[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-children":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,78,112,141,171,202,230,257,283,304,325,360],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100411614","electrophysiologic-sleep-phenotyping-and-sleep-dependent-neuro-maturation-in-clinical-and-healthy-pediatric-populations-100411614",false,"NCT04639830","Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations","* INCLUSION CRITERIA :\n\nInclusion criteria for Group A (No known risk)\n\n-Consent: Parent\u002Fcaregiver (legal guardian) can give consent. NIH employees children are eligible to participate with the exception of NIMH employees children.\n\nComments: Parents will provide consent for all minors. Verbal assent will be obtained from minors 7 years and older when applicable.\n\n* The child is between 6 months \\& 76 months at the time of enrollment for the main study.\n\nComments: Prescreening assessment\n\n-Apnea hypopnea index (AHI) \\\u003C 2\u002Fhour and no other evidence of sleep disordered breathing (SDB)\n\nInclusion criteria for Group B (Known risk)\n\n-Consent: Parent\u002Fcaregiver (legal guardian) can give consent. NIH employees children are eligible to participate with the exception of NIMH employees children.\n\nComments: Parents will provide consent for all minors. Verbal assent will be obtained from minors 7 years and older when applicable.\n\n-The child is between 6 months \\& 76 months at the time of enrollment for the main study.\n\nComments: Screening assessment\n\n-The child meets any one or more of the following:\n\n1. Enrolled in early intervention\n2. Getting any targeted therapies\n3. Neurodevelopmental or neuropsychiatric disorder\n4. Failed ITC (ages 6 months - 24 months)\n5. Failed the EI screener (\\>24 months)\n6. Child s first degree relative has been diagnosed with a neurodevelopmental disorder, such as autism or schizophrenia, or severe mental illness, such as major depressive disorder or bipolar disorder\n\n   Comments: Screening assessment\n   * Apnea hypopnea index (AHI) \\\u003C= 2\u002Fhour and no other evidence of sleep disordered breathing (SDB)\n\n   EXCLUSION CRITERIA:\n\n   Exclusion criteria for Group A (No known risk)\n\n   -Meets inclusion criteria for Group B (known risk)\n\n   Comments: Screening assessment\n\n   -Any chronic or acute medical condition severe enough to interfere with overnight sleep study acquisition, such as a tracheotomy, uncontrolled seizure disorder, or ventilator dependency, or history of stroke or major neurologic insult. Taking any medications that is known to change sleep parameters within 2 weeks of screening polysomnogram.\n\n   Comments: Screening assessment: Medical history\n\n   -Any history of early intervention or diagnosis of a condition that put the child at risk for neurodevelopmental problems (e.g., genetic disorder, prenatal exposures, extreme prematurity)\n\n   Screening assessment: Medical history\n\n   Primary language other than English in the home\n\n   Comments: Screening assessment\n\n   -Apnea hypopnea index (AHI) \\>2\u002Fhr or any other evidence of sleep disordered breathing (SDB)\n   * The children of NIMH employees and staff may not take part.\n\n   Comments: Screening assessment\n\n   Exclusion criteria for Group B (Known risk)\n\n   -Any chronic or acute medical condition severe enough to interfere with completion overnight sleep study acquisition, such as a tracheotomy, uncontrolled seizure disorder, or ventilator dependency.\n\n   Comments: Screening assessment: Medical history\n\n   -Primary language other than English in the home\n\n   Comments: Screening assessment\n\n   -Diagnosed with any of the following common genetic disorders associated with intellectual impairment: Fragile X, Down Syndrome, PraderWilli, Rett, Angelman, Phelan -McDermid, Smith-Lemli-Opitz, identified with a disorders of autonomic dysfunction that might compromise breathing function (examples include congenital central hypoventilation syndrome, familial dysautonmia), disorders of skeletal deformities (Marfan, achondroplasia), a neurogenic condition (spinal muscular atrophy, Duchenne muscular dystrophy, myotonic dystrophy), congenital myopathies or storage diseases (mucopolysaccharidosis, NCL, Wilsons, etc.)\n\n   -The children of NIMH employees and staff may not take part.\n\n   Comments: Screening assessment\n\n   -Apnea hypopnea index \\> 2\u002Fhr or any other evidence of sleep disordered breathing (SDB)",true,"ALL","6 Months","8 Years",{"count":20,"type":21},244,"ESTIMATED","OBSERVATIONAL","Background:\n\nDuring the first few decades of life, the brain changes dramatically in shape and function. Sleep lets researchers measure these changes. Researchers want to create a database of sleep and neurodevelopmental data in a group of infants and children to learn more.\n\nObjective:\n\nTo address a knowledge and data gap in the field of sleep and neurodevelopment in infants and children.