[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heart-rate-variability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heart-rate-variability":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,52,110,136,174,199,228,254,283,309,337,367,393,417,444,472,497,524,548,588],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100436177","job-stress-in-ophthalmology-physicians-and-residents-100436177",false,"NCT04959838","JOB STRESS in OPHthalmology Physicians and Residents","Monitoring of JOB STRESS Related to Night Shifts in OPHthalmology Physicians and Residents","JOBSTRESS-OPH","Inclusion Criteria:\n\n* Ophthalmologists defined as physicians who completed the ophthalmology DES (Specialized studies diploma), as well as ophthalmology residents defined as a resident registered in the ophthalmology DES working during the inclusion period in the ophthalmology department of the university hospital center of Clermont-Ferrand.\n* Ability to give a written informed consent to participate in research.\n* Affiliation to a social security system.\n* Age between 18 and 65 years old\n\nExclusion Criteria:\n\n* Participant refusal to participate\n* Children under the age of 18, pregnant and breastfeeding women, protected adults (individuals under guardianship by court order), adults deprived of their liberty.","ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Ophthalmology physicians and residents work under stress conditions during night emergency ophthalmology shifts. Under time pressure, that is a characteristic of the urgency of care, they must use all their cognitive resources to make an accurate diagnosis and to provide accurate decisions, with sometimes surgical emergency acts. In addition, in France, they work at night following by an usual day work, and they can also work 48 consecutive hours during weekends, followed by a work day … i.e. 60 consecutive hours of work … Long working hours with a short recovery time has been demonstrated to be a major factor of stress and fatigue. Even if not demonstrated on ophthalmologists, those working conditions may contribute to symptoms of mental exhaustion and physical fatigue (sleep deprivation), often accompanied by a loss of motivation at work. This may leads to a feeling of loss of time control; stress can also distort the perception of time and leads to hasty actions or delayed decision-making. The combined effects of stress, feelings of loss of time control, and fatigue necessarily have an impact on work performance and work quality, with a high risk of medical error. Moreover, prolonged stress may expose ophthalmologists to a higher risk of multiple diseases, predominantly systemic inflammation and coronary heart disease.\n\nThe main hypothesis is that prolonged work (up to 60 consecutive working hours) may impact on HRV, comparatively to a typical working day.",[28,29],"Stress","Heart Rate Variability",[31,32,33,34,35,36,37,38],"ophthalmologists","on-call duty","stress","surgical simulator","heart rate variability","sleep","questionnaires","actimetry","RECRUITING","2026-06-15",{"date":42,"type":43},"2026-06-16","ACTUAL",{"date":45,"type":43},"2021-07-06",{"date":47,"type":22},"2027-07",{"name":49,"class":50},"University Hospital, Clermont-Ferrand","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":63,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":79,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":51},"100640521","neurofinance-human-stress-trial-during-financial-and-informational-volatility-100640521","NCT07622589","NeuroFinance Human Stress Trial During Financial and Informational Volatility","NeuroFinance Human Stress Trial During Financial and Informational Volatility (NFHST)","NFHST","Inclusion Criteria:\n\n* Adults age 18 years and older.\n* Ability to provide informed consent.\n* Willingness and ability to comply with study procedures and remote monitoring requirements.\n* Access to a compatible smartphone, tablet, or internet-connected device for decentralized study participation.\n* Willingness to utilize wearable physiologic monitoring technologies during the study period.\n* Participants with varying degrees of financial market exposure, occupational stress exposure, or digital media exposure are eligible.\n* Healthy volunteers and participants with self-reported stress-related symptoms may be enrolled.\n* Ability to read and understand English-language consent and study materials.\n\nExclusion Criteria:\n\n* Individuals unable or unwilling to provide informed consent.\n* Individuals unable to comply with remote monitoring procedures or wearable device usage requirements.\n* Active medical or psychiatric instability that, in the opinion of study investigators, may interfere with study participation or data integrity.\n* Current incarceration or institutionalization limiting voluntary participation.\n* Participation in another interventional clinical trial that may substantially interfere with physiologic monitoring outcomes.\n* Any condition that would significantly impair safe study participation as determined by the study investigators.",true,{"count":62,"type":22},2500,"24 Months","OBSERVATIONAL","The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven stress environments affect human physiologic and behavioral health. Participants will undergo remote monitoring using wearable biosensors, cardiovascular telemetry devices, sleep tracking systems, heart rate variability monitoring, and behavioral analytics platforms. The study will use artificial intelligence and machine learning systems to analyze relationships between external financial and informational events and biologic stress responses, including autonomic nervous system activity, sleep disruption, cardiovascular strain, emotional resilience, and inflammatory signaling. The goal of the study is to develop predictive digital biomarkers and AI-assisted forecasting systems capable of identifying stress-related physiologic deterioration before clinical manifestation.",[67,68,69,70,71,72,73,74,75,76,77,29,78],"Psychological Stress","Anxiety","Emotional Stress","Autonomic Nervous System Dysfunction","Sleep Disturbance","Insomnia","Behavioral Health","Cognitive Fatigue","Occupational Stress","Financial Stress","Burnout Syndrome","Neurobehavioral Manifestations",[80,81,82,83,84,85,29,86,87,88,89,90,91,92,93,94,95,96,97,98],"NeuroFinance","Financial Stress Medicine","Wearable Biosensors","Artificial Intelligence","Machine Learning","Digital Biomarkers","Sleep Monitoring","Behavioral Analytics","Cardiovascular Telemetry","Decentralized Clinical Trial","Emotional Resilience","Physiologic Stress","Market Volatility","Economic Uncertainty","Social