[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemiparesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemiparesis":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,82,105,134,156,178,203,225,257,311,339,362,389,416,445,470,497,520,540,566,593,629,655,682],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630040","repetitive-transcranial-magnetic-stimulation-in-cardiac-autonomic-dysfunction-100630040",false,"NCT07482501","Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction","The Effect of Repetitive Transcranial Magnetic Stimulation on Cardiac Autonomic Dysfunction in Patients With Stroke","Inclusion Criteria:\n\n* Participants aged 35-80 years admitted to the Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Unit for neurological rehabilitation after stroke\n* Participants with a history of stroke of at least 3 months\n* Neurologically and medically stable participants willing to participate regularly in the study\n* Participants capable of following commands\n\nExclusion Criteria:\n\n* Serious cardiac disease, uncontrolled hypertension\n* Epilepsy or history of antiepileptic drug use\n* Intracranial metallic implants\n* Inner ear implants\n* Malignancy\n* Active infection\n* Skin infection or open wound in the intervention area\n* Brain lesions or medications that may alter the seizure threshold\n* Increased intracranial pressure\n* Uncontrolled migraine\n* Fracture or surgery on the hemiplegic side within the last 6 months\n* Pregnancy","ALL","35 Years","80 Years",{"count":21,"type":22},44,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke.",[28,29,30],"Stroke","Autonomic Dysfunction","Hemiparesis",[32,33,34],"Repetitive Transcranial Magnetic Stimulation","Hemiplegia","Neurological Rehabilitation","RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":39},"2026-03-26",{"date":43,"type":22},"2026-11-15",{"name":45,"class":46},"Afyonkarahisar Health Sciences University","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100641665","efficacy-of-tele-cpass-compared-to-in-person-cpass-therapy-for-upper-extremity-motor-recovery-100641665","NCT07661849","Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery","Efficacy of Tele-CPASS, a Telerehabilitation Intervention Using Critical Periods After Stroke Study (CPASS) Compared to In-person CPASS for Upper Extremity Motor Recovery","Inclusion Criteria:\n\n* Age 21 years or older\n* Neuroimaging-confirmed stroke within 40 days prior to enrollment\n* Persistent hemiparesis resulting in impaired upper extremity function, defined by a score of 0 to 3 on the NIH Stroke Scale motor arm item\n* Able to participate in all study-related activities, including 1-year follow-up\n* Short Blessed Memory Orientation and Concentration Scale score less than 8\n* Able to follow 2-step commands\n* Montreal Cognitive Assessment (MoCA) score greater than 25\n* No upper extremity injury or condition that limited upper extremity use prior to the stroke\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Persistent disabling neurologic condition, such as multiple sclerosis, Parkinsonism, amyotrophic lateral sclerosis, or dementia requiring medication\n* Clinically significant fluctuations in mental status within 72 hours prior to randomization\n* Active psychosis, psychosis within the prior 2 years, active substance abuse, or prior substance abuse\n* Dense sensory loss, defined by a score of 3 or 4 on the NIH Stroke Scale sensory item\n* Ataxia out of proportion to weakness in the affected arm, defined by a score greater than 1 on the NIH Stroke Scale ataxia item\n* Not expected to survive 12 months because of other illnesses\n* Pregnancy\n* Severe aphasia\n* Receipt of botulinum toxin or expectation of receiving botulinum toxin during the study period","21 Years",{"count":57,"type":22},42,[25],"This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke. Stroke often leads to long-term difficulty using the affected arm in daily activities, and access to in-person therapy can be limited. This study aims to determine whether therapy delivered remotely can provide similar benefits to standard in-clinic care.\n\nParticipants who recently experienced a stroke will be randomly assigned to receive 20 hours of upper extremity rehabilitation therapy either in person or through a telehealth platform. Both groups will receive the same type and amount of therapy focused on practicing meaningful, patient-selected daily activities. Participants will complete assessments before treatment, immediately after treatment, and at 6 and 12 months to measure recovery of arm function, real-world arm use, and participation in daily life.\n\nThe results of this study will help determine whether telerehabilitation can improve access to effective stroke recovery interventions while maintaining clinical effectiveness comparable to in-person therapy.",[28,30,61,62],"Upper Extremity Impairments","Stroke Rehabilitation",[64,65,66,67,68,69,70,71],"Telerehabilitation","Telehealth","Stroke rehabilitation","Upper extremity recovery","Motor recovery","Critical period plasticity","Wearable sensors","Accelerometry","2026-06-16",{"date":74,"type":39},"2026-06-22",{"date":76,"type":39},"2025-09-01",{"date":78,"type":22},"2029-08-31",{"name":80,"class":46},"University of Texas, El Paso",3,{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":12,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100642560","effect-of-task-oriented-training-with-functional-electrical-stimulation-on-balance-in-children-with-hemiparesis-100642560","NCT07648511","Effect of Task Oriented Training With Functional Electrical Stimulation on Balance in Children With Hemiparesis","Inclusion Criteria:\n\n1. The age of the selected children will be ranged from 6 to 9 years.\n2. Able to follow simple instructions.\n3. Degree of spasticity is ranging from 1to 1+ according to modified Ashworth scale.\n4. The level of motor function of the children will be levels I-II according to Gross Motor Function Classification System.\n\nExclusion Criteria:\n\nThe children will be excluded if they have one or more of the following criteria:\n\n1. Visual, hearing disorders.\n2. Recent Botox injection or orthopedic surgery in the lower limb in the last 6 months before the start of the study.\n3. Any fixed deformity of lower limb.","6 Years","9 Years",{"count":91,"type":22},36,[25],"To investigate the efficacy of combination of task-oriented training and Functional electrical stimulation of ankle dorsiflexor muscles on:\n\n1. Strength of ankle muscles in children with hemiparesis.\n2. Balance in children with hemiparesis.",[30,95],"Children, Only","2026-06-10",{"date":98,"type":39},"2026-06-15",{"date":100,"type":39},"2026-04-05",{"date":102,"type":22},"2026-07-05",{"name":104,"class":46},"Cairo University",{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100639040","personalized-robotic-telerehabilitation-for-upper-limb-functional-recovery-after-stroke-in-a-home-based-setting-100639040","NCT07590349","Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting","ROBOHOME","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of stroke with residual upper-limb motor impairment\n* Upper-limb functional impairment defined by a Fugl-Meyer Assessment for Upper Extremity (FMA-UE) score between 20 and 50\n* Ability to understand study procedures and provide written informed consent\n* Availability of a home environment suitable for telerehabilitation\n\nExclusion Criteria:\n\n* Presence of severe neurological or musculoskeletal disorders affecting the upper limb\n* Severe spasticity (Modified Ashworth Scale ≥3)\n* Severe upper-limb pain (Numerical Rating Scale \\>4)\n* Skin lesions, infections, or conditions preventing safe use of wearable devices\n* Participation in another interventional clinical trial\n* Any medical or cognitive condition that may interfere with compliance or safe participation in the study","18 Years",{"count":114,"type":22},70,[25],"Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence. Conventional rehabilitation approaches are often limited by accessibility, intensity, and long-term adherence, highlighting the need for innovative, home-based solutions.\n\nThis study aims to evaluate the effectiveness of a personalized robotic telerehabilitation program for upper-limb recovery in individuals with post-stroke motor impairment. The intervention combines a wearable robotic device with a virtual reality-based platform, enabling patients to perform structured, task-oriented exercises in a home environment under remote supervision.