[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemianopsia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemianopsia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,75,115,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100635877","effectiveness-of-a-visual-telerehabilitation-program-on-visual-perception-in-children-adolescents-and-young-adults-with-hemianopsia-consecutive-to-a-brain-tumour-100635877",false,"NCT07558395","Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour","REVIIH-BT","Inclusion Criteria:\n\n* Male and Female\n* 10 - 40 years old\n* Diagnosed hemianopsia (\\>12 months)\n* History of diagnosis brain tumour\n* Being stable for the tumour for \\> 6 months (either on therapy or not)\n* Visual acuity ≤ 0.7 LogMAR\n* Ability to follow the visual and auditory stimuli and training instructions\n* Home WiFi access\n* Ability to attend all on site visits\n* Affiliation to the Social Security or beneficiary of such social protection\n\nExclusion Criteria:\n\n* Age\\\u003C 10 years old of \\> 40 years old\n* Ocular disease\n* Inability to perform during testing or training\n* 3 consecutive VRISE scores \\\u003C 25 at inclusion\n* History of vertigo\n* Prior vision rehabilitation interventions\n* Recreational or medicinal consumption of psychoactive drugs\n* Persons under court protection\n* Interpupillary distance \\\u003C 54mm","ALL","10 Years","40 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","Evaluate the efficiency of audiovisual stimulation in virtual reality for improving the visual perception of children, adolescents, and young adults with hemianopia resulting from pediatric brain tumors. These individuals can lose up to 50% of their visual field, significantly impacting their independence, mobility, and daily lives.",[27,28,29,30],"Hemianopsia","Virtual Reality","Visual Rehabilitation","Pediatric Brain Tumor",[32,33,34,35],"brain tumor","pediatric","visual rehabilitation","virtual reality","NOT_YET_RECRUITING","2026-04-23",{"date":39,"type":40},"2026-04-30","ACTUAL",{"date":42,"type":21},"2026-05-15",{"date":44,"type":21},"2029-09",{"name":46,"class":47},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",8,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100534621","hemianopsia-rehabilitation-after-stroke-or-brain-injury-100534621","NCT06241209","Hemianopsia Rehabilitation After Stroke or Brain Injury","Inclusion Criteria:\n\nAll patients 18 years of age or older with a homonymous hemianopsia or quadrantopsia, who can provide informed consent, and communicate in English.\n\nExclusion Criteria:\n\n* The flashing lights from thge automated perimeter and PowerPoint program can potentially trigger photic seizures. Therefore patients with light-induced seizures are excluded.","18 Years",{"count":57,"type":21},40,[24],"In patients with hemianopsia following stroke or brain injury, we will determine if stimulating the visual field with images from a PowerPoint slide set can increase the visual field.",[27,61,62],"Visual Field Defect, Peripheral","Visual Impairment","RECRUITING","2026-03-13",{"date":66,"type":40},"2026-03-16",{"date":68,"type":40},"2024-01-25",{"date":70,"type":21},"2028-12-15",{"name":72,"class":73},"University of Alberta","OTHER",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":74},"100445805","improving-visual-field-deficits-with-noninvasive-brain-stimulation-100445805","NCT05085210","Improving Visual Field Deficits With Noninvasive Brain Stimulation","Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery","Inclusion Criteria:\n\n1. 18 years of age or older.\n2. Presence of some intact visual cortical areas (other than primary visual cortex) in the damaged brain hemisphere. This assessment will be made from MRI or CT scans of the subject's head, which will be obtained via standard release from their neurologist.\n3. First ever ischemic or hemorrhagic stroke with damage to primary visual cortex, and rendered blind over a portion of their visual field.\n\n   * Ischemic stroke patients will be either subacute (within 6 months of their stroke) or chronic (more than 6 months)\n   * Hemorrhagic stroke patients will be chronic only (greater than 6 months)\n4. Must demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field as measured by visual perimetry.\n5. Imaging evidence that the stroke is primarily affecting the visual cortex.\n6. Willing and able to participate in the study protocol and to comply with study procedures.\n\nExclusion Criteria:\n\n1. No evidence of damage to the primary visual cortex.\n2. Visual cortex damage as a result of a subsequent stroke (not primary).\n3. Total cortical blindness, covering both left and right visual fields.\n4. Unable to fixate visual targets precisely or unable to perform the visual training exercises as directed.\n5. Complete loss of reading abilities.\n6. Current or prior history of any neurological disorder other than stroke, such as epilepsy, a progressive neurologic disease (e.g. multiple sclerosis) or intracranial brain lesions other than the qualifying stroke lesion.\n7. Current history of poorly controlled migraines including chronic medication for migraine prevention.\n8. History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or immediate (1st degree relative) family history of epilepsy; with the exception of a single seizure of benign etiology (e.g. febrile seizure) in the judgment of the investigator.\n9. History of fainting spells of unknown or undetermined etiology that might constitute seizures.\n10. Past or current history of major depression, bipolar disorder or psychotic disorders, or any other major psychiatric condition.\n11. Participants who are suffering from one-sided attentional neglect as determined by standard neuropsychological tests: figure cancellation and line bisection tasks.\n12. Contraindication for receiving tRNS.\n13. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.).\n14. Any complex, uncontrolled\u002Funstable or terminal medical illness.\n15. Substance abuse or dependence within the past six months.\n16. Medications will be reviewed by the responsible MD (Drs. Sandeep Kumar or Dan Press) and a decision about inclusion will be made based on the following: The patient's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination of CNS active drugs.