Media Exposure","Cognitive Performance","Stress Forecasting","Precision Wellness","Remote Patient Monitoring","NOT_YET_RECRUITING","2026-05-27",{"date":102,"type":43},"2026-06-03",{"date":104,"type":22},"2026-07-15",{"date":106,"type":22},"2029-06-30",{"name":108,"class":109},"Truway Health, Inc.","INDUSTRY",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":51},"100633846","comparison-of-heart-rate-variability-analysis-durations-and-their-relationship-with-blood-pressure-100633846","NCT07531992","Comparison of Heart Rate Variability Analysis Durations and Their Relationship With Blood Pressure","Comparison of Heart Rate Variability Analysis Durations and Their Relationship With Blood Pressure: A Methodological Comparative Study","HRV-BP","Inclusion Criteria:\n\n* Healthy adults aged 18 to 40 years\n* Willing and able to provide informed consent\n* Able to comply with pre-assessment instructions, including restrictions related to caffeine intake and strenuous physical activity\n* No condition preventing heart rate variability and blood pressure measurements\n\nExclusion Criteria:\n\n* History of diagnosed cardiovascular, neurological, or autonomic nervous system disease\n* Known arrhythmia or pacemaker use\n* Regular use of medications that may affect heart rate variability, such as beta blockers or antiarrhythmic drugs\n* Acute infection, fever, or any condition affecting general health status on the day of assessment\n* Severe motion artifact during measurement or technically unusable recordings","40 Years",{"count":120,"type":22},40,[25],"This observational study aims to compare heart rate variability (HRV) parameters obtained from different analysis durations in healthy adults and to examine how these parameters relate to resting blood pressure values. HRV is a noninvasive measure commonly used to assess autonomic nervous system activity. Standard short-term HRV analysis is typically based on 5-minute recordings, but shorter and longer analysis durations are also used in research and practice. This study will evaluate whether HRV values derived from 1-minute, 5-minute, 10-minute, and 20-minute analysis windows differ from one another and whether their relationships with systolic blood pressure, diastolic blood pressure, and mean arterial pressure change according to analysis duration. Participants will attend a single study visit. After a rest period, resting blood pressure and pulse will be measured, and a continuous HRV recording will be obtained using a chest strap device. The study is designed to provide methodological information on the comparability of different HRV analysis durations under the same physiological conditions.",[29],[29,125,126],"HRV","Autonomic Nervous System","2026-04-13",{"date":129,"type":43},"2026-04-15",{"date":131,"type":22},"2026-05-01",{"date":133,"type":22},"2026-09-15",{"name":135,"class":50},"Sinop University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":173},"100491531","auricular-vagus-stimulation-and-heart-rate-variability-100491531","NCT05680337","Auricular Vagus Stimulation and Heart Rate Variability","Transcutaneous Electrical Auricular Vagus Stimulation and Heart Rate Variability","Inclusion Criteria:\n\n* Sinus rhythm at the time of registration\n\nExclusion Criteria:\n\n* Frequent ventricular \u002F supraventricular extrasystole, 2d\u002F3d degree AV Block\n* Taking glucocorticosteroids in the last 1 month\n* Taking any antiarrhythmics, except beta blockers\n* Severe chronic renal or liver pathology","75 Years",{"count":145,"type":22},600,[25],"Transcutaneous electrical stimulation of the auricular vagus nerve (TENS) is a promising method of neuromodulation of the autonomic nervous system in patients with various pathologies. The use of this method requires the determination of a reliable biomarker of successful activation of the vagus nerve using TENS. Currently, most studies focus on the assessment of heart rate variability (HRV) as a marker of the functioning of the autonomic nervous system.\n\nDespite the physiological justification of HRV as a biomarker for TENS, the data on the effects of TENS on HRV are ambiguous. In some studies, a significant decrease in the ratio of spectral characteristics (LF\u002FHF) in active TENS was found in comparison with fictitious stimulation (sham), which indicated an increase in the parasympathetic component of HRV. However, other studies have not revealed an increase in HRV.",[149,29],"Vagus Nerve Stimulation",[151,152,153,154,155,35,156,157,158,159,160,161,162],"auricular stimulation","auricular vagus nerve stimulation","heart rate","transcutaneous vagus nerve stimulation (TENS)","vagus nerve stimulation (VNS)","power of high-frequency oscillations (HF)","power of low-frequency oscillations (LF)","power of very low frequency oscillations (VLF)","power of ultra-low frequency oscillations (ULF)","LF\u002FHF","index centralization (IC)","index of vegetative balance (IVB)","2025-06-17",{"date":165,"type":43},"2025-06-18",{"date":167,"type":43},"2022-12-01",{"date":169,"type":22},"2026-07-01",{"name":171,"class":172},"Bakulev Scientific Center of Cardiovascular Surgery","OTHER_GOV",3,{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":180,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":51},"100590183","exploring-the-relationship-between-heart-rate-variability-hrv-training-load-and-endurance-performance-100590183","NCT06964100","Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance","Inclusion Criteria:\n\nActively participating in cardiovascular training (3-5 days\u002Fweek).\n\nAble to run a 5K (3.1 miles) distance at a self-selected location, three times over 8 weeks.\n\nAge 18-65 years.\n\nSubject is willing to refrain from vigorous exercise (light physical activity only) 24 hours prior to timed 5K assessment.\n\nSubject is willing to avoid alcohol consumption 24 hours prior to 5K assessment.\n\nSubject is willing to provide consent.\n\nSubject is able to continuously wear their activity tracker, including during sleep, except when submerged underwater (i.e., swimming, bathing).\n\nSubjects must have compatible wearable device (Android, Apple Health, Dexcom, Fitbit, Garmin, Health Connect, Oura, Polar, Whoop, and Withings).\n\nExclusion Criteria:\n\nIndividual has a condition the Investigator believes would interfere with his ability to provide informed consent, comply with the project\u002Fstudy protocol, which might confound the interpretation of the project\u002Fstudy results or put the person at undue risk.\n\nThose with a medical history that would interfere with the results of this study.\n\nThose that have ≥1 risk factor for cardiovascular disease according to the American College of Sports Medicine.