[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heavy-drinking\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heavy-drinking":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,76,104,133,159,183],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100638177","reset-challenge-reducing-high-risk-drinking-for-cancer-prevention-100638177",false,"NCT07591428","Reset Challenge: Reducing High-risk Drinking for Cancer Prevention","Feasibility and Preliminary Efficacy of a 30-Day Reset Challenge","Inclusion Criteria:\n\n* Adults +18\n* Individuals who drink alcohol regularly\n* Further inclusion criteria will be determined via a Zoom screening with a member of the research staff.\n* Current Oklahoma Resident\n\nExclusion Criteria:\n\n\\- Exclusion criteria will be determined via a Zoom screening with a member of the research staff.","ALL","18 Years","120 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a single-arm, non-randomized, prospective study to evaluate the feasibility and preliminary efficacy of a 30-day mobile Health (mHealth) Reset Challenge for reducing high-risk drinking.",[27,28,29],"Alcohol Drinking","Heavy Drinking","Binge Drinking",[31,32,33,34,35],"Daily drinking","Binge or Heavy Drinking","Dry January","Abstinence Challenge","30-day break","RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2026-06-10",{"date":44,"type":21},"2028-04",{"name":46,"class":47},"University of Oklahoma","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100478376","affirmative-psychotherapy-for-sexual-minority-womens-mental-and-behavioral-health-100478376","NCT05509166","Affirmative Psychotherapy for Sexual Minority Women's Mental and Behavioral Health","A Unified Protocol to Address Sexual Minority Women's Minority Stress, Mental Health and Hazardous Drinking","EQuIP","Inclusion Criteria:\n\n1. be 18 years of age or older\n2. be fluent in English\n3. self-identify as lesbian, bisexual, queer, pansexual, or other non-heterosexual identity\n\n3\\) report at ≥ 8 standard drinks\u002Fweek, on average, in the past 30 days, OR report at least 2 heavy drinking days ( ≥ 4 drinks in one day) in the past 30 days 4) currently experience a Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 depression or anxiety disorder (screened initially using a cutoff of ≥ 2 on the Brief Symptom Inventory-4 and further confirmed by diagnostic interview via the DIAMOND) 5) report at least minimum motivation to reduce drinking (measured by the Readiness Ruler) 6) live in New York, New Jersey, and Pennsylvania and planning to stay for at least the next 4 months\n\nExclusion Criteria:\n\n1. report current mental health treatment ≥1 day\u002Fmo\n2. report having received any CBT in the past 3 months\n3. report current alcohol or drug abuse treatment, except mutual self-help (e.g., Alcoholics Anonymous)\n4. need alcohol detoxification indicated by ≥9 on Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar)\n5. exhibit active psychosis or active mania, as assessed by the Structured Clinical Interviews for DSM-5 Disorders (SCID) Psych Screen\n6. exhibit active suicidality or active homicidality, as assessed by the SCID-Psych Screen\n7. be currently legally mandated to attend treatment\n8. demonstrate gross cognitive impairment, as assessed with the Telephone Interview for Cognitive Status",true,{"count":59,"type":21},274,[24],"The purpose of this 2-arm randomized controlled trial is to assess the efficacy of a 10-session lesbian, gay, bisexual, transgender, and queer (LGBTQ)-affirmative cognitive-behavioral psychotherapy (CBT) delivered via telehealth in a large sample of sexual minority women (SMW) in New York, New Jersey and Pennsylvania. The investigators will assess whether the EQuIP (Empowering Queer Identities in Psychotherapy) treatment demonstrates significant reductions in heavy drinking (HD) and mental health symptoms (e.g., depression) compared to LGBTQ-affirmative treatment-as-usual.",[28,63],"Mental Health Issue",[65,66],"LGBTQ","Cognitive Behavioral Therapy","2026-06-11",{"date":69,"type":40},"2026-06-15",{"date":71,"type":40},"2023-02-01",{"date":73,"type":21},"2027-10-01",{"name":75,"class":47},"Yale University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100632683","exploring-the-effects-of-brief-mindfulness-training-with-vagal-nerve-stimulation-on-alcohol-cue-reactivity-among-young-adult-heavy-drinkers-100632683","NCT07516873","Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers","Exploring the Feasibility and Acceptability of Brief Mindfulness Training With Vagal Nerve Stimulation for Reducing Alcohol Consumption Among Young Adults","Inclusion Criteria:\n\n* Currently living in Massachusetts.