[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemianopia-homonymous\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemianopia-homonymous":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,81,106,146,173,201],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100565164","comparative-efficacy-of-saccadic-and-biofeedback-training-in-homonymous-hemianopia-100565164",false,"NCT06638619","Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia","Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia: A Comprehensive Eye Movement Pilot Study","Inclusion Criteria:\n\n* Diagnosis of stroke\n* Presence of hemianopia with central vision involvement\n* Stroke occurred at least 6-months before enrollment\n\nExclusion Criteria:\n\n* Presence of hemianopia with macular sparing\n* Diagnosis of hemispatial neglect","ALL","18 Years","89 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training. The study will look at how eye movements and reading performance change after training. Researchers will compare the results of two groups: one group will complete five clinical training sessions using an eye-tracking machine for 30 minutes each, while the other group will do at-home reading exercises for 20 minutes a day, 5 days a week, for 6 weeks. The goal is to see if there is a difference in performance between the two types of training.",[27],"Hemianopia, Homonymous",[29,30,31],"stroke","vision","hemianopia","NOT_YET_RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":21},"2026-06",{"date":40,"type":21},"2026-12",{"name":42,"class":43},"University of Alabama at Birmingham","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100642991","home-based-vision-rehabilitation-guided-by-brain-imaging-100642991","NCT07635329","Home-based Vision Rehabilitation Guided by Brain Imaging","Behavioral Rehabilitation Through Image-Guided Home-based Training","BRIGHT","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing visual field loss.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n5. Eligible for MRI based on standard safety screening.\n\nExclusion Criteria:\n\n1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.\n2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Ocular disease or disorder.",{"count":53,"type":21},100,[24],"The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.\n\nUsing a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.",[57,58,59,60,61,62,63,64,65],"Visual Field Defect","Stroke","Hemianopia Homonymous","Quadrantanopia","Cortical Blindness","Visual Field Defect, Peripheral","Visual Field Loss","Traumatic Brain Injury","Brain Tumor",[67,29,30,68,69],"neuroplasticity","TBI","brain tumor","RECRUITING","2026-06-03",{"date":73,"type":36},"2026-06-09",{"date":75,"type":21},"2026-07-01",{"date":77,"type":21},"2030-03-31",{"name":79,"class":43},"Georgetown University",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":80},"100507979","ameliorating-stroke-induced-hemianopia-via-multisensory-training-100507979","NCT05894434","Ameliorating Stroke-induced Hemianopia Via Multisensory Training","Inclusion Criteria:\n\n* Age \\>= 18 years old\n* Homonymous hemianopia diagnosed and referred by a neurologist, confirmed with Humphrey test (Goldmann size V) on first visit. Hemianopia must have been evident for at least 6 months for inclusion in the first experiment and \\\u003C1 month for inclusion in the second\n* Cognitively normal, defined as having normal activities of daily living OR has received a cognitive adjudication of normal through the Wake Forest University School of Medicine or equivalent within the past 12 months\n* MRI compatible\n* Has reliable transportation or is able to use transportation provided by the study\n* English speaking\n\nExclusion Criteria:\n\n* Current major medical problems that might independently affect cognition, vision, or interfere with ability to attend study visits. This includes pathology of the retina or optic nerve explanatory of blindness\n* Unable or unwilling to attend scheduled testing and training sessions, including the 12 month follow up\n* Current diagnosis of a major neurological disorder that could interfere with the ability to follow task instructions (Dementia, Parkinson's disease, etc.) or that may interfere with the rehabilitation paradigm (uncorrected asymmetric hearing loss, deafness, hemineglect)\n* Unwilling or unable to provide consent for study participation\n* Current stroke symptoms deemed exclusionary by a study physician. This will be reviewed on a case-by-case basis by a study physician to determine whether factors may affect study outcomes, aims, or integrity\n* Taking medication that could negatively influence safety during the intervention\n* Enrolled in another interventional research study \\\u003C= 3 months prior to beginning this study\n* Self-reports regularly drinking \\> 14 alcoholic beverages a week or current illicit drug use",{"count":88,"type":21},72,[24],"This study seeks to determine the extent of the visual capabilities