[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-obesity-metabolically\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-obesity-metabolically":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100577561","natural-course-of-initially-metabolic-healthy-obese-individuals-healthy-obesity-100577561",false,"NCT06799897","Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?","Inclusion Criteria:\n\n* Signed Informed Consent Form\n* Age between 18 and 60 years\n* BMI 30-50 kg\u002Fm2\n* Knowledge of German, which requires sufficient written and allow oral patient education\n\nInclusion criteria for initially healthy group\n\n* Blood pressure \\\u003C 140\u002F90 mmHg\n* Normal glucose metabolism\n\n  * HbA1c \\\u003C 6.5 %\n  * Fasting Glucose \\\u003C 7.0 mmol\u002Fl\n* Normal lipid metabolism\n\n  o LDL-cholesterol \\\u003C 5.0 mmol\u002Fl\n* ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)\n* TG \\> 1.7 mmol\u002Fl\n* HDL-cholesterol \\> 1.0 mmol\u002Fl (male) \u002F \\> 1.3 mmol\u002Fl (female)\n* Fasting glucose ≥ 5.6 mmol\u002Fl\n* BP ≥ 130\u002F85 mmHg\n\nExclusion Criteria:\n\n* Pregnancy\n* Medication and \u002F or pathologies that prevent a safe execution of the fat tissue biopsies\n* History of or planned bariatric operation\n* Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)\n* Active Malignant tumor (\\\u003C2a remission)",true,"ALL","18 Years","60 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:\n\n1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison?\n2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?",[25],"Healthy Obesity, Metabolically",[27,28],"Obesity","Healthy","RECRUITING","2025-05-26",{"date":32,"type":33},"2025-05-30","ACTUAL",{"date":35,"type":33},"2023-01-18",{"date":37,"type":21},"2026-01-18",{"name":39,"class":40},"ETH Zurich","OTHER"]