\n\nEligibility:\n\nChildren ages 6 months to 76 months who may or may not be at risk for neurodevelopmental and neuropsychiatric disorders. Also, children ages 6 months to 8 years who have a referral for a sleep study.\n\nDesign:\n\nParticipants will have neurodevelopmental testing. They will have a medical, psychiatric, and family history. They will have a physical and neurological exam. They will be interviewed and complete surveys. They will give a cheek swab and\u002For blood sample.\n\nSome participants will have 1 study visit that lasts 2 days.\n\nOther participants will have up to 4 study visits. Each visit will last 2 days. Visits occur every 8 months to 1 year, for a total participation time of 2 years.\n\nParticipants will have a 20-minute daytime electroencephalogram (EEG), if possible. This EEG session will be used to calibrate the machine for the overnight study.\n\nParticipants will take part in an inpatient overnight sleep study. Electrodes will be placed on the participants. For young children, parents will help place the EEG leads. Other sensors may also be placed. A gauze cap will be placed on participants head to protect the leads and keep the participants from moving them. 'Lights out' will occur as close to participants bedtime as possible.",[25,26,27,28],"Healthy Children","Children With Neurodevelopmental Disorders","Children With Neuropsychiatric Disorders","Children With Behavioral Syndromes",[30,25,31,32,33,34],"SLEEP STUDY","Neurogenetic Syndrome","Abnormal Neurodevelopment","EEG","Natural History","RECRUITING","2026-06-04",{"date":38,"type":39},"2026-06-05","ACTUAL",{"date":41,"type":39},"2021-11-09",{"date":43,"type":21},"2027-04-15",{"name":45,"class":46},"National Institute of Mental Health (NIMH)","NIH",5,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":15,"sex":16,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100637366","adapted-frenkle-exercises-versus-dynamic-balance-training-in-school-going-children-100637366","NCT07619807","Adapted Frenkle Exercises Versus Dynamic Balance Training in School Going Children","Comparison of Adapted Frenkel Exercises and Dynamic Balance Training on Balance, Gait, Mobility, and Motor Coordination in School-Going Children","DBT","Inclusion Criteria:\n\n1. Healthy school-going children aged 8-10 years\n2. Both male and female participants\n3. No history of neurological, orthopedic, or developmental disorders\n4. Informed parental consent and child assent obtained\n5. MMSE score ≥ 24\n6. TUG score \\\u003C 20 seconds\n7. Pediatric Berg Balance Scale score ≥ 40\n\nExclusion Criteria:\n\n1. History of diagnosed balance or coordination issues.\n2. Children with orthopedic and motor impairments.\n3. Behavior or attention disorders limiting participation.\n4. Neuromuscular conditions, Visual and mental disorders","10 Years",{"count":58,"type":21},36,"INTERVENTIONAL",[61],"NA","A randomized clinical trial will be conducted at Realm Educational School. Children aged 6-12 years will be randomly assigned to either the AFE or DBT group using convenient sampling. Participants must be physically active and free from neurological, orthopedic, or cognitive impairments, while those with sensory impairments or recent musculoskeletal injuries will be excluded. Outcome measures will include the Pediatric Balance Scale (PBS), Y-Balance Test, Observational Gait Scale (OGS), Timed Up and Go (TUG) test, and BOT-2. Pre- and post-intervention assessments will evaluate the effectiveness of both interventions on balance, gait, mobility, and motor coordination.",[25],[65],"Balance, Motor coordination, Gait, Frenkel Exercises","NOT_YET_RECRUITING","2026-06-01",{"date":69,"type":39},"2026-06-02",{"date":71,"type":21},"2026-06",{"date":73,"type":21},"2026-08-01",{"name":75,"class":76},"Riphah International University","OTHER",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":15,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":59,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":111},"100637512","phase-4-prevention-with-ismigen-of-rtis-in-kids-100637512","NCT07578012","Prevention With Ismigen of RTIs in Kids","A Randomized Double-blind Placebo-controlled Study to Demonstrate the Efficacy of PMBL® Sublingual Tablets in Reducing the Incidence of Respiratory Tract Infections in Children Aged 3-12 Years (PIRTIK).","PIRTIK","Inclusion Criteria:\n\n1. Children of both genders aged from 3 to 12 years.\n2. Written informed consent obtained from the parents\u002Flegally authorized representatives\n3. Written assent obtained from the subject from 7 years\n4. Subject presenting with a susceptibility to respiratory tract infections according to the investigator\n5. No respiratory tract infection within 15 days before the randomization visit\n6. All girls of childbearing potential have a negative pregnancy urine testing at randomization visit and are informed and their parents as well of the requirement for contraception during the study.