\n\nAge: Men ≥ 45 yrs; Women ≥ 55 yrs.\n\nFamily History: Heart attack, \"bypass surgery\", or sudden death before the age of 55 yrs for father\u002Fbrother, or before 65 yrs for mother\u002Fsister.\n\nCigarette Smoking: Current smoker, or have quit \\\u003C 6 months, or exposed to environmental smoke.\n\nSedentary lifestyle: Not participating in moderate (sweating) physical activity at least 3 days\u002Fweek for 3-months.\n\nObesity: Body mass index ≥ 30 kg\u002Fm2 or waist girth 102 cm (40 inches) for men and 88 cm (35 inches) for women.\n\nHypertension: Systolic Blood Pressure ≥ 140 mmHg and\u002For Diastolic ≥90 mmHg, or taking medication.\n\nDyslipidemia: LDL ≥130 mg\u002Fdl, or HDL \\\u003C 40 mg\u002Fdl, or taking medication. Or triglycerides (TG) \\> 200 \\> mg\u002Fdl.\n\nPre-diabetes: Impaired fasting glucose (IFG) ≥ 100 mg\u002Fdl or oral glucose tolerance test (OGTT) ≥ 140 or ≤ 199 mg\u002Fdl confirmed by two different measurements.\n\nUnder the care of a physician.\n\nSleep disorders.\n\nUsing prescription medications that would impact sleep.\n\nIf female, you are not pregnant, planning to get pregnant or currently breast feeding.\n\nNot able to wear activity tracker continuously.\n\nLack of proficiency in English.\n\nLack of proficiency or access to the internet and email address.\n\nParticipation in another clinical trial within the past 30 days.\n\nSubject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",{"count":181,"type":22},200,"The ability of smart phones, aided by wearable devices (e.g. smart watches), to collect a variety of data, including physical activity, heart rate, and other exercise metrics, may provide a unique opportunity to understand real-world variability. The primary objective of this study is to test user engagement, app functionality, and feasibility of the newly developed Gatorade Sports Science Institute (GSSI) Labs App to conduct Real-World research studies. The secondary purpose of this study is to determine if Training Intensity (%Heart Rate maximum) in minutes during low heart rate variability (HRV) periods (below HRV baseline consecutive days) will have a negative relationship with post-study 5K (5 kilometer) running times as measured by their activity tracker, which could lead to personalized training recommendations using HRV. This study is conducted remotely, there are no in-person visits.",[29],[35,125,185,186,187,188,189],"real world","activity tracker","app engagement","app functionality","remote","2025-04-30",{"date":192,"type":43},"2025-05-09",{"date":194,"type":43},"2025-04-04",{"date":196,"type":22},"2025-12-30",{"name":198,"class":109},"PepsiCo Global R&D",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":208,"conditions":209,"keywords":217,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":51},"100589414","mechanisms-and-prognosis-of-stroke-heart-syndrome-100589414","NCT06954103","Mechanisms And Prognosis of Stroke-Heart Syndrome","MAP-SHS","Inclusion Criteria:\n\n1. Patients admitted within 48 hours of onset, confirmed by CT\u002FMRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke).\n2. Moderate-to-severe stroke with NIHSS ≥ 5.\n\nExclusion Criteria:\n\n1. Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.).\n2. Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.).\n3. Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH).\n4. History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms).\n5. Concomitant systemic diseases such as renal failure (eGFR \\\u003C 30), autoimmune disorders, severe infections, etc.\n6. History of dementia, depression, or other psychiatric disorders.\n7. Poor compliance and inability to cooperate with follow-up.",{"count":207,"type":22},658,"The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, and emotional issues post-stroke. The research is expected to uncover novel blood biomarkers and brain network mechanisms associated with stroke-heart syndrome, providing potential targets and theoretical foundations for pharmacological treatments or physical interventions. Furthermore, it aims to establish a risk early-warning system for major cardiovascular complications post-stroke, enabling early identification, early intervention, and integrated brain-heart management to improve clinical outcomes for stroke patients.",[210,211,212,213,214,215,216,29],"Stroke","Myocardial Injury","Heart Failure","Acute Coronary Syndromes","Arrhythmia","Sudden Cardiac Death","Takotsubo Syndrome",[218],"Stroke-heart syndrome","2025-04-23",{"date":221,"type":43},"2025-05-01",{"date":223,"type":43},"2025-03-01",{"date":225,"type":22},"2028-04-01",{"name":227,"class":50},"Chensheng Pan",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":235,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":173},"100587501","heart-rate-variability-and-music-listening-100587501","NCT06929208","Heart Rate Variability and Music Listening","Investigating the Association Between Heart Rate Variability and Music Listening Prior to Procedures: A Pilot Cohort Study","Inclusion Criteria:\n\n1. America Society of Anaesthesiologist (ASA) 1 to 3 adults undergoing procedures (surgery, pain procedures);\n2. Able to read and understand English and\u002For Chinese;\n3. Not receiving opioid prior to the procedures.\n\nExclusion Criteria:\n\n1. With chronic pain;\n2. Opioid and drug abuse;\n3. Scheduled postoperative Intensive care unit (ICU) admission;\n4. With baseline non-sinus heart rhythm or on pacemaker support.","21 Years","90 Years",{"count":238,"type":22},120,[25],"High anxiety levels may lead to negative outcomes, and previous studies have shown that music listening could reduce periprocedural anxiety and depression. Recent evidence suggests that a lower heart rate variability (HRV) may be associated with anxiety and depression disorders, but the association of these HRV parameters with preoperative mood in the procedural settings are less defined.