[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heat-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heat-stress":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,56,83,113,138,164,189,222,245,265,287,327,356,383,414,435,455,486],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100644136","working-in-the-heat-at-simulated-altitude-effects-of-normobaric-hypoxia-on-physiological-strain-100644136",false,"NCT07664462","Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain","Effects of Normobaric Hypoxia on Initial Stay Time and Physiological Strain During Moderate-Intensity Work in the Heat in Young and Older Males","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Are regularly exposed to hypoxic environments (e.g., high altitudes)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","MALE","18 Years","70 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments. Current occupational heat-stress guidelines aim to limit excessive increases in core body temperature and physiological strain through the use of work-rest schedules. However, these guidelines do not provide clear direction on the safe, maximum duration of continuous work that can be performed before heat-mitigation controls should be implemented, known as the initial stay time. Recent work has generated initial stay time recommendations for young and older workers performing moderate-intensity work in the heat, but these estimates were developed under normoxic conditions. In many occupational settings, workers may be exposed to additional environmental stressors such as hypoxia, including work at altitude or in oxygen-reduced environments. Hypoxia can increase cardiovascular strain, reduce arterial oxygen saturation, and alter exercise tolerance, potentially compromising the effectiveness of heat-stress guidance developed under normal oxygen conditions. Older workers may be especially vulnerable due to age-related reductions in thermoregulatory and cardiovascular function. To date, it remains unclear whether hypoxia alters physiological strain during work in the heat or whether current initial stay time and recovery recommendations remain protective under combined heat and hypoxic stress.\n\nThe primary objective of this study is to determine whether exposure to hypoxia increases physiological strain during moderate-intensity work in the heat in young and older males. Specifically, investigators will assess whether normoxia-derived initial stay times and recovery recommendations for work at 29°C wet-bulb globe (37.5°C, 35% RH) temperature remain effective when workers are exposed to hypoxia equivalent to 14% inspired oxygen (simulating \\~3000 m in altitude). Healthy young and older males will complete simulated occupational heat exposure under two conditions: heat alone and combined heat plus hypoxia. Participants will perform moderate-intensity treadmill work based on age-specific initial stay times, followed by prescribed work-rest cycles and seated recovery. Measures of core temperature, cardiovascular strain, oxygen saturation, skin temperature, hydration status, perceptual responses, mood, symptoms of environmental stress, and cognitive function will be assessed to determine whether hypoxia modifies responses to work in the heat. This study will provide important evidence on whether occupational heat-stress guidance requires refinement when workers are exposed to combined heat and hypoxic stress.",[27,28,29,30,31,32,33],"Body Temperature Changes","Heat Stress","Heat Exposure","Heat Fatigue","Hypoxia, Altitude","Work Related Stress","Physiological Stress",[35,36,37,38,39,40,41,42,43],"Heat Strain","Thermoregulation","Exercise","Simulated altitude","Core temperature","Occupational Heat Stress","Aging","Hypoxia","Hyperthermia","RECRUITING","2026-06-17",{"date":47,"type":48},"2026-06-24","ACTUAL",{"date":45,"type":21},{"date":51,"type":21},"2027-02-28",{"name":53,"class":54},"University of Ottawa","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":16,"minAge":64,"maxAge":18,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":55},"100641555","consecutive-occupational-heat-exposure-with-and-without-overnight-cooling-100641555","NCT07656519","Consecutive Occupational Heat Exposure With and Without Overnight Cooling","Physiological Responses to Consecutive Days of Occupational Heat Exposure With and Without Overnight Access to Cooling","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening",true,"50 Years",{"count":66,"type":21},10,[24],"Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments. Current occupational heat-stress guidelines are designed to limit excessive increases in core body temperature and physiological strain during work in the heat through the use of work-rest schedules. However, these guidelines are largely based on single-day heat exposures and assume that workers recover in cool indoor environments between shifts. During heat events, many workers may instead recover in homes or accommodations that remain overheated, particularly in the absence of air conditioning. Inadequate overnight cooling may impair the body's ability to dissipate heat, increase physiological strain, and reduce tolerance to heat exposure on subsequent workdays. Older adults may be especially vulnerable due to age-related impairments in heat-loss capacity. To date, the effects of recovering in an overheated indoor environment on physiological strain and thermoregulatory function during repeated occupational heat exposure remain poorly understood, limiting the development of evidence-based recommendations to protect workers during prolonged heat events.