\n* Aged 21-29 years old.\n* Consume either more than 14 standard drinks of alcohol per week OR at least 5 standard drinks in one day per week (in past 30 days).\n* Have sufficient English fluency to understand procedures and questionnaires.\n* Have the capacity and ability to provide informed consent.\n* Scores at least 15 points on the PACS at screening. Participants who score between 10 and 14 pts will undergo additional doctoral-level review to assess eligibility.\n\nExclusion Criteria:\n\n* Current or past diagnosis of a substance use disorder based on the Quick Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) Module C (Substance Use Disorders).\n* Active prescription for sedative\u002Fhypnotics, opioids, or anesthetic medications.\n* Active prescription for medications used to treat alcohol use disorder (AUD), e.g., naltrexone, disulfiram, acamprosate, etc.\n* Active psychosis or schizophrenia-spectrum disorder diagnosis.\n* Bipolar I disorder history or severe level of mania.\n* Severe symptoms of PTSD.\n* Acute suicidality or self-injurious behavior.\n* Cognitive inability as demonstrated by the inability to complete an informed consent assessment with \\>90% accuracy after 2 attempts.\n* Current participation in another experimental intervention research study.\n* Current daily mindfulness practice \\>10 minutes per day.\n* Participation in an 8-week intensive Mindfulness-Based Intervention or residential meditation retreat in past 3 years.\n* Expected medical hospitalization in the next 2 months; or are currently pregnant.\n* Expected incarceration in the next 2 months.\n* Presence of electronic implants, such as heart pacemakers, defibrillators, or pumps.\n* Presence of a cardiac rhythm disorder.\n* History of seizures.\n* Presence of skin disorders or malignant diseases in the area in or around the left ear.\n* Lack of alcohol craving as assessed by the PACS during screening (score of \\\u003C 10 points).","21 Years","29 Years",{"count":86,"type":21},50,[24],"The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption. All participants will complete a brief (1-week) mindfulness intervention, and participants will be randomized to receive either active or inactive Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) during two in-person laboratory visits. Heart rate variability data and self-report survey data will be collected to assess the impact of the intervention on autonomic regulation, alcohol consumption, and additional clinical measures.",[28],[28,91,92,93,94],"Mindfulness","Vagus Nerve Stimulation","Alcohol Cue Reactivity","Heart Rate Variability","2026-05-08",{"date":97,"type":40},"2026-05-12",{"date":99,"type":40},"2026-03-06",{"date":101,"type":21},"2026-08",{"name":103,"class":47},"Cambridge Health Alliance",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},"100477022","alcohol-roc-training-100477022","NCT05491551","Alcohol-ROC-Training","Brief Training for Heavy Drinking Young Adults: Regulation of Alcohol Craving","A-ROC-T","Inclusion Criteria:\n\n(1) Young adults ages 18-26 years, who (2) report ≥ 3 heavy drinking days (i.e., heavy drinking defined by \\>3 drinks for women, \\>4 drinks for men) in the prior month; (3) are motivated to quit or reduce drinking; (4) are fluent in English and have a 6th grade or higher reading level; (5) have access to a computer with working internet; (6) use a working smartphone; (7) can commit to the full length of the protocol; and (8) are willing to be randomized to intervention condition.