\n\nIn this prospective cohort pilot study, the study team will investigate the association between HRV and psychological vulnerability (anxiety, depression) in the presence of music listening before procedures. A total of 120 patients about to undergo procedures (surgery, procedures) will be recruited in three healthcare institutions in Singapore (KK Women's and Children's Hospital, Singapore General Hospital, Changi General Hospital). Patients will be asked to have their ECG readings recorded before, during, and after music listening. Preprocedural information (e.g., demographic, clinical) and psychological scores will be collected.",[29,68,242],"Depression",[68,242,244],"Heart rate variability","2025-04-12",{"date":247,"type":43},"2025-04-16",{"date":249,"type":22},"2025-04",{"date":251,"type":22},"2027-12",{"name":253,"class":172},"KK Women's and Children's Hospital",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":262,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":264,"conditions":265,"keywords":271,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":51},"100586452","modulation-of-the-inflammatory-response-in-bariatric-surgery-100586452","NCT06915558","Modulation of the Inflammatory Response in Bariatric Surgery","Modulation of the Inflammatory Response to Surgical Trauma: Comparison of Three Anesthetic Techniques in Bariatric Surgery Patients","MRICBx3","Inclusion Criteria:\n\n* Patients scheduled for bariatric surgery.\n* Age 18-65 years.\n* BMI ≥ 30 kg\u002Fm².\n* ASA physical status II-III.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Chronic opioid use before surgery.\n* Severe renal or hepatic failure.\n* Uncontrolled psychiatric disorders.\n* Significant intraoperative complications requiring protocol deviation.",{"count":263,"type":22},90,"This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids.\n\nThe study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response.\n\nThe results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.",[266,267,268,269,270,29],"Obesity","Bariatric Surgery Candidate","Inflammation","Postoperative Pain","Opioid-Free Anesthesia",[270,272,273,274,35],"Opioid-Based Anesthesia","Inflammatory Markers","Surgical Stress Response",{"date":276,"type":43},"2025-04-08",{"date":278,"type":43},"2024-12-02",{"date":280,"type":22},"2025-12-02",{"name":282,"class":50},"Hospital HM Nou Delfos",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":60,"sex":17,"minAge":291,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":294,"conditions":295,"keywords":298,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":305,"leadSponsor":307,"locationsCount":4},"100570610","predicting-postoperative-delirium-with-heart-rate-variability-obtained-by-analgesia-nociception-index-100570610","NCT06709482","Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index","Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index - A Prospective Clinical Pilot Study","DANI","Inclusion Criteria:\n\n1. \\> 50 years of age\n2. Scheduled for elective moderate to major risk traumatology or orthopedic surgery (excluding spine surgery) and anticipated duration of general anaesthesia ≥ 60 minutes.\n\nExclusion Criteria:\n\n1. Delirium before surgery.\n2. Patients with emergency surgery\n3. Contraindication to general anesthesia\n4. ASA ≥ 4.\n5. Terminal disease.\n6. h\u002Fo documented dementia, MoCA Score \\\u003C18\n7. h\u002Fo atrial fibrillation\n8. h\u002Fo Parkinson´s disease \u002F Multiple system atrophy \u002F Pure autonomic failure\n9. h\u002Fo autonomic dysfunction (neurogenic autonomic dysfunction)\n10. h\u002Fo stroke\u002Fintracerebral hemorrhage\n11. Cerebral neoplasia\n12. h\u002Fo chronic central nervous disorder (e.g. multiple sclerosis)\n13. Major Depression\n14. Language, vision, or hearing impairments that may compromise delirium or cognitive assessments.\n15. h\u002Fo malignant hyperthermia\n16. h\u002Fo structural muscle disease\n17. h\u002Fo substance abuse\n18. h\u002Fo polyneuropathy\n19. h\u002Fo psychiatric disease\n20. h\u002Fo or current substance use disorder (DSM V)","50 Years",{"count":293,"type":22},150,"The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative inflammation and delirium. The main question it aims to answer is: Do patient with increased sympathetic nervous system activity develop postoperative delirium (POD) more often than patients with increased parasympathetic tone?",[296,29,297],"POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE","Biomarkers",[299,300,35],"postoperative delirium","inflammation","2025-03-06",{"date":303,"type":43},"2025-03-07",{"date":223,"type":22},{"date":306,"type":22},"2026-12-01",{"name":308,"class":50},"Medical University Innsbruck",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":316,"targetDuration":4,"studyType":23,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":335,"locationsCount":51},"100578607","eastern-principles-acceptance-and-commitment-therapy-for-injury-prevention-among-nurses-and-nursing-aides-100578607","NCT06813495","Eastern Principles Acceptance and Commitment Therapy For Injury Prevention Among Nurses and Nursing Aides","Prevention of Injuries Among Nurses and Nursing Aides Using Eastern Principles Acceptance and Commitment Therapy: Clinical Trial and Dissemination Research","Inclusion Criteria:\n\n* USA: Employed as a nurse or nursing aide in a long-term care facility within a 120 mile radius of Bowling Green, Ohio.\n* Thailand: Employed as a nurse or nursing aide in Chiang Mai, Thailand or Krung Thep Bangkok), Thailand.\n* At least 18 years of age.\n* Able to attend scheduled assessment and intervention appointments.\n\nExclusion Criteria:\n\n• There are no a-priori exclusion criteria. However, if a participant reports significant psychological distress or a diagnosable mental health condition at the baseline assessment, they will be referred for an alternative treatment.",{"count":317,"type":22},255,[25],"This clinical trial will evaluate the effectivness of an Eastern Principles Acceptance and Commitment Therapy intervention (EPACT) relative to an estabished traditional Western-based Acceptance and Commitment Therapy intervention (ACT) and a no treatment control group. The participants for the study will be nurses and nursing aides (NNAs) who work in long-term care settings in the USA and Thailand. The primary dependent variables are work-related injuries, work stress and burnout, wellbeing, musculoskeletal symptoms, time off from work due to injury. High frequency heart rate variability will also be investigated as a predictor of responsiveness to the interventions.\n\nThe study has three primary aims:\n\n1. To compare the EPACT NNA intervention to an established traditional Western ACT NNA intervention and a no-treatment control group.\n2. To identify predictors of ACT NNA and EPACT NNA responsiveness to the interventions and injury likelihood across time.\n3. To assess EPACT NNA's feasibility and effectiveness across cultures.\n\nUSA participants working in Ohio will be randomly assigned to one of three groups: EPACT NNA (n = 80), ACT NNA (n = 80), or a no treatment control group (n = 80). All participants will participate in an assessment session where study questnnaires are completed and a baseline high frequency HRV measurement is collected. Subsequent to the assessment, the EPACT NNA and ACT NNA participants will attend two 2.5 hour sessions spaced one week apart. The control group will have no further in-person meetings with the researchers. One-month after completing the intervention (4 weeks after the baseline assessment) a follow-up survey will be sent to participants for the first follow-up. Three months after baseline, the second follow-up survey will be sent to participants.