[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-older-adults":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,76,98,122,151,185,212,239,264,314],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100582385","neural-representations-of-memory-transformation-memtrans-100582385",false,"NCT06862622","Neural Representations of Memory Transformation (MEM_TRANS)","Task-based Synchronous Electroencephalography and Functional Magnetic Resonance Imaging (EEG-fMRI) to Explore Neural Representations of Memory Maintenance in the Aging Brain.","Inclusion Criteria:\n\n* Age 18 years or older (80 of the final sample will be ≥60years of age)\n* Cognitively unimpaired, ambiguous, or mildly impaired cognitive function, defined as a score of ≥18 in the Montreal Cognitive Assessment (MOCA).\n* No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head\n* Ability to give consent for study participation\n* Ability to perform a computer task requiring responding to visual cues and typing on a standard computer keyboard with both index and middle fingers for 30 minutes daily.\n\nExclusion Criteria:\n\n* Inability to use both index and middle fingers to type on a standard computer keyboard\n* Dementia defined as a score of \\\u003C18 in the Montreal Cognitive Assessment (MOCA)\n* Uncorrected vision, hindering perception of visual cues presented on a standard computer screen\n* Medication use at the time of study that may interfere with learning, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, and dextromethorphan.\n* Neuromuscular disorders that affect fine motor control of the hands.\n* Presence of neurological or psychiatric disorders\n* Presence of scalp injury or disease\n* Prior intracranial surgery\n* Prior brain radiotherapy\n* Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation\n* Metal in the head or neck\n* Contraindications to MRI (such as severe claustrophobia, implanted medical devices)",true,"ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","Investigators overarching goal is to provide evidence for the link between altered spatiotemporal (where and when) neural mechanisms and the extent of changed memory maintenance in healthy older adults and to identify potential neural markers of compensatory function (cognitive resource). Investigators preliminary studies suggest that healthy older adults, compared to younger adults, benefit behaviorally from increased coupling between frontal and parietal brain waves when retrieving and updating well-consolidated visuomotor sequence memory via stronger top-down cognitive control of memory maintenance. Thus, Investigators central hypothesis is that the dynamics across cortical and subcortical regions (i.e., spatiotemporal representations) during transitions between different levels of memory stability indicate the efficiency of memory maintenance. The rationale is that while temporal and spatial neural signatures carry distinct mechanistic information, the joint definition of spatial and temporal representations will allow the differentiation of compensatory versus neurodegenerative mechanisms.",[25],"Healthy Older Adults",[27,28,29,30,31],"Aging","Healthy Volunteer Studies","memory","fMRI","EEG","NOT_YET_RECRUITING","2026-06-21",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":21},"2026-08-01",{"date":40,"type":21},"2026-09-30",{"name":42,"class":43},"Medical University of South Carolina","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100642470","interactive-effects-of-sodium-and-potassium-on-vascular-health-in-older-adults-100642470","NCT07649005","Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults","Exploring the Interactive Effects of Sodium and Potassium Intake on Vascular Health in Older Adults","Inclusion Criteria:\n\n* Adults ages 55-75 years\n* At least one-year post-menopause (females)\n* Willing and able to attend laboratory visits\n\nExclusion Criteria:\n\n* BMI ≥35 kg\u002Fm2\n* Seated blood pressure \\>135\u002F85 mmHg\n* Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke)\n* Taking exogenous hormones or hormone replacement therapy\n* Following a vegan or gluten free diet\n* Significant weight loss (\\>10% of body weight) in the last 6 months, or actively trying to lose weight\n* Current or recent use of a diuretic (within the past 6 months) (e.g. spironolactone, eplerenone)\n* Current or recent use of a potassium binding medication (within the past 6 months)\n* Current use of blood pressure lowering medications (e.g. ACE inhibitors, calcium channel blockers, diuretics, vasodilators, beta blockers, AngII receptor blockers)\n* Current or recent use of the medication trimethoprim\n* Elevated blood lipids (LDL cholesterol ≥190 mg\u002FdL)\n* Elevated serum potassium level (\\>5.1 mmol\u002FL)\n* Elevated BUN (\\>22 mg\u002FdL)\n* Elevated creatinine (\\>1.2 mg\u002FdL)\n* Low eGFR (\\\u003C90 mL\u002Fmin\u002F1.73 m²)\n* Current or recent use of tobacco, nicotine, or illicit drugs\n* Radical hysterectomy or oophorectomy (females)","55 Years","75 Years",{"count":54,"type":21},30,"INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are:\n\n1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults.\n2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex.\n\nParticipants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.",[25],[61,62,63,64],"sodium","potassium","endothelial function","cardiovascular disease risk factors","RECRUITING","2026-06-11",{"date":68,"type":36},"2026-06-15",{"date":70,"type":36},"2026-03-24",{"date":72,"type":21},"2027-06-30",{"name":74,"class":43},"Florida State University",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":55,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100640864","the-effects-of-immersive-virtual-reality-based-exergaming-combined-with-transcranial-direct-current-stimulation-on-executive-functions-in-healthy-older-adults-100640864","NCT07591194","The Effects of Immersive Virtual Reality-Based Exergaming Combined With Transcranial Direct Current Stimulation on Executive Functions in Healthy Older Adults","Inclusion Criteria:\n\n(1) Age between 60 to 70 years old; (2) Right-handed (Edinburgh Handedness Inventory (Chinese version) \\> 40); (3) Normal overall cognitive function (Montreal Cognitive Assessment (Beijing version) ≥ 26).\n\nExclusion Criteria:\n\n(1) Musculoskeletal injury; (2) neurological\u002Fneurodegenerative disorders (e.g., Alzheimer's disease); (3) history of brain infections or cerebrovascular diseases; (4) psychiatric disorders (e.g., major depressive disorder, schizophrenia); (5) unstable or chronic medical conditions (e.g., cardiac disease, seizures (personal\u002Ffamily history)); (6) hearing and visual impairments (e.g., color blindness and conditions severely affecting the ability to see the screen or distinguish colors); (7) metal implants (e.g., pacemakers); (8) brain stimulation or exercise training intervention within the past 6 months; (9) failure to meet safety criteria for brain stimulation (e.g., pregnancy)","60 Years","70 Years",{"count":85,"type":21},24,[57],"The goal of this clinical trial is to investigate the acute effects of immersive virtual reality (VR)-based exergaming combined with transcranial direct current stimulation (tDCS) on executive functions in healthy older adults. The main questions it aims to answer are:\n\n* Does VR-based exergaming combined with tDCS improve executive function performance in healthy older adults compared with a control condition?\n* Do single interventions (tDCS alone or VR-based exergaming alone) improve executive function performance compared with the control condition?\n* Does the combined intervention produce greater improvements in executive function performance than either intervention alone? Researchers will compare four intervention conditions to evaluate differences in executive function performance following each session.\n\nParticipants will:\n\n* Complete four intervention sessions in a randomized crossover sequence, with a washout period of at least 7 days between sessions\n* Receive the following intervention conditions:\n* sham-tDCS + VR-video\n* tDCS + VR-video\n* sham-tDCS + VR-exergaming\n* tDCS + VR-exergaming\n* Complete executive function assessments immediately after each session, including:\n* the Flanker task for inhibitory control\n* the more-odd shifting task for cognitive flexibility\n* the Corsi block-tapping task for working memory",[25],"2026-05-09",{"date":91,"type":36},"2026-05-15",{"date":93,"type":21},"2026-05-20",{"date":95,"type":21},"2026-06-25",{"name":97,"class":43},"Beijing Sport University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":17,"minAge":105,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":55,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":118,"leadSponsor":120,"locationsCount":75},"100627463","individualized-dual-task-training-for-balance-and-mobility-in-older-adults-100627463","NCT07448961","INDIVIDUALIZED DUAL-TASK TRAINING FOR BALANCE AND MOBILITY IN OLDER ADULTS","EFFECTS OF SENSORİAL AND COGNİTİVE INDİVİDUALİZED DUAL-TASK TRAİNİNG ON FUNCTİONAL BALANCE, MOBİLİTY, AND DUAL-TASK PERFORMANCE İN OLDER ADULTS: A RANDOMİZED CONTROLLED TRİAL","Inclusion Criteria:\n\n* Aged 65 years and older.\n* Living independently in the community.\n* Ability to walk at least 10 meters without the use of an assistive device (e.g., cane, walker).\n* Cognitively intact, defined as a Montreal Cognitive Assessment (MoCA) score of 24 or higher.\n* Stable medical condition allowing for participation in an 8-week exercise program.\n* Willingness to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* History of neurological disorders affecting movement or cognition (e.g., Stroke, Parkinson's Disease, Dementia).\n* Acute or chronic orthopedic conditions that severely limit gait or balance (e.g., recent lower limb fracture or major joint replacement within the last 6 months).