[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heart-arrest\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heart-arrest":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,43,80,104,136,170,199,228,253,276,303],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100327542","effectiveness-of-exercise-after-an-icd-100327542",false,"NCT03544489","Effectiveness of Exercise After an ICD","Clinical Effectiveness of Exercise After an ICD (E-ICD)","E-ICD","Inclusion Criteria:\n\n* ICD implantation for primary or secondary prevention of sudden cardiac arrest, -ability to read, speak and write English,-\n* access to a reliable phone for 6 months after study entry,\n* able to ambulate without assist devices for at least 5-10 minutes\u002Fday\n* greater than 18 years of age.\n\nExclusion Criteria:\n\n* current diagnosis of serious mental disorder,\n* regular non-medical use of illicit drugs (opiates, cocaine, amphetamines, etc.), -unstable angina, myocardial infarction, ICD shock or heart surgery within previous 3 months\n* pregnancy\n* concurrent participation in an exercise program \\> 5 days\u002Fweek.","ALL","18 Years",{"count":20,"type":21},210,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will test an exercise intervention (E-ICD) following an implantable cardioverter defibrillator.",[27,28,29],"Heart Arrest","Implantable Defibrillator User","Physical Activity","RECRUITING","2026-04-21",{"date":33,"type":34},"2026-04-23","ACTUAL",{"date":36,"type":34},"2025-05-01",{"date":38,"type":21},"2029-06-30",{"name":40,"class":41},"University of Washington","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":5},"100578285","the-ventilation-during-in-hospital-cardiac-arrest-study-100578285","NCT06809309","The Ventilation During In-hospital Cardiac Arrest Study","The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study","VENT-IHCA","Inclusion Criteria:\n\n1. In-hospital cardiac arrest\n2. Age ≥ 18 years\n3. \\>1minute of recorded ventilation data\n\nExclusion Criteria:\n\n1. Documented do-not-attempt cardiopulmonary resuscitation order\n2. Invasive mechanical circulatory support at the time of the cardiac arrest",{"count":52,"type":21},900,"OBSERVATIONAL","The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.\n\nThe main questions it aims to answer are:\n\nWhat ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?\n\nResearchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.",[56,57,27],"Cardiac Arrest (CA)","In-Hospital Cardiac Arrest",[59,60,61,62,63,64,65,66,67,68,69,70],"prospective observational study","ventilation","manual ventilation","cardiac arrest","in-hospital cardiac arrest (IHCA)","bag-valve-mask (BVM)","tidal volume","ventilation rate","intra-arrest ventilation","cardiopulmonary ventilation (CPR)","resuscitation","adult","2026-03-27",{"date":73,"type":34},"2026-03-30",{"date":75,"type":34},"2025-02-01",{"date":77,"type":21},"2027-06",{"name":79,"class":41},"University of Aarhus",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":42},"100593119","the-effect-of-specialty-care-on-recovery-from-cardiac-arrest-trial-the-sparc-trial-100593119","NCT07002294","The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)","SPARC","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest\n* Resuscitated from cardiac arrest with palpable pulse in the emergency department\n* Treated at one of participating hospital emergency departments\n* Age ≥18 years\n\nExclusion Criteria:\n\n* Known prior advanced directives or decision to limit critical care\n* Known pre-arrest dependent functional status (e.g., living in a skilled nursing facility, hospice or bedbound)\n* Arrest in the emergency department \\>4 hours after arrival\n* Traumatic etiology of arrest\n* Known to have opted-out from the SPARC trial",{"count":88,"type":21},1618,[24],"This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers.\n\nThe main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days.\n\nParticipants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.",[56,27,92],"Heart Arrest, Out-Of-Hospital",[62],"NOT_YET_RECRUITING","2026-02-03",{"date":97,"type":34},"2026-02-05",{"date":99,"type":21},"2026-06",{"date":101,"type":21},"2032-01",{"name":103,"class":41},"University of Pittsburgh",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100463958","predictive-outcome-in-comatose-patients-100463958","NCT05321459","Predictive Outcome in Comatose Patients","New Predictive Tool of Awakening in Comatose Patients in the Intensive Care Unit","PRECOM","Inclusion Criteria:\n\n* Age above18 years old\n* Patient affiliated to a French Heath Care Insurance\n* Admitted in the intensive care unit (ICU) for coma post extra- or intra-hospital cardiac arrest (CA) with shockable or non-shockable rhythm\n* Persistent coma on day 3 after post CA, defined by the inability to respond to a verbal command in an appropriate manner (motor Glasgow components ≤ 3) and at the time of neurophysiological recordings (D3-D7 ± week -end).