\n7. A cooperative attitude and ability to correct use of PMBL® tablet.\n\nExclusion Criteria:\n\n1. Subject treated with bacterial lysates within the previous 6 months prior to V1 or ongoing treatment.\n2. Body temperature ≥ 37.5°C at the randomization visit.\n3. Pregnant\u002FLactating female or with sexual activity without hormonal contraception, intrauterine device or barrier methods.\n4. Primary or secondary immunodeficiency, cystic fibrosis, bronchiectasis, alpha-1 antitrypsin deficiency, malignancy, endocrinological diseases or other chronic respiratory diseases, except asthma and allergic rhinitis.\n5. Known sensitivity to the components of study medication.\n6. Any major surgery within the last 3 months prior to study enrolment or planned to occur within the duration of study.\n7. Treatment with the following medications:\n\n   1. Injection or oral administration of steroids within 4 weeks prior to study enrolment.\n   2. Previous and\u002For concomitant immunosuppressants, immunostimulants, allergen-immunotherapy or gamma globulins within 6 months prior to study enrolment.\n8. Inability to understand or comply with study procedures or with study treatment intake.\n9. Subject participating in another interventional clinical study at the time of screening visit.","3 Years","12 Years",{"count":89,"type":21},224,[91],"PHASE4","Although the efficacy of PMBL® sublingual tablets is evident to most prescribers, the clinical studies available to demonstrate the efficacy of this bacterial lysate in preventing recurrent respiratory tract infections have undeniable methodological biases. To demonstrate the efficacy of PMBL® in the pediatric population without questionable bias, a randomized double-blind Placebo-controlled study will be conducted: one arm of children presenting with a risk of recurrent respiratory tract infections will be treated with PMBL® for a 3-month period, 10 days per months during the fall-winter whereas subjects of the Placebo arm will receive sublingual tablet indistinguishable from PMBL® but without active ingredients. Both groups of subjects will be followed for four additional months. To improve the accuracy of data and the tracking of respiratory tract infections (RTI), a diary will be provided to each subject, allowing them to report the event as soon as it occurs. If necessary, a visit may be planned to enable the investigator to assess the event accurately.",[94,25],"Respiratory Tract Infections (RTI)",[94,96,97,98,99,100],"Bacterial Lysates","PMBL® sublingual tablets","Recurrent Respiratory Tract Infections","Ismigen","Incidence","2026-05-05",{"date":103,"type":39},"2026-05-11",{"date":105,"type":21},"2026-05",{"date":107,"type":21},"2027-04",{"name":109,"class":110},"Lallemand Pharma AG","INDUSTRY",8,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":15,"sex":16,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":59,"phases":122,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100630662","phase-2-to-investigate-the-effects-of-bifidobacterium-animalis-subsp-lactis-xltg11-on-growth-and-development-incidence-of-allergy-and-immune-function-in-infants-100630662","NCT07490587","To Investigate the Effects of Bifidobacterium Animalis Subsp. Lactis XLTG11 on Growth and Development, Incidence of Allergy and Immune Function in Infants","Inclusion Criteria:\n\n* Term infants are 37≤ gestational age \\\u003C 42 weeks, and the birth weight is between 2500g and 4000g (only applicable to 0\\~12 months old)\n* Breastfed or mixed-fed healthy infants and young children, aged 0\\~3 (inclusive) years old, gender is not limited\n* The allergy risk score calculated by the Infant Allergy Risk Assessment Table is ≥6(Refer to the National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention: Investigation and Research on Allergy Symptoms and Risk Factors in Infants and Young Children)\n* Family primary guardians agree to collect fecal samples of infants and young children during this study\n* Have not used antibiotics in the past month\n* Have not used probiotics in the past three months\n* Family primary guardians committed not to add additional Bifidobacterium dietary supplements to infants and young children during the intervention period\n* The guardians of the enrolled subjects agree to participate in this interventional study and sign a written informed consent form, and are able to understand and fill in forms such as infant diaries as required\n* Signed informed consent and willing to follow up at the time specified in the trial\n\nExclusion Criteria:\n\n* The mother of the infant has a history of diabetes, hepatitis B, HIV and other infectious diseases\n* Clinicians diagnosed with allergic diseases (including but not limited to eczema, asthma, allergic proctocolitis, allergic rhinitis, hay fever, etc.) at the time of enrollment of infants and young children\n* Infants and young children who are known to be allergic to the ingredients of probiotic products\n* In