\n\nExclusion Criteria:\n\n(1) Current (past 12 months) clinically-severe alcohol use disorder (AUD; e.g., history of seizures, delirium, or hallucinations during withdrawal) or current severe alcohol withdrawal; (2) Current (past 12 months) clinically-severe substance use disorder (except tobacco) or current severe drug withdrawal; (3) serious other psychiatric illness by history or examination; (4) severe or unstable physical disease within the past 6 months; (5) psychoactive medications (e.g., mood stabilizers) that have not been at a stable dose unless determined to be on a stable dose of medication by the study psychiatrist; (6) current use of any investigational medication; (7) color blindness; (8) biological females who are pregnant; and (9) notable dislike to any particular type of alcoholic beverage depicted in study stimuli; (10) Participants who will not complete at least 70% of past day EMA reports in the pre-intervention phase will not be randomized; (11) Participants who cannot understand or follow study-related instructions (e.g., unable to correctly use the intervention strategies, indicate lack of understanding of study instructions despite multiple attempts).","26 Years",{"count":114,"type":21},177,[24],"The goal of the proposed study is to examine whether brief training in regulation of craving (ROC-T) affects alcohol drinking. The study will consist of a basic screening (phone and online), and in person visit to determine eligibility and conduct pre-intervention baseline assessments, 1-4 training (ROC-T) visits, a post-intervention assessment visit, and 1-2 phone\u002Fonline follow up assessments.The two active conditions of ROC-T are based on cognitive-behavioral treatments (CBT) and mindfulness-based treatments (MBT).",[29,28,118,119],"Young Adult","Heavy Drinker",[29,28,118,119,121,66,122,123],"Regulation of Craving","Neurocognitive Training","Mindfulness-Based Therapy","2026-02-17",{"date":126,"type":40},"2026-02-19",{"date":128,"type":40},"2022-09-28",{"date":130,"type":21},"2027-12",{"name":75,"class":47},2,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":140,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":48},"100614290","aerobic-exercise-addition-to-cognitive-behavioural-treatment-in-impotence-metabolic-syndrome-drinkers-100614290","NCT07277673","Aerobic Exercise Addition to Cognitive Behavioural Treatment in Impotence Metabolic-syndrome Drinkers","Is There a Benefit of Aerobic Exercise Addition to Cognitive Behavioural Treatment in Heavy Drinking Men With Impotence and Metabolic Syndrome?","Inclusion Criteria:\n\n* heavy drinking men (forty)\n* men who complain metabolic syndrome\n* men who complain impotence\n\nExclusion Criteria:\n\n* cardiac problems\n* renal or hepatic or respiratory or neurogenic diseases,","MALE","35 Years","45 Years",{"count":144,"type":21},40,[24],"Cognitive Behavioural Treatment is used as treatment for Heavy Drinking, Impotence, and Metabolic Syndrome. The efficacy of adding aerobic training to this treatment is not tested till now.",[28,148,149],"Metabolic Syndrome","Impotence","2025-11-29",{"date":152,"type":40},"2025-12-11",{"date":154,"type":40},"2025-10-10",{"date":156,"type":21},"2026-02-15",{"name":158,"class":47},"Cairo University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":57,"sex":166,"minAge":17,"maxAge":142,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":173,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":4},"100561504","phase-1-helpline-pilot-factorial-trial-100561504","NCT06591026","Helpline Pilot Factorial Trial","Helpline Delivery of Brief Interventions for Postpartum Heavy Episodic Drinking","Inclusion Criteria:\n\n* Resides full-time in the United States\n* Age 18-45 years\n* Gave birth to an infant within the prior 4 weeks\n* Speaks and reads English\n* Owns a text-enabled cell-phone\n* Receives a score of 2 or more on the T-ACE alcohol risk screener\n* Reports ONE of the following: (a) drinking weekly or more often in the prior month; or (b) having 4 or more standard drinks at one time at least monthly in the 12 months prior to becoming pregnant.