[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemiplegia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemiplegia":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,35,0,25,[9,49,76,106,137,163,197,231,260,285,313,341,365,390,421,442,466,497,520,547,566,587,617,638,661],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100643075","effects-of-wearable-vibratory-devices-on-arm-function-in-subacute-stroke-patients-100643075",false,"NCT07641790","Effects of Wearable Vibratory Devices on Arm Function in Subacute Stroke Patients","Effects of Wearable Vibratory Devices for Upper Limb Function Among Subacute Hemiplegic Patients: A Randomized Controlled Trial","WEVIB-HEMI","Inclusion Criteria:\n\n* Unilateral hemiplegia secondary to stroke\n* Age between 30 and 60 years\n* Subacute stage (3 to 6 months post-stroke)\n* Fugl-Meyer Assessment (FMA) score between 20 and 50\n* Able to follow simple verbal commands\n\nExclusion Criteria:\n\n* Previous peripheral nerve injury or surgery affecting the upper limb\n* Fixed contractures or bony fractures in the affected limb\n* Complete sensory loss of the upper limb\n* Co-existing neurological conditions (e.g., Parkinson's, MS, Dementia)\n* Unstable cardiovascular conditions","ALL","30 Years","60 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","Hemiplegia, or paralysis of one side of the body, often results from stroke and severely limits arm function. Standard physiotherapy helps, but recovery is often slow. This study tests if adding a wearable vibratory device to standard therapy improves arm movement better than standard therapy alone. Thirty patients with subacute stroke (3-6 months) will be split into two groups. One group will receive usual physiotherapy, while the other will receive usual physiotherapy plus the vibratory device for 8 weeks. Doctors will measure changes in spasticity (muscle stiffness), motor function, and daily independence before and after treatment.",[29,30],"Hemiplegia","Stroke",[32,33,34,35],"Vibration","Upper Extremity","Physical Therapy","Subacute Stroke","RECRUITING","2026-06-06",{"date":39,"type":40},"2026-06-11","ACTUAL",{"date":42,"type":40},"2026-02-01",{"date":44,"type":23},"2026-07-15",{"name":46,"class":47},"University of Faisalabad","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100643146","brain-controlled-spinal-cord-stimulation-in-participants-with-chronic-stroke-for-lower-and-upper-limb-rehabilitation-100643146","NCT07610850","Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation","Stroke-BSI","Inclusion Criteria:\n\n* Must be between 18-70 years old at the time of enrolment.\n* Must have suffered from a subcortical including brain stem stroke that occurred at least 9 months but not more than 10 years prior to enrolment.\n* Must have a score lower than 25 on the Fugl-Meyer upper-limb scale.\n* Must be able to stand with or without assistive device for 30 seconds.\n* Must have a score higher than 22 at the Montreal Cognitive Assessment.\n* Must present right or left hemiplegia.\n* Must have completed primary standard of care rehabilitation.\n* Must provide and sign the study's Informed Consent prior to any study-related procedures.\n* Must be able to understand and interact with the study team in French or English.\n* Must agree to comply in good faith with all conditions of the study and to attend all scheduled appointments.\n* Must use effective contraception for women of childbearing capacity.\n* Must be able to withhold antiplatelet\u002Fanticoagulation agents perioperatively for the time of the surgeries (if applicable).\n\nExclusion Criteria:\n\n* Must not be pregnant or breast feeding (if applicable).\n* Must not have the intention to become pregnant during the study (if applicable).\n* Must not have any diseases and conditions that would increase the morbidity and mortality of the implantation surgery.\n* Must not have any mental instability, including a diagnosis of personality disorder, psychosis, substance abuse, or severe depression as assessed by the psychologist.\n* Must not have any other medical conditions that would make the subject unable to participate in testing in the judgment of the investigators (e.g., major cognitive disorder, renal failure, hepatic dysfunction, epilepsy, etc.).\n* Must not have ongoing significant dysphagia or aspiration difficulties or require ventilator support.\n* Must not have any active implanted device, such as a pacemaker or other neurostimulator.\n* Must not have any spinal anatomical abnormalities or incompatibilities with the implanted system precluding surgery.\n* Must not have severe spasticity of the upper limb or lower limb (Modified Ashworth Scale \\> 3).\n* Must not have indication requiring frequent MRIs.\n* Must not participate in another clinical study using drugs or medical devices that might interfere with the outcomes of the study.\n* Must not be the investigator him\u002Fherself, his\u002Fher family members, employees, and other dependent persons.","18 Years","70 Years",{"count":59,"type":23},3,[26],"The purpose of this clinical study is to evaluate the preliminary safety and effectiveness of using a cortical recording device (ECoG) combined with cervical and lumbar targeted epidural electrical stimulation (EES) of the spinal cord to restore voluntary motor functions of upper and lower limbs in participants with chronic stroke suffering from mobility impairment.