[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heat-strain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heat-strain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,78,112,151,179],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100641877","mitigation-of-health-effects-in-outdoor-workers-by-reducing-exposure-to-heat-and-air-pollution-100641877",false,"NCT07634952","Mitigation of Health Effects in Outdoor Workers by Reducing Exposure to Heat and Air Pollution","Innovative Solutions Across the MEDiterranean for Mitigation of Climate Change-related heaLth rIsks in Outdoor Workers","ISMED-CLIM OW","Inclusion Criteria:\n\n* 18-65 years old\n* Municipality outdoor workers\n* Regularly working outdoors for al least 6 hours per day\n* Living in León (Spain) or Trikala (Greece)\n* Clinically healthy\n* No history of diabetes mellitus type 2 (DM2)\n* No history of arterial hypertension\n\nExclusion Criteria:\n\n* Currently smoking\n* Presence of any smoking residents in the household\n* Not residing at the household for at least 5 days a week\n* Planning to move from the current home within the next two months\n* No access to Wi-Fi or 4G\u002F5G mobile phone\n* Severe chronic conditions (congestive heart failure, ischemic heart disease, significant valvular heart disease, DM2, inflammatory diseases, renal failure, or active cancer)\n* Drugs abuse\n* Alcohol abuse\n* Psychiatric disorders\n* Severe mental disability that interferes with answering questions or following instructions",true,"ALL","18 Years","65 Years",{"count":22,"type":23},102,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health effects in outdoor workers.\n\nThe main questions it aims to answer are:\n\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce personal ambient temperature exposure, measured using a wearable device (iButton)?\n* Does the intervention (combination of behavioral recommendations for air pollution mitigation and use of indoor air cleaners) reduce indoor exposure to air pollution, measured using indoor air quality sensors (Purple Air)?\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce physiological strain experienced by individuals working in hot environments, measured using the Heat Strain Score Index?\n\nResearchers will compare measurements between outdoor workers carrying out their activities in the absence of intervention (control group), those carrying out their activities with behavioural recommendations (recommendation intervention group) and those carrying out their activities with both behavioural recommendations for heat mitigation and continuous use of indoor air cleaners in their house (heat and air pollution mitigation intervention group) to see if changes in temperature exposure and physiological strain are different between intervention groups.\n\nParticipants will:\n\n* Wear the wearable devise for continuous personal ambient temperature monitoring (ibutton) daily for a period of three months\n* Have their core temperature measured using an eCelsius medical capsule in three repeated assessments\n* Complete the Heat Strain Score Index questionnaire in three repeated assessments\n* Provide samples of urine, blood, saliva and hair for measurement of various biomarkers in three repeated assessments",[29],"Heat Strain",[31,32,33,34],"outdoor workers","heat strain","intervention","personal ambient temperature exposure","RECRUITING","2026-06-12",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":39},"2026-05-01",{"date":43,"type":23},"2027-07-31",{"name":45,"class":46},"University of Cyprus","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100591692","early-phase-1-the-kidneys-response-to-exercise-in-heat-and-the-impact-of-vitamin-b3-on-this-response-100591692","NCT06983730","The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response","Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress","Inclusion Criteria:\n\n* Healthy volunteer\n* Any race\n* Estimated glomerular filtration rate greater than 90 ml\u002Fmin\u002F1.73m2\n* Urine albumin\u002Fcreatinine ratio less than 30mg\u002Fg\n* Nonsmoker\n* No regular dietary supplements, particularly vitamin B3\n* Physically fit, defined as having a VO2 max of between 35 and 60mL\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Medical condition preventing safe participation in exercise during heat\n* Allergy to Vitamin B3\n* Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications","45 Years",{"count":57,"type":23},28,[59],"EARLY_PHASE1","The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:\n\n* How do the chemicals produced by the body change under conditions of higher versus lower heat stress?\n* What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?",[29,62,63],"Healthy Volunteer Study","Kidney Dysfunction",[65,66,67,68],"NAD+","Niacinamide","Vitamin B3","Experimental heat strain","2026-02-03",{"date":71,"type":39},"2026-02-05",{"date":73,"type":39},"2026-01-26",{"date":75,"type":23},"2028-06",{"name":77,"class":46},"Beth Israel Deaconess Medical Center",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100591585","beat-the-heat-boston-100591585","NCT06982339","Beat the Heat Boston","Beat the Heat: Impacts of Heat on Health in Boston and Strategies to Address Them","Inclusion Criteria:\n\n* reside in Roxbury, Dorchester, East Boston or Mattapan MA\n* age 55-95 years old\n* speak English or Spanish\n* do not have air conditioning in the home\n* living with at least one of the following conditions: chronic CVD (hypertension, hyperlipidemia, diabetes, history of stroke or myocardial infarction, atrial fibrillation, or heart failure), chronic pulmonary disease (asthma, COPD\u002Femphysema, interstitial lung disease), chronic neurologic disease (stroke, Parkinson's disease, or other chronic neurologic conditions), chronic mental health conditions (including anxiety disorder, major depression, bipolar disorder), and\u002For history of hospitalization (defined as spending at least one night in the hospital) for any reason within the past three years.