\n\nThe surveys assess demographic characteristics, organizational variables, work-related injuries, work stress, and well-being.\n\nA second RCT study will be conducted in Thailand comparing EPACT NNA (n = 40) to a no-treatment control group (n = 40) among nurses and nursing aides working in healthcare settings. The same outcome measures and procedures will be used.\n\nThis research aims to develop a culturally-informed, evidence-based intervention that integrates both Western and Eastern mindfulness principles to address the high rates of work-related injuries among NNAs.",[321,322,323,324,325,326,327,328,29],"Well-Being, Psychological","Work Injury","Musculoskeletal Pain","High Frequency Heart Rate Variability","Burnout","Mindfulness","Self-Compassion","Acceptance and Commitment Therapy","2025-02-03",{"date":331,"type":43},"2025-02-07",{"date":333,"type":43},"2023-05-01",{"date":131,"type":22},{"name":336,"class":50},"Bowling Green State University",{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":60,"sex":344,"minAge":345,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":354,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":365,"locationsCount":51},"100426198","trajectory-of-psychological-distress-among-infertility-women-100426198","NCT04829877","Trajectory of Psychological Distress Among Infertility Women","Trajectory of Psychological Distress Among Infertility Women: Efficacy and Mechanism of Mind-body Intervention With Heart Rate Variability Biofeedback","Inclusion Criteria:\n\n* 20-year-old and above\n* Seeking infertility care\n* Contemplating pregnancy\n* Intended to start their ART cycle\n* Able to speak Taiwanese or Mandarin\n\nExclusion Criteria:\n\n* Diagnosis of cardiovascular disease, depressive disorder, anxiety disorder, cardiac arrhythmia\n* Already had started their ART treatment\n* Taking medications that might affect ANS activity","FEMALE","20 Years","60 Years",{"count":348,"type":22},750,[25],"Background: Infertility is a serious reproductive health issue and affects 48.5 million couples worldwide. Women undergoing fertility treatment often experienced psychological distress but also social stigma that is close linked to later pregnancy outcome. Despite the advancement in assisted reproductive technology, effective interventions for reducing stress, anxiety, and depressive symptoms for infertility women remain lacking.\n\nObjectives: The objective of this proposal is to evaluate the efficacy of web-based mind-body intervention combining HRV biofeedback on the infertility women's anxiety symptoms, levels of depression, HRV function, mindful awareness, infertility self-efficacy, and pregnancy rates.\n\nMethods: We plan to conduct a randomized controlled trial on the web-based mind-body intervention combining heart rate variability biofeedback. Eligible women will be recruited and randomized into three groups. Intention-to-treat analysis and mixed regression modeling will be used to estimate the effectiveness of the interventions.\n\nAnticipatory results: Effective strategies will be determined for infertility women.",[352,29,353],"Infertility","Biofeedback",[355,356,35,357,358],"infertility","mind-body intervention","biofeedback","psychological distress","2025-01-24",{"date":361,"type":43},"2025-01-27",{"date":363,"type":43},"2022-04-19",{"date":249,"type":22},{"name":366,"class":50},"Taipei Medical University",{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":60,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":23,"phases":375,"briefSummary":376,"conditions":377,"keywords":379,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":51},"100577400","effectiveness-of-information-technology-assisted-horticultural-therapy-program-on-heart-rate-variability-stress-depression-and-happiness-among-older-adults-resident-in-long-term-care-facilities-100577400","NCT06797804","Effectiveness of Information Technology-Assisted Horticultural Therapy Program on Heart Rate Variability, Stress, Depression and Happiness Among Older Adults Resident in Long-Term Care Facilities","Inclusion Criteria:\n\n1. Agree to participate in this study\n2. Elderly persons aged 65 and above living in long-term care facilities\n3. Live in long-term care facilities for at least three months\n4. No gender restrictions\n5. Be aware, able to communicate in Mandarin and Taiwanese, and be able to express opinions\n6. The upper limbs can move freely and there is no disease that causes tremors in the hands (such as Parkinson's disease, hepatic encephalopathy, etc.)\n\nExclusion Criteria:\n\n1. Has participated in gardening-related activities within one month of receiving the case\n2. Those diagnosed with terminal illness or whose health condition is rapidly deteriorating\n3. Those suffering from Parkinson's disease, serious heart disease, dementia, mental illness (e.g. schizophrenia, bipolar disorder, etc.)\n4. Mini-Mental State Examination (MMSE) with cognitive impairment (MMSE scores below 16 points for individuals with no formal education, below 21 points for those with elementary education, and below 24 points for those with junior high school education or higher.)\n5. Those who are unable to participate in the event due to severe speech, vision or hearing impairment",{"count":374,"type":22},76,[25],"This study aims to address existing research gaps by investigating the effects of technology-assisted horticultural therapy on stress, depression, and happiness among older adults residing in long-term care facilities. By examining the modulation of the autonomic nervous system, the findings will provide a foundation for developing comprehensive health promotion programs that integrate traditional therapeutic practices with modern technology to enhance the well-being of the aging population.",[29,28,242,378],"Happiness",[380,381,382,383],"Horticultural Therapy","Older adults","Information and communication technology","Mental health","2025-01-21",{"date":386,"type":43},"2025-01-28",{"date":388,"type":43},"2024-11-14",{"date":390,"type":22},"2026-10-08",{"name":392,"class":50},"National Taipei University of Nursing and Health Sciences",{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":23,"phases":402,"briefSummary":403,"conditions":404,"keywords":406,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":51},"100559311","effects-of-zazen-meditation-in-patients-with-acute-myocardial-infarction---randomized-clinical-trial-100559311","NCT06562478","Effects of Zazen Meditation in Patients With Acute Myocardial Infarction - Randomized Clinical Trial","Effects of Zazen Meditation on Physiological and Psychological Aspects in Patients With Acute Myocardial Infarction - Randomized Clinical Trial","Inclusion Criteria:\n\n* Recent acute myocardial infarction\n* Both sexes\n* \\>18 years old\n* Availability to attend the hospital at least twice a week during the study period\n* Agree to the study and sign the Free and Informed Consent Form.