[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hematopoetic-stem-cell-transplant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hematopoetic-stem-cell-transplant":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,79,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100612320","phase-1-ruxolitinib-enhanced-haplo-hct-for-children-and-young-adults-with-sickle-cell-disease-100612320",false,"NCT07252050","Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease","Ruxolitinib-Enhanced Conditioning for Pediatric and Young Adult Patients With Symptomatic Sickle Cell Disease Undergoing Haploidentical Hematopoietic Cell Transplantation","RUX-HAPLO","Inclusion Criteria:\n\n1. Participants with any genotypic form of SCD aged 12 - 45 years at enrollment with ≥1 of the following:\n\n   1. History of stroke and\u002For vasculopathy, including evidence of asymptomatic cerebrovascular disease for pediatric patients.\n   2. Recurrent moderate-severe acute chest syndrome (ACS)\n   3. Recurrent vaso-occlusive pain episodes requiring parenteral analgesia despite the institution of supportive care.\n   4. Need for chronic transfusion therapy to prevent vaso-occlusive complications (i.e. pain, stroke, and ACS).\n   5. For adult patients, an echocardiographic finding of tricuspid valve regurgitant jet velocity (TRJV) ≥ 2.7 m\u002Fsec.\n2. Participants must have an HLA haploidentical first degree relative (parent, sibling, or half sibling) who is willing and able to donate bone marrow.\n3. Participants must meet institutional eligibility criteria for HCT.\n\nExclusion Criteria:\n\n1. Presence of an HLA-matched sibling who is willing and able to donate bone marrow.\n2. Uncontrolled infection, evidence of active TB, Hepatitis B or C infection, or HIV seropositivity or infection.\n3. Previous HCT or solid organ transplant.\n4. CNS revascularization procedure, myocardial infarction, pulmonary embolus or deep vein thrombosis in the past 6 months.\n5. Use of medications which significantly interfere with ruxolitinib metabolism.\n6. Known hypersensitivity or severe reaction to ruxolitinib or any component of the conditioning regimen or its excipients.\n7. Inability to swallow and retain oral medication (use of nasogastric or gastrostomy tube permitted).\n8. History of malignancy except resected basal cell carcinoma or treated carcinoma in-situ.\n9. Participation in another clinical trial involving an investigational or off-label use of a drug or device in the past 3 months.\n10. Currently pregnant or breast feeding.\n11. Clinically significant, uncontrolled autoimmune disease.\n12. High-titer anti-donor specific HLA antibodies (without review and approval by Study Chair).\n13. Participant (or guardian) inability or unwillingness to comply with the dose schedule and study evaluations, comprehend or sign informed consent and utilize a highly effective method of contraception (for participants of child-bearing potential).\n14. Any condition that would, in the investigator's judgment, interfere with full participation in the study, pose a significant risk to the subject, or interfere with interpretation of study data.","ALL","12 Years","45 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This trial will determine whether adding ruxolitinib to a reduced intensity conditioning (RIC) regimen reduces the rate of graft failure following haploidentical (haplo) hematopoietic cell transplant (HCT) for children and young adults with sickle cell disease (SCD).\n\nThis study will enroll and treat up to 24 participants. Recruitment is expected to last for about 2 years and participants will be followed for an additional 2 years post-HCT.",[29,30,31,32,33],"Sickle Cell Disease","Hematopoetic Stem Cell Transplant","Haploidentical Hematopoietic Stem Cell Transplant","Haploidentical Stem Cell Transplantation","Graft Failure",[35,36,37,38,39,40],"Sickle cell disease","Hematopoietic cell transplant","Ruxolitinib","Pediatric","Young Adult","Haplo","RECRUITING","2026-06-02",{"date":44,"type":45},"2026-06-04","ACTUAL",{"date":47,"type":22},"2026-06-08",{"date":49,"type":22},"2029-11-19",{"name":51,"class":52},"Arkansas Children's Hospital Research