\n\nExclusion Criteria:\n\n\\- Lack a location in their home suitable for installation of the AC unit provided during the research study.","55 Years","95 Years",{"count":88,"type":23},100,[26],"The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults. The main questions it aims to answer are:\n\nHow does the presence of an air conditioning unit affect heat stress, heat strain, mental health, and healthcare utilization among older adults who did not previously have access to air conditioning?\n\nHow, and in what conditioners, do older adults use air conditioning once it is installed in their home?\n\nResearchers will compare participants in arms with (A) and without (B) air conditioning units in the first summer season; this will allow them to assess the effect of air conditioners. In the second summer season, both arms will have air conditioning units, but those in the year two distribution arm (B) will receive an electricity subsidy, while those in the year one AC distribution arm (A) will not, allowing researchers to assess the effect of an electricity subsidy.\n\nParticipants will be randomized to receive an air conditioner and financial support for electricity costs in either the first summer season or the second summer season of the study.\n\n* Heat stress, heat strain, mental health, and healthcare utilization will be assessed via participant survey.\n* Air conditioner utilization will be assessed via continuous load monitoring devices.\n* Indoor air temperature will be assessed via continuous data loggers.",[92,93,94,95,96,29],"Hot Weather; Adverse Effect","Heat Effect","Heat Stress","Heat Stroke, Heat Exhaustion","Heat Exposure",[98,99,100,101],"Cooling","Air conditioner","Heat related illness","stepped wedge","2026-01-21",{"date":104,"type":39},"2026-01-22",{"date":106,"type":39},"2025-05-19",{"date":108,"type":23},"2026-10-15",{"name":110,"class":46},"Harvard School of Public Health (HSPH)",1,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":17,"sex":119,"minAge":19,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":133,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":150},"100589696","biological-impacts-of-rising-temperatures-on-maternal-fetal-and-newborn-health-a-cohort-study-birth-cohort-100589696","NCT06957769","Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)","BIRTH","Inclusion Criteria:\n\n* Single or multiple live pregnancy confirmed through ultrasound\n* Gestational age less than or equal to 13 weeks and 6 days at enrollment\n* At least 18 years of age\n* Permanent resident of the study district and plans to deliver within the district\n* Willing and able to attend study clinic visits and comply with study procedures throughout pregnancy\n\nExclusion Criteria:\n\n• Plan to relocate outside the district for more than 3 months during the study period","FEMALE",{"count":121,"type":23},6000,"OBSERVATIONAL","The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies. The study also aims to understand how the body responds to heat stress during pregnancy and how this might lead to pregnancy complications and birth problems like early birth or low birth weight.\n\nThe main questions that the study aims to answer are:\n\n1. What are the acute and chronic effects of environmental heat exposure on pregnancy and birth outcomes across different trimesters?\n2. Through which biological pathways does heat stress impact maternal, fetal, and infant health across varying gestational ages?\n3. How do socio-demographic factors, maternal characteristics, and nutritional status of women modify the relationship between environmental heat exposure and adverse pregnancy outcomes?\n\nThe study will take place in rural parts of Sindh, Pakistan. These areas often experience extreme heat and have limited access to electricity or cooling systems like fans or air conditioners.\n\nThis study will include pregnant women who are in their first trimester (under 14 weeks of pregnancy). Before starting any study activities, researchers will explain the study to each woman in a language she understands and ask for her written permission to take part (informed consent).\n\nAt the beginning of the study, participants will visit a study clinic. During this visit, researchers will check their height and weight, perform an ultrasound, and collect a small amount of blood for testing. Participants will also be asked to wear a small device that measures the air temperature and humidity in their surroundings.\n\nThe researchers will follow each participant during her pregnancy, with visits during the second and third trimesters at the study clinic. At each visit, researchers will check how much heat the participant has been exposed to using the data from the device and from her own answers to a simple questionnaire. The questionnaire will have questions about their heat exposure at work, home, type of clothing, and how they deal with hot weather. Serial ultrasound, blood and urine tests will be conducted so researchers can study signs of stress, hydration, and other changes in the body. A smaller group of participants will also wear a device to measure their body skin temperature, heart rate, physical activity and sleep during pregnancy.