\n\nExclusion Criteria:\n\n* Unstable angina\n* Extensive residual myocardial ischemia (at rest or on exertion)\n* Inadequate blood pressure response during exercise\n* Congestive heart failure class III or IV\n* Severe lung disease\n* Difficulty or inability to walk\n* Pacemaker\n* Participation in other clinical trials",{"count":401,"type":22},44,[25],"Introduction: Coronary Artery Disease (CAD) remains the leading cause of death in Brazil, with literature indicating that in patients post-acute myocardial infarction, reduced Heart Rate Variability (HRV) has been established as a risk factor. One of the studied practices to aid in rehabilitation is meditation, believed to alter physiological aspects related to stress such as respiratory rate, oxygen consumption, carbon dioxide production, and systolic blood pressure, suggesting a better sympathetic-vagal balance. Objective: To assess the effects of Zazen meditation practice on heart rate variability in patients with recent acute and chronic myocardial infarction. Methodology: Randomized Clinical Trial. Chronic assessments will include: HRV with Polar H10 heart rate monitor, Quality of Life assessment with SF36 Quality of Life and Health questionnaire, Spiritual assessment with WHOQOL SR Spirituality, Religiosity, and Personal Beliefs questionnaire, Biochemical Parameters with ultra-sensitive PCR and cortisol, Ventricular Ejection Fraction (VEF), and 6-minute Walk Test (6MWT). Acute assessments will include: HRV with Polar H10 heart rate monitor, before and after a meditation session, in time and frequency domains. Sample size calculation was performed using Winpepi software version 11.43, with a power of 80% and significance level of 5%, determining a sample of 44 individuals. For intra-group differences analysis, ANOVA for repeated measures and\u002For its non-parametric counterpart, Friedman Test, will be used. For proportion analysis and comparison, Chi-square Test will be used. Expected Results: It is expected that the findings will contribute to a better understanding of the potential benefits that a meditation intervention may bring to patients who have experienced acute myocardial infarction.",[29,405],"Acute Myocardial Infarction",[407,35],"Myocardial Infarction","2024-08-16",{"date":410,"type":43},"2024-08-20",{"date":412,"type":43},"2024-02-05",{"date":414,"type":22},"2026-07-31",{"name":416,"class":50},"Hospital de Clinicas de Porto Alegre",{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":423,"eligibilityCriteria":424,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":425,"enrollmentInfo":426,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":430,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":51},"100556991","helping-overcome-pressure-and-exhaustion-empowerment-classes-for-southeast-asian-migrant-care-workers-100556991","NCT06532305","Helping Overcome Pressure and Exhaustion: Empowerment Classes for Southeast Asian Migrant Care Workers","The Effects of Empowerment Classes on Burnout Syndrome and Emotional Stress Among Southeast Asian Migrant Care Workers: A Randomized Crossover Study","HOPE","Inclusion Criteria:\n\n* Indonesian migrant care workers responsible for caring for patients in homes or care institutions.\n* Aged 18 years or older.\n\nExclusion Criteria:\n\n* Individuals unable to read the informed consent form or questionnaires in Indonesian.","99 Years",{"count":238,"type":22},[25],"As Taiwan's population ages, Southeast Asian migrant care workers are widely employed to fill the care labor gap. These workers often face symptoms of burnout and emotional stress due to long working hours and high-pressure environments. This study aims to evaluate the effects of empowerment classes on reducing burnout symptoms and emotional stress among Southeast Asian migrant care workers. The empowerment classes are designed based on expert consensus and cover three core areas: mental health and stress management, dementia care skills, and language and communication skills. The curriculum is tailored to the practical needs and cultural backgrounds of the migrant workers. A total of 120 Indonesian care workers will be randomly assigned to two groups. The first group will undergo a three-month empowerment course, while the second group will initially participate in social gatherings. Afterward, the groups will switch interventions. The study will last for 12 months, and each participant will complete seven assessments, including heart rate variability measurements and online questionnaires. The questionnaires will include the Patient Health Questionnaire-2 (PHQ-2), the Copenhagen Burnout Inventory (CBI), the Life and Cultural Adaptation Questionnaire, and the Language Proficiency Questionnaire. The study anticipates that the empowerment classes will reduce burnout symptoms and emotional stress, while enhancing cultural adaptation and language proficiency among migrant care workers.",[29,325,242],[431,432,433,434],"empowerment","burnout","dementia","migrant care worker","2024-08-04",{"date":437,"type":43},"2024-08-06",{"date":439,"type":22},"2024-07-26",{"date":441,"type":22},"2025-07-25",{"name":443,"class":50},"National Taiwan University Hospital",{"id":445,"slug":446,"hasResults":11,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":451,"enrollmentInfo":452,"targetDuration":4,"studyType":23,"phases":454,"briefSummary":455,"conditions":456,"keywords":459,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":4},"100554587","mindfulness-based-self-compassion-and-vagal-nerve-stimulation-on-heart-rate-variability-psychological-resilience-and-sleep-quality-100554587","NCT06501027","Mindfulness-Based Self-Compassion and Vagal Nerve Stimulation on Heart Rate Variability, Psychological Resilience, and Sleep Quality","The Effect of Mindfulness-Based Self-Compassion Intervention and Vagal Nerve Stimulation on Heart Rate Variability, Psychological Resilience, and Sleep Quality in Earthquake Survivors","Inclusion Criteria:\n\n* Adults aged between 18 and 35,\n* who have been exposed to an earthquake and have relocated to Istanbul,\n* who are accessing psychological first aid information channels.