\n\nThe primary objective of this study is to determine whether overnight recovery in an overheated indoor environment increases physiological strain during repeated occupational heat exposure in older adults. Specifically, investigators will assess whether recovery at the recently proposed upper indoor temperature limit of 26°C and 45% relative humidity (RH) (PMID: 38329752) is sufficient to attenuate elevations in core temperature during subsequent work in the heat compared with recovery in an overheated indoor environment (31°C, 45% RH) representative of conditions commonly experienced during extreme heat events. Healthy older adults will complete two consecutive days and nights of simulated moderate-intensity occupational heat exposure, with overnight recovery occurring in either the 26°C or 31°C condition. Measures of core temperature, cardiovascular strain, heat-loss capacity, hydration status, sleep quality, cognitive function, mood, and perceptual responses will be assessed to determine the impact of overnight recovery conditions on responses to repeated heat exposure. Whole-body heat-loss capacity will also be evaluated before and after the exposure protocol as assessed during incremental, intermittent exercise protocol performed in an air calorimeter.",[27,28,29,30,32,33],[35,36,37,39,71,41,72,73,43],"Occupational heat stress","Heat wave","Sleep","NOT_YET_RECRUITING","2026-06-14",{"date":77,"type":48},"2026-06-18",{"date":79,"type":21},"2026-07-01",{"date":81,"type":21},"2027-08-31",{"name":53,"class":54},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":55},"100613515","suitability-of-a-26-c-indoor-environment-for-mitigating-heat-strain-in-young-adults-100613515","NCT07267598","Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults","Evaluating the Effectiveness of a 26 °C Indoor Temperature Limit to Mitigate Physiological Strain in Young, Habitually Active Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* Healthy young adults without chronic disease (e.g., type 1 diabetes, hypertension)\n\nExclusion Criteria:\n\n* Endurance trained (i.e., engaged in regular physical training activities more than 3 times a week for more than 1 hour per session).\n* Undergoing passive heat exposures such as regular of saunas, warm-water immersion, other.\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Current pregnancy","ALL","29 Years",{"count":66,"type":21},[24],"While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289\u002FEHP11651), this guideline has not been verified in young, habitually active adults. Public health recommendations during hot weather typically emphasize staying in cool environments, avoiding strenuous activity, wearing lightweight clothing, and maintaining adequate hydration. However, young adults may be less likely to follow these guidelines. They often do not reduce their physical activity during extreme heat events and may overdress for fashion, cultural, or religious reasons. These behaviors can impose an additional thermoregulatory burden and lead to greater physiological strain during heat exposure, even though young adults generally have a higher capacity for heat dissipation than older individuals. Accordingly, it is important to evaluate whether an indoor temperature limit of 26 °C is sufficient to protect young, habitually active adults.\n\nTo address this gap, the investigators aim to assess changes in body temperature and cardiovascular strain in young, habitually active adults (18-29 years) during an 8-hour exposure to the recommended indoor upper temperature limit of 26 °C and 45% relative humidity (humidex of 29, considered comfortable). Participants will complete two conditions:\n\nA) seated rest while dressed in light clothing (T-shirt, shorts, and socks), and B) light exercise (stepping to simulate activities of daily living, 4-4.5 METs) performed once per hour (except for the lunch hour) while dressed in light clothing plus an additional insulating layer (sweatshirt and sweatpants).\n\nThis experimental design will allow investigators to determine the effects of added clothing insulation and light activity-representative of typical daily behaviors-on physiological strain in young adults, and to assess whether refinements to the recommended 26 °C indoor temperature limit are warranted for this population.",[28,33,96],"Cognitive Change",[98,99,72,36,100,101,43,102,103,104],"Indoor overheating","Indoor temperatures","Heat strain","Heat vulnerability","Thermal comfort","Activities of daily living","Clothing insulation","2026-06-12",{"date":107,"type":48},"2026-06-16",{"date":109,"type":48},"2025-11-07",{"date":111,"type":21},"2026-12-30",{"name":53,"class":54},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":63,"sex":120,"minAge":17,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":132,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":55},"100606332","the-impact-of-wearing-the-hijab-on-whole-body-heat-loss-during-exercise-heat-stress-100606332","NCT07174180","The Impact of Wearing the Hijab on Whole-body Heat Loss During Exercise-heat Stress","The Effect of Wearing the Hijab on Dry and Evaporative Heat Exchange During Moderate-intensity Exercise Performed in Hot-dry Environments","Inclusion Criteria:\n\n* healthy young female (18-35 years)\n* non smoking\n* English or French speaking\n* ability to provide informed consent\n\nExclusion Criteria:\n\n* claustrophobia\n* engaged in endurance training\n* acute or chronic illness\n* sedentary (not engaged in any form of physical