\n* Severe visual or hearing impairment that prevents following instructions or performing tasks.\n* Uncontrolled cardiovascular or pulmonary disease.\n* Currently participating in another structured exercise or dual-task training program.\n* Inability to commit to the 8-week training schedule.","65 Years",{"count":107,"type":21},48,[57],"The goal of this clinical trial is to prevent functional decline and improve mobility in healthy older adults aged 65 and over. The main questions it aims to answer are:\n\nWhat is the effect of individualized dual-task training on functional balance and mobility compared to standard training? Does personalized sensory and cognitive training significantly reduce the dual-task cost during walking tasks? Researchers will compare the Individualized Dual-Task Group to a Standardized Dual-Task Group and a Single-Task Control Group to see if personalized adjustments in sensory and cognitive loads lead to superior improvements in balance, gait speed, and motor-cognitive interference.\n\nParticipants will:\n\nComplete an initial assessment of motor and cognitive capacities to determine individual baseline levels.\n\nParticipate in a supervised exercise program 3 days a week for 8 weeks, with each session lasting 40-45 minutes.\n\nPerform motor tasks such as walking, obstacle crossing, and balance exercises while simultaneously engaging in cognitive tasks (e.g., counting, verbal fluency).\n\n(For the individualized group) Undergo weekly adjustments in exercise difficulty, including sensory manipulations like surface changes and head movements based on their performance.",[25,111,112,113],"Postural Balance","Dual Task Exercises in Elderly People","Dual Task Cost","2026-04-29",{"date":116,"type":36},"2026-05-05",{"date":114,"type":36},{"date":119,"type":21},"2027-04",{"name":121,"class":43},"Sezen Karaborklu Argut",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":105,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":55,"phases":131,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":75},"100634917","health-web-tem-10-an-interprofessional-web-based-group-intervention-supporting-healthy-ageing-100634917","NCT07545915","Health Web Te@m (1.0) an Interprofessional Web-based Group Intervention Supporting Healthy Ageing","Health Web Te@m (1.0) an Interprofessional Web-based Group Intervention Supporting Healthy Ageing: a Study Protocol for a Feasibility Study","Inclusion Criteria:\n\n* 65 years or older and retired\n* live in ordinary housing\n* experience a changed life situation that can pose a risk of reduced social participation and health\n* have access to a computer or tablet, access to and experience of using the Internet and e-mail\n* able to express themselves in speech and assimilate information\n\nExclusion Criteria:\n\n* have an ongoing application to nursing home\n* disease or conditions that affect the ability to provide informed consent and participate in data collection and the intervention",{"count":130,"type":21},27,[57],"The goal of this study is to evaluate the feasibility of Health Web - Te@m 1.0 for older adults in selected primary healthcare settings in northern Sweden. More specifically, the feasibility will be assessed through the following objectives:\n\n* Explore older adults' experiences of the intervention process, acceptability, and perceptions of the value of participating in Health Web - Te@m.\n* Explore professionals' experiences of acceptability, value, and implementation potential of delivering Health Web - Te@m in primary healthcare settings.\n* Evaluate adherence to Health Web - Te@m among older adults and professionals.\n* Evaluate the assessments' ability to detect potential outcomes of Health Web - Te@m.",[25],[135,136,137,138,139,140,141],"complex interventions","healthy ageing","older adults","interprofessional team","meaningful activity","digitalization","group intervention","2026-04-16",{"date":144,"type":36},"2026-04-22",{"date":146,"type":36},"2025-11-03",{"date":148,"type":21},"2026-12",{"name":150,"class":43},"Luleå Tekniska Universitet",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":16,"sex":17,"minAge":105,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":55,"phases":162,"briefSummary":163,"conditions":164,"keywords":170,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":75},"100633108","acute-power-training-effects-in-older-adults-100633108","NCT07522398","Acute Power Training Effects in Older Adults","Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults","APTE-OA","Inclusion criteria:\n\nParticipants must:\n\n* Be 65 to 85 years old.\n* Be able to live independently and perform everyday activities without help.\n* Not have regularly done resistance or strength training in the past year.\n* Be able to understand study instructions and communicate in the study language.\n* Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.\n\nExclusion criteria\n\nParticipants will not be eligible if they have any of the following:\n\n* Unstable heart disease, neurological disease, acute infection, or fever.