\n\nParticipants will be allocated to either a robotic-assisted telerehabilitation program or a control condition based on virtual reality-based rehabilitation alone. Motor recovery will be assessed using standardized clinical scales, including the Fugl-Meyer Assessment for Upper Extremity (FMA-UE), along with measures of functional performance, patient-reported outcomes, and treatment adherence.\n\nBy integrating robotic assistance with telemedicine, this study seeks to enhance rehabilitation intensity, improve patient engagement, and facilitate continuity of care beyond traditional clinical settings. The results are expected to support the development of accessible, personalized rehabilitation pathways for individuals with stroke-related upper-limb disability.",[28,30,118,119,120],"Upper Extremity Paresis","Motor Impairment","Rehabilitation",[122,123,64,33],"stroke","Robotics","NOT_YET_RECRUITING","2026-05-14",{"date":127,"type":39},"2026-05-15",{"date":129,"type":22},"2026-06-01",{"date":131,"type":22},"2027-05-30",{"name":133,"class":46},"University of Campania Luigi Vanvitelli",{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100277824","assessment-of-a-physio-neuro-platform-synphne-for-home-based-retraining-of-hand-function-in-stroke-survivors-100277824","NCT02896348","Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors","Inclusion Criteria:\n\n* Ischemic or hemorrhagic stroke at least 6 months prior study enrollment ;\n* Moderate upper-extremity hemiparesis (initial score on the Upper Extremity Fugl-Meyer Assessment between 21 and 55 out of 66) ;\n* Ability to extend at least 2 fingers in the affected hand 10 degrees at any joint with pain-free passive range of motion at least 50% in all joints below the elbow.\n\nExclusion Criteria:\n\n* Cognitive impairment resulting to inability to follow instructions (as assessed with the MMSE) and inability to sustain attention for more than 10 minutes;\n* Current participation in upper-extremity therapy program;\n* Treatment with Botox injections in the affected arm in the previous 3 months and no planned Botox injections before the end of the study;\n* Aphasia sufficient to limit comprehension and completion of the treatment protocol;\n* No more than moderate impairments in paretic UE sensation, passive range of motion, and pain that would limit ability to engage in therapy;\n* Increased muscle tone as indicated by score of \\>\u002F= 3 on the Modified Ashworth Scale;\n* Previous diagnosis of dementia;\n* Previous diagnosis of neurological diseases other than Stroke;\n* History of seizures disorder and\u002For a seizure occuring within the last 6 months;\n* Other conditions affecting function of the stroke affected upper limb;\n* Severe pain in the stroke affected upper limb;\n* Terminal diseases with expected survival \\\u003C1 year;",{"count":141,"type":22},40,[25],"The goal of this study is to:\n\n1. Assess the usability of the SynPhNe device in a home environment.\n2. Evaluate the efficacy of the SynPhNe home use device to improve motor hand function in chronic stroke subjects as compared to standard care alone.",[28,30],[30,28,120,146],"Home-based","2026-05-04",{"date":149,"type":39},"2026-05-06",{"date":151,"type":39},"2025-02-26",{"date":153,"type":22},"2027-03",{"name":155,"class":46},"Spaulding Rehabilitation Hospital",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":163,"sex":17,"minAge":112,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":47},"100478371","improving-myoelectric-prosthetic-and-orthotic-limb-control-100478371","NCT05509101","Improving Myoelectric Prosthetic and Orthotic Limb Control","Improving Myoelectric Prosthetic and Orthotic Limb Control Using Predictive Regression Algorithms and High-count Surface Electrodes","Inclusion Criteria:\n\n* First-ever ischemic or hemorrhagic stroke\n* Chronic Stroke (at least 6 months since onset)\n* Chronic hemiparesis\n* Functional range of motion for contralateral arm\n\nExclusion Criteria:\n\n* Individuals who are currently Incarcerated",true,"70 Years",{"count":166,"type":22},45,[25],"The purpose of this study is to improve control of myoelectrically-controlled advanced orthotic devices (an exoskeleton device that use the body's muscle signals to drive movements of a robotic brace) by using advanced predictive decode algorithms, and the use of high count (\\> 8) surface electromyographic (sEMG) electrodes.",[30],"2026-04-29",{"date":149,"type":39},{"date":173,"type":39},"2017-03-01",{"date":175,"type":22},"2027-12-31",{"name":177,"class":46},"University of Utah",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":163,"sex":17,"minAge":185,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":202},"100250792","motor-and-cognitive-functions-in-acquired-and-developmental-brain-damaged-patients-100250792","NCT02543424","Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients","Studies of the Diagnosis, Rehabilitation and Links Between Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients","Inclusion Criteria:\n\n* Congenital cerebral palsy and acquired brain injury children and adult patients\n* Presenting upper limb paresis and\u002For hemineglect\n* Between the age of 3 to 90.\n* Able to understand and carry out simple verbal instruction\n\nExclusion Criteria:\n\n* IQ \\\u003C 70\n* Severe aphasia, attentional disorder or psychiatric disorders\n* Neurodegenerative disorders","5 Years",{"count":187,"type":22},400,[25],"Neurological pathologies cause important and permanent disabilities in every day life. These pathologies can follow stoke, affecting two people per one thousand each year or cerebral palsy, affecting two births per one thousand each year. To date, the diagnosis and the rehabilitation of motor and cognitive problems has been carried out separately by different domains. For example, physiotherapists have focused on motor problems and neuropsychologists have focused on cognitive functions. However, a number of studies have demonstrated a link between motor and cognitive abilities in adults and children. The present study has three main aims: (1) to better evaluate motor and cognitive problems in brain damaged patients (all ages), (2) to understand the link between motor and cognitive abilities in patients and healthy participants and, (3) to propose new types of therapies based on the link between motor and cognitive functions.",[191,192,30],"Cerebral Palsy","Perceptual Disorders","2026-04-24",{"date":195,"type":39},"2026-04-27",{"date":197,"type":39},"2015-04",{"date":199,"type":22},"2028-12",{"name":201,"class":46},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain",2,{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":23,"phases":212,"briefSummary":213,"conditions":214,"keywords":215,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":47},"100395972","myhand-2-an-active-hand-orthosis-for-stroke-patients-100395972","NCT04436042","MyHand 2: An Active Hand Orthosis for Stroke Patients","MyHand 2","Inclusion Criteria:\n\n* Adults over 18 years old\n* History of stroke(s) with most recent stroke at least six months ago\n* Upper extremity weakness with impaired ability to complete daily activities with affected hand\n* Full passive range of motion in all digits\n* Intact cognition to follow directions\n* Gross control of proximal upper extremity musculature\n\nExclusion Criteria:\n\n* Other neurological conditions besides stroke\n* Other orthopedic conditions to affected upper extremity\n* Significant spasticity in affected upper extremity that impairs device fit",{"count":211,"type":22},60,[25],"This study is designed to further develop and test the hardware and software components of the MyHand device based on user feedback and results from our pilot study. The goal is to refine the device so that is more effective and easier for stroke patients to use to increase their hand function.",[28,30],[28,120,30,123],"2026-04-07",{"date":218,"type":39},"2026-04-13",{"date":220,"type":39},"2020-03-06",{"date":222,"type":22},"2029-01",{"name":224,"class":46},"Columbia University",{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":23,"phases":236,"briefSummary":237,"conditions":238,"keywords":240,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":47},"100352577","rtms-plus-ccfes-mediated-functional-task-practice-for-severe-stroke-100352577","NCT03870672","rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke","Contralaterally