activity)\n* physical restriction limiting physical activity","FEMALE","35 Years",{"count":123,"type":21},12,[24],"The hijab (headscarf and cloak) is a Muslim dress, which covers the head, neck and chest, and conceals the female hair, leaving the face uncovered. It is worn by Muslim women worldwide including young Muslim women engaging in sports and exercise. As with any clothing worn on the body, the hijab can impact heat dissipation during exercise, potentially leading to increased body temperature and discomfort, especially in warmer environments. However, the extent to which the hijab may restrict heat loss remains unclear. This study aims to assess dry and evaporative heat exchange in young women performing moderate-intensity intermittent exercise in dry heat conditions (40°C, 15% relative humidity).",[28,127],"Temperature Change, Body",[39,37,129,130,100,36,131],"Females","Garment","Hot weather",{"date":107,"type":48},{"date":134,"type":48},"2025-06-13",{"date":136,"type":21},"2026-12-31",{"name":53,"class":54},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":63,"sex":90,"minAge":17,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":4},"100642770","carbohydrate-or-protein-drinks-before-exercise-in-the-heat-100642770","NCT07646990","Carbohydrate or Protein Drinks Before Exercise in the Heat","The Impact of Pre-Exercise Meal Composition on Metabolic Heat Production and Thermal Strain During Exercise in a Hot Environment","Inclusion Criteria:\n\n* Able to walk or run up to 5 mph on a treadmill\n* Able to consume products containing dairy (no allergy or dietary restrictions)\n\nExclusion Criteria:\n\n* Following a diet that excludes any macronutrient group (low-carb or low-fat)\n* Diagnosed cardiovascular or metabolic diseases (hypertension, diabetes)\n* Diagnosed heat illness in past 3 months (heat exhaustion, heat stroke)","45 Years",{"count":147,"type":21},16,[24],"This project examines whether consuming a high-protein or high-carbohydrate beverage before exercise in the heat impacts metabolism and heat balance during exercise, with the following research questions:\n\n1. Does a high-protein vs. high-carbohydrate pre-exercise drink impact metabolism and body temperature responses during a treadmill walking in the heat?\n2. Does a high-protein or high-carbohydrate drink change oxygen use and heat production during treadmill walking in the heat?",[28,151,152],"Diet Induced Thermogenesis","Protein Consumption",[154],"high protein diet, exercise, hot environment","2026-06-10",{"date":157,"type":48},"2026-06-15",{"date":159,"type":21},"2026-06-04",{"date":161,"type":21},"2027-05",{"name":163,"class":54},"Providence College",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":90,"minAge":17,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":22,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":55},"100637161","efficacy-and-safety-of-modified-orsamr-and-khulood-ors-in-diabetic-pilgrims-during-hajj-100637161","NCT07618702","Efficacy and Safety of Modified ORS(Amr and Khulood ORS) in Diabetic Pilgrims During Hajj","Efficacy and Safety of Modified Oral Rehydration Salts (ORS) in Diabetic Pilgrims With Heat Stress and Dehydration During the Hajj Mass Gathering: A Three-Arm, Active-Controlled, Randomized Clinical Trial","AA-HAMS-ORS","Inclusion Criteria:\n\n* Diabetic pilgrims attending Hajj.\n* Age between 18 and 80 years.\n* Willingness to participate and provide informed consent.\n* Diagnosis of Type 1 or Type 2 Diabetes Mellitus.\n\nExclusion Criteria:\n\n* Patients with severe renal failure.\n* Patients with acute cardiovascular events.\n* Patients unable to take oral fluids.\n* Pregnancy or breastfeeding.\n* Participation in another clinical trial within the last 30 days.","80 Years",{"count":174,"type":21},200,[24],"Heat stress and dehydration are significant risks for diabetic pilgrims during the Hajj, often leading to severe complications. Standard Oral Rehydration Salts (ORS) are effective for rehydration but may cause hyperglycemia in diabetic patients due to their glucose content. This study aims to evaluate the efficacy and safety of a modified ORS formula ( Amr and khulood ORS) , specifically designed for diabetic individuals, in maintaining hydration without adversely affecting blood glucose levels. The study will involve a randomized controlled trial comparing the modified ORS (Amr and khulood ORS) with standard ORS among diabetic pilgrims experiencing heat stress. Key outcomes include hydration status, electrolyte balance, and glycemic control.",[178,28],"Diabetes Mellitus","2026-05-24",{"date":181,"type":48},"2026-06-01",{"date":183,"type":21},"2026-06",{"date":185,"type":21},"2027-06",{"name":187,"class":188},"Amr kamel khalil Ahmed","OTHER_GOV",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":208,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":55},"100635950","effects-of-hot-baths-prior-or-after-a-damaging-protocol-on-muscle-function-and-hsp70-expression-100635950","NCT07559344","Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression","Prehotemp","Inclusion Criteria:\n\n* Sex: Healthy, athletic men practicing track and field (10 to 12 hours\u002Fweek)\n* Age: 19 to 25 years old\n* Social security coverage\n* Signed informed consent\n\nExclusion Criteria:\n\n* Age over 26 years\n* Low level of physical activity (less than 8 hours per week)\n* Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)\n* Exposure to an altitude of 2500m within 15 days prior to the protocol\n* Presence of arterial hypotension:\n* Systolic blood pressure below 90 mmHg\n* Diastolic blood pressure below 60 mmHg\n* A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.