\n\nExclusion Criteria:\n\n* Resides outside of the United States\n* Age under 18 years or over 45 years\n* Did not give birth to an infant within the prior 4 weeks\n* Cannot speak and read English\n* Does not own a text-enabled cell-phone\n* Does not receive a score of at least 2 on the T-ACE alcohol risk screener\n* Does not report either drinking weekly or more often in the past month or having 4 or more standard drinks at least monthly in the 12 months prior to becoming pregnant\n* Scores greater than 4 on the AUDIT-C, indicating an alcohol use disorder","FEMALE",{"count":168,"type":21},120,[170],"PHASE1","The pilot factorial trial will (1) evaluate feasibility, acceptability, and fidelity of the intervention components (Aim 2.1), and (2) collect proof-of-concept data on the impact of the components on the proximal (motivation, self-efficacy, and self-regulation) and distal (quantity and frequency of HED) outcomes (Aim 2.2). Participants will include 120 postpartum mothers recruited from social media. The investigators will conduct a pilot 2X2X2 balanced full factorial trial, with 4 factors (1 constant, 3 randomized to 2 levels each) and 8 study conditions. The 4 factors will include: (1) Standard Helpline (constant); (2) Motivational Interviewing (yes vs. no); (3) Coping skills training (yes vs. no); (4) Automated messaging (yes vs. no). Participants will be randomly assigned to one of 8 study conditions, which will determine which combination of intervention components participants receive.",[28],"NOT_YET_RECRUITING","2025-01-14",{"date":176,"type":40},"2025-01-15",{"date":178,"type":21},"2025-12-01",{"date":180,"type":21},"2027-07-31",{"name":182,"class":47},"The National Center on Addiction and Substance Abuse at Columbia University",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":194,"overallStatus":173,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":204,"locationsCount":4},"100575836","study-of-nitrate-rich-juice-on-cognitive-function-in-heavy-alcohol-drinkers-a-two-stage-adaptive-design-real-world-clinical-trial-100575836","NCT06777459","Study of Nitrate-Rich Juice on Cognitive Function in Heavy Alcohol Drinkers: a Two-Stage Adaptive Design Real-World Clinical Trial","Inclusion Criteria:\n\nA. Individuals with a history of heavy alcohol consumption (as defined below), who have continued heavy drinking within the past week and have no plans to quit drinking within the next month.\n\nB. Individuals with a history of heavy alcohol consumption who are currently hospitalized due to alcohol dependence or alcohol use disorder, and are still undergoing treatment.\n\nThe CDC (Centers for Disease Control and Prevention) defines heavy alcohol consumption as follows: For males: more than 15 standard alcoholic drinks per week. For females: more than 8 standard alcoholic drinks per week. Here, one standard drink unit is approximately 14 grams of pure alcohol- C. A Montreal Cognitive Assessment (MoCA) score greater than 13.\n\nExclusion Criteria:\n\nA. Individuals with a history of or current infectious diseases. B. Individuals with a history of or current severe cardiovascular, cerebrovascular, hepatic, or renal diseases.\n\nC. Individuals who are allergic to any substances used in the trial, such as beets.",{"count":190,"type":21},43,[24],"It is known that alcohol consumption can lead to cognitive impairment and dysregulation of inflammatory responses. A preliminary randomized controlled trial conducted by our research team has suggested that nitrate may improve cognition in hospitalized patients with alcohol dependence. To further expand the population and applicability, this study aims to explore the effects of nitrate on cognition in a real-world population of heavy drinkers. The researchers have designed a two-stage clinical trial: the first stage involves the analysis of existing data, and the second stage will recruit 43-54 new participants for a 14-day dietary inorganic nitrate (nitrate-rich beetroot juice, \\~750 mg NO3- \u002Fd) intervention.",[28],[28,195,196,197,198],"Cognitive Function","Nitrate","Two-stage adaptive design","Real World Study","2025-01-10",{"date":176,"type":40},{"date":176,"type":21},{"date":203,"type":21},"2025-12-31",{"name":205,"class":47},"Peking University Sixth Hospital"]