Controlled FES Combined With Brain Stimulation for Severe Upper Limb Hemiplegia","rTMS+CCFES","Inclusion Criteria:\n\n* age 18 to 90 years old at time of randomization\n* greater than 6 months since a first clinical cortical or subcortical, ischemic or hemorrhagic stroke\n* severe upper limb hemiparesis defined as less than 10° active wrist extension or less than 10° active thumb abduction\u002Fextension or less than 10° active extension in at least two additional digits (i.e., will not meet minimum CIMT criteria)\n* ability to follow 3-stage commands and can remember 2 items from a list of 3 items after 3 minutes\n* adequate active movement of shoulder and elbow to position the paretic hand on one's lap for performance of functional task practice and CCFES-assisted hand opening exercises\n* skin intact on hemiparetic arm\n* surface electrical stimulation of the paretic finger and thumb extensors produces functional hand opening without pain\n* able to hear and respond to cues from stimulator\n* completed occupational therapy at least 2 months prior to enrollment (no concomitant OT)\n* full volitional hand opening\u002Fclosing of the non-paretic hand\n* ability to follow instructions for putting on and operating the CCFES stimulator or a caregiver available to provide assistance\n\nExclusion Criteria:\n\n* metal implant in the head\n* history of seizures as an adult\n* history of alcohol or substance abuse less than 10yrs prior to enrollment\n* intake of anticonvulsants or anti-depressants contraindicated with TMS\n* cardiac pacemaker or other programmable implant","90 Years",{"count":235,"type":22},72,[25],"This study is a necessary and important step in the development of a new therapy for upper limb functional recovery in patients with severe motor impairment. It is the first clinical trial of non-invasive brain stimulation (repetitive transcranial magnetic stimulation or rTMS) delivered to excite the undamaged hemisphere (specifically the contralesional higher motor cortices or cHMC) in stroke. Therefore, this study will determine whether the positive results obtained in our short-term pilot study can be made to last longer and produce functional benefits in severe patients with the application of brain stimulation in combination with long-term rehabilitation therapy. Rehabilitation therapy administered is called contralaterally controlled functional electrical stimulation (CCFES). Determining whether combining rTMS facilitating the cHMC with CCFES produces synergistic gains in functional abilities in severe patients is necessary for acceptance by the clinical community and to move this technology toward commercialization and widespread dissemination. The proposed study will determine whether the combination of rTMS facilitating the cHMC with CCFES produces greater improvements in upper extremity function in severe participants who are ≥6 months from stroke onset than the combination of rTMS facilitating the damaged hemisphere (specifically the ipsilesional primary motor cortex, iM1) and CCFES or the combination of sham rTMS and CCFES. The secondary purposes are to define which patients benefit most from the treatments, which may inform future device and treatment development and clinical translation, and to explore what distinct effects the three treatments have on the brain. To accomplish these purposes, we are conducting a clinical trial that enrolls severe stroke patients.",[28,33,239,30],"Cerebrovascular Accident (CVA)",[241,28,242,120,243,244,245,246,247],"Upper limb","CVA","Brain Stimulation","CCFES","Motor Cortex","TMS","Motor Recovery","2026-03-20",{"date":250,"type":39},"2026-03-24",{"date":252,"type":39},"2019-05-14",{"date":254,"type":22},"2026-12-31",{"name":256,"class":46},"The Cleveland Clinic",{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":23,"phases":267,"briefSummary":268,"conditions":269,"keywords":278,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":309,"locationsCount":47},"100612195","development-and-efficacy-of-a-novel-cost-effective-gait-training-device-utilized-at-home-for-stroke-survivors-100612195","NCT07250425","Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors","Development of a Novel, Cost-Effective Gait Training Device Utilized at Home for the Neurological Patient Population","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* First-ever ischemic or hemorrhagic stroke confirmed by medical record.\n* 3 months to 5 years post-stroke at time of enrollment.\n* Presence of lower-extremity motor impairment limiting walking function.\n* Able to stand for at least 30 minutes with no more than minimal assistance (with or without a device).\n* Medically stable and cleared by a physician to participate in moderate-intensity ambulation exercise.\n* Living in a home environment that can safely accommodate device installation (e.g., adequate space, appropriate flooring, and power access) as determined by the study team.\n* Able to understand study procedures and provide informed consent (or have a legally authorized representative), with sufficient cognitive and communication skills to follow simple instructions.\n* If assistance is required for transfers or device set-up, availability of a caregiver or assistant willing to participate in training and device use.\n\nExclusion Criteria:\n\n* Unstable cardiovascular, respiratory, or other medical conditions that contraindicate moderate- to high-intensity walking exercise (e.g., unstable angina, decompensated heart failure, uncontrolled arrhythmias).\n* Severe musculoskeletal or orthopedic conditions limiting safe participation in supported stepping (e.g., unstable fractures, severe contractures preventing positioning in the device).\n* Severe spasticity or movement disorders that would preclude safe use of the device, based on investigator judgment.\n* Severe cognitive impairment, aphasia, or behavioral disturbance that would prevent informed consent or safe participation.\n* Progressive neurological conditions (e.g., progressive neurodegenerative disease) expected to significantly worsen over the 12-week study period.\n* Current participation in another interventional trial targeting gait or lower-extremity function.\n* Any other condition that, in the opinion of the investigators, would make participation unsafe or interfere with study adherence or outcome interpretation.","75 Years",{"count":266,"type":22},20,[25],"This pilot, parallel-group randomized controlled trial will evaluate the feasibility, safety, usability, and preliminary efficacy of the Rise\\&Walk InHome (RWH), a novel robotic gait training device designed for home use after stroke. Twenty adults with lower-extremity motor impairment following a first-ever stroke (3 months to 5 years post-event) will be randomized 1:1 to either (1) RWH-assisted home walking plus usual care or (2) usual care alone for 12 weeks. Participants in the intervention group will receive an in-home RWH device, complete a structured device training program, and be instructed to perform 30-minute RWH walking sessions four times per week (48 sessions total). All participants will undergo standardized outcome assessments at baseline, weeks 4, 8, and 12, including the 6-Minute Walk Test (primary outcome), 10-Meter Walk Test, daily step count via wearable activity tracker, and health-related quality of life (SF-36). Additional feasibility and usability outcomes include device use and adherence, patient satisfaction and motivation, ease of use, perceived exertion, and adverse events. Findings will inform the feasibility of in-home deployment of the RWH device and provide preliminary effect-size estimates to guide the design of a larger efficacy trial.",[28,270,271,272,273,247,274,275,276,30,277],"Neurological Diseases or Conditions","Hemiparesis;Poststroke\u002FCVA","Gait Disorders, Neurologic","Post Stroke Fatigue","Walking Difficulty","Balance Impairment","Falls Prevention","Mobility Limitation",[279,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302],"in-home rehabilitation","Robotic-Assisted Gait Training","gait training device","stroke recovery","functional mobility","rehabilitation technology","remote monitoring","rehabilitation robotics","Fitbit Step Tracking","Self-Directed Gait Training","high-intensity gait training","Neurorehabilitation Research","Lower Limb Rehabilitation","Motor Function Recovery","Physical Therapy","Walking