Falling",[190,191,192,193,194,195,196,197,198,199,200,201,202],"visual motor imagery","kinesthetic motor imagery","postural control","virtual reality therapy","interactive video games","balance platform with pressure sensor","surface electromyography","balance confidence","fall risk","mobility","cognitive processing speed","smartphone gyroscope sensor dataset","action observation","2025-05-05",{"date":205,"type":43},"2025-05-08",{"date":207,"type":43},"2023-11-01",{"date":209,"type":23},"2025-12",{"name":211,"class":50},"Muğla Sıtkı Koçman University",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":223,"phases":4,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":4},"100574004","an-intrinsic-capacity-identification-and-management-programme-for-older-adults-in-singapores-primary-care-100574004","NCT06753643","An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care","Implementing the National Frailty Policy in Singapore's Primary Care: A Pilot Feasibility Study of The Intrinsic Capacity ProMotion in PrimAry Care for The Frail Program (IMPACTFrail)","IMPACTFrail","Older Adults\n\nInclusion Criteria:\n\n* being a patient of the polyclinic site\n* aged 60 years and above\n* Clinical frailty score (CFS) of 4 - 5\n* Not done comprehensive geriatric assessment (CGA) in the past 12 months (based on available medical records or self-report)\n* Not a current patient of geriatric specialist outpatient clinic (based on available medical records or self-report).\n\nExclusion Criteria:\n\n* Do not meet inclusion criteria above\n\nHealthcare Staff (for qualitative study)\n\nInclusion Criteria:\n\n* aged 21 years and above\n* Involved in the IMPACTFrail program as an implementer and\u002For a healthcare administrator with authority to make implementation decisions.\n\nExclusion Criteria:\n\n* Do not meet inclusion criteria above","100 Years",{"count":222,"type":23},180,"OBSERVATIONAL","The IMPACTFrail program is an intrinsic capacity (IC) identification and management program for mildly frail older adults. Specifically, it delivers the three-tier approach recommended in the National Frailty Strategy Policy Report. The program's core functions include the segmentation of older persons using the Clinical Frailty Scale (CFS) score followed by secondary IC screening for CFS 4 to 5 (Tier 1), follow-up clinical assessment to confirm IC losses (Tier 2) and needs-directed management and tracking of their health (Tier 3).\n\nThe investigator aims to conduct a multi-site feasibility study on a small group of older adult study participants (n=30 per polyclinic).\n\nThe feasibility study has a few components. First, a qualitative study will assess its feasibility (implementation, appropriateness, acceptability, practicality, adaptability) as perceived by older adults, healthcare providers, and healthcare administrators. Second, the investigator aims to collect process indicators to track its implementation progress. Third, program costs will be estimated. Fourth, the investigator will develop a logic model and theory of change, and cluster-specific detailed written program descriptions. Lastly, the investigator aims to triangulate the findings and assess the feasibility for larger-scale implementation. This study is guided by implementation science frameworks and guidelines for conducting feasibility studies.",[31,110],"2024-12-22",{"date":228,"type":43},"2024-12-31",{"date":230,"type":23},"2025-03-01",{"date":232,"type":23},"2026-02-28",{"name":234,"class":235},"Geriatric Education and Research Institute","OTHER_GOV"]