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.\n* Use of whey protein, casein, or amino acid supplements in the month before the study.\n* Acute or chronic injuries to the legs or lower body muscles.\n* Any injury or condition that prevents safe leg extension exercises.\n* Recent lower-limb joint replacement (less than 6 months ago).\n* Dependence on walking aids.\n* Current participation in another interventional trial.","85 Years",{"count":161,"type":21},42,[57],"The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.\n\nThe main questions the study aims to answer are:\n\n* How does the level of fatigue during power training acutely affect strength, movement, and muscle function?\n* How does it affect recovery, muscle soreness, and how hard the exercise feels?\n\nResearchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.\n\nParticipants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.\n\nDuring the study, participants will:\n\n* Perform power training on a pneumatic leg press machine\n* Complete strength and mobility tests before and after exercise\n* Provide small blood samples to measure body responses to exercise\n* Rate how hard the exercise feels\n* Report muscle soreness for up to two days after exercise\n\nThe results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.",[165,166,167,168,169,25],"Muscle Power","Functional Performance","Older Adults (65 Years and Older)","Neuromuscular Function","Physiological Responses",[171,172,27,165,173,174,168,166,169,175],"Power Training","Older Adults","Velocity Loss","Resistance Training","Exercise Fatigue","2026-04-03",{"date":178,"type":36},"2026-04-13",{"date":180,"type":21},"2026-04-20",{"date":182,"type":21},"2027-01",{"name":184,"class":43},"Hasselt University",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":16,"sex":17,"minAge":105,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":55,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":210,"locationsCount":75},"100631023","effects-of-dynamic-neuromuscular-stabilization-exercises-versus-balance-exercises-in-older-adults-100631023","NCT07495280","Effects of Dynamic Neuromuscular Stabilization Exercises Versus Balance Exercises in Older Adults","Effects of Dynamic Neuromuscular Stabilization Exercises Versus Balance Exercises on Functional Outcomes, Balance, and Quality of Life in Older Adults","Inclusion Criteria:\n\n* Older adults aged 65 and over, of both sexes\n* Ability to walk independently and perform basic daily living activities without assistance\n* Willingness to participate and written consent\n\nExclusion Criteria:\n\n* Severe neurological disorders or advanced cognitive impairment\n* Serious cardiopulmonary or systemic diseases that would prevent participation in exercise\n* History of orthopedic surgery or acute trauma within the last 6 months\n* Psychiatric disorders or communication difficulties that would prevent participation",{"count":193,"type":21},18,[57],"The aim of this study is to compare the effects of Dynamic Neuromuscular Stabilization (DNS) based exercises and balance exercises on functional capacity, balance, muscle strength, and quality of life in older adults.",[197,25],"Age-Related Balance Impairment",[199,172,200,201,202,203],"Dynamic Neuromuscular Stabilization","Functional Capacity","Quality of Life","Hand Grip Strength","Balance","2026-03-22",{"date":206,"type":36},"2026-03-27",{"date":208,"type":21},"2026-03-30",{"date":91,"type":21},{"name":211,"class":43},"Yeditepe University",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":16,"sex":17,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":223,"conditions":224,"keywords":226,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":238},"100561342","brain-activity-cognitive-function-and-walking-ability-in-parkinsons-disease-100561342","NCT06588920","Brain Activity, Cognitive Function, and Walking Ability in Parkinson's Disease","Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson's Disease","Inclusion Criteria:\n\n* Diagnoses of idiopathic Parkinson disease\n* Stable dopaminergic medicine ≥ 2 weeks\n* Able to walk 10 meters without aid\n* Mini-Mental Status Examination ≥ 24 points\n* No uncorrected visual or auditory disorders\n* Education at least junior high school\n* No other disease may affect balance\n\nExclusion Criteria:\n\n* Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders\n* History of brain surgery (e.g. deep brain stimulation)","40 Years","80 Years",{"count":222,"type":21},70,"The dual-task automated walking performance in people with Parkinson\\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.",[25,225],"Parkinson Disease",[227,228,229],"Executive function","Gait","Electroencephalography","2026-03-20",{"date":70,"type":36},{"date":233,"type":36},"2024-10-09",{"date":235,"type":21},"2027-08-31",{"name":237,"class":43},"National Yang Ming Chiao Tung