Endurance","task specific walking practice","neurological recovery","stroke rehabilitation","home exercise program","Rise&Walk InHome","daily step count","6-minute walk test","10-meter walk test","2026-03-06",{"date":305,"type":39},"2026-03-09",{"date":307,"type":22},"2026-08",{"date":307,"type":22},{"name":310,"class":46},"Healing Innovations",{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":164,"enrollmentInfo":319,"targetDuration":4,"studyType":321,"phases":4,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":331,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":47},"100460583","neuroplasticity-after-proprioceptive-rehabiliation-100460583","NCT05277519","Neuroplasticity After Proprioceptive Rehabiliation","Neuroplasticity Induced by Functional Muscle Tendon Vibrations in Patients With Acquired Brain Injury","VibraLCA","Inclusion Criteria:\n\n* hemiparesis at least transient in lower limb following an acquired brain injury (stroke or traumatic brain injury)\n* French spoken\n* Affiliated to a French social insurance\n* No previous traumatic, vascular or neurodegenerative injuries\n* Having presented during the acute phase or presenting a motor deficit of one of the lower limbs\n* Presenting an absence of autonomy of walking at the entrance of the rehabilitation department\n* In the sub-acute phase, i.e. from 15 days to 6 months after the accident\n* Presenting moderate cognitive disorders allowing them to understand instructions and give their consent\n\nExclusion Criteria:\n\n* strong cognitive disorders\n* maintenance of justice, tutelage, legal guardianship\n* Pregnancy and breastfeeding\n* Outpatients who do not have weekly follow-up in the rehabilitation department",{"count":320,"type":22},56,"OBSERVATIONAL","Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances neuroplasticity. The aim of the research is to study the activity in cerebrospinal circuitry to evaluate the neuroplastic changes during and after instrumented proprioceptive rehabilitation relying on sequences of muscle vibration in subacute stroke stages.",[28,30,324],"Traumatic Brain Injury",[326,327,328,329,330],"Neuroplasticity","Electrophysiology","MRI","Neurophysiology","Muscle vibration",{"date":305,"type":39},{"date":333,"type":39},"2022-06-16",{"date":335,"type":22},"2026-12-15",{"name":337,"class":338},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":12,"sex":17,"minAge":346,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":4},"100628291","comparison-of-eeg-timed-vs-repetitive-robot-therapy-for-chronic-stroke-100628291","NCT07459725","Comparison of EEG-Timed vs. Repetitive Robot Therapy for Chronic Stroke","Exploratory Comparison of Movement Observation\u002FImagery-Timed Robot Activation and Repetitive Robot Activation on Training Effects and Neurophysiological Responses in Chronic Stroke Patients","Inclusion Criteria:\n\n* Patients diagnosed with stroke.\n* Adults aged 19 to 85 years old at the time of screening.\n\nExclusion Criteria:\n\n* Patients with severe, uncontrolled medical conditions.\n* Patients with uncontrolled hypertension, diabetes mellitus, or renal disease.\n* Patients with severe cognitive impairment that prevents them from following instructions for motor tasks (Mini-Mental State Examination \\[MMSE\\] score of 15 or below).\n\nNote: Patients with an MMSE score of 15 or below may still be included if the Principal Investigator (or a delegated physician) determines that they have the capacity to perform the tasks and provide informed consent.","19 Years","85 Years",{"count":266,"type":22},[25],"This clinical trial compares two types of robotic hand rehabilitation-brain wave (EEG)-timed therapy versus simple repetitive therapy-to see which is more effective for recovering hand function in patients with chronic stroke. Participants will be randomly assigned to either group and will attend sessions using a wearable robotic hand device while wearing an EEG cap. In the EEG-timed group, the robot assists hand movements when participants successfully imagine moving and create specific brain signals, whereas in the repetitive group, the robot moves the hand automatically at set intervals. Both groups will receive a matched dose of robotic training to ensure a fair comparison of how the brain and hand function respond to the therapy.",[28,352,30],"Chronic Stroke","2026-03-05",{"date":355,"type":39},"2026-03-10",{"date":357,"type":22},"2026-03-16",{"date":359,"type":22},"2028-12-31",{"name":361,"class":46},"Seoul National University Bundang Hospital",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":17,"minAge":370,"maxAge":19,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":373,"briefSummary":374,"conditions":375,"keywords":379,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":387,"locationsCount":4},"100618145","effect-of-mental-arithmetic-priming-on-gait-and-balance-in-stroke-100618145","NCT07327814","Effect of Mental Arithmetic Priming on Gait and Balance in Stroke","Mental Calculus Can Enhance Gait Performance in Post-Stroke Patients: A Randomized Controlled Trial","MA-Stroke","Inclusion Criteria:\n\n* Diagnosis of stroke.\n* Mini-Mental State Examination (MMSE) score ≥ 23.\n* Ability to walk 10 meters independently (with or without assistive device).\n\nExclusion Criteria:\n\n* Hemianopia.\n* Wernicke's aphasia or Global aphasia.\n* Orthopedic injuries or recent surgeries affecting the lower limbs.","60 Years",{"count":372,"type":22},17,[25],"This study investigates the effect of cognitive priming through mental arithmetic on functional mobility in post-stroke patients. It hypothesizes that performing mental calculations (addition, subtraction, multiplication) prior to movement stimulates frontoparietal networks, thereby improving gait speed and dynamic balance compared to a passive control condition.",[28,30,376,377,378],"Gait Disorders","Posture","Disorders",[28,30,377,380,376],"Balance","2026-02-10",{"date":383,"type":39},"2026-02-12",{"date":385,"type":22},"2026-02-11",{"date":129,"type":22},{"name":388,"class":46},"Lebanese University",{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":23,"phases":398,"briefSummary":399,"conditions":400,"keywords":403,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":47},"100624063","safety-and-effectiveness-of-spatial-stimelmd-ssmd-in-subjects-with-upper-limb-neuromotor-impairments-100624063","NCT07404761","Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments","A Multicenter, Randomized, Controlled Study to Evaluate the Efficacy and Safety of the SSMD in Neuromotor Rehabilitation","Inclusion Criteria:\n\n1. Adults aged 18-80 years.\n2. Clinically confirmed diagnosis of stroke or TBI within the past 12 months.\n3. Presence of moderate to severe neuromotor impairment in at least one limb, as evidenced by medical evaluation and a score \\\u003C35 on the Fugl-Meyer Upper Extremity motor subscale (FMA-UE).\n4. Capacity and willingness to provide informed consent, indicating understanding of the study purpose, procedures, and potential risks and benefits.\n5. Subject is able to adhere to the study schedule and cognitively capable to perform the treatment.\n6. Stable medical condition without ongoing acute complications that could interfere with participation.\n\nExclusion Criteria:\n\n1. Presence of contraindications to electrical stimulation (ES), including implanted electronic medical devices (e.g., pacemakers, insulin pumps) or conditions that may be exacerbated by electrical stimulation (e.g., uncontrolled epilepsy).\n2. Individuals with medical conditions, which are prone to seizures or motion sensitivity, at the investigator's discretion.\n3. Individuals with light sensitivity, as the AR component may involve visual stimuli that could cause discomfort or adverse reactions in these patients.\n4. Individuals with acute physical conditions or injuries that could interfere with the proper placement of the electrodes or safe use of the device.\n5. Presence of spinal shock or unresolved acute spinal cord dysfunction, characterized by complete loss of reflexes, flaccid paralysis, or autonomic instability.\n6. Current participation in other clinical trials that could confound the study results.\n7. Severe cognitive impairment that precludes the ability to provide informed consent or reliably adhere to the study protocol, as determined by cognitive screening and clinical judgment.