the opinion of the investigator, the subject has other reasons that make it unsuitable to participate in this clinical study","0 Months","36 Months",{"count":121,"type":21},366,[123],"PHASE2","This study is a 180-day randomized, double-blind, placebo-controlled trial involving healthy infants and young children under 3 years of age with elevated allergy risk. Participants are randomized to receive either Bifidobacterium animalis subsp. lactis XLTG11 probiotic or placebo daily. The primary clinical outcomes assessed are incidence and day-level burden of allergic, respiratory, and gastrointestinal symptoms. To investigate potential mechanisms, fecal samples were collected pre- and post-intervention for shotgun metagenomic sequencing to analyze changes in gut microbiota composition, functional pathways (KEGG, COG, GO), and mucosal immune markers (β-defensin 2, LL-37, calprotectin, sIgA) associated with clinical improvements.",[25],[127,128,129,130],"children","probiotic","allergy","bifidobacterium","2026-03-26",{"date":133,"type":39},"2026-04-01",{"date":135,"type":39},"2024-01-01",{"date":137,"type":21},"2026-06-30",{"name":139,"class":76},"Min-Tze LIONG",2,{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":59,"phases":150,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":77},"100604293","outdoor-science-education-and-child-well-being-in-primary-schools-protocol-for-a-cluster-randomized-controlled-trial-on-learning-connection-to-nature-eco-anxiety-and-stress-100604293","NCT07147634","Outdoor Science Education and Child Well-being in Primary Schools: Protocol for a Cluster Randomized Controlled Trial on Learning, Connection to Nature, Eco-anxiety, and Stress","Bio-Explo","Inclusion Criteria:\n\n* Primary schools need to have a deprivation index equal to or superior to 1 (with 10 being the maximum) and be located in Montreal, Longueuil or Laval (QC).\n* Teachers have to show some interest in outdoor education but are not obliged to have already done some before in order to be included.\n* Only 5th and 6th grade teachers are included.\n* Primary schools with two teachers interested in participating in the project.\n\nExclusion Criteria:\n\n* Alternative schools or those welcoming recently arrived non-Francophone students are not included.",{"count":149,"type":21},1000,[61],"The goal of this randomized controlled trial is to learn if an outdoor science education intervention can improve primary school students' learning and well-being when compared to an indoor classroom-based science education intervention. The main questions it aims to answer are:\n\n* Will students who engage in outdoor science learning produce higher-quality observations of living organisms than students who receive instruction exclusively in an indoor, classroom-based context, when both groups are invited to make observations in an unfamiliar natural environment?\n* Does an outdoor education intervention embedded within the science curriculum contribute to children's connection to nature, eco-anxiety and stress?\n\nParticipants will:\n\n* Receive a science education intervention 2h\u002Fweek for a total of 5 weeks, either indoors or outdoors\n* Answer questionnaires before and after the intervention\n* Participate in a field day-trip after the intervention where they will be asked to observe living organisms.",[25],[154,155,156,157,158,159,160,161],"Stress","School-Based Intervention","Cluster Randomized Controlled Trial","Primary School","Connection to Nature","Eco-anxiety","Science Learning","Outdoor Education","2025-12-26",{"date":164,"type":39},"2025-12-31",{"date":166,"type":39},"2025-09-02",{"date":168,"type":21},"2026-11",{"name":170,"class":76},"Université de Sherbrooke",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":59,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":140},"100600235","clinical-performance-and-antibacterial-effect-of-alkasite-bioactive-material-in-restoring-pulpotomized-primary-molars-100600235","NCT07094854","Clinical Performance and Antibacterial Effect of Alkasite Bioactive Material in Restoring Pulpotomized Primary Molars","Clinical Performance and Antibacterial Effect of a Bulk Fill Alkasite Bioactive Material in Restoring Pulpotomized Primary Molars(Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Cooperative children (Positive or definitely positive) according to the Frankl's behaviour rating scale.\n* Children free of any systemic disease or special health care needs (ASA1).\n* Completion of an informed consent to participate in the study.\n* Second primary molar tooth with occluso-proximal carious lesions indicated for pulpotomy.\n* Restorable tooth.\n* Radiographically at least two-thirds of the root length is present.\n* Presence of neighboring and opposing teeth.\n\nExclusion Criteria:\n\n* Clinical signs or symptoms of irreversible pulpitis or non- vitality.\n* Radiographic signs of degeneration including internal or external root resorption, furcation involvement.