\n17. All female participants that are pre-menopausal will be required to have a pregnancy test; any participant who is pregnant or breastfeeding will not be enrolled in the study.\n18. Subjects who, in the investigator's opinion, might not be suitable for the study.\n19. A hair style or head dress that prevents electrode contact with the scalp or would interfere with the stimulation (for example: thick braids, hair weave, afro, wig).\n20. Additional criteria for Group 1b only: Contraindication for using VR technology, specifically an implanted medical device such as a pacemaker, implanted defibrillator, deep brain or vagal nerve stimulator. Participants with a history of seizures are already excluded per the above criteria.","80 Years",{"count":84,"type":21},24,[24],"This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.",[61,88,62,27,89,90,91,92,93],"Stroke","Quadrantanopia","Cortical Blindness","Visual Field Defect Homonymous Bilateral","Occipital Lobe Infarct","Visual Fields Hemianopsia",[95,96,97,98,99,100,101,102,103,104,105],"Visual Field defects","Occipital Stroke","Ischemic Stroke","visual cortex","noninvasive brain stimulation","transcranial direct current stimulation","visual training","visual recovery","vision loss","quadrantanopia","Hemorrhagic stroke","2026-03-03",{"date":108,"type":40},"2026-03-04",{"date":110,"type":40},"2022-01-25",{"date":112,"type":21},"2026-06",{"name":114,"class":73},"Beth Israel Deaconess Medical Center",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":16,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":136,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":74},"100519758","vision-loss-impact-on-navigation-in-virtual-reality-100519758","NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"21 Years","75 Years",{"count":57,"type":21},[24],"The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[129,89,130,131,132,27,92,61,133,134,135],"Stroke, Ischemic","Hemianopsia, Homonymous","Hemianopia, Homonymous","Hemianopia","Vision Loss Partial","Quadrantanopsia","Stroke Hemorrhagic",[137,138,139,140,141,142,143,144],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","stroke","2026-01-07",{"date":147,"type":40},"2026-01-09",{"date":149,"type":40},"2023-11-28",{"date":151,"type":21},"2028-10",{"name":153,"class":73},"University of Rochester",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":5},"100543942","visual-telerehabilitation-in-children-adolescents-and-young-adults-with-hemianopsia-consecutive-to-a-brain-tumour-100543942","NCT06362434","Visual Telerehabilitation in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour","Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour.","HHREHAB","Inclusion Criteria:\n\n* Diagnosed hemianopsia (\\> 18 months).\n* History of a diagnosis of brain tumour\n* Being stable for the tumour for \\>18 months (either on therapy or not)\n* Male and female\n* 10 - 40 years old\n* Ability to follow the visual and auditory stimuli and training instructions.\n* Online auditory test positive (-5dbHL to 60dbHL range) at 125 Hz (for research purposes only)\n* Home Wi-Fi access.\n\nExclusion Criteria:\n\n* \\< 10 years old.\n* \\> 40 years old.\n* Ocular disease\n* Both eyes with media opacity that impairs microperimetry testing.\n* Inability to perform during testing and training.\n* Recreational or medicinal consumption of psychoactive drugs.\n* 3 consecutive VRISE (cybersickness) scores \\< 25 at inclusion.\n* History of vertigo or dizziness.\n* Prior vision rehabilitation interventions.",{"count":163,"type":21},50,[24],"Brain malignancies are the most common cause of death from cancer in the pediatric population and a major source of morbidity amongst survivors. Many children with a brain tumour often suffer from visual field defects (hemianopia) dramatically impacting their daily life with poorer social interaction, difficulties learning, playing sports and engaging with peers. Practically, they bump into people and objects and have problems in finding their way in unfamiliar places and in detecting incoming objects in their blind field. There is growing recognition of the diverse and deep impact of hemianopia on physical and mental health, quality of life, and social outcomes of the affected individuals and their family. However, despite the frequent impact of brain tumours on the visual function and functional vision, ophthalmologic evaluations are not standard of care for all brain tumour patients and there are no standardized protocols of vision loss management in the pediatric population with hemianopia. There is an unmet need of restoring perception in the blind field in individuals with hemianopia consecutive to pediatric brain tumor.\n\nOur laboratory has developed a visual rehabilitation procedure based on the combination of adaptative audio and visual target tracking in a 3D environment in virtual reality. Participants perform audiovisual stimulation at home in a headset, with remote control from the laboratory. Preliminary on data on paediatric patients with hemianopia consecutive to a brain tumour indicate feasibility and potential effectiveness of a 6-week Re:Vision program on visual fields, visual perception and quality of life.\n\nOur objective is to evaluate the effectiveness of Re:Vision, an 8-week visual telerehabilitation program, on visual perception in 50 individuals aged 10-40 years old with hemianopia consecutive to a pediatric brain tumor in a phase IIa\u002Fb multi-centric clinical study across Canada.\n\nThis intervention provides more equitable access to individuals, with the ability to receive rehabilitation therapy at home without supervision by a healthcare professional, meaning that Canadians living outside urban centres could take advantage of specialized therapies with remote supervision. This is the first study that could lead to a major change in the management of these patients. It could open the door for visual rehabilitation strategies to other population of visually impaired children, significantly impacting public health strategies.",[27],[168,169,170,171,172,173],"pediatric brain tumor","visual fields","quality of life","reading","MRI","SD-OCT","2024-04-08",{"date":176,"type":40},"2024-04-12",{"date":178,"type":21},"2024-06-01",{"date":180,"type":21},"2027-06-01",{"name":182,"class":73},"University Health Network, Toronto"]