\n* A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.\n* Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.\n* Participant under guardianship\u002Fconservatorship or deprived of liberty.","19 Years","25 Years",{"count":199,"type":21},96,[24],"Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.\n\nThis study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.",[203,204,28,205,206,207],"Recovery","Mechanical Stress","HSP70","Cumulative Response","Hot-water Immersion",[203,209,210,205,211,212],"mechanical stress","heat stress","cumulative response","hot-water immersion","2026-04-23",{"date":215,"type":48},"2026-04-30",{"date":217,"type":48},"2026-02-16",{"date":219,"type":21},"2027-02",{"name":221,"class":54},"Centre Hospitalier Universitaire, Amiens",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":90,"minAge":17,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":55},"100622415","heat-stress-in-individuals-with-schizophrenia-100622415","NCT07383324","Heat Stress in Individuals With Schizophrenia","Impact of Indoor Overheating on Physiological Strain in Individuals With Schizophrenia","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed consent.\n* Individuals with and without schizophrenia or schizoaffective disorder.\n\nExclusion Criteria:\n\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity\n* Any history of diagnoses for other psychiatric disorders deemed to make participation in the study inadvisable.","85 Years",{"count":66,"type":21},[24],"Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population. Emerging evidence demonstrates that elevated temperatures acutely worsen mental health symptoms and significantly increase the risk of heat related morbidity and mortality. For people living with schizophrenia, prolonged exposure to heat can exacerbate psychiatric symptoms, impair judgment and decision making, and reduce the ability to engage in protective behaviors such as increasing hydration, reducing clothing, improving ventilation, or seeking cooler environments. As a result, individuals with schizophrenia may experience higher rates of heat related illness. To date our understanding of heat exposure effects in individuals with schizophrenia remains incomplete, hindering the development of evidence-based strategies to protect them.\n\nThus, the primary objective of this exploratory study is to gather preliminary data on the effects of indoor overheating on physiological responses (core body temperature and cardiovascular function), cognitive performance (attention, working memory, and reaction time), and mood in adults with schizophrenia. Specifically, we will assess whether maintaining indoor conditions at the upper recommended temperature limit for older adults (26°C, 45% relative humidity \\[RH\\]; PMID: 38329752) is sufficient to mitigate physiological strain compared with exposure to a hot indoor environment (36°C, 45% RH) representative of non-air-conditioned homes during extreme heat events in individuals with schizophrenia. In both conditions, the individual will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (4-4.5 METS) each hour (excluding the lunch period) to reflect typical daily activities of daily living.",[28,33,96],[98,99,72,36,235,100,101,43,236,102,237],"Schizophrenia","Mental health","Physical activity","2026-04-20",{"date":213,"type":48},{"date":241,"type":48},"2025-11-08",{"date":243,"type":21},"2027-07-01",{"name":53,"class":54},{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":63,"sex":90,"minAge":252,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":258,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":263,"leadSponsor":264,"locationsCount":55},"100613024","impact-of-indoor-overheating-on-physiological-strain-in-children-100613024","NCT07261202","Impact of Indoor Overheating on Physiological Strain in Children","A Preliminary Study Assessing the Effectiveness of a 26 °C Indoor Temperature Limit on Physiological Responses in Children","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed assent.\n\nExclusion Criteria:\n\n* Chronic health conditions\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity","10 Years","15 Years",{"count":66,"type":21},[24],"Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children. Compared with adults, children are more susceptible to heat related illness due to less efficient thermoregulatory systems and difficulty recognizing early signs of heat stress. In addition, prolonged heat exposure can adversely affect their mental health, contributing to cognitive decline, heightened anxiety, and irritability. As children spend substantial time in hot environments at school and at home, and as these conditions intensify with climate change, actions to safeguard their health are essential. Yet our understanding of heat exposure effects in children remains incomplete, hindering the development of evidence based strategies to protect them.