University",2,{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":246,"targetDuration":4,"studyType":55,"phases":247,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":75},"100626428","effects-of-feedback-and-aging-on-aiming-movements-in-virtual-reality-100626428","NCT07435506","Effects of Feedback and Aging on Aiming Movements in Virtual Reality","Performing Fitts' Tasks in Virtual Reality With and Without Augmented Feedback: a Comparison Between Young and Older Adults","Inclusion Criteria:\n\n* Aged 18-28 (young adults \\[YA\\] group) or 65-75 (healthy older adults \\[HOA\\] group)\n* Right-handed\n* Normal or corrected-to-normal vision (glasses or contact lenses permitted)\n* Clear and comfortable vision through the head-mounted display during a brief fitting (very bulky glasses may be incompatible)\n* No self-reported history of neurological or psychiatric disorders, as confirmed by participant report and cross-checked against a standardized list of relevant medications\n* Able to provide informed consent and follow experimental instructions in French or English\n\nAdditional criteria for HOA\n\n* Normal cognitive functioning (Montreal cognitive assessment \\[MoCA\\] score ≥ 26)\n* No self-reported acute or chronic pain in the dominant arm, shoulder, or elbow that would preclude performing repetitive arm movements in space.\n* Self-reported full functional range of motion in the dominant arm (able to extend the arm fully without discomfort or restriction)\n\nExclusion Criteria:\n\n* Individuals currently playing video games more than 5 hours\u002Fweek.\n* Uncorrected visual, auditory, or motor impairments that would interfere with task performance.\n* Participant height outside the range of 1.50-1.80 m.\n* Self-reported diagnosis of a neurodegenerative disease (e.g., Parkinson's disease, Alzheimer's disease)\n* Self-reported use of medications known to significantly affect cognitive or motor function (a list of relevant medications will be presented during screening).\n* Cervical pain that could preclude wearing the VR headset during the full duration of the experimental session.\n* Self-reported history of severe motion sickness or vestibular issues that could be exacerbated by VR exposure\n* High susceptibility to cybersickness, as assessed via the Visually Induced Motion Sickness Susceptibility Questionnaire which was developed specifically for pre-exposure screening; cut-off: ≥ 12.\n* Individuals for whom the headset cannot be properly adjusted, e.g., due to an interpupillary distance outside the adjustment range of the head-mounted display (i.e., \\\u003C53 mm or \\>75 mm).",{"count":54,"type":21},[57],"This study has two main objectives: First, to better understand how a motor task commonly used by researchers, known as the Fitts' task, is performed in virtual reality. It consists of reaching a target, which may be large or small, by extending the right arm. This task is similar to movements commonly performed in everyday life. It is also increasingly used in virtual reality video games designed to train older adults or patients with functional limitations. Secondly, the investigators aim to describe how age influences performance in this task by comparing young adults and older adults. This can help better adapt the protocols used in virtual reality to the characteristics of users. It is of particular interest how movements change when the task becomes more difficult, whether these changes differ between young adults and older adults, and whether the information and feedback provided through virtual reality can improve the quality of motor performance. What is expected of participants: Participants will be seated comfortably, wearing a lightweight virtual reality headset and holding a controller in their right hand that will be used to reach for a target by keeping the controller within the target for about one second. The targets will vary in size, so some trials will seem easier and others more difficult. The task is simply to move as quickly as possible while remaining accurate (hitting the target). This instruction is important, and the experimenter will repeat it regularly during the experiment. The task will be performed under different conditions: sometimes participants will see the actual configuration of the experimental device in the physical world through the headset, and other times they will see the same configuration presented in virtual reality. In some virtual reality conditions, participants will also receive additional visual information indicating whether the target has been hit correctly. Short breaks are scheduled at regular intervals. Additional breaks can be asked for at any time when needed. The most important point is to avoid any fatigue or discomfort. If participants experience any, they are asked and encouraged to inform the experimenter. Before starting the experiment, participants will undergo a short training session to familiarize themselves