that can be restored in hemianopic stroke patients by a multisensory training technique and evaluate changes in the brain that the training induces. The effectiveness of the technique will be evaluated in two interventional contexts: patients whose blindness is long-standing and stable, and another in which intervention is as soon as possible after the stroke.",[27,92],"Cortical Blindness, Unspecified Side of Brain",[94,95,96],"multisensory","visual perception","neurorehabilitation","2026-04-22",{"date":99,"type":36},"2026-04-23",{"date":101,"type":21},"2026-08",{"date":103,"type":21},"2027-07",{"name":105,"class":43},"Wake Forest University Health Sciences",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":129,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":80},"100519758","vision-loss-impact-on-navigation-in-virtual-reality-100519758","NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"21 Years","75 Years",{"count":117,"type":21},40,[24],"The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[121,60,122,27,123,124,125,62,126,127,128],"Stroke, Ischemic","Hemianopsia, Homonymous","Hemianopia","Hemianopsia","Occipital Lobe Infarct","Vision Loss Partial","Quadrantanopsia","Stroke Hemorrhagic",[130,131,132,133,134,135,136,29],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","2026-01-07",{"date":139,"type":36},"2026-01-09",{"date":141,"type":36},"2023-11-28",{"date":143,"type":21},"2028-10",{"name":145,"class":43},"University of Rochester",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":113,"sex":16,"minAge":114,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":80},"100603304","mechanisms-of-visual-restoration-after-occipital-stroke-100603304","NCT07134777","Mechanisms of Visual Restoration After Occipital Stroke","Mechanisms of Visual Restoration After Occipital Stroke (MOVROS)","MOVROS","Cortically Blind Subjects (n=50)\n\nInclusion:\n\n* Subjects between 21 and 80 years of age\n* Subjects must be residents of the United States or Canada\n* Subjects must exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 80 years (verified by MRI and\u002For CT scans)\n* Subjects with reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.\n* Subjects must be able to fixate on visual targets reliably for 1000ms, with jitter over less than 1-deg of visual angle.\n\n  o Note: This will be initially assessed by review of visual field reports as supplied by subjects during the screening process. However, we will be unable to fully assess their fixation ability until they start the psychophysics testing in our lab. If at that time we discover that they are unable to maintain adequate fixation, they will be withdrawn from the study.\n* Subjects must be willing, able, and competent to provide their own informed consent\n* Subjects must have their own home computer (desktop or laptop) and reliable internet access\n* All subjects must have normal cognitive abilities and memory, sufficient to be able to understand and follow written and oral instructions in English, as well as to remember how to complete visual training at home, on their own, as instructed, for several months.\n* Justification: We can only accept English-speaking subjects due to a lack of resources for supporting those who would require interpreter services. As all of our subjects are required to spend 3-5 days in lab with rigorous testing and training requirements, we must be able to communicate clearly and with minimal misunderstandings. This would require for up to 5-full days of in person interpreter services, for which we do not have funding. Additionally, ongoing communications take place by phone, email, and\u002For text as a part of home training (for routine check-ins and technical support for example) in the intervals between laboratory visits. This would require us to essentially have \"on demand\" access to interpreter services, which is simply not feasible.\n* Subjects must be safe and willing to undergo magnetic resonance imaging (MRI) scans\n\nExclusion:\n\n* Subjects who have past or present ocular disease interfering with visual acuity\n* Subjects with best-corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Subjects who have documented or suspected damage to the dorsal Lateral Geniculate Nucleus\n* Subjects who have diffuse whole-brain degenerative processes\n* Subjects who have experienced traumatic brain injury\n* Subjects who have any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Subjects who have oculomotor defects deemed by study staff to potentially interfere with training ability or outcome measures (i.e., by impairing stable fixation during testing or training)\n* Subjects who have documented history of drug\u002Falcohol abuse\n* Subjects who are currently taking neuroactive medications which would impact training, as determined by PI\n* Subjects who have cognitive, memory or seizure disorders\n* Subjects with one-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n* Subjects who have contradictions to MRI scanning will be excluded. These contraindications include: a) central nervous system aneurysm clips; b) implanted neural stimulator; c) implanted cardiac pacemaker or defibrillator; d) cochlear implant; e) ocular foreign body (e.g., metal shavings); f) insulin pump; g) metal shrapnel or bullet; h) any implanted device that is incompatible with MRI.