\n* Pathologic mobility detected by placing the points of a pair of tweezers in the occlusal fossa and gently rocking the tooth buccolingually.\n* Reported usage of local or systemic antibiotics, chlorhexidine or fluoride mouthwashes within the last 2 weeks.\n* Child with parafunctional habits.","5 Years","9 Years",{"count":181,"type":21},40,[61],"The study aims to evaluate the clinical performance of Cention-Forte (CF) material in the restoration of pulpotomized second primary molars compared to conventional stainless steel crowns (SSC), and also to assess the restorations' antibacterial effect on salivary cariogenic bacterial count.",[25],[186,187,188,189,190,191,192],"Cention Forte","Alkasite","bioactive","pulpotomy","primary teeth","stainless steel crown","bulk fill","2025-07-23",{"date":195,"type":39},"2025-07-30",{"date":197,"type":21},"2025-07",{"date":199,"type":21},"2026-08",{"name":201,"class":76},"Noha Fouad",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":15,"sex":16,"minAge":209,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":59,"phases":213,"briefSummary":214,"conditions":215,"keywords":216,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":77},"100595225","physical-activity-intervention-100595225","NCT07029685","Physical Activity Intervention","Effect of an Ecological Model-Based Physical Activity Intervention on Improving Obesity Parameters and Quality of Life in Preschoolers 4 to 6 Years of Age","Inclusion Criteria:\n\nBe enrolled in the selected establishment Have the consent of the parents or legal guardian to participate in the activity Have the consent of the child when asked to participate\n\nExclusion Criteria:\n\nHealth impairments that limit participation in the physical activity intervention Have completed less than 80% of the intervention program","4 Years","6 Years",{"count":212,"type":21},180,[61],"Obesity is a problem that affects almost every region of the world. In Chile, data indicate that the prevalence of obesity in preschool children aged 4 to 6 years is 58%, which increases as they reach adolescence and adulthood. The role played by physical inactivity in the development of obesity is so relevant that it has been established that in children it is one of the factors that most contributes to the development of obesity. Among factors that influence adherence to healthy lifestyles are motor competence (CM) and physical condition (CF); Both CM and CF are factors that generate an underlying mechanism that decreases the risk of obesity and promotes health. Health-related quality of life \\[HRQoL\\] refers to an individual's subjective perception of the impact of health status on their physical, psychological, and social functioning. Overweight and obesity influence HRQoL. Physical activity interventions applied from an early age have proven to be a useful means of preventing childhood obesity, being more effective when implemented in the school environment and is key to achieving long-term results. The ecological model of physical activity favors modifying active lifestyle behaviors including intrapersonal, interpersonal, organizational, community, physical-environmental and political factors. Using the ecological model, physical activity interventions have managed to increase the levels of physical activity since the child and the entire environment that surrounds him or her are involved, that is, they have included the biological and behavioral, along with the motivational, school, in addition to taking into account environmental, cultural and socioeconomic aspects. The general objective of the project is to determine the effect of a physical activity intervention based on the ecological model, in the improvement of obesity parameters and quality of life in preschoolers from 4 to 6 years old. The study is experimental through a cluster-randomized clinical trial; of pre and postest.\n\nThe methodological approach is mixed. Physical Condition will be measured through the PREFIT battery with the following components:\n\nbody composition (weight, waist circumference; hip circumference, BMI); Musculoskeletal capacity (upper body strength, lower body strength; speed\u002Fagility); Cardiorespiratory capacity. Motor competence will be measured through the Children's Movement Assessment Battery (MABC-2) with the following components: Manual dexterity; Marksmanship and catch; Balance. Health-related quality of life will be assessed through the KINDL-R questionnaire for parents, in the validated version in Spanish; Sedentary behaviour and physical activity ActiGraph wGT3X-BT accelerometers will be used. To determine the effect, statistical tests will be applied for intragroup analysis and intrasubject repeated measures, considering p \\\u003C.05 as significance. When statistically significant differences are found, the effect size will be calculated. In addition, the use of mixed regression models is contemplated where the models will be