\n\nExclusion Criteria:\n\n* Individuals with a psychiatric diagnosis","35 Years",{"count":453,"type":22},26,[25],"This study was conducted to determine the effects of a mindfulness-based self-compassion intervention and vagal nerve stimulation on heart rate variability, psychological resilience, and sleep quality in earthquake victims.\n\nDesign: \"The study was designed as a randomized experimental research, where pre- and post-intervention measurements were administered to Intervention I and Intervention II groups.\"",[29,457,458],"Psychological Resilience","Sleep Quality",[460,461,462],"Mindfulness-Based Self-Compassion Intervention","Vagal Nerve Stimulation","earthquake victims","2024-07-11",{"date":465,"type":43},"2024-07-15",{"date":467,"type":22},"2024-07-12",{"date":469,"type":22},"2024-10-01",{"name":471,"class":50},"İstanbul Yeni Yüzyıl Üniversitesi",{"id":473,"slug":474,"hasResults":11,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":4,"eligibilityCriteria":478,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":346,"enrollmentInfo":479,"targetDuration":4,"studyType":23,"phases":480,"briefSummary":481,"conditions":482,"keywords":486,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":51},"100554944","effect-of-atenolol-versus-ivabradine-on-hrv-in-trs-patients-on-clozapine-with-tachycardia-a-randomised-control-trial-100554944","NCT06505668","Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.","Effect Of Atenolol Versus Ivabradine On Heart Rate Variability In Treatment Resistant Schizophrenia Patients On Clozapine With Tachycardia: A Randomized Control Trial.","Inclusion Criteria:\n\nAll patients coming for treatment at the Out-patient department and In-patient department of the Department of Psychiatry fulfilling the following are included:\n\n1. Patients diagnosed with TRS (TRRIP consensus) receiving clozapine.\n2. Aged between 18 to 60 years of either sex\n3. Having baseline heart rate of \\>100\u002Fminute.\n4. Written informed consent from Legally Authorized representative.\n\nExclusion Criteria:\n\nPatients with any one of the following are excluded from the study:\n\n1. Already receiving Atenolol or Ivabradine.\n2. Patients having any contraindication to using Atenolol or Ivabradine.\n3. Receiving any other medication other than Clozapine known to cause autonomic dysregulation.\n4. Active substance use.\n5. Serious medical or neurological comorbidity.",{"count":120,"type":22},[25],"Clozapine is the only drug approved for Treatment Resistant Schizophrenia. However, it has been associated with many adverse drug reactions including agranulocytosis, myocarditis, sialorrhea, constipation, orthostasis, tachycardia. There are many factors that have impacted the use of clozapine in TRS patients including physician hesitation, patient denial, stopping of drug due to Adverse drug reactions.\n\nAlthough Tachycardia should not be the reason to stop clozapine, but data shows that it leads to discontinuation of drugs in significant patient population. If patient on clozapine develops tachycardia; first orthostasis, myocarditis and systemic infection should be ruled out. Tachycardia traditionally have been treated with B1 adrenergic blockers such as Atenolol. But the problem with beta blocker medications is that significant proportion develops hypotension.\n\nRecently developed Ivabradine slows heart rate via I(f) current, and is not associated with much cardiac adverse effects. Recent Clinical trials have been carried out to show its effects on Clozapine associated tachycardia which shows promising results. Some studies suggest using Ivabradine in patient population that have contraindication for beta blockers.\n\nAlthough both of these drugs are used widely in clinical practice, but as Ivabradine is relatively new drug there have been no head-to-head comparison with Atenolol. A recent meta-analysis tried to compare treatment efficacy in these patients, but found no studies that met their inclusion criteria. This current study attempts to make such comparison and guide further research.",[483,484,29,485],"Treatment Resistant Schizophrenia","Clozapine Adverse Reaction","Tachycardia",[487,488,35],"Clozapine","Treatment resistant schizophrenia",{"date":490,"type":43},"2024-07-17",{"date":492,"type":43},"2023-08-01",{"date":494,"type":22},"2025-06-30",{"name":496,"class":50},"All India Institute of Medical Sciences, Bhubaneswar",{"id":498,"slug":499,"hasResults":11,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":504,"enrollmentInfo":505,"targetDuration":4,"studyType":23,"phases":507,"briefSummary":508,"conditions":509,"keywords":512,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":51},"100550700","compare-the-effects-of-different-avns-parameters-on-neck-pain-hrv-balance-in-collegiate-atheletes-100550700","NCT06450483","Compare the Effects of Different AVNS Parameters on Neck Pain, HRV, Balance in Collegiate Atheletes","Comparing the Effects of Different Auricular Vagus Nerve Stimulation (AVNS) Parameters on Neck Pain Intensity, Heart Rate Variability (HRV), and Balance in Collegiate Athletes: A Randomized Comparative Effectiveness Design","Inclusion Criteria:\n\n* Gender: Male and female Healthy collegiate athletes based in UAE\n* Age range: 18-26 years\n* Physical activity level: High score on the International Physical Activity Questionnaire\n* BMI: Within the range of 20-25\n* Neck pain level: Mild to moderate score on the Neck Pain Disability Index Questionnaire\n\nExclusion Criteria:\n\n* Recent injury: Had an injury within the last three months\n* Age: Over 26 years or below 18 years\n* Physical activity level: Scored moderate or low on the International Physical Activity Questionnaire\n* BMI: Above 25 or below 20\n* Neck pain level: Scored severe on the Neck Pain Disability Index Questionnaire","26 Years",{"count":506,"type":22},70,[25],"This study looks at how auricular vagus nerve stimulation (AVNS) affects neck pain, heart rate variability, and balance in college athletes, additionally, if different settings of auricular vagus nerve stimulation (AVNS) affect neck pain, heart rate variability, and balance in college athletes. The participants will be split into two groups, each receiving AVNS with different settings.