\n\nExclusion Criteria:\n\n* Decision to limit resuscitation therapies taken by the resuscitation team\n* Inability to perform the auditory evoked potentials (AEP) (deafness, skin lesion or any condition preventing to record AEP).\n* Opposition by the trusted person or by the patient once he\u002Fshe wakes up",{"count":113,"type":21},100,"Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity\u002Fspecificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death.\n\nThe investigators hypothesize that the \"PRECOM\" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict neurological prognosis at 3 months with high sensitivity and specificity.",[116,27,117],"Coma","Cardiopulmonary Resuscitation",[119,120,121,122,123,124,125],"Post cardiac arrest for comatose patients","Electroencephalography","Somatosensory evoked potentials","Auditory evoked potentials","Prognosis","Algorithms","Classification","2025-12-16",{"date":128,"type":34},"2025-12-23",{"date":130,"type":34},"2023-11-15",{"date":132,"type":21},"2028-05-29",{"name":134,"class":41},"Assistance Publique - Hôpitaux de Paris",7,{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":148,"conditions":149,"keywords":156,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":42},"100452609","phase-4-rehabilitation-for-survivors-of-out-of-hospital-cardiac-arrest-100452609","NCT05173740","Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest","The ROCK Trial. A Multidisciplinary Rehabilitation Intervention Targeted Return-to-work in Sudden Out-of-hospital Cardiac Arrest Survivors A Pragmatic Randomised Controlled Trial","Inclusion criteria:\n\n* All adult survivors with first time out-of-hospital cardiac arrest\n* Discharged from the Hospitals will be assessed eligible for inclusion\n\nExclusion criteria:\n\n* Survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions\n* Patients that cannot understand and fulfil the study surveys (in Danish)\n* Patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without ICU treatment","65 Years",{"count":145,"type":21},214,[147],"PHASE4","This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.\n\nParticipants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting RTW plus usual care compared to usual care alone.",[150,27,117,151,152,153,154,155],"Cardiac Arrest","Return to Work","Return-to-work","Rehabilitation","Recovery of Function","Cardiac Rehabilitation",[157,158,27,117,159,152,160,153,154,155],"Labour marked","Cardiac arrest","Return to work","Back to Work","2025-12-01",{"date":163,"type":34},"2025-12-08",{"date":165,"type":34},"2022-02-01",{"date":167,"type":21},"2028-07-31",{"name":169,"class":41},"Rigshospitalet, Denmark",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":42},"100546956","phase-2-perampanel-for-status-epilepticus-prophylaxis-post-cardiac-arrest-100546956","NCT06401707","PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest","PROSPER","Inclusion Criteria:\n\n* Age ≥18 years old\n* Non-traumatic, out-of-hospital cardiac arrest\n* Comatose on admission - defined as not following commands\n* Return of spontaneous circulation (ROSC) within less than 45 minutes from the time of cardiac arrest (defined as the time of 911 or EMS (emergency medical services) witnessed arrest)\n* Admission to the intensive care unit at Zuckerberg San Francisco General Hospital\n\nExclusion Criteria:\n\n* Acute cerebral hemorrhage or infarction\n* Pregnancy\n* Prisoner\n* Severe kidney function impairment with creatinine clearance inferior to 30 ml\u002Fmin\n* Severe liver impairment with liver function tests five times above the upper limit of normal\n* Electrographic or electroclinical seizures diagnosis using American Clinical Neurophysiology criteria confirmed by an epileptologist after cardiac arrest",{"count":178,"type":21},52,[180],"PHASE2","Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.",[27,183,184],"Seizures","Status Epilepticus",[186,187,188,189],"heart arrest","seizure","status epilepticus","prophylaxis","2025-07-02",{"date":192,"type":34},"2025-07-08",{"date":194,"type":34},"2024-05-20",{"date":196,"type":21},"2026-10-20",{"name":198,"class":41},"University of California, San Francisco",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":206,"enrollmentInfo":207,"targetDuration":209,"studyType":53,"phases":4,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100528361","national-registry-of-cardioneuroablation-in-recurrent-reflex-syncope-100528361","NCT06159764","National Registry of Cardioneuroablation in Recurrent Reflex Syncope","CANVAS-R","Inclusion Criteria:\n\n* Patients aged 18 or more\n* Recurrent vasovagal syncope (≥2 episodes during the last year) with an asystolic component (≥3 second pause) recorded during a spontaneous episode. The asystole can be related to sinus arrest or paroxysmal AV block.