adjusted for baseline values and age. It is hypothesized that the physical activity intervention based on the ecological model will lead to a 3% decrease in body fat, improves anthropometric measurements, physical condition, improved competence and health-related quality of life.",[25],[217,218,219,220],"Physical activity","Body composition","preschool","physical fitness","2025-06-11",{"date":223,"type":39},"2025-06-19",{"date":225,"type":21},"2025-08-01",{"date":227,"type":21},"2025-12-15",{"name":229,"class":76},"Andrés Godoy Cumillaf",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":15,"sex":16,"minAge":237,"maxAge":56,"enrollmentInfo":238,"targetDuration":4,"studyType":59,"phases":240,"briefSummary":241,"conditions":242,"keywords":243,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":77},"100593361","functional-training-and-dynamic-play-exercise-on-gross-motor-skills-physical-fitness-and-balance-in-healthy-children-100593361","NCT07005440","Functional Training and Dynamic Play Exercise on Gross Motor Skills, Physical Fitness, and Balance in Healthy Children","Comparison of Functional Training and Dynamic Play Exercise on Gross Motor Skills, Physical Fitness, and Balance in Healthy Children","Inclusion Criteria:\n\n* Age 7-10 years\n* Both genders\n* Cognition MMSE score \\> 25\n* Class grades 2-5\n* BMI between 5th - 85th percentiles\n* Able to stand and walk independently\n* PBBS score \\> 40\n* TGMD-2 \\> 13\n* TUDS \\> 10 secs\n\nExclusion Criteria:\n\n* Pes Planus \\& Pes cavus\n* Scoliosis\n* Genu valgum\n* Genu varum\n* Juvenile Idiopathic Arthritis\n* Presence of Asthma\n* Acute orthopedic problem and any history of surgery past 6 months\n* Visual, vestibular, or balance disorders","7 Years",{"count":239,"type":21},38,[61],"This study aims to explore and compare two distinct approaches to physical activity: functional training and dynamic play exercises, focusing on their effects on children's gross motor skills, physical fitness and balance.\n\nA randomized clinical trial will be conducted. The study will be conducted at Primary school of Lahore in a total duration of 10 months. Sample size will be 38. There will be two groups. Non-probability convenient sampling techniques will be used. The sample having the following characteristics will be included; Age 7-10 years, Both genders, Cognition MMSE score \\> 25, Class grades 2-5 , BMI between 5th - 85th percentiles, Able to stand and walk independently, PBBS score \\> 40, TGMD-2 \\> 13, TUDS \\> 10 secs. The population having the following characteristics will be excluded from the study; Pes Planus \\& Pes cavus, Scoliosis, Genu valgum, Genu varum, Juvenile Idiopathic Arthritis, Presence of Asthma, Acute orthopedic problem and any history of surgery past 6 months, visual, vestibular, or balance disorders. The tools that will be included in this study are: Pediatrics balance scale, Test for gross motor development (TGMD-2) and Time up and downstairs test (TUDS). SPSS version 27 will be used for data analyses.",[25],[244,245,246,247,248],"Gross motor skills","Physical fitness","Functional training","Dynamic play exercises","Balance","2025-05-27",{"date":251,"type":39},"2025-06-05",{"date":253,"type":39},"2025-04-16",{"date":255,"type":21},"2025-07-07",{"name":75,"class":76},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":15,"sex":16,"minAge":210,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":267,"conditions":268,"keywords":270,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":77},"100591096","symptoms-pulmonary-function-muscle-strength-exercise-capacity-and-frailty-in-esophageal-atresia-vs-healthy-peers-100591096","NCT06975982","Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers","Comparison of Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty Level in Individuals With Esophageal Atresia and Healthy Individuals","Esophageal atresia group\n\nInclusion Criteria:\n\n* Children with esophageal atresia who are willing to participate in the study\n* Being between the ages of 6-18,\n* Being able to cooperate with the assessments\n\nExclusion Criteria:\n\n* Being unable to cooperate with the assessments,\n* Having an orthopedic, neurological or cardiovascular problem that may affect the assessments,\n* Having a lung infection or upper respiratory tract infection in the last four weeks,\n* Being an active smoker,\n* Not being willing to participate in the study,\n\nControl group\n\nInclusion Criteria:\n\n* Being between the ages of 6-18,\n* Being willing to cooperate with the tests to be performed,\n* Being willing to participate in the study.