\n\nThe goal is to establish a direct bridge between the motor intention of the participant and the spinal cord, which should not only improve or restore voluntary control of arm and leg movement and support immediate mobility, but also promote neurological recovery when combined with neurorehabilitation.",[30,29],[64,65,66],"Spinal cord stimulation","Brain computer interface","Brain spine interface","2026-06-03",{"date":69,"type":40},"2026-06-08",{"date":71,"type":23},"2026-09-01",{"date":73,"type":23},"2032-10",{"name":75,"class":47},"Ecole Polytechnique Fédérale de Lausanne",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100628920","combined-mirror-therapy-and-soft-robotic-glove-for-hand-recovery-after-stroke-100628920","NCT07467915","Combined Mirror Therapy and Soft Robotic Glove for Hand Recovery After Stroke","Effect of Combining Mirror Therapy With Soft Robotic Glove on Hand Function Recovery in Post-Stroke Hemiplegic Patients: A Randomized Controlled Trial","MT-SRG","Inclusion Criteria:\n\nAdults aged 18-70 years with first-ever ischemic or hemorrhagic stroke confirmed by imaging (CT or MRI)\n\nModerate upper limb motor impairment (Fugl-Meyer Assessment Upper Extremity \\[FMA-UE\\] score 20-50)\n\nAbility to follow simple instructions (Six-Item Cognitive Impairment Test, 6CIT)\n\nAbility to sit independently for at least 30 minutes\n\nMedically stable and cleared to participate in rehabilitation interventions\n\nWillingness to provide informed consent and adhere to the study protocol\n\nExclusion Criteria:\n\nSevere upper limb spasticity (Modified Ashworth Scale ≥ 3)\n\nCognitive or psychiatric disorders interfering with participation\n\nOther neurological or musculoskeletal conditions affecting upper limb function (e.g., Parkinson's disease, multiple sclerosis, fractures)\n\nPrior exposure to intensive Mirror Therapy or Soft Robotic Gloves\n\nVisual impairment that cannot be corrected with glasses or contact lenses\n\nUncontrolled cardiovascular or other medical conditions that would prevent safe participation",{"count":85,"type":23},104,[26],"Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life. Various rehabilitation approaches have been developed to improve motor recovery, including mirror therapy and robotic-assisted training. Mirror therapy uses visual feedback to stimulate neural plasticity and enhance motor recovery, while soft robotic gloves assist repetitive hand movements and facilitate functional training.\n\nThis randomized controlled trial aims to investigate the effect of combining mirror therapy with a soft robotic glove on hand function recovery in patients with post-stroke hemiplegia. Participants will be randomly assigned to different intervention groups receiving mirror therapy, soft robotic glove training, combined therapy, or conventional rehabilitation.\n\nThe primary outcome will assess improvement in upper limb motor function using validated clinical assessment tools. Secondary outcomes will evaluate functional hand performance and activities of daily living. The findings of this study may contribute to improving rehabilitation strategies for stroke survivors and provide evidence for integrating innovative rehabilitation technologies into clinical practice.",[30,29,89],"Upper Limb Motor Impairment",[91,92,93,94,95,96],"Mirror Therapy","Soft Robotic Glove","Stroke Rehabilitation","Hand Function Recovery","Upper Limb Rehabilitation","Post-Stroke Hemiplegia","2026-05-08",{"date":99,"type":40},"2026-05-13",{"date":101,"type":40},"2026-04-08",{"date":103,"type":23},"2026-12-17",{"name":105,"class":47},"University of Baghdad",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":12,"sex":18,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":24,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100631966","immediate-effects-of-pettlep-based-aomi-on-upper-limb-kinematics-in-stroke-survivors-100631966","NCT07507552","Immediate Effects of PETTLEP-Based AOMI on Upper Limb Kinematics in Stroke Survivors","Immediate Effects of PETTLEP-Based AOMI on Upper Limb Kinematics in Stroke Survivors: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Female and male adults aged 40 to 80 years with a diagnosis of unilateral ischemic or hemorrhagic stroke.\n* Residual voluntary movement activity of the affected upper limb.\n* Mild to moderate spasticity (Modified Ashworth Scale ≤ 3).\n* Adequate cognitive function to understand and follow verbal instructions (Mini-Mental State Examination ≥ 21).\n* Medically stable patients, with no active or uncontrolled systemic illness.\n* Ability to sit unsupported for at least 30 minutes and be able to perform brief cognitive-motor exercises.\n\nExclusion Criteria:\n\n* Other central nervous system disorders (e.g., Parkinson's disease, multiple sclerosis, traumatic brain injury).\n* Musculoskeletal or orthopedic conditions causing restriction of movement in the upper-limb (such as fixed contractures, severe joint deformities, shoulder subluxation).\n* Severe sensory deprivation, visual neglect, or inattention that interferes with completion of the task or the ability to engage in motor imagery.