\n* Subjects who have conditions that preclude MRI scanning, e.g., morbid obesity, claustrophobia.","80 Years",{"count":53,"type":21},"OBSERVATIONAL","This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.",[61,159,126,160,123,59,125],"Stroke Ischemic","Visual Fields Hemianopsia",[162,163,164],"occipital stroke","vision loss","Homonymous quadranopsia","2025-11-26",{"date":167,"type":36},"2025-12-04",{"date":169,"type":36},"2025-10-17",{"date":171,"type":21},"2029-08-01",{"name":145,"class":43},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":180,"maxAge":154,"enrollmentInfo":181,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":188,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":199,"locationsCount":80},"100395123","feasibility-tests-for-various-prism-configurations-for-visual-field-loss-100395123","NCT04424979","Feasibility Tests for Various Prism Configurations for Visual Field Loss","Visual Field Expansion Through Innovative Multi-Periscopic Prism Design","Inclusion Criteria:\n\n* Visual field loss, either peripheral field loss or hemianopic field loss\n* Visual acuity of at least 20\u002F50 in the better eye\n* In sufficiently good health to be able to complete sessions lasting 2-4 hours\n* Able to independently walk short distances\n* Able to give voluntary, informed consent\n* Able to speak English\n\nExclusion Criteria:\n\n* Any physical or mental impairments, including cognitive dysfunction, balance problems or other deficits that could impair the ability to walk or use the prism spectacles\n* A history of seizures in the last 6 months\n* Hemispatial neglect (subjects with hemianopic field loss only)","7 Years",{"count":20,"type":21},[24],"The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking. The study will involve multiple visits (typically four) to Schepens Eye Research Institute for fitting and testing with the prism glasses. The overall objective is to determine best designs and fitting parameters for implementation in prism devices for future clinical trials.",[27,185,62,186,187],"Tunnel Vision","Visual Field Constriction Bilateral","Visual Field Defect Homonymous Bilateral",[189,190,124,191,192],"Visual field expansion","Prisms","Tunnel vision","Visual field loss","2025-09-22",{"date":195,"type":36},"2025-09-23",{"date":197,"type":36},"2020-11-06",{"date":40,"type":21},{"name":200,"class":43},"Massachusetts Eye and Ear Infirmary",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":113,"sex":16,"minAge":114,"maxAge":154,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":80},"100525398","effect-of-visual-retraining-after-stroke-100525398","NCT06121219","Effect of Visual Retraining After Stroke","Effect of Visual Retraining on Visual Loss Following Cortical Damage","urochester","Cortically Blind Subjects\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Residents of the United States or Canada\n* Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years)\n* Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus.\n* Able to fixate on visual targets reliably for 1000ms\n* Must have a home computer (desktop or laptop) and reliable internet access\n* Willing, able, and competent to provide informed consent\n* Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months.\n\nExclusion:\n\n* Past or present eye disease interfering with visual acuity\n* BCVA worse than 20\u002F40 in either eye\n* Damage to the dorsal Lateral Geniculate Nucleus\n* Diffuse whole brain degenerative processes\n* History of traumatic brain injury\n* Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Documented history of drug\u002Falcohol abuse\n* Currently taking neuroactive medications which would impact training, as determined by PI\n* Presence of cognitive or seizure disorders\n* One-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n\nControl Subjects (n = 50)\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Report no history of neurological disorder.\n* Competent and responsible, as determined by the Principal Investigator.\n\nExclusion:\n\n* Presence of damage to the visual system\n* Presence of an active disease process involving their nervous system.\n* Cognitive or seizure disorders\n* Best corrected visual acuity worse than 20\u002F40 in either eye\n* Presence of vision field loss from ocular disease or disorder",{"count":53,"type":21},[24],"This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.",[126,213,59,123,60,121,214,61],"Vision; Loss, Both Eyes","Stroke - Occipital Infarction","2025-07-10",{"date":217,"type":36},"2025-07-16",{"date":219,"type":36},"2024-09-05",{"date":221,"type":21},"2032-01",{"name":145,"class":43}]