\n* Scheduled cardioneuroablation procedure\n* Estimated residual battery life ≥ 1 year.\n* Patient affiliated to or beneficiary of national health security scheme.\n* Patient who have received an information notice and has not objected to the use of their data in the registry.\n\nExclusion Criteria:\n\n* Contraindication to anticoagulation therapy: major bleeding, risk of major bleeding, severe hepatic disease\n* Contraindication to cardiac CT: contrast medium allergies\n* Intracardiac thrombus\n* Patient detained by judicial or administrative decision.","100 Years",{"count":208,"type":21},50,"12 Months","This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own cardioneuroablation program",[212,213,27],"Syncope, Vasovagal","Bradycardia",[215,216,217],"cardioneuroablation","vasovagal syncope","registry","2025-06-12",{"date":220,"type":34},"2025-06-17",{"date":222,"type":34},"2024-11-27",{"date":224,"type":21},"2026-01-31",{"name":226,"class":41},"University Hospital, Bordeaux",14,{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":42},"100504673","phase-2-burst-suppression-to-stop-refractory-status-epilepticus-post-cardiac-arrest-100504673","NCT05851391","buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest","buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)","RESTORE","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. Non-traumatic, out-of-hospital cardiac arrest\n3. Comatose on admission - defined as not following commands\n4. Return of spontaneous circulation (ROSC) within less than 45 minutes\n5. Admission to the intensive care unit\n6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous\n\nEEG monitoring within 7 days from ROSC\n\nExclusion Criteria:\n\n1. Acute cerebral hemorrhage or infarction\n2. Pregnancy\n3. Prisoners",{"count":237,"type":21},30,[180],"RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.",[241,27,184,242,183,243,244],"Hypoxia-Ischemia, Brain","Refractory Status Epilepticus","Anoxic-Ischemic Encephalopathy","Anoxia-Ischemia, Cerebral","2025-05-12",{"date":247,"type":34},"2025-05-15",{"date":249,"type":34},"2023-08-07",{"date":251,"type":21},"2027-04-30",{"name":198,"class":41},{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":262,"briefSummary":263,"conditions":264,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":42},"100556863","phase-4-evaluation-of-clinical-impact-of-the-type-of-cardioplegia-used-in-the-patient-undergoing-major-cardiac-surgery-100556863","NCT06530641","Evaluation of Clinical Impact of the Type of Cardioplegia Used in the Patient Undergoing Major Cardiac Surgery.","Evaluation of Clinical Impact of the Type of Cardioplegia Used in the Patient Undergoing Major Cardiac Surgery with Extracorporeal Circulation. CARDIO-HEART Clinical Trial.","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Patients with cardiac pathology and indication for major cardiac surgery with extracorporeal circulation and aortic clamping.\n\nExclusion Criteria:\n\n1. Pregnancy.\n2. Aortic arch procedures.\n3. Procedures in which hypothermia \\\u003C28ºC is expected during the intervention.\n4. Minimally invasive procedures \"Port Access\".\n5. Active endocarditis.\n6. Emerging procedures.\n7. Isolated aortic valve replacements.\n8. Decision of the main surgeon not to participate in the study due to other clinical criteria.",{"count":261,"type":21},600,[147],"Phase IV clinical trial of a single-blind, prospective and longitudinal randomized intervention comparing patients undergoing major cardiac surgery with extracorporeal circulation who are administered Custodiol crystalloid cardioplegia versus Buckberg blood cardioplegia.",[265,266,27],"Cardiac Surgery","Cardioplegia","2025-03-13",{"date":269,"type":34},"2025-03-17",{"date":271,"type":34},"2024-12-01",{"date":273,"type":21},"2026-12",{"name":275,"class":41},"Lourdes Montero Cruces",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":22,"phases":286,"briefSummary":287,"conditions":288,"keywords":291,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":42},"100557390","synergy-of-elevation-of-the-head-and-thorax-and-reboa-during-out-of-hospital-cardiac-arrest-100557390","NCT06537492","Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest","Synergy of Elevation of the Head and Thorax and Resuscitative Endovascular Balloon Occlusion of the Aorta During Out-of-Hospital Cardiac Arrest: a Pilot Study","GRAVITY2","Inclusion Criteria:\n\n* Patient with age over or equal to 18 years old\n* Patient with a witnessed medical cardiac arrest and with a no-flow duration under 10 min\n* Patient with EtCO2 greater than 20 mmHg at REBOA team arrival\n* Patient located in the Grenoble Metropolitan area\n* Patient affiliated to French social security\n\nExclusion Criteria:\n\n* Patient with ROSC before REBOA placement.\n* Patient eligible to extracorporeal life support (according to local guidelines).