\n\nTo address this gap, the investigators aim to evaluate whether an indoor temperature limit of 26 °C (45 percent relative humidity), the upper threshold recommended to protect older adults, can effectively prevent dangerous increases in physiological strain and declines in cognitive function in children during a simulated daylong heatwave. The preliminary study will assess physiological and cognitive responses in children aged 10 to 15 years during a 6 hour exposure (approximating a typical school day) to two conditions: (1) the recommended indoor temperature upper limit (26 °C) and (2) a high heat condition representative of homes and schools without air conditioning during extreme heat events (36 °C). In both conditions, children will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (6-6.5 METS) each hour (excluding the lunch period) to reflect typical daily activity in a school setting. This experimental design will allow investigators to determine whether maintaining indoor temperatures at the recommended upper limit for older adults sufficiently mitigates physiological strain in children.",[28,33,96],[98,99,72,36,259,100,101,43,260,102,237],"Adolescent","Youth",{"date":213,"type":48},{"date":241,"type":48},{"date":136,"type":21},{"name":53,"class":54},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":63,"sex":90,"minAge":272,"maxAge":229,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":277,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":55},"100607511","suitability-of-the-26-c-indoor-temperature-upper-limit-for-older-adults-impacts-of-clothing-and-daily-activity-100607511","NCT07189507","Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity","Evaluation of the 26 °C Indoor Temperature Upper Limit Considering Clothing Insulation and Daily Activity in Older Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to your diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","65 Years",{"count":66,"type":21},[24],"While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289\u002FEHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat production accompanying activities of daily living or the restriction to heat loss caused by clothing insulation. To safeguard the health of older adults, health agencies worldwide recommend the remain in cool space indoors, avoid strenuous activity, wear lightweight clothing, and drink cool water regularly throughout the day. However, older adults do not sense heat as well as their younger counterparts. Consequently, they may not take appropriate countermeasures to mitigate physiological strain from indoor overheating. This may include overdressing despite high indoor temperatures. In other cases, individuals may wear insulated clothing in hot weather to observe cultural or religious modesty requirements, which serve as expressions of faith and identity rather than a tool for thermoregulation. Further, individuals may be unaware of the consequences of increases in physical activity on heat gain and may therefore not adjust their normal day-to-day activity levels to prevent potentially dangerous rises in body temperature. Consequently, this may necessitate a lowering of recommended upper indoor temperature limit during hot weather.\n\nTo address these important considerations, on separate occasions the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 8 hours to the recommended indoor temperature upper limit of 26°C and 45% relative humidity equivalent humidex of 29 (considered comfortable) while they A) perform seated rest dressed in light clothing (t-shirt, shorts and socks), B) perform light exercise (stepping exercise to simulate activities of daily living, 4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing, C) perform light exercise (4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants) and D) perform seated rest dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants). With this experimental design, investigators will assess the effects of added clothing insulation and light activity, representative in activities of daily living on physiological strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required.",[28,33],[98,99,72,36,100,101,43,278,102,279,280],"Elderly","Clothing","Activity",{"date":213,"type":48},{"date":283,"type":48},"2025-09-23",{"date":285,"type":21},"2027-03-31",{"name":53,"class":54},{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":63,"sex":90,"minAge":17,"maxAge":272,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":297,"briefSummary":298,"conditions":299,"keywords":304,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":326},"100632159","title-icarus---psycho-physiological-profiling-of-low-and-high-heat-resilient-individuals-100632159","NCT07510061","Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals","Physiological Phenotyping","ICARUS","Study Population\n\nHealthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe).\n\nInclusion Criteria\n\n* Age 18-65 years (or your protocol-specific age range)\n* Healthy as determined by medical history screening questionnaire\n* Able to provide written informed consent\n* Able to complete heat exposure and light exercise protocol\n* No heat acclimatization or extensive sun exposure in the previous 4 weeks\n* Fitzpatrick skin type I-IV (if applicable for UV testing)\n* Willing to undergo blood sampling, urine collection, and skin biopsy\n\nExclusion Criteria\n\n* History of cardiovascular, metabolic, neurological, or dermatological disease\n* History of heat-related illness (e.g., heat stroke)\n* Use of medications affecting thermoregulation or cardiovascular function\n* Smoking or substance abuse\n* Pregnancy or breastfeeding\n* Abnormal ECG or uncontrolled hypertension\n* Recent severe sunburn or UV treatment\n* Contraindications to skin biopsy\n* Inability to tolerate heat exposure during screening",{"count":296,"type":21},80,[24],"The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure.\n\nThe Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe.\n\nAdvanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies.\n\nGlobal warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and public health, where Icarus aims at providing a highly improved basis for preventing heat-related disease, advising or nudging people towards pro-health behavior, including smarter use of technologies to mitigate heat stress, or adjusting medication to reduce adverse effects during heat events. In support of the sustainability agenda, our framework also forms a novel basis for developing advising algorithms relevant for optimization of climate change mitigation policy-making.",[300,301,302,43,28,303],"Skin Cancer","Heat Tolerance","Heat-related Illness","Ultraviolet Radiation-Related Skin Damage",[28,305,306,307,43,308,309,310,311,312,313,40,314,315,316],"Heat-Related Illness","Heat Vulnerability","Heat Intolerance","Environmental Heat Exposure","Thermal Stress","Ultraviolet Radiation Exposure","Skin DNA Damage","Cardiovascular Strain (Heat-Induced)","Cognitive Impairment (Heat-Induced)","Climate Change and Health","Heat Resilience","Heat Acclimatization","2026-03-27",{"date":319,"type":48},"2026-04-03",{"date":321,"type":48},"2025-11-01",{"date":323,"type":21},"2027-04-30",{"name":325,"class":54},"University of Thessaly",2,{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":63,"sex":120,"minAge":17,"maxAge":145,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":342,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":55},"100630591","indigenous-nutritional-supplements-for-pregnancy-to-improve-resilience-in-environmental-heat-100630591","NCT07489664","Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat","INSPIRE","Inclusion Criteria:\n\n1. Women aged 18-45 years belonging to a low to middle socioeconomic status, residing in Mithi, Districts in Sindh.\n2. Planning to conceive within the study time frame and expect to become pregnant within four months of starting nutritional intervention.\n3. Women who confirm their pregnancy during the first trimester i.e., before 8 weeks of gestational age.\n\nExclusion Criteria:\n\n1. Women using long-lasting contraceptives such as IUDs, implants, and injectable methods like Depo-Provera.\n2. Women with a history of multiple miscarriage or stillbirths.\n3. Women with known chronic diseases, such as cardiovascular disorders, hepatic disorders, renal disorders, and infectious diseases.\n4. Women suffering from severe malnutrition (WHO: Underweight i.e., having BMI \\\u003C 16 Kg\u002Fm2 or obese having BMI ≥ 30 Kg\u002Fm2).\n5. Women having severe anemia (WHO: Severe anemia i.e., Hb \\\u003C 7g\u002FdL).\n6. Women currently enrolled in BISP supplementation programs or taking any supplements other than iron and folic acid (IFA) will be excluded from the study.\n7. Those who do not become pregnant within three months of supplementation during pre-conception.",{"count":335,"type":21},292,[24],"The purpose of this study is to learn whether a simple, traditional, and balanced meal made from local foods, eaten once a day during pregnancy, can help women in rural Pakistan stay healthier in hot weather and give birth to healthier babies. Climate change has made heat a serious challenge for pregnant women, especially in areas with limited resources. This study will explore whether an indigenous meal that is culturally acceptable and easy to prepare can improve resilience to heat stress and support better outcomes for both mothers and newborns.\n\nThe study will focus on two main questions:\n\n* Can this daily balanced meal reduce the harmful effects of heat stress during pregnancy?\n* Does it improve newborn health, especially birth weight?\n\nResearchers will compare women who eat the balanced local meal every day with women who continue their usual meals. They will check changes in women's health, levels of key vitamins and nutrients, and their babies' birth outcomes.\n\nDuring the study, participants will:\n\n* Either eat the balanced local meal daily or continue their usual meals.\n* Share information on their health, diet, and heat exposure.\n* Provide small samples, such as blood and stool, to study nutrient levels and gut health.\n* Have their newborns' health and growth measured at birth.",[28,339,340,341],"Pregnancy","Women of Reproductive Age","Nutrition Status",[343,344,345,346],"Local Food-Based Diet to Improve Birth Outcomes and Heat Resilience in Pregnant Women","maternal depression","placental transcriptomics","microbiome","2026-03-19",{"date":349,"type":48},"2026-03-24",{"date":351,"type":21},"2026-03",{"date":353,"type":21},"2028-12",{"name":355,"class":54},"Aga Khan University",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":90,"minAge":4,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":22,"phases":365,"briefSummary":366,"conditions":367,"keywords":368,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":55},"100591348","heat-stress-exposure-among-low-income-residents-in-bangladesh-and-evaluation-of-indoor-interventions-100591348","NCT06979258","Heat Stress Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions","Heat Stress: Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions","Inclusion Criteria for the house:\n\n* House is located in an informal settlement in an urban area in Bangladesh\n* The house has a corrugated iron roof and corrugated iron walls\n* The household plans to remain in the house from Feb-Nov\n\nExclusion Criteria for the house\n\n* There is an inhabited structure about the house\n* The landlord does not allow the proposed intervention\n\nInclusion Criteria for the participant:\n\n* Lives in an eligible household\n\nExclusion Criteria for the participant\n\n* Has access to air conditioning in their home or place of work\n* Reports they are pregnant\n* Has hypertension, as measured by study staff\n* Has diabetes, as measured by study staff\n* Self-reports cardiovascular disease \u002F chronic cardiac condition\n* Self-reports respiratory disease \u002F chronic respiratory condition",{"count":364,"type":21},1539,[24],"The goal of this clinical trial is to learn if infrastructure and equipment installed to cool homes reduce adverse health outcomes. The main questions it aims to answer are:\n\nWhat is the impact of the intervention on indoor heat stress? What is the impact of the intervention on personal exposure to heat stress? What is the impact of the intervention on health outcomes, including heart rate, and heart rate variability, and sleep quality?