\n8. Women who are pregnant, nursing, or who plan to become pregnant while in the trial.",{"count":397,"type":22},150,[25],"This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or traumatic brain injury (TBI).\n\nParticipants will be randomized to receive either SSMD therapy plus standard rehabilitation care or standard functional electrical stimulation (FES) plus standard care. Subjects will complete approximately 25 supervised treatment sessions over 5-6 weeks, with assessments at baseline, mid-treatment, post-treatment (primary endpoint), and a 1-month follow-up.\n\nThe primary effectiveness endpoint is improvement in upper-limb motor function measured by the Fugl-Meyer Upper Extremity (FMA-UE) assessment. Secondary outcomes include movement metrics, EMG signal strength, functional independence, usability measures, and adverse event monitoring.\n\nThe study plans to enroll approximately 150 subjects to achieve 126 completers, across 2-6 clinical sites.",[28,401,30,402,324],"Upper-limb Motor Impairment","Spinal Cord Injury",[404,405,406],"randomized","ssmd","neuromotor rehabilitation","2026-02-08",{"date":385,"type":39},{"date":410,"type":39},"2025-12-22",{"date":412,"type":22},"2026-12-30",{"name":414,"class":415},"Motion Informatics LTD","INDUSTRY",{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":12,"sex":17,"minAge":423,"maxAge":424,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":432,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":47},"100595599","effect-of-botulinum-toxin-type-a-on-motor-function-in-children-with-cerebral-palsy-100595599","NCT07034547","Effect of Botulinum Toxin Type A on Motor Function in Children With Cerebral Palsy","Effect of Botulinum Toxin Type A on Functionality and Quality of Life in Children and Adolescents With Spastic Hemiparetic Cerebral Palsy GMFCS I-II at Teletón Santiago: A Prospective Single-Group Trial","Inclusion Criteria:\n\n* Spastic hemiparesis type Cerebral Palsy\n* Gross Motor Classification System I-II\n* Age 8 to 17 years (based on validation ages for scales to be used)\n* Minimum of 6 months since last botulinum toxin injection\n* Informed consent signed by legal guardian and assent from users aged 12 to 17 years\n\nExclusion Criteria:\n\n* Cognitive impairment that prevents following instructions for functional assessments\n* Limitation of joint range not caused by spasticity\n* Patients diagnosed with other diseases causing spasticity, different from cerebral palsy\n* Patients with other neuromuscular diseases","8 Years","17 Years",{"count":426,"type":22},30,[25],"Project Identification and Researchers Title: \"Changes in functionality and quality of life when applying the botulinum toxin type A infiltration protocol in children and adolescents with cerebral palsy of the spastic hemiparesis type GMFCS I and II, from the Teletón Institute Santiago: A prospective single-group trial.\"\n\nThis project is led by a group of physiatrists from the Teletón Institute, along with a team of co-investigators specialized in kinesiology, occupational therapy, and nursing.\n\nStudy Relevance The study aims to generate scientific evidence on the effectiveness of the BoNT-A infiltration protocol in the functionality and quality of life of children with spastic hemiparesis. The results could optimize therapeutic interventions at the Teletón Institute, improve patient well-being, and expand the coverage of therapeutic services for spasticity.\n\nProblem Statement Cerebral palsy (CP) is the most common motor disability in childhood, with an estimated prevalence of 1.6 per 1,000 live births in developed countries and between 1 and 2 per 1,000 live births in Chile. Spastic CP requires multidisciplinary management, including BoNT-A infiltration. Although BoNT-A has been shown to reduce spasticity, there is a gap in knowledge regarding its impact on overall functionality and quality of life.\n\nResearch Question What changes occur in functionality and quality of life when applying the BoNT-A infiltration protocol from the Teletón Institute Santiago in children aged 8 to 17 years, diagnosed with cerebral palsy of the spastic hemiparesis type GMFCS I and II?\n\nStudy Objectives General Objective: To compare the results in functionality and quality of life before BoNT-A infiltration, at 4 weeks, and at 12 weeks, in children and adolescents diagnosed with cerebral palsy of the spastic hemiparesis type GMFCS I and II.\n\nSpecific Objectives: To evaluate the effect of the infiltration protocol on the functionality of the upper and lower limbs, and on the quality of life of the children and their families.\n\nHypothesis The BoNT-A infiltration protocol has a positive effect on the functionality of the upper and lower limbs and on the quality of life of children with spastic cerebral palsy.\n\nMethod The study is a prospective single-group trial, following participants over time to compare the results of the BoNT-A infiltration protocol. The target population includes children with spastic hemiparesis cerebral palsy GMFCS I-II referred to the botulinum toxin infiltration clinic at the Teletón Institute Santiago. A non-probabilistic convenience sampling will be used, selecting individuals who meet the inclusion and exclusion criteria.\n\nProcedure Patients will be selected and evaluated before infiltration, at 4 weeks, and at 12 weeks post-infiltration. The infiltration will be performed under ultrasound and electrostimulation guidance. Evaluations will include functionality and quality of life scales, such as the Ashworth Scale, Tardieu Scale, Bilan 400 Points Functional Hand Scale, GMFM-88, KIDSCREEN-27, and Goal Attainment Scale.\n\nData Collection Data collection will be carried out through clinical record review, clinical observation, and application of scales. A homologation protocol will be implemented among operators to standardize the use of the scales.\n\nVariables Variables include age, sex, laterality, GMFCS, infiltrated muscles, infiltration dose, educational level, participation in a school integration program, physical activity, manual functionality, lower limb functionality, quality of life, and goal attainment.\n\nStatistical Analysis A database will be created in Microsoft Excel, and qualitative and quantitative variables will be analyzed. Chi-square tests, repeated measures ANOVA, and Friedman tests will be used to compare measurements over time.\n\nEthical Considerations The study complies with ethical principles of scientific validity, social utility, researcher competence, favorable risk-benefit ratio, equitable selection of subjects, informed consent, and protection of the privacy and confidentiality of participants.",[430,431,30],"Cerebral Palsy (CP)","Spasticity Due to Cerebral Palsy",[433,434,435],"botulinum toxin","quality of life","Physical Functional Performances","2025-12-09",{"date":438,"type":39},"2025-12-17",{"date":440,"type":39},"2025-06-11",{"date":442,"type":22},"2026-05-30",{"name":444,"class":46},"Instituto Teletón Chile",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":163,"sex":17,"minAge":453,"maxAge":454,"enrollmentInfo":455,"targetDuration":4,"studyType":321,"phases":4,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":47},"100615351","behavioral-assessment-method-index-100615351","NCT07291479","Behavioral Assessment Method Index","Development of Upper Extremity Behavioral Assessment Methods for Reach-and-grasp and Physical Rehabilitation.","BAM","Inclusion Criteria:\n\n* Between 8 and 36 months old at baseline\n* Full Term Birth (37 to 41 weeks gestation)\n* Healthy development (meeting age-appropriate milestones)\n\nExclusion Criteria:\n\n* Diagnosed or suspected impairments (auditory, visual, cognitive or motor)","4 Months","36 Months",{"count":456,"type":22},80,"The overall goal of this study is to develop and improve assessment methods for children with and without perinatal arterial ischemic stroke (PAS)\u002Fhemiparetic cerebral palsy (HCP). The focus is on behaviors of the arms and hands and includes other domains of child development like fine motor, gross motor, language, cognition, and social-emotional skills. This study involves 1) the use of data, including video recordings, from \"I-ACQUIRE - Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation\" (NCT03910075) and 2) a prospective longitudinal observational data collection with a typically developing cohort using a comprehensive assessment battery (play, fine motor, gross motor, language, cognition, and social emotional