\n\nThe study hypothesizes that vagus nerve stimulation (VNS) will reduce pain perception in college athletes. It is expected that auricular vagus nerve stimulation (AVNS) will decrease heart rate variability (HRV) in this population. Additionally, it is anticipated that college athletes undergoing AVNS will exhibit improved balance. The Investigators also believe that AVNS will decrease neck pain and enhance neck function. Finally, it is proposed that different AVNS parameters will have varying effects on pain intensity, HRV, and balance in collegiate athletes.",[510,29,511],"Neck Pain","Balance",[513,125,511,510,514],"AVNS","Collegiate athletes","2024-06-12",{"date":517,"type":43},"2024-06-13",{"date":519,"type":43},"2024-05-29",{"date":521,"type":22},"2024-07-08",{"name":523,"class":50},"University of Sharjah",{"id":525,"slug":526,"hasResults":11,"nctId":527,"briefTitle":528,"officialTitle":528,"acronym":529,"eligibilityCriteria":530,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":531,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":533,"conditions":534,"keywords":536,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":547},"100526723","the-ecostress-study-influence-of-the-objective-structured-clinical-examination-on-stress-among-medical-student-100526723","NCT06138457","The ECOSTRESS Study: Influence of the Objective Structured Clinical Examination on Stress Among Medical Student","ECOSTRESS","Inclusion Criteria:\n\n* All medical student that agree to participate\n\nExclusion Criteria:\n\n* All medical student that disagree to participate",{"count":532,"type":22},100,"We will assess stress using heart rate variability during examination on medical student. Three time of measurement will be performed. First standardized objective clinical examination, second classic table examination and third a control day.",[29,28,535],"Medical Student",[33,537,538,35],"exam","medical student","2023-11-14",{"date":541,"type":43},"2023-11-18",{"date":543,"type":43},"2023-06-29",{"date":545,"type":22},"2030-06-29",{"name":49,"class":50},2,{"id":549,"slug":550,"hasResults":11,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":554,"eligibilityCriteria":555,"healthyVolunteers":60,"sex":17,"minAge":556,"maxAge":557,"enrollmentInfo":558,"targetDuration":4,"studyType":23,"phases":560,"briefSummary":561,"conditions":562,"keywords":571,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":51},"100523862","effects-of-a-relaxation-and-guided-imagery-intervention-in-school-context-100523862","NCT06101225","Effects of a Relaxation and Guided Imagery Intervention in School Context","RCT of the Effects of a Relaxation, Guided Imagery Intervention and Socioemotional Learning on the Psychophysiological Well-being, Socioemotional Regulation, Cognitive and Academic Development of Children in School","MR","Inclusion Criteria:\n\n* Attend the 3rd and 4th grade of the selected school (8-11 years-old)\n\nExclusion Criteria:\n\n* The participant classes have benefited from the RegularMind intervention previously;\n* Not being able to provide self-report due to intellectual, physical or sensory disabilities.","7 Years","12 Years",{"count":559,"type":22},240,[25],"Specific aims - To test the effects of a relaxation and guided imagery intervention with socioemotional learning content on a range of socioemotional, physiological, cognitive and academic outcomes of school-aged children, measured through self-reports, neuropsychological and physiological measures, as well as teachers and parent's reports.",[563,564,565,378,566,567,68,568,29,569,570],"Mental Health Wellness 1","Positive and Negative Affect","Social Skills","Self Esteem","Self-Regulation, Emotion","Cognitive Change","Stress, Psychological","Physical Activity",[572,573,574,575,576,577,578],"Guided Imagery","Relaxation","Well-being","Socioemotional Learning","Emotional Self-regulation","Psychophysiology","Randomized controled trial","2023-11-05",{"date":581,"type":43},"2023-11-07",{"date":583,"type":43},"2023-10-09",{"date":585,"type":22},"2026-06-30",{"name":587,"class":50},"Universidade Autónoma de Lisboa",{"id":589,"slug":590,"hasResults":11,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":346,"enrollmentInfo":595,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":597,"conditions":598,"keywords":601,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":605,"completionDateStruct":607,"leadSponsor":609,"locationsCount":51},"100512303","obesity-and-bariatric-surgery-according-to-a-biopsychosocial-perspective-100512303","NCT05950698","Obesity and Bariatric Surgery According to a Biopsychosocial Perspective.","The Assessment of Psychophysiological Markers by Analyzing the Heart Rate Variability, Blood Pressure, Anxiety and Depression, Eating Behavior, and Quality of Life Before and After Bariatric Surgery.","Inclusion Criteria:\n\n* Obese and liberated patients for the bariatric surgery.\n* informed consent.\n* Males and females between 18 and 60 years old .\n\nExclusion Criteria:\n\n* Those taking hypoglycemic medications (biguanides, sulfonylureas, glinides, acarbose, GLP-1 analogues, SGLT-2 inhibitors, DPP-IV inhibitors, and insulin) and hyperglycemic medications (corticoids, high dose thiazide diuretics, beta blockers, diazoxide and octreotide), very restrictive diets (intermittent fasting and ketogenic diet), pregnant women, history of neurological disorder, chronic pulmonary, cardiovascular, hepatic and\u002For renal diseases, in treatment for alcohol or drug abuse, smoking, severe psychiatric disorders (schizophrenia, bipolar disorder), vitamin B12 deficiency, iron-deficiency, anemia, those with neurodegenerative brain disease or cerebrovascular disease, and those who refuse to sign the informed consent form.",{"count":596,"type":22},50,"* The main goal of this prospective longitudinal observational study is to investigate the psychophysiological indicators by analyzing HRV, blood pressure, symptoms of anxiety and depression, eating behavior and quality of life during the follow-up of the general health status of patients with obesity undergoing the bariatric surgery by Roux-en-Y reconstruction reduction gastroplasty (GRYR) technique.\n* The main question it aims to answer is: Does bariatric surgery changes the variables studied (HRV, anxiety, depression, eating behavior, quality of life)?\n* Type of study: prospective longitudinal observational study\n* Participant population: 50 patients, both females and males, aged between 18 and 60 years, will be submitted to bariatric surgery with Roux-en-Y reconstruction reduction gastroplasty technique.\n\nPatients will be evaluated for five times: before the bariatric surgery and 3-6-12-24 months after the bariatric surgery.",[266,29,599,242,600],"Anxiety Disorders","Quality of Life",[266,244,68,242,600],"2023-07-10",{"date":604,"type":43},"2023-07-18",{"date":606,"type":43},"2022-10-20",{"date":608,"type":22},"2026-10-20",{"name":610,"class":50},"Rio de Janeiro State University"]