[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healty-controls\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healty-controls":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100612198","motor-evoked-potential-and-cortical-silent-period-in-migraine-100612198",false,"NCT07250464","Motor Evoked Potential and Cortical Silent Period in Migraine","Investigation of Motor Evoked Potential and Cortical Silent Period in Migraine Patients","Inclusion Criteria:\n\n* Age 18-45 years.\n* Right-handed individuals.\n* Migraine patients: diagnosed according to International Headache Society (IHS) criteria.\n* Healthy controls: no history of migraine or other neurological disorders.\n* Able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* History of epilepsy or other seizure disorders.\n* Presence of metal implants, pacemakers, or other contraindications to TMS.\n* Pregnancy or breastfeeding.\n* History of significant neurological or psychiatric disorders.\n* Use of medications that significantly alter cortical excitability (e.g., antiepileptics, benzodiazepines) in the last 2 weeks.\n* Any musculoskeletal condition preventing safe participation in EMG\u002FTMS procedures.",true,"ALL","18 Years","45 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods. To this end, Motor Evoked Potential (MEP) and Cortical Silence Period (CSP) parameters obtained using Transcranial Magnetic Stimulation (TMS) will be measured and comparisons will be made between migraine patients and healthy controls. Since CSP duration is used specifically in the evaluation of GABA-B-mediated inhibitory mechanisms, it has the potential to directly measure the effect of migraine on cortical inhibition.",[28,29],"Migraine","Healty Controls",[31,32,33,34],"cortical silent period","migraine","single motor unit","transcranial magnetic stimulation","NOT_YET_RECRUITING","2025-11-26",{"date":38,"type":39},"2025-11-28","ACTUAL",{"date":41,"type":22},"2025-12-01",{"date":43,"type":22},"2026-02-01",{"name":45,"class":46},"Istanbul Gelisim University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100590978","hemodynamic-responses-and-brain-activity-during-dual-tasks-in-copd-patients-versus-healthy-individuals-100590978","NCT06974448","Hemodynamic Responses and Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals","Comparison of Frontal Hemodynamic Responses and Electrical Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals","Inclusion Criteria for the COPD Group:\n\n* Being diagnosed with COPD\n* Being between the ages of 40-65\n* Not having a history of exacerbations in the last 4 week\n* Being willing to participate in the study\n\nInclusion criteria for the Control Group\n\n* Being between the ages of 40-65\n* Being willing to participate in the study\n\nExclusion Criteria for COPD Group :\n\n* Known alpha-1 anti-trypsin deficiency\n* Presence of ischemic heart disease, uncontrolled hypertension, and diabetes mellitus\n* Presence of obstructive sleep apnea syndrome\n* Untreated tumors\n* Known history of dementia\n* Existing musculoskeletal, neuromuscular, or neurological diseases that may prevent participation in the tests\n* Not being willing to participate in the study\n\nExclusion criteria for the Control Group:\n\n* Having a known chronic health problem\n* Not being willing to participate in the study","40 Years","65 Years",{"count":58,"type":22},32,"OBSERVATIONAL","Abstract\n\nCognitive dysfunction is joint in patients with chronic obstructive pulmonary disease (COPD).\n\nIn particular, there are effects in tasks that require attention, executive functions, and working memory related to the prefrontal cortex. These effects make it difficult to perform two tasks simultaneously and cause performance errors. The number of studies investigating the effects of cognitive impairments on dual-task performance in COPD is limited. In these studies, no tests were applied specifically for attention and working memory areas; therefore, the brain's neural activity was not investigated during these tests. Multimodal approaches are recommended for a comprehensive assessment of the functional activity of the brain. Multimodal approaches provide more accurate results than single-modality approaches. In the integrated electroencephalography (EEG)-functional near-infrared spectroscopy (fNIRS) approach, EEG provides adequate temporal resolution, while fNIRS offers better spatial resolution and is robust to noise. There is no study in COPD where simultaneous fNIRS-EEG measurements were made during both cognitive tests and dual tasks. In our study, the simultaneous measurement of frontal hemodynamic responses and electrical brain activity in both cognitive tests and dual-task conditions and the examination of the relationship between the results and arterial stiffness, balance, exercise capacity, anxiety, depression, and quality of life scores, which are reported to be related to cognitive function in COPD, constitute the original aspect of our study. The study will include 16 COPD and 16 healthy individuals. The same assessments will be made in both groups, and the results will be compared. General and task-specific cognitive tests, prefrontal cortex oxygenation (fNIRS), electrical brain activity (EEG), exercise capacity, muscle oxygenation, arterial stiffness, balance, respiratory function, dyspnea, depression, anxiety, and quality of life will be evaluated. As a result of this study is expected to determine the effects of cognitive function and dual-task on frontal hemodynamic responses and electrical brain activity in COPD.",[62,29],"COPD - Chronic Obstructive Pulmonary Disease",[62,64,65,66,67],"dual task","cognitive function","electroencephalogram","Functional Near-Infrared Spectroscopy","2025-05-07",{"date":70,"type":39},"2025-05-16",{"date":72,"type":22},"2025-05-15",{"date":74,"type":22},"2026-10-09",{"name":76,"class":46},"Hacettepe University"]