skills). The current study is called the BAM Index. No intervention or treatment is provided as part of the BAM Index. The I-ACQUIRE study is an RCT that includes an intervention. The BAM index study is a use of data from the I-ACQUIRE cohorts and a prospective observational study of a typically developing cohort (children without stroke or cerebral palsy) over time. The results of this work will develop, test, refine, and validate a new methodology based on reach-and-grasp and other behaviors related to child development that will have profound and lasting impact on assessment and selection of treatment strategies for pediatric physical rehabilitation of children. The use and reuse of video technology is also well-suited to remote or virtual assessment. This proposal will add to our current knowledge by 1) yielding a psychometrically robust and alternative approach to measuring upper extremity function in children with stroke and\u002For hemiparetic cerebral palsy and 2) defining specific parameters about how to promote closer-to-normal upper extremity function in children with motor disability.",[459,460,30,191],"Infant Development","Perinatal Stroke","2025-12-05",{"date":463,"type":39},"2025-12-18",{"date":465,"type":39},"2023-07-07",{"date":467,"type":22},"2026-06",{"name":469,"class":46},"Ohio State University",{"id":471,"slug":472,"hasResults":12,"nctId":473,"briefTitle":474,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":17,"minAge":88,"maxAge":112,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":483,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":47},"100557324","effects-and-mechanisms-of-sensory-afferent-electrostimulation-on-upper-limb-function-in-patients-with-hemiparesis-100557324","NCT06536634","Effects and Mechanisms of Sensory Afferent Electrostimulation on Upper Limb Function in Patients With Hemiparesis","SAES","Inclusion Criteria:\n\n* Diagnosis of unilateral cerebral palsy\u002Fhemiparesis, following unilateral brain lesion, e.g. perinatal\u002Fchildhood stroke (acquired prior to the age of 16 years)\n* consistent and stable limitation of hand functions\n* chronic state (time since lesion \\>2 years)\n* aged 6-18 years\n* parental informed consent if \\\u003C14 years, informed consent of the patient if \\>14 years\n\nExclusion criteria:\n\n* psychiatric disease that prevents the participant form informed participation and compliance in an adequate manner\u002Fsetting\n* Bilateral brain lesion\n* Recent Botulinum toxin-injections injections (UL, \\\u003C 6 months)\n* Hand surgery on paretic hand \\\u003C 2 years\n* Trauma to UL in the last year\n* Medical conditions that prevent training of the UL\n* Participation in other afferent stimulation studies\n* Electrical stimulation therapy in the last 6 months\n* Intensive training of the UL (therapy more than 1x\u002Fweek, \\\u003C 6 months)\n\nIf MRI and TMS is performed, additionally:\n\n• MRI and TMS contradictions, such as\n\n* implanted Metal devices (e.g. braces, implant)\n* implanted shunt system\n* in girls and women: pregnancy\n* claustrophobia\n* Active epilepsy",{"count":478,"type":22},34,[25],"The goal for this project is to investigate the effects of a 5-week SAES therapy in addition to conventional therapy on both behavioural (sensory and motor) and neurological measures and the underlying mechanisms of treatment response.\n\nThe goal of this project to investigate the effects of a 5-week SAES therapy in addition to conventional therapy.\n\nThe aim is to investigate whether SAES is more effective than conventional therapy alone in children with hemiparesis. The investigators will assess the efficacy of SAES using novel clinical assessment such as kinematic evaluations and modern neurophysiological measures, namely transcranial magnetic stimulation (TMS) and resting-state functional MRI (rs-fMRI).\n\nIt will be expected a benefit for children with hemiparesis after SAES training which may lead to improved bimanual and unimanual functions. Benefits have been reported in adults and in preliminary studies also in children.\n\nType of study: Randomised controlled clinical trial\n\nParticipants with hemiparesis will be included in the study. The study group will receive the SAES training with a glove or adhesive electrodes as a home-based training during 30 minutes per day, 5x\u002Fweek, for 5 weeks, combined with conventional occupation therapy.\n\nResearchers will compare the SAES group with a group of patients with comparable conditions who receive the prescribed conventional occupational therapy and\u002For physiotherapy (treatment as usual, TAU)",[30,482],"Unilateral Cerebral Palsy",[484,328,246,485,486,487],"Sensory afferent electrostimulation","Motor function","Sensory function","Sensor","2025-11-17",{"date":490,"type":39},"2025-11-20",{"date":492,"type":39},"2025-01-01",{"date":494,"type":22},"2027-10-01",{"name":496,"class":46},"Insel Gruppe AG, University Hospital Bern",{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":163,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":506,"briefSummary":507,"conditions":508,"keywords":509,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":47},"100562052","mapping-corticoreticulospinal-motor-control-in-chronic-hemiparetic-stroke-100562052","NCT06598150","Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke","Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord fMRI in Chronic Hemiparetic Stroke","Inclusion Criteria:\n\n* Adults aged at least 18y\n* Able to perform shoulder abduction task (confirmed during screening and initial examination)\n* Safe to undergo MRI\n* Able to follow visual instructions using MRI-compatible vision correction goggles\n* No brainstem or cerebellar lesions\n* No severe concurrent medical problems\n* Cognitive\u002Fattentional capacity to focus on a task\n* Able to communicate in English or Spanish\n\nAdditional inclusion criteria for stroke participants:\n\n* Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project\n* Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).\n\nExclusion Criteria:\n\n* MRI contraindications\n* Severe claustrophobia\n* Pregnant women\n* Prisoners\n* Vulnerable populations\n* Diagnosis\u002Fhistory of:\n* multiple sclerosis\n* brain tumor\n* brain radiation\n* traumatic brain injury\n* dementia\n* Parkinson's disease\n* Concurrent enrollment in an intervention study\n* Concurrent use of medications known to suppress central nervous system activity",{"count":505,"type":22},32,[25],"This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.",[28,30],[510],"functional magnetic resonance imaging","2025-09-26",{"date":513,"type":39},"2025-10-01",{"date":515,"type":39},"2023-05-20",{"date":517,"type":22},"2026-08-31",{"name":519,"class":46},"Northwestern University",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":527,"briefSummary":528,"conditions":529,"keywords":530,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":47},"100503231","mechanisms-of-open-and-hidden-placebo-in-stroke-recovery-100503231","NCT05832567","Mechanisms of Open and Hidden Placebo in Stroke Recovery","Inclusion Criteria:\n\n1. Adults with hemiparesis due to chronic stroke\n2. Stroke duration of 6 months or more\n3. Fugl-Meyer scale upper extremity motor assessment score of \\> 11 and ≤ 56\n4. Pre-stroke disability (defined as a score of \\\u003C 3 on the Modified Rankin Scale)\n5. Age 18 or older\n\nExclusion Criteria:\n\n1. Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex\n2. Unable to understand instructions\n3. TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump\n4. Concurrent unstable medical conditions\n5. A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)\n6. Joint or paretic extremity pain likely to interfere with assessments\n7. Pregnancy",{"count":320,"type":22},[25],"This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.",[28,30],[122,531],"placebo","2025-09-15",{"date":534,"type":39},"2025-09-17",{"date":536,"type":39},"2023-09-11",{"date":538,"type":22},"2026-06-30",{"name":155,"class":46},{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":546,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":347,"enrollmentInfo":548,"targetDuration":4,"studyType":23,"phases":549,"briefSummary":550,"conditions":551,"keywords":553,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":47},"100498115","novel-non-invasive-brain-stimulation-techniques-in-neurological-rehabilitation-100498115","NCT05766059","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation: Cross-modal Paired Associative Stimulation (PAS) Protocols to Promote Plastic Reorganization in Stroke and Phantom Limb Pain Patients","StimNeuro","Inclusion criteria for stroke patients:\n\n* age from 18 to 85 years\n* single, unilateral, hemispheric stroke (cortical or sub-cortical areas)\n* stroke confirmed by neuroimaging (CT or MRI)\n* stroke at least 4 months before enrollment\n* hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented\n\nExclusion criteria for stroke patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)\n* other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome)\n\nInclusion criteria for PLP patients:\n\n* age from 18 to 90 years\n* amputation of one part of the upper limb at least 2 months before enrollment\n* presence of stable phantom limb pain at least 2 months prior to enrollment\n\nExclusion criteria for PLP patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological, orthopedical or psychiatric conditions",{"count":91,"type":22},[25],"Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called \"mirror-PAS\"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction.\n\nParticipants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.",[28,30,552],"Phantom Limb Pain",[554,555,28,556,557],"Transcranial Magnetic Stimulation","Paired Associative Stimulation","Motor cortex","Phantom limb pain","2025-09-11",{"date":534,"type":39},{"date":561,"type":39},"2023-02-08",{"date":563,"type":22},"2026-09-30",{"name":565,"class":46},"Istituto Auxologico Italiano",{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":572,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":321,"phases":4,"briefSummary":575,"conditions":576,"keywords":577,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":47},"100599249","stability-of-hemiparetic-patients-during-a-daily-complex-task-100599249","NCT07082036","Stability of Hemiparetic Patients During a Daily Complex Task","Study of the Stability of Post-stroke Hemiparetic Patients During a Task Involving Picking up an Object on the Ground. Reflection Questioning the Conventional Rehabilitation of These Patients","HemiSym","Inclusion Criteria:\n\nAll:\n\nMale or female ≥ 18 years\n\nFor patients :\n\n* Haemiparesis after a single unilateral hemispheric Stroke.\n* Stroke ≥ 6 months\n* Asymmetry of support between the 2 lower limbs (distribution of body weight) in a standing position at the expense of the paretic lower limb \\> 10%.\n* Able to stand alone, without technical aids or equipment, with feet the width of the pelvis\n* Able to pick up an object from the ground alone (minimum score 3\u002F4 item 9 of the Berg Balance Scale).\n* Patient informed and having signed a consent form\n\nFor healthy subjects:\n\n\\- Similar characteristics (in terms of sex, age range and BMI class) to those of one of the patients already included.\n\nExclusion Criteria:\n\n\\-",{"count":235,"type":22},"Among the repercussions of hemiparesis following stroke, disturbed stability is responsible for a high risk of falls. Picking up objects from the ground, frequently trained in rehabilitation due to its risk of falling and its frequency in daily life, is a task requiring balance. To date, however, it has been little studied. We suggest that stability conditions the asymmetry adopted by patients. We hypothesise that asymmetric support at the expense of the paretic lower limb provides better stability during an unstable functional task (picking up an object from the ground) compared with the symmetrical support traditionally imposed in rehabilitation.\n\nPostural control involves stability (maintaining balance despite constraints) and orientation (posture adopted, such as the distribution of supports). Hemiparetic patients show a lack of stability and, with regard to orientation, an asymmetry in the distribution of body weight to the detriment of the paretic limb. Symmetrisation of weight distribution has been one of the predominant concepts in rehabilitation.",[30],[578,579,580,581,582,583],"Hemiparetic patients","Stability","Orientation","Postural control","Strategy","Motion","2025-07-15",{"date":586,"type":39},"2025-07-24",{"date":588,"type":39},"2024-11-05",{"date":590,"type":22},"2026-11",{"name":592,"class":46},"Assistance Publique - Hôpitaux de Paris",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":23,"phases":602,"briefSummary":603,"conditions":604,"keywords":612,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":626,"locationsCount":628},"100524306","effects-of-atalante-exoskeleton-on-gait-recovery-in-non--or-poorly-ambulatory-patients-with-hemiparesis-in-the-acutesubacute-phase-month-1-to-4-100524306","NCT06107010","Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute\u002FSubacute Phase (Month 1 to 4)","EarlyExo","Inclusion Criteria:\n\n* \\>18 years old\n* First clinically significant disability due to stroke\n* Hemiparesis in acute-subacute phase (1 to 4 months since lesion) due to a stroke\n* Functional Ambulation Category score (FAC) \\\u003C2\n* Patient with health insurance\n* Informed and willing to sign an informed consent form approved by the Ethics Committee. For clarity, if a motor impairment prevents the subject from signing by himself, he\u002Fshe can still be included if the signature can be done by an impartial witness.\n\nExclusion Criteria:\n\n* Muscle overactivity in hip adductors, hamstrings, quadriceps and plantar flexors, which interferes with exoskeleton use, based on clinician investigator's opinion\n* Recent fracture (\\\u003C 3 months) or any therapy inducing secondary osteoporosis\n* Excessive joint mechanical pain in the lower limbs based on clinician investigator's opinion\n* Pressure sore grade I or more over contact zones with Atalante system, according to the International Pressure Ulcer Classification System NPUAP - EPUA\n* Medical contra-indication to medium intensity physical strain\n* Orthostatic hypotension (loss of \\> 20 mmHg systolic BP after 3 minutes in standing position)\n* Uncontrolled seizures\n* Morphological contra-indications to the use of Atalante (as per user's manual)\n* Pregnant woman\n* Adults who lack the capacity to provide informed consent, and all those persons deprived of their liberty in prisons or other places of detention\n* Concurrent participation in another interventional trial",{"count":601,"type":22},66,[25],"The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.\n\nThis clinical investigation is designed to test the hypothesis that early and intense introduction of walking sessions assisted by the Atalante exoskeleton, in a sample of hemiparetic patients with still non or poor ambulatory capacities (FAC 0 or 1) between one- and four-months post stroke, would result in a better recovery of functional walking compared to a control group only receiving conventional therapy. Improved recovery will be measured through the proportion of patients reaching a FAC score of 4 or higher at the end of the intervention period. The tested hypothesis is that this proportion will be higher in the Exo group.\n\nThe duration of the intervention period in both groups is 6 weeks.\n\n* For the Exo group: 3 sessions per week (i.e., 18 one-hour sessions) with the Atalante device and 2 sessions per week (i.e., 12 one-hour sessions) of conventional therapy.\n* For the Control group: 5 sessions per week of conventional therapy (i.e., 30 one-hour sessions).