\n\nExclusion Criteria:\n\n* Having a musculoskeletal problem that may affect exercise performance,\n* Having any known chronic disease,\n* Having a lung infection or upper respiratory tract infection in the last four weeks,\n* Being an active smoker,\n* Not willing to participate in the study.","18 Years",{"count":266,"type":21},20,"Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life. In children with esophageal atresia, structural abnormalities due to congenital anomalies and tracheoesophageal fistula, tracheomalacia, respiratory problems, recurrent respiratory tract infections, structural abnormalities, surgical interventions for repair and treatment, and decreased physical activity levels may negatively affect pulmonary function, effective coughing, muscle strength, exercise capacity, posture, motor function, and quality of life. This study aims to compare physical characteristics, body composition, pulmonary function and muscle strength, peak cough flow, posture assessment, peripheral muscle strength test, motor function, exercise capacity, physical activity level, fatigue, frailty and quality of life between children with esophageal atresia and their healthy peers.",[269,25],"Esophageal Atresia",[271,272,217,273],"Esophageal atresia","Exercise capacity","Muscle strength","2025-05-22",{"date":276,"type":39},"2025-05-29",{"date":278,"type":39},"2024-10-24",{"date":280,"type":21},"2027-10-24",{"name":282,"class":76},"Hacettepe University",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":15,"sex":16,"minAge":178,"maxAge":87,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":77},"100591922","urdu-translation-of-revised-high-level-mobility-assessment-tool-himat-in-healthy-children-100591922","NCT06986720","Urdu Translation of Revised High-Level Mobility Assessment Tool (HiMAT) in Healthy Children","Urdu Translation of Psychometric Properties Analysis of Revised High-Level Mobility Assessment Tool (HiMAT) in Healthy Children","Inclusion Criteria:\n\n* Children with age group 5-12 years\n* No condition affecting mobility of children\n* Able to understand and follow instruction.\n* Can speak \\& understand language\n\nExclusion Criteria:\n\n* Children with visual impairments.\n* Children with conditions affecting their mobility.\n* Children with any history of surgery in the past one year.\n* Children with any cardiorespiratory comorbidities.\n* Children with muscle strain, ligament sprain or joint laxity in lower extremities.\n* Cognition less than 20 on Mini Mental State Examination (MMSE).\n* Children with any history of any foot deformity",{"count":291,"type":21},80,"The ability to move with ease is labelled as mobility. Limitations in mobility are frequent, recovery of these skills is crucial for physical performance which gives children valuable social possibilities and has long-term advantages for their physical and mental health. The high-level mobility assessment tool (HiMAT) is a unidimensional performance to measure the degree of high-level mobility in traumatic brain injury patients. The revised HiMAT has been utilised recently in paediatric populations to assess clinical trial outcomes and measure high-level motor skills.\n\nUrdu translation of revised HiMAT will be executed by using forward backwards translation method. Two bilingual translators fluent in both Urdu and English languages will facilitate the researcher in the translation of the tool. This final translated version will be then tested for validity and reliability on all participants of the study. The psychometric properties of the tool will be assessed including reliability, internal consistency, and item discrimination.",[25],[295],"revised HiMAT, Urdu translation, validation, mobility","2025-05-15",{"date":298,"type":39},"2025-05-23",{"date":300,"type":39},"2025-05-12",{"date":302,"type":21},"2025-07-16",{"name":75,"class":76},{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":15,"sex":16,"minAge":237,"maxAge":56,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":312,"conditions":313,"keywords":314,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":323,"leadSponsor":324,"locationsCount":4},"100588575","correlation-of-gross-motor-movement-and-balance-with-screen-time-in-healthy-children-100588575","NCT06943183","Correlation of Gross Motor Movement, and Balance With Screen Time in Healthy Children","Inclusion Criteria:\n\n* Children between ages 7 to 10 years\n* Children with screen time exposure of more than 2 hours per day on a weekday (30,\n* Screen time exposure through television, smartphones, tablets, laptops or computers.\n* Children with exposure of screen time more than 3 hours on a weekend\n\nExclusion Criteria:\n\n* Children with Pediatric balance score: below 45.\n* Children with TGMD-2 Score: below 30 (less than 10\" percentile).\n* Children who have had orthopedic surgery within the previous 6 months.