[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heat-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heat-stroke":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,38,57,82,109,130,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100557395","application-of-an-early-in-hospital-temperature-management-protocol-for-heat-stroke-patients-100557395",false,"NCT06537557","Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients","Inclusion Criteria:\n\n* Patients admitted to the emergency department and diagnosed with heat stroke according to the China expert consensus on Heat Stroke\n\nExclusion Criteria:\n\n* transferred from another hospital and body temperature \\\u003C 39.5℃; discharged within 4 hours, and subsequent body temperature or outcomes were unavailable; required immediate cardiopulmonary resuscitation; had other serious diseases, such as massive cerebral haemorrhage or severe trauma.","ALL","18 Years",{"count":18,"type":19},188,"ESTIMATED","INTERVENTIONAL",[22],"NA","Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and\u002For strenuous exercise. It is defined by an elevated core temperature exceeding 40°C and central nervous system abnormalities, accompanied by multi-organ dysfunction. The severity of cellular and tissue damage in heat stroke patients depends on the peak temperature reached and the duration of hyperthermia. Rapid reduction of core temperature can halt cellular damage, quickly reverse organ dysfunction, and improve patient outcomes. Therefore, early identification and rapid cooling are crucial to prevent irreversible damage and death in heat stroke patients. However, there is a lack of systematic and specific protocols to guide emergency medical staff in the standardized and effective management of body temperature in heat stroke patients. To address this, our research team previously developed an early in-hospital temperature management protocol for heat stroke patients based on the best available evidence, expert consultations, and expert panel meetings. This study aims to validate the feasibility and effectiveness of the protocol through clinical research, providing a basis for clinical practice.",[25],"Heat Stroke","RECRUITING","2026-05-24",{"date":29,"type":30},"2026-05-27","ACTUAL",{"date":32,"type":30},"2024-07-01",{"date":34,"type":19},"2026-12-30",{"name":36,"class":37},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":44,"targetDuration":4,"studyType":20,"phases":46,"briefSummary":47,"conditions":48,"keywords":49,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":51,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":5},"100510245","non-inferiority-study-of-the-effect-of-non-cooling-blanket-on-body-temperature-in-patients-with-heat-stroke-100510245","NCT05923931","Non-inferiority Study of the Effect of Non-cooling Blanket on Body Temperature in Patients With Heat Stroke","Inclusion Criteria:\n\n* ≥ 18 years old\n* diagnosed as heat stroke\n* informed consent of patients or family members\n\nExclusion Criteria:\n\n* need immediate cardiopulmonary resuscitation\n* body temperature \\<39.5℃ on admission\n* with the underlying disease of severe organ damage\n* pregnant women",{"count":45,"type":19},126,[22],"The goal of this clinical trial is to test the cooling effect of cooling blanket in patients with heat stroke. The main questions it aims to answer are:\n\n* the cooling rate of cooling blanket in patients with heat stroke\n* the relationship between cooling blanket and outcomes in patients with heat stroke\n\nParticipants will accept the cooling blanket or non-cooling blanket according to the randomization group.\n\nResearchers will compare cooling rate and outcomes to see if the cooling blanket can accelerate the cooling speed and improve the prognosis of patients in heat stroke.",[25],[50],"heat stroke, cooling blanket, cooling rate, outcomes",{"date":29,"type":30},{"date":53,"type":30},"2023-05-28",{"date":55,"type":19},"2027-03",{"name":36,"class":37},{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100581203","genetic-risk-factor-for-heat-stroke-100581203","NCT06847256","Genetic Risk Factor for Heat Stroke","Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration","Inclusion Criteria:\n\n* Previously genotyped as a CF carrier or control\n* Comfortable speaking\u002Freading English\n\nExclusion Criteria:\n\n* Previously genotyped as a CF patient\n* Diagnosis of Type 1 or Type 2 diabetes\n* History of heart attack, stroke, heart failure, or atherosclerosis\n* Currently pregnant\n* Currently taking beta blockers or diuretics\n* Prisoner status\n* Unable to provide own written informed consent","60 Years",{"count":66,"type":19},200,"OBSERVATIONAL","The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.\n\nThe primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.\n\nThis will be accomplished with two smaller projects- Aim 1 and Aim 2.\n\nAim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat.\n\nAim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.",[70,25,71],"Carrier State","Dehydration","2026-04-21",{"date":74,"type":30},"2026-04-27",{"date":76,"type":30},"2025-11-19",{"date":78,"type":19},"2026-12",{"name":80,"class":37},"University of Iowa",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":15,"minAge":16,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":81},"100451196","study-on-the-establishment-of-a-system-for-early-warning-and-prognostic-evaluation-of-patients-with-heat-stroke-100451196","NCT05155358","Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke","Inclusion Criteria:\n\n1. The patient voluntarily signs an informed consent form;\n2. Adult patients who meet the criteria for heat stroke;\n3. Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years old or \\>90 years old;\n2. Patients with advanced tumors, Pregnancy or lactation;\n3. Patients who missed out during treatment and whose data are incomplete.",true,"90 Years",{"count":91,"type":19},150,"Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.",[25,94,95,96,97,98],"Early Waking","MODS","Proteinosis","Liver Injury","Kidney Injury","NOT_YET_RECRUITING","2025-08-10",{"date":102,"type":30},"2025-08-14",{"date":104,"type":19},"2025-08-31",{"date":106,"type":19},"2027-12-31",{"name":108,"class":37},"Xijing Hospital",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":88,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":20,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":81},"100563927","use-of-sodium-bicarbonate-as-prophylaxis-for-kidney-damage-in-patients-with-heatstroke-100563927","NCT06622525","Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke","Inclusion Criteria:\n\n* Admitted to the General Hospital of Mexicali with the diagnosis of heat stroke.