\n\nParticipants will have cooling infrastructure and\u002For equipment installed in their home; have heat stress sensors installed inside and outside their home and wear personal heat stress monitors; allow some biological functions such as heat rate, heat rate variability, and sleep quality.",[28],[210,369,370,371,372,373],"cooling","heart rate","heart rate variability","sleep quality","Bangladesh","2026-02-17",{"date":376,"type":48},"2026-02-20",{"date":378,"type":48},"2025-05-12",{"date":380,"type":21},"2029-03-31",{"name":382,"class":54},"University of California, Berkeley",{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":90,"minAge":390,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":22,"phases":394,"briefSummary":395,"conditions":396,"keywords":400,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":55},"100591585","beat-the-heat-boston-100591585","NCT06982339","Beat the Heat Boston","Beat the Heat: Impacts of Heat on Health in Boston and Strategies to Address Them","Inclusion Criteria:\n\n* reside in Roxbury, Dorchester, East Boston or Mattapan MA\n* age 55-95 years old\n* speak English or Spanish\n* do not have air conditioning in the home\n* living with at least one of the following conditions: chronic CVD (hypertension, hyperlipidemia, diabetes, history of stroke or myocardial infarction, atrial fibrillation, or heart failure), chronic pulmonary disease (asthma, COPD\u002Femphysema, interstitial lung disease), chronic neurologic disease (stroke, Parkinson's disease, or other chronic neurologic conditions), chronic mental health conditions (including anxiety disorder, major depression, bipolar disorder), and\u002For history of hospitalization (defined as spending at least one night in the hospital) for any reason within the past three years.\n\nExclusion Criteria:\n\n\\- Lack a location in their home suitable for installation of the AC unit provided during the research study.","55 Years","95 Years",{"count":393,"type":21},100,[24],"The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults. The main questions it aims to answer are:\n\nHow does the presence of an air conditioning unit affect heat stress, heat strain, mental health, and healthcare utilization among older adults who did not previously have access to air conditioning?\n\nHow, and in what conditioners, do older adults use air conditioning once it is installed in their home?\n\nResearchers will compare participants in arms with (A) and without (B) air conditioning units in the first summer season; this will allow them to assess the effect of air conditioners. In the second summer season, both arms will have air conditioning units, but those in the year two distribution arm (B) will receive an electricity subsidy, while those in the year one AC distribution arm (A) will not, allowing researchers to assess the effect of an electricity subsidy.\n\nParticipants will be randomized to receive an air conditioner and financial support for electricity costs in either the first summer season or the second summer season of the study.\n\n* Heat stress, heat strain, mental health, and healthcare utilization will be assessed via participant survey.\n* Air conditioner utilization will be assessed via continuous load monitoring devices.\n* Indoor air temperature will be assessed via continuous data loggers.",[397,398,28,399,29,35],"Hot Weather; Adverse Effect","Heat Effect","Heat Stroke, Heat Exhaustion",[401,402,403,404],"Cooling","Air conditioner","Heat related illness","stepped wedge","2026-01-21",{"date":407,"type":48},"2026-01-22",{"date":409,"type":48},"2025-05-19",{"date":411,"type":21},"2026-10-15",{"name":413,"class":54},"Harvard School of Public Health (HSPH)",{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":63,"sex":90,"minAge":272,"maxAge":4,"enrollmentInfo":420,"targetDuration":4,"studyType":22,"phases":422,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":55},"100560863","phase-4-aging-beta-blockers-and-thermoregulatory-responses-100560863","NCT06582680","Aging, Beta Blockers, and Thermoregulatory Responses","Inclusion Criteria:\n\n* Healthy and free of any significant medical problems\n* Normal resting electrocardiogram\n* 65+ years of age\n* Controlled cholesterol of less than 200 mg\u002Fdl\n* Controlled blood pressure of less than 140\u002F90 mmHg\n\nExclusion Criteria:\n\n* Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia\n* Serious abnormalities detected on routine screening\n* Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating\n* Current smokers, as well as individuals who regularly smoked within the past 3 years\n* body mass index ≥31 kg\u002Fm2",{"count":421,"type":21},22,[423],"PHASE4","This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.",[28,41],"2025-10-21",{"date":428,"type":48},"2025-10-23",{"date":430,"type":48},"2024-10-04",{"date":432,"type":21},"2026-09-30",{"name":434,"class":54},"University