\n* Cognition Score below 26 on MMSE (Mini-Mental State Examination).",{"count":311,"type":21},429,"Gross motor function involves large muscle control for activities like walking, running, and sports, and is essential for balance and coordination. Excessive screen time may hinder gross motor development by reducing physical activity, affecting strength and coordination. Structured activities like free play and exercise are key to minimizing these effects. A cross-sectional study will be conducted over 10 months in public and private schools in Lahore. Children aged 7-10 will be included. Screen time will be assessed through demographic data, and gross motor skills evaluated using the TGMD-2. Exclusion criteria: PBS \\\u003C 20, TGMD-2 \\\u003C 30, recent orthopedic surgery, and MMSE \\\u003C 26. Data will be analyzed in SPSS v25 using descriptive statistics and correlation. This study explores the impact of screen time on children's physical development, particularly gross motor skills and balance",[25],[315,316,317,318],"Gross motor movement","balance","screen time","school-aged children","2025-04-17",{"date":321,"type":39},"2025-04-24",{"date":253,"type":21},{"date":302,"type":21},{"name":75,"class":76},{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":15,"sex":16,"minAge":178,"maxAge":87,"enrollmentInfo":332,"targetDuration":4,"studyType":59,"phases":334,"briefSummary":335,"conditions":336,"keywords":345,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":77},"100576898","improvements-in-daily-activity-and-exercise-in-school-children-the-actchild-study-100576898","NCT06791278","Improvements in Daily Activity and Exercise in School Children: the ActChild Study","ActChild","Inclusion Criteria:\n\n* Schoolchildren, 0.-1. Grade, 5-8 years of age,\n* Resident in Aarhus Municipality\n\nExclusion Criteria:\n\n\\- None",{"count":333,"type":21},600,[61],"The goal of this clinical trial is to assess the health-related effects of an exercise intervention in children aged 5-8 years.\n\nMain research questions:\n\n* Does a municipality-driven exercise intervention improve physical activity levels in children?\n* Does a municipality-driven exercise intervention improve sleep parameters in children?\n* Does a municipality-driven exercise intervention improve eating behaviors in children?\n* Does a municipality-driven exercise intervention improve quality of life in children?\n\nStudy Design:\n\nParticipants will be assigned to either:\n\n* Intervention group: Attend 1-2 weekly sessions of 45-60 minutes of child-friendly exercise for 1 year.\n* Control group: Receive no intervention.\n\nData Collection:\n\nParticipants will:\n\n* Complete questionnaires at baseline, and at 1-year, 3-year, and 5-year follow-ups.\n* Wear accelerometers for 7 consecutive days at baseline, and at 1-year, 3-year, and 5-year follow-ups.",[25,337,338,339,340,341,342,343,344],"Children","Children in School","Child Health","Child Behavior","Physical Activity","Sleep","Eating Behaviors","Child Obesity",[346,337,347,348,349,342,341,350],"Exercise Intervention","School Children","CEBQ","Eating Behavior","Quality of Life","2025-01-22",{"date":353,"type":39},"2025-01-24",{"date":355,"type":21},"2025-02-04",{"date":357,"type":21},"2032-12",{"name":359,"class":76},"University of Aarhus",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":15,"sex":16,"minAge":18,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":59,"phases":371,"briefSummary":372,"conditions":373,"keywords":374,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":77},"100537330","plants-optimizing-development-study-pods-100537330","NCT06276426","Plants Optimizing Development Study (PODS)","Plants Optimizing Development Study","PODS","Inclusion Criteria:\n\n* Child assent and parent\u002Fguardian consent\n* Free of any food allergy\n* 8-11 years of age\n* Tanner scale score of ≤ 2\n* 20\u002F20 or corrected vision\n* No antibiotic usage in the past 3 months\n* ≤1 serving\u002Fd of soy food habitual consumption\n\nExclusion Criteria:\n\n* Non-assent or consent by child assent and\u002For parent\u002Fguardian\n* Presence of any food allergy\n* Younger than 8 years or older than 11 years\n* Presence of specific neurological and genetic disorders (i.e., Autism, Cerebral Palsy, Multiple Sclerosis, Down syndrome)\n* Presence of endocrine, metabolic, and gastrointestinal disease e.g., hypertension, diabetes, celiac disease\n* Tanner scale score of \\> 2\n* Not 20\u002F20 or uncorrected vision\n* Antibiotic usage in the past 3 months\n* \\>1 serving\u002Fd of soy food habitual consumption","11 Years",{"count":370,"type":21},96,[61],"This study aims to conduct a randomized clinical trial to measure the effects of a 3-month daily mixed-soy food intervention vs. a control group receiving isocaloric foods on reproductive hormones, body composition, metabolic risk, fecal microbiota, and cognition among 8-11-year-old children. Additionally, this study will assess soy food intake immediately following participation in the clinical trial to determine changes in soy food acceptance in children.",[25],[375,376,377,378,379,380],"soy","isoflavones","cognition","body composition","fecal microbiota","metabolic risk","2024-04-16",{"date":383,"type":39},"2024-04-17",{"date":385,"type":39},"2024-03-18",{"date":387,"type":21},"2026-09-30",{"name":389,"class":76},"University of Illinois at Urbana-Champaign"]