\n* CA of traumatic origin (including drowning or hanging).\n* Patients whose size is not adapted to the LUCAS device: height of the sternum from 170 to 303 mm or maximum chest width of 449 mm. The use of the LUCAS device is not subject to a patient weight condition.\n* Cardiac arrest for which resuscitation seems unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, advance personal directives of no-resuscitation).\n* Obvious pregnancy at inclusion.\n* Subject in a period of exclusion from another clinical investigation.\n* Patients with a femoral arterial access site that cannot accommodate an 8 Fr (minimum) introduces sheath",{"count":285,"type":21},35,[24],"Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries. Automated head and chest elevation during cardiopulmonary resuscitation (AHUP-CPR) improves cerebral perfusion by decreasing the intracranial pressure and increasing cerebral perfusion in experimental pig studies. The addition of an impedance threshold device (ITD) and active chest compression-decompression device (ACD) improved hemodynamics and cerebral perfusion. In addition, early implementation of AHUP-CPR in patients with out-of-hospital cardiac arrest (OHCA) was associated with improved survival to hospital discharge, in a multicenter observational study. A 2-year prospective clinical trial in Grenoble evaluating this combination was just completed. This study showed for the first time that the value of end-tidal CO2 (EtCO2), a surrogate for cardiopulmonary resuscitation (CPR) quality and cardiac output, measured with this combination therapy, was significantly higher than with standard CPR.\n\nResuscitative endovascular balloon occlusion of the aorta (REBOA) has recently been proposed during CPR. This technique temporarily diverts blood flow to the coronary and cerebral circulation. Its beneficial effect on hemodynamics, cerebral blood flow and survival has been experimentally validated. In several feasibility studies, encouraging results were observed by slightly optimizing cerebral perfusion and coronary pressure when REBOA was used in combination with standard CPR.\n\nIn a porcine model of cardiac arrest, the addition of REBOA to AHUP CPR was associated with a marked improvement in coronary perfusion pressure and near-normalization of cerebral perfusion pressure. These two interventions act synergistically. REBOA directs flow and pressure to the heart and brain, while AHUP CPR improves preload on the right side of the heart and reduces intracranial pressure.\n\nThe aims of this clinical investigation are to assess the feasibility of placing a REBOA catheter combined with automated CPR with head and chest elevation, and to quantify the associated changes in clinical parameters for OHCA.",[27,289,290,117],"Cardiac Arrest, Out-Of-Hospital","Cardiopulmonary Arrest",[292,293],"Resuscitative endovascular balloon","Head-up cardiopulmonary resuscitation","2024-07-31",{"date":296,"type":34},"2024-08-05",{"date":298,"type":21},"2024-10",{"date":300,"type":21},"2026-01",{"name":302,"class":41},"University Hospital, Grenoble",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":309,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":311,"targetDuration":4,"studyType":22,"phases":313,"briefSummary":314,"conditions":315,"keywords":316,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":328},"100519841","early-cessation-of-sedation-and-ttm-in-patients-with-a-favourable-eeg-after-cardiac-arrest-100519841","NCT06048796","Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest","Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest: a Feasibility and Safety Study","SELECT","Inclusion Criteria:\n\n* Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation.\n* Age 18 years or older.\n* Continuous EEG measurement started within 12 hours after cardiac arrest.\n* Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019).\n* Possibility to stop sedative treatment within three hours after identification of a favourable EEG pattern.\n* Written informed consent (deferred).\n\nExclusion Criteria:\n\n* A known history of another medical condition with limited life expectancy (\\\u003C6 months).\n* Any progressive brain illness, such as a brain tumour or neurodegenerative disease.\n* Pre-admission Glasgow Outcome Scale Extended score of 4 or lower.\n* Reason other than neurological condition to continue sedation and\u002For ventilation.\n* Follow-up impossible due to logistic reasons.",{"count":312,"type":21},40,[24],"The objective of this study is to estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (\\\u003C 12 h) favourable EEG pattern (indicating no or mild postanoxic encephalopathy).",[241,27],[317,318],"EEG","targeted temperature management (TTM)","2024-05-10",{"date":321,"type":34},"2024-05-13",{"date":323,"type":34},"2024-03-12",{"date":325,"type":21},"2026-10",{"name":327,"class":41},"Medisch Spectrum Twente",2]