with the task and the device.",[25,250],"Healthy Young Adults",[252,253,254],"Virtual reality","Motor-cognitive","Interactions","2026-02-23",{"date":257,"type":36},"2026-02-27",{"date":259,"type":21},"2026-03-01",{"date":261,"type":21},"2026-06",{"name":263,"class":43},"Aix Marseille Université",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":55,"phases":274,"briefSummary":275,"conditions":276,"keywords":277,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":238},"100614095","acute-cardiovascular-and-neuromuscular-responses-to-walking-with-blood-flow-restriction-bfr-in-older-adults-100614095","NCT07275138","Acute Cardiovascular and Neuromuscular Responses to Walking With Blood Flow Restriction (BFR) in Older Adults","Acute Cardiovascular and Neuromuscular Responses to Walking With Blood Flow Restriction in Older Adults: a Study Protocol for a Randomized Crossover Trial","Inclusion Criteria:\n\n• Aged between 60 and 90 years.\n\nExclusion Criteria:\n\n* Being institutionalized.\n* Peripheral vascular disease, defined by an ankle-brachial index (ABI) outside the normal range (0.9-1.4).\n* Uncontrolled arterial hypertension (\\>180\u002F110 mmHg).\n* Any contraindication to exercise, based on self-reported medical history and PAR-Q+.","90 Years",{"count":273,"type":21},20,[57],"The goal of this clinical trial is to explore how walking combined with different levels of partial blood flow restriction (BFR) affects cardiovascular, neuromuscular, and movement (kinematic) variables in older adults.\n\nThe main questions it aims to answer are:\n\nDoes walking with BFR increase internal effort, as shown by cardiovascular changes, and is this effect proportional to the level of restriction?\n\nDoes walking with BFR temporarily reduce neuromuscular control, and is this reduction greater at higher restriction levels?\n\nDoes walking with BFR change gait movement patterns?\n\nThis study uses a crossover design, meaning that each participant will complete all four conditions and serve as their own control.\n\nParticipants will:\n\nTake part in walking sessions under four conditions with different levels of restriction: BFR40%, BFR80%, SHAM (0% BFR), and CON (without BFR).\n\nHave their cardiovascular responses, muscle performance, and gait movement patterns measured.\n\nReport their perceptions of the sessions, including Rate of Perceived Exertion (RPE), satisfaction, and possible side effects.",[25],[278,279,137,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302,303,304],"Blood Flow Restriction (BFR)","walking exercise","Gait Kinematic","Cardiovascular Response","Neuromuscular Performance","Crossover Study","Physical Function","safety","Endurance training","Low-impact exercise","Aerobic exercise","Physical activity","functionality","Elderly","Senior","Age 60+","Community-dwelling","Non-institutionalized","Partial Blood Flow Restriction","Limb Occlusion Training","Vascular Occlusion Training","KAATSU Training","Low-load resistance training with BFR","Occlusion exercise","walking","walking training","exercise training","2025-11-28",{"date":307,"type":36},"2025-12-10",{"date":309,"type":21},"2025-12-08",{"date":311,"type":21},"2026-01",{"name":313,"class":43},"Universidade da Coruña",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":16,"sex":17,"minAge":105,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":55,"phases":323,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":339,"locationsCount":75},"100595996","a-computer-based-memory-strategy-training-program-for-older-adults-100595996","NCT07039708","A Computer-based Memory Strategy Training Program for Older Adults","A Computer-based Memory Strategy Training Program to Promote Everyday Performance in Healthy Older Adults, Older Adults With Memory Complaints, Mild Cognitive Impairment and Mild Dementia","Inclusion Criteria:\n\nGroup 1: healthy older adults aged 65 years or above Group 2: older adults aged 65 years or above with memory complaints Group 3: older adults aged 65 or above with mild cognitive impairment\n\nExclusion Criteria (for all groups 1, 2 and 3)\n\n\\- have depression and other clinical conditions that may affect their cognition.",{"count":322,"type":21},60,[57],"A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people. The aim of the E-MinD Life is to delay functional deterioration associated with possible cognitive changes in healthy older adults, older adults with memory complaints, mild cognitive impairment (MCI) and mild dementia. This project will pilot-test the E-MinD Life in Chinese healthy older adults, older adults with memory complaints, MCI and mild dementia.",[25,326,327],"Memory Complaints","Mild Cognitive Impairment (MCI)",[329,330,331,137,332],"computer-based","memory training","activities of daily living","feasibility","2025-09-15",{"date":335,"type":36},"2025-09-19",{"date":337,"type":36},"2025-02-10",{"date":148,"type":21},{"name":340,"class":43},"The Hong Kong Polytechnic University"]