of Texas Southwestern Medical Center",{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":63,"sex":90,"minAge":442,"maxAge":229,"enrollmentInfo":443,"targetDuration":4,"studyType":22,"phases":444,"briefSummary":445,"conditions":446,"keywords":447,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":55},"100580872","influence-of-indoor-humidity-on-physiological-strain-in-older-adults-during-a-simulated-heat-wave-100580872","NCT06842953","Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave","Is an Adjustment in the Recommended Indoor Temperature Upper Limit of 26°C Required During Higher Levels of Humidity?","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","60 Years",{"count":66,"type":21},[24],"Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself. At high levels of humidity, the efficiency of sweating decreases causing a greater rise core temperature and burden on the cardiovascular system. In this context, increasing temperatures and humidity with climate change thus pose a potential compound risk for human health. While humidity's role in heat-health outcomes could substantially alter projections of health burdens from climate change, the impact of humidity on physiological strain in vulnerable people in relation to the indoor environment has yet to be evaluated. In a recent study delineating the physiological effects of the proposed 26°C indoor upper limit (PMID: 38329752), relative humidity was set to 45% in all conditions based on indoor humidity standards by the American Society of Heating and Air-Conditioning Engineers. However, it is unknown whether a refinement of the recommended indoor temperature limit of 26°C is required in situations where humidity cannot be maintained at this level.\n\nOn separate occasions, the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 10 hours at the recommended indoor temperature limit of 26°C and 45% relative humidity (equivalent humidex of 29 (considered comfortable)) (experimental condition A), to 26°C with a relative humidity of 15% (equivalent humidex of 23 (considered comfortable); humidex is used to measure the perceived temperature taking into account the humidity)) (experimental condition B), to 26°C with a relative humidity of 85% (equivalent humidex of 37 (considered somewhat uncomfortable)) (experimental condition C), and to 31°C and 45% relative humidity with an equivalent humidex of 37 (considered somewhat uncomfortable) that is similar to experimental condition C. With this experimental design, investigators will assess the effects of indoor humidity in driving human heat strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required. Further, by evaluating changes in relation to ambient conditions with a similar humidex, the investigators can assess how individuals perceive and respond to both heat and humidity.",[28,33],[72,98,36,100,278,101,43,102],{"date":449,"type":48},"2025-06-15",{"date":451,"type":48},"2025-03-14",{"date":453,"type":21},"2026-09-01",{"name":53,"class":54},{"id":456,"slug":457,"hasResults":11,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":63,"sex":90,"minAge":196,"maxAge":4,"enrollmentInfo":462,"targetDuration":4,"studyType":22,"phases":464,"briefSummary":465,"conditions":466,"keywords":469,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":55},"100587950","ethanol-consumption-in-the-heat-100587950","NCT06935045","Ethanol Consumption in the Heat","Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure","Inclusion Criteria:\n\n* Male or Female above the age of 19\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence\n* Been hospitalized due to COVID-19\n* Pregnant\u002FBreastfeeding\n* Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)",{"count":463,"type":21},34,[24],"Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1\u002F5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.\n\nTherefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.",[467,28,468],"Alcohol Consumption","Age",[470,210,471,472,473,474,475,476],"alcohol","heat wave","sweating","core temperature","micturition","perception","behaviour","2025-04-11",{"date":479,"type":48},"2025-04-18",{"date":481,"type":48},"2023-12-04",{"date":483,"type":21},"2025-08",{"name":485,"class":54},"Lakehead University",{"id":487,"slug":488,"hasResults":11,"nctId":489,"briefTitle":490,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":63,"sex":90,"minAge":17,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":494,"phases":4,"briefSummary":495,"conditions":496,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":55},"100580859","impact-of-extreme-heat-on-myocardial-blood-flow-and-flow-reserve-in-young-and-older-adults-100580859","NCT06842784","Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults","Inclusion Criteria:\n\n* Healthy male and female individuals\n* 18-35 years or 65+ years of age\n* Free of any underlying moderate to serious medical conditions\n\nExclusion Criteria:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.\n* Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.\n* Abnormalities detected on routine screening.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* Body mass index of greater than 30 kg\u002Fm\\^2\n* Pregnant individuals",{"count":493,"type":21},24,"OBSERVATIONAL","Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.",[41,28,43,35],"2025-02-18",{"date":499,"type":48},"2025-02-24",{"date":501,"type":48},"2025-02-03",{"date":503,"type":21},"2027-02-01",{"name":434,"class":54}]