\n* Meeting the operational definition (exposure to heat, body temperature at admission greater than 40 degrees Celsius).\n* CPK level greater than 1000 U\u002FL.\n* Having informed consent from the patient or the legally responsible adult.\n\nExclusion Criteria:\n\n* Exclusion of the heat stroke diagnosis during their evaluation.\n* Lack of serum creatinine levels at the time of admission to the protocol.",{"count":81,"type":19},[22],"This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. It is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. The intervention will be conducted at the General Hospital of Mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.",[25,119,120],"Acute Kidney Injury","Acute Kidney Injury Due to Hypovolaemia","2024-09-30",{"date":123,"type":30},"2024-10-02",{"date":125,"type":30},"2024-05-01",{"date":127,"type":19},"2025-10-01",{"name":129,"class":37},"Hospital General de Mexicali",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":146,"leadSponsor":148,"locationsCount":149},"100510072","early-body-temperature-targets-and-relationship-with-prognosis-in-patients-with-heat-stroke-100510072","NCT05921682","Early Body Temperature Targets and Relationship With Prognosis in Patients With Heat Stroke","Inclusion Criteria:\n\n* ≥ 18 years; ② diagnosed as heat stroke; ③ Informed consent from patients or family members.\n\nExclusion Criteria:\n\n* need immediate cardiopulmonary resuscitation; ② transferred from another hospital; ③ with severe underlying organ insufficiency; ④ pregnant women.",{"count":137,"type":19},100,"The goal of this observational study is to explore the optimal target body temperature in first 24 hours and the relationship between body temperature and adverse outcomes of heat stroke.\n\nThe main questions it aims to answer are:\n\n* the optimal target body temperature at 0.5 h, 2 h, and the lowest body temperature of heat stroke.\n* the best body temperature at the cutting point of stop cooling.\n* The relationship between the volume and speed of ice saline infusion and the cooling effect.",[25],[141],"heat stroke, body temperature, outcomes","2024-09-18",{"date":144,"type":30},"2024-09-20",{"date":53,"type":30},{"date":147,"type":19},"2026-03",{"name":36,"class":37},6,{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":88,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":159,"conditions":160,"keywords":161,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":81},"100504373","study-of-thermoregulation-in-exercise-heat-stroke-in-the-military-environment-100504373","NCT05847465","Study of Thermoregulation in Exercise Heat Stroke in the Military Environment","EXPLO-MITO","Inclusion Criteria:\n\n* Be included in the main EXPLO-CCE study;\n* Subject trained or re-trained at 2 aerobic sessions per week;\n* At least 2 months from the exercise heat stroke experience\n\nExclusion Criteria:\n\n* Subject with a current medication treatment (for the control group only),\n* Subject with a contraindication to the ingestion of a thermal capsule, namely:\n\n  * Weight less than 37 kg\n  * Inflammatory, motor or obstructive disease of the digestive tract\n  * History of digestive surgery\n  * Participant requiring a CT or MRI scan prior to removal of the thermal capsule (scheduled scan)\n  * Presence of an implantable electronic device (e.g. pacemaker)",{"count":158,"type":19},50,"The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32).\n\nThe Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and clinical settings. Unlike the walk-run test, it is performed under controlled conditions, both environmentally (temperature control, humidity, etc.) and in terms of effort intensity. In addition, there are published interpretation criteria for this test allowing to characterize thermoregulation profiles and to distinguish between Heat Intolerant (HI) and Heat Tolerant (HT) patients.\n\nThe reproducibility of this test and its performance in a climatic chamber allows a true comparison of thermophysiological responses (heart rate, rectal and skin temperatures, skin blood flow and sweat loss), which was not possible with the run-walk test, which was more a field test validating a physical aptitude for recovery (so-called \"occupational\" test) than a physiological exploration evaluating a response to stress by comparing it with the expected response in a population of young, healthy, properly trained subjects. Moreover, the HTT is a much less physiologically demanding test than the 8-km run. The HTT, which corresponds to a 2-hour walk at 5 km\u002Fh with a 2% slope at 40°C and 40% relative humidity, is a so-called \"compensable\" thermal stress; that is, under these conditions of exercise and environment, when the individual has normal thermoregulatory capacities, a thermal equilibrium plateau is reached during the second hour, when the individual's thermolysis capacities make it possible to compensate for the production of heat by the exercise and the gain of heat related to the environment. On average, this plateau is between 38° and 39°C. This is clearly not the case with our experience of physiological monitoring of the 8-km walk-run which rarely allows a temperature plateau to be reached and is accompanied by a temperature rise constantly above 39°C. In addition to being performed in the laboratory, this test is therefore completely safe.\n\nFor all these reasons (reproducibility, relevance, predictive value of recurrence), this test has been used for more than 30 years by the Israeli army for the assessment of these cases of exercise heat stroke before their return to work. There is therefore a fair amount of published data and hindsight on the use and interest of this test. The Israeli test has the highest level of recommendation (Grade A) of all the other published heat tolerance tests. Also, the availability of a climatic chamber means that this test can now be proposed as one of the explorations available to clinicians who have to decide on the fitness of soldiers after exercise heat stroke.",[25],[162],"Heat tolerance test","2023-08-01",{"date":165,"type":30},"2023-08-02",{"date":167,"type":30},"2023-05-09",{"date":169,"type":19},"2027-05",{"name":171,"class":37},"Direction Centrale du Service de Santé des Armées"]