Institute","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100462509","aromatherapy-inhaler-use-for-hsct-distress-100462509","NCT05302583","Aromatherapy Inhaler Use for HSCT Distress","Aromatherapy Inhaler Use for Hematopoietic Stem Cell Transplant Patient Distress","Inclusion Criteria:\n\n* Autologous and Allogeneic patients admitted to E1 for planned HSCT\n* Patients with hematologic malignancies requiring HSCT\n* No allergies to lavender or peppermint essential oils\n* Must have received chemotherapy during preparative regimen (single or multi-agent regimen)\n* Adult patient over 18 years of age\n* Able to speak, read, and comprehend English\n* Willing and capable of providing informed consent\n\nExclusion Criteria:\n\n* Patients admitted for Chimeric Antigen Receptor T cell (CART) infusion\n* Patients receiving a transplant for a germ cell tumor diagnosis\n* Unexpected\u002Funplanned admission (e.g., neutropenic fever, confusion, clinical deterioration)\n* Immune effector cell-associated neurotoxicity syndrome (ICANS) grade 1 through 4\n* History of scleroderma\n* History of atrial fibrillation\n* Known history of G6PD deficiency\n* Allergic to lavender or peppermint essential oils\n* Pediatric patient 18 years of age or less\n* Unable to speak, read, and comprehend English\n* Unwilling or incapable of providing informed consent","18 Years",{"count":62,"type":22},50,[64],"NA","This randomized controlled trial will evaluate the feasibility and acceptability of an inhaled aromatherapy stick for patients during the acute inpatient phase after hematopoietic cell transplantation (HCT) . The study will also explore whether aromatherapy use is associated with short-term changes in patient-reported cancer-related distress and coping self-efficacy.",[67,68,30,69],"Cancer Distress","Cancer Coping","Aromatherapy","2026-05-29",{"date":42,"type":45},{"date":73,"type":45},"2025-06-16",{"date":75,"type":22},"2026-06",{"name":77,"class":52},"Stanford University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":18,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":102,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100632820","phase-1-phase-i-clinical-trial-of-thinkk-adoptive-immunotherapy-after-allogeneic-hematopoietic-transplantation-in-children-with-leukemia-or-neuroblastoma-100632820","NCT07518654","Phase I Clinical Trial of ThINKK Adoptive Immunotherapy After Allogeneic Hematopoietic Transplantation in Children With Leukemia or Neuroblastoma","Phase I Clinical Trial of Therapeutic Inducers of Natural Killer Killing (ThINKK) Adoptive Immunotherapy: Feasibility, Safety and Pharmacodynamics in Children Undergoing Allogenic Hematopoietic Transplantation for Leukemia or Neuroblastoma","ThINKK-01","Inclusion Criteria:\n\n1. Between 2 and less than 13 years old at time of informed consent form signature.\n2. Diagnosis of acute leukemia or neuroblastoma.\n3. Allogenic hematopoietic stem cell transplantation 30 to 90 days prior to eligibility confirmation.\n4. Blood NK cell counts ≥ 100 x 10E+6 cells\u002FL at least once before eligibility confirmation.\n5. Life expectancy of ≥ 3 months per investigator's judgment at time of eligibility confirmation.\n6. Patient or legally acceptable representative has provided informed consent based on local regulations and\u002For guidelines prior to any study-specific activities\u002Fprocedures being initiated.\n\nExclusion Criteria:\n\n1. Current grade 3 or 4 acute GvHD (per MAGIC criteria).\n2. Relapse of primary malignancy, or any other active malignancy.\n\n   1. For leukemia, defined as either morphological relapse or Minimal Residual Disease (MRD) ≥0.01% as measured by flow cytometry. MRD detected by polymerase chain reaction (PCR) does not constitute an exclusion criterion.\n   2. For neuroblastoma, defined as a progressive disease.\n3. Ongoing therapy with systemic corticosteroids (equivalent to a prednisone dose \\>0.5 mg\u002Fkg\u002Fday). Patients actively undergoing corticosteroid tapering during Screening may be enrolled once they have reached a prednisone-equivalent dose ≤ 0.5 mg\u002Fkg\u002Fday with Sponsor-Investigator approval, with the expectation that the taper will continue.\n4. Ongoing systemic therapy with cyclosporine.