\n\nWhen the baby is born, researchers will collect information about the birth, including the baby's weight and length, the time of delivery, and whether there were any complications during birth. After delivery, both the mother and baby will be followed for up to 12 months. During this time, the research team will check the health of both the mother and baby and see how heat exposure during pregnancy may affect the baby's growth over time. At delivery, placental weight and volume will be collected for a smaller group of women. Breastmilk sampling will also be done for this group of women to understand the effect of high temperatures on breastmilk quality.\n\nThis study does not involve any treatment or medicine. Instead, researchers will observe the participants to learn how real-life heat exposure affects them during pregnancy. The findings from this study may help public health officials and governments find better ways to protect pregnant women and babies from the harmful effects of climate change and extreme heat, especially in places with limited resources.",[125,126,127,128,129,29,130,131,132],"Low Birth Weight Baby","Small for Gestational Age (SGA)","Preterm Birth","Pregnancy Complications","Birth Outcome, Adverse","Infant Morbidity","Infant Mortality","Neonatal Mortality",[134,135,136,137,138,139,140],"heat stress","high ambient temperature","climate change","birth outcomes","pregnancy","cohort study","Pakistan","2025-11-26",{"date":143,"type":39},"2025-12-03",{"date":145,"type":39},"2025-05-07",{"date":147,"type":23},"2028-06-30",{"name":149,"class":46},"Aga Khan University",3,{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":24,"phases":161,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":111},"100583164","effect-of-exercise-and-heat-stress-on-acute-cardiometabolic-adaptations-in-healthy-young-adults-100583164","NCT06872762","Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults","Does Heat Stress Improve the Acute Metabolic and Cardiovascular Adaptations to Exercise","Inclusion Criteria:\n\n-regularly physically active as determined via ParQ+\n\nExclusion Criteria:\n\n* smokers\n* bronchial asthma\n* chronic obstructive pulmonary disease\n* obese\n* alcoholism\n* requiring daily medications that may effect responses to exercise,\n* anti-arrhythmogenics\n* inhalers\n* history of cardiovascular, respiratory, neurological, skeletal muscle disease\n* irregular\u002Fabsent menstrual cycle (females)\n* unexpected responses to pre-experimental exercise tests\n* previous diagnosis of heat stroke","50 Years",{"count":160,"type":23},15,[26],"Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy. More and more research is showing that regular environmental stress, for example heat and hypoxia, can further improve physical health. Astronauts aboard the international space station (ISS) exercise for 1-2 hours every day to avoid physical deconditioning that would otherwise cause them to age rapidly in space. Although physical exercise is very effective in remedying this deconditioning, today's astronauts still have physiological changes that indicate accelerated aging. This is a cause for concern given NASA's priority to travel to mars within the next decade; a mission that will require at least double the duration in space for our astronauts. The investigators think that the complete absence of environmental stress, i.e., heat, may be contributing to the accelerated aging that occurs during spaceflight. Our study will assess the health effects of adding heat stress to exercise that could be performed in space by astronauts. The goal is to inform best practice for astronauts to avoid physical deconditioning during long-duration spaceflight. This information will also be relevant to life on earth as spaceflight is a model of inactivity here on earth. Therefore, the potential benefits of adding heat stress will likely translate to life in space and on earth.",[164,29,165],"Exercise","Control Condition",[167,32,168,169],"exercise","glucose tolerance test","arterial compliance","2025-03-06",{"date":172,"type":39},"2025-03-12",{"date":174,"type":39},"2025-03-01",{"date":176,"type":23},"2026-05-21",{"name":178,"class":46},"Northern Arizona University",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":187,"conditions":188,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":111},"100580859","impact-of-extreme-heat-on-myocardial-blood-flow-and-flow-reserve-in-young-and-older-adults-100580859","NCT06842784","Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults","Inclusion Criteria:\n\n* Healthy male and female individuals\n* 18-35 years or 65+ years of age\n* Free of any underlying moderate to serious medical conditions\n\nExclusion Criteria:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.\n* Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.\n* Abnormalities detected on routine screening.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* Body mass index of greater than 30 kg\u002Fm\\^2\n* Pregnant individuals",{"count":186,"type":23},24,"Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.",[189,94,190,29],"Aging","Hyperthermia","2025-02-18",{"date":193,"type":39},"2025-02-24",{"date":195,"type":39},"2025-02-03",{"date":197,"type":23},"2027-02-01",{"name":199,"class":46},"University of Texas Southwestern Medical Center"]