\n\nThe study will include 66 patients (33 in each arm) and takes place in two French centers, two German centers and one Spanish center.",[605,606,607,608,609,610,30,271,611],"Stroke, Acute","Stroke, Ischemic","Stroke, Subacute","Stroke Hemorrhagic","Cerebrovascular Disorders","Cerebrovascular Accident","Hemiparesis\u002FHemiplegia (One Sided Weakness\u002FParalysis)",[123,120,613,614,28,615,616,617,618],"Powered Exoskeleton","Walking recovery","Acute stroke","Subacute stroke","Functional Ambulation Category","Randomized controlled study","2025-01-30",{"date":621,"type":39},"2025-02-04",{"date":623,"type":39},"2023-06-12",{"date":625,"type":22},"2026-02-28",{"name":627,"class":415},"Wandercraft",5,{"id":630,"slug":631,"hasResults":12,"nctId":632,"briefTitle":633,"officialTitle":634,"acronym":635,"eligibilityCriteria":636,"healthyVolunteers":163,"sex":17,"minAge":112,"maxAge":264,"enrollmentInfo":637,"targetDuration":4,"studyType":23,"phases":638,"briefSummary":639,"conditions":640,"keywords":641,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":653,"locationsCount":202},"100217940","human-machine-system-for-the-h2-lower-limb-exoskeleton-100217940","NCT02114450","Human-Machine System for the H2 Lower Limb Exoskeleton","Human Machine Interface System With the H2 Lower Limb Exoskeleton for Rehabilitation","H2-NeuroExo","Inclusion Criteria:\n\n* Sub-acute or chronic stroke i.e., interval of at least 3 months or interval of at least 6 months from stroke to time of enrollment, respectively;\n* Cognitive ability to assimilate and participate actively in the treatment protocol (Mini Mental State Examination score \\> 24 points, out of a total 30 indicating normal cognitive ability);\n* Modified Rankin scale scores 2-4 (Mild-Moderate functional disability post-stroke);\n* Modified Ashworth Scale of Spasticity score \\\u003C= 2 (ranges from 0-4 with 4 reflecting maximum spasticity);\n* Have no skin integrity issues;\n* Sufficient passive range of motion at the hip (at least 90 deg flexion, 15-20 deg extension), knee (90 deg flexion, complete extension) and ankle (15 deg dorsiflexion, 15 deg plantarflexion);\n* Have no contraindications to standing or walking; able to stand with assistive device for at least 5 minutes, and able to walk with assistive device for 10 m.\n\nExclusion Criteria:\n\n* Severe cognitive and\u002For visual deficit;\n* Hemineglect (determined based on medical record or initial clinical assessment);\n* Severe sensory deficit;\n* Joint contractures of any extremity that limits normal range of motion during ambulation with assistive devices;\n* Skin lesions that may hinder or prevent the application of exoskeleton;\n* Uncontrolled angina;\n* Severe chronic obstructive pulmonary disease;\n* Other medical contraindications; any medical co-morbidities that would prevent standard rehabilitation.\n\nInclusion criteria for healthy, able-bodied participants:\n\n* Able to understand and sign the consent form\n* Age 18-75 years\n\nExclusion criteria for healthy, able-bodied participants:\n\n\\- History of neurological, neuromuscular or physical disability.",{"count":211,"type":22},[25],"This research study will investigate the use of smart lower limb robotic exoskeleton (developed by the CSIC, Spain) in rehabilitation after stroke. It will compare robotic-assisted rehabilitation with supervised motor practice. Additionally, it will also examine the use of noninvasive scalp electroencephalography (EEG) to learn specific brain wave patterns associated with learning to walk on the powered lower limb exoskeleton. The findings will be used to understand human-robot interaction and to design smart orthotic devices that can be controlled by thought activity and assist those that have lost all or part of their walking abilities.",[28,30],[28,642,643,644,645],"Paresis","Gait rehabilitation","Human-Machine Interaction","Wearable Robotic Devices","2024-10-26",{"date":648,"type":39},"2024-10-30",{"date":650,"type":39},"2015-11-20",{"date":652,"type":22},"2029-12",{"name":654,"class":46},"University of Houston",{"id":656,"slug":657,"hasResults":12,"nctId":658,"briefTitle":659,"officialTitle":660,"acronym":661,"eligibilityCriteria":662,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":663,"enrollmentInfo":664,"targetDuration":4,"studyType":23,"phases":665,"briefSummary":666,"conditions":667,"keywords":671,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":678,"leadSponsor":680,"locationsCount":81},"100560284","associative-peripheral-stimulation-for-reduction-of-motor-impairment-during-acute-period-of-stroke-recovery-100560284","NCT06575140","Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery","Pilot Randomized Controlled Trial Assessing Associative Peripheral Stimulation (APS) for Reduction of Motor Impairment During Acute Period of Stroke Recovery","APS-PILOT","Inclusion Criteria:\n\n1. Confirmed ischemic or hemorrhagic stroke no earlier than 7 days prior to enrollment;\n2. Presentation of hemiparesis or paralysis of the upper extremity due to stroke;\n3. Ability to comprehend and follow study instructions;\n4. Ability to initiate finger extension (≥3°) at least three times per minute;\n5. Fugl-Meyer Assessment (Upper Extremity) score of \\\u003C47.\n\nExclusion Criteria:\n\n1. Contraindications, intolerance, or high sensitivity to the experimental protocol;\n2. History of upper-extremity disability prior to the index stroke;\n3. Neurological conditions (other than stroke) affecting motor function;\n4. Treatment of spasticity\u002Fincreased tone in the affected upper extremity (e.g., with Botox injection);\n5. Lack of access to a safe and suitable place of discharge for experimental sessions and follow-up visits.","79 Years",{"count":266,"type":22},[25],"Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement. This pilot study investigates whether APS applied during the acute phase of stroke recovery may reduce impairment and improve function in the affected upper extremity.",[28,605,606,668,30,271,669,670,118],"Stroke, Hemorrhagic","Weakness of Extremities as Sequela of Stroke","Stroke Sequelae",[62,672],"Associative Peripheral Stimulation","2024-08-28",{"date":675,"type":39},"2024-08-30",{"date":677,"type":39},"2021-12-18",{"date":679,"type":22},"2024-12",{"name":681,"class":46},"Ahmed A. Rahim",{"id":683,"slug":684,"hasResults":12,"nctId":685,"briefTitle":686,"officialTitle":687,"acronym":4,"eligibilityCriteria":688,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":689,"enrollmentInfo":690,"targetDuration":4,"studyType":23,"phases":691,"briefSummary":692,"conditions":693,"keywords":694,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":697,"lastUpdatePostDateStruct":698,"startDateStruct":700,"completionDateStruct":702,"leadSponsor":704,"locationsCount":47},"100533262","neural-mechanisms-of-music-intervention-chronic-arm-hemiparesis-following-stroke-a-single-case-series-eeg-study-100533262","NCT06223529","Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study","The Neural Mechanisms of Music Intervention for Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study","Inclusion Criteria:\n\n1. Aged 18+\n2. Ischemic stroke\n3. Three weeks to 60 months post-stroke\n4. 12 to 49\u002F57 Action Research Arm Test (ARAT) score \\*\n5. Able to follow instructions and consent\n6. Right-hand dominant\n\nExclusion Criteria:\n\n1. Hemorrhagic stroke\n2. No movement in arm\n3. Unable to move thumb and one finger. Loss of sensation and proprioceptive impairment will not lead to exclusion.\n4. Unable to consent to participate\n5. Currently receiving music therapy\n6. Left-hand dominant\n7. Ambidextrous\n8. Not registered with a GP. We will require GP details to inform them in case of any incidental findings in the EEG.","110 Years",{"count":628,"type":22},[25],"The aims of the study are to recruit five participants with stroke upper limb hemiparesis and determine the effects on neural reorganisation of a three-week music intervention using electroencephalogram measures.\n\nSecondly, the researchers will measure for changes in arm function before and after the three-week music intervention.\n\nThis is a single-arm pre-\u002Fpost experiment\n\nPrimary research questions:\n\nWhat are the neuroplastic changes induced by Therapeutic Instrumental Music Performance (TIMP)?\n\nSecondary research questions What are the functional changes in hemiparetic arm and hand induced by TIMP?\n\nParticipants will be recruited once they have completed their statutory community stroke rehabilitation.\n\nThey will receive 15 X music therapy sessions in their home over three-weeks. Exercises will be delivered by trained clinicians, including music therapists and stroke rehabilitations specialists.\n\nExercises will be facilitated for full range of arm movement, using a range of percussion instruments on stands and handheld, and iPad with touchscreen instruments, which include keyboards and string instruments that can be played using pinch-grip, holding a stylus\u002Fplectrum.\n\nPre-\u002Fpost intervention period EEG recordings will made. Stroke Specific Quality of Life (SSQoL), Action Research Arm Test and nine-hole-peg-test data will be collected from participants in their homes at weeks: 1, 4, 7 and 10.",[28,30,146],[695,696],"Neurologic Music Therapy","electroencephalography","2024-07-30",{"date":699,"type":39},"2024-07-31",{"date":701,"type":39},"2024-07-01",{"date":703,"type":22},"2025-05-01",{"name":705,"class":46},"Anglia Ruskin University"]