\n5. Administration or planned administration of any prohibited treatment listed in ad hoc section.\n6. Aspartate aminotransferase and alanine aminotransferase serum levels ≥5 times the upper limit of normal.\n7. Direct bilirubin serum levels ≥3 times the ULN (unless due to Gilbert syndrome).\n8. Baseline estimated glomerular filtration rate \\\u003C 50 mL\u002Fmin\u002F1.73 m2, as determined using the Bedside Schwartz equation for \\\u003C 18 years of age.\n9. Grade 4 diarrhea (ie, life-threatening consequences with urgent intervention indicated).\n10. O2 Sat saturation \\\u003C90% on room air by pulse oximetry.\n11. Uncontrolled life-threatening symptomatic infection(s).\n12. Blood pressure below the 5th percentile for age, sex, and height last 24 hours.\n13. Ongoing therapy with intravenous vasopressor agent.\n14. Any condition that, in the opinion of the Investigator, would compromise the safety of the patient, would prevent full participation in this study, or would interfere with the evaluation of any study endpoints.\n15. Pregnancy or breastfeeding or absence of highly effective methods of contraception for males and females of childbearing potential who engage in heterosexual intercourse","2 Years",{"count":89,"type":22},12,[25],"A first-in-class adoptive immunotherapy we called ThINKK, for Therapeutic Inducers of Natural Killer (NK) cell Killing, have been designed for use after hematopoietic stem cell transplantation (HSCT), where the proper stimulation of graft-derived NK cells has been shown to prevent relapse.\n\nThINKK immunotherapy builds on our earlier research on NK cells and plasmacytoid dendritic cells (PDC) in cord blood and after HSCT. PDC are the sentinels of the immune system. Upon viral nucleic acids detection, PDC secrete a vast array of chemokines and cytokines that stimulate NK cells. PDC stimulation enhances NK cells killing of infected cells that express stress-induced molecules. Cancer cells also express stress-related molecules at their surface. However, NK cells do not receive PDC stimulation when fighting cancer. ThINKK therapy is designed to provide this necessary stimulation.",[93,94,95,96,97,98,99,100,101,30],"Leukaemia (Acute Lymphoblastic)","Leukaemia (Acute Myeloid)","Neuroblastoma","Neuroblastoma, Metastatic","Leukaemia, Lymphoblastic, Acute","Leukemia Acute Myeloid","Leukemia (Both ALL and AML)","Leukemia Acute Myeloid - AML","Hematopoetic Stem Cell Transplantation",[103,104,105,106],"Thinkk","NK cells","pdc","immunotherapy","NOT_YET_RECRUITING","2026-04-02",{"date":110,"type":45},"2026-04-08",{"date":112,"type":22},"2026-05-01",{"date":114,"type":22},"2029-05-01",{"name":116,"class":52},"Michel Duval",2,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":78},"100601182","psychosocial-and-behavioral-intervention-for-stem-cell-transplant-patients-and-their-family-caregivers-100601182","NCT07107165","Psychosocial and Behavioral Intervention for Stem Cell Transplant Patients and Their Family Caregivers","Adapting After Discharge From Allogeneic SCT: Partnering Together; Dyadic Intervention to Improve Patient-Family Caregiver Team-Based Management of the Medical Regimen After Allogeneic Hematopoietic Cell Transplantation","Inclusion Criteria:\n\n* Patient undergoing a stem cell transplant at the University of Pittsburgh Hillman Cancer Center\n* 18 years or older\n* having a family caregiver age 18 years or older also willing to participate in the study\n* willing to accept randomization\n\nExclusion Criteria:\n\n* Prior history of stem cell transplant\n* Non-English speaking",{"count":126,"type":22},208,[64],"Adherence to the medical regimen after stem cell transplant is challenging for both patients and their family caregivers. The investigators propose a randomized clinical trial testing two brief psychosocial interventions to determine if either improves patient and family caregiver psychosocial and health-related outcomes.",[130,30,101],"Stem Cell Transplant",[132,133],"stem cell transplant","hematopoietic stem cell transplant","2026-03-26",{"date":136,"type":45},"2026-04-01",{"date":138,"type":45},"2025-07-01",{"date":140,"type":22},"2027-07",{"name":142,"class":52},"University of Pittsburgh"]