\n* Uncontrolled seizures, severe cardiovascular instability, or any other contraindication to imagery.","40 Years","80 Years",{"count":116,"type":23},28,[26],"The purpose of this study is to investigate the immediate effects of a mental practice technique, called Physical, Environment, Task, Timing, Learning, Emotion, Perspective (PETTLEP)-based Action Observation and Motor Imagery (AOMI), on arm movement in stroke survivors. Stroke often causes difficulty in moving the arm smoothly, leading patients to compensate by using their back or shoulder. In this study, participants will either receive a single session of the AOMI training (watching and mentally practicing a reach-to-grasp movement) or a control relaxation task. The researchers will use a smartphone-based motion capture system (OpenCap) to measure if the mental practice immediately improves the smoothness of the arm movement and reduces compensatory body movements.",[30,29,120],"Hemiplegia and\u002For Hemiparesis Following Stroke",[122,123,30,124,125,126],"Motor imagery","Action observation","OpenCap","Kinematics","Upper limb rehabilitation","NOT_YET_RECRUITING","2026-04-05",{"date":130,"type":40},"2026-04-09",{"date":132,"type":23},"2026-04-01",{"date":134,"type":23},"2027-03-20",{"name":136,"class":47},"Istinye University",{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":18,"minAge":113,"maxAge":114,"enrollmentInfo":145,"targetDuration":4,"studyType":24,"phases":147,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":48},"100577092","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-application-on-respiratory-functions-in-stroke-patients-100577092","NCT06793800","Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients","Effect of TAVNS Application on Respiratory Functions in Stroke Patients","TAVNS","Inclusion Criteria:\n\n* Being a chronic stroke patient with an ischemic or hemorrhagic stroke diagnosis made 1-3 years ago\n* Having been diagnosed with stroke for the first time\n* Ability to understand and follow simple verbal instructions\n* Being between the ages of 40 and 80\n* No conditions affecting perioral muscles, such as facial paralysis or swallowing disorders\n* No visual, auditory, or communication problems\n* No cardiopulmonary disorders\n* No additional neurological, cardiovascular, orthopedic, or similar conditions causing balance problems\n* Mini Mental State Examination (MMSE) score ≥24\n* No surgical operations or Botox applications in the last 6 months\n* Scoring 2 or below on the Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Presence of infection, ulcer, or scar on the auricle\n* Metallic implants in the skull, hypersensitivity, injury, or inflammation inside the ear\n* Chronic pulmonary and\u002For cardiac diseases\n* Resting heart rate below 60 beats per minute\n* Devices such as pacemakers or cochlear implants\n* Uncontrolled hypertension\n* Chronic obstructive pulmonary disease (COPD) or asthma unrelated to stroke\n* History of surgical operation or Botox application within the last 6 months\n* Presence of aphasia, apraxia, or neglect syndrome\n* History of 2 or more strokes (SVO)\n* Comorbid conditions affecting respiratory functions (e.g., Multiple Sclerosis, Parkinson's, spinal cord injury, contractures, deformities after fractures, active upper or lower respiratory infections, etc.)\n* Lack of cooperation",{"count":146,"type":23},50,[26],"The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients. It aims to explore TAVSS as a potential complementary approach in enhancing rehabilitation outcomes for this population.",[29,150],"Respiratory Function Loss",[152,153,154],"hemiplegia","Vagus Nerve Stimulation","Respiration","2026-03-31",{"date":132,"type":40},{"date":158,"type":40},"2025-08-05",{"date":160,"type":23},"2027-07-30",{"name":162,"class":47},"Fenerbahce University",{"id":164,"slug":165,"hasResults":12,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":48},"100352577","rtms-plus-ccfes-mediated-functional-task-practice-for-severe-stroke-100352577","NCT03870672","rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke","Contralaterally Controlled FES Combined With Brain Stimulation for Severe Upper Limb Hemiplegia","rTMS+CCFES","Inclusion Criteria:\n\n* age 18 to 90 years old at time of randomization\n* greater than 6 months since a first clinical cortical or subcortical, ischemic or hemorrhagic stroke\n* severe upper limb hemiparesis defined as less than 10° active wrist extension or less than 10° active thumb abduction\u002Fextension or less than 10° active extension in at least two additional digits (i.e., will not meet minimum CIMT criteria)\n* ability to follow 3-stage commands and can remember 2 items from a list of 3 items after 3 minutes\n* adequate active movement of shoulder and elbow to position the paretic hand on one's lap for performance of functional task practice and CCFES-assisted hand opening exercises\n* skin intact on hemiparetic arm\n* surface electrical stimulation of the paretic finger and thumb extensors produces functional hand opening without pain\n* able to hear and respond to cues from stimulator\n* completed occupational therapy at least 2 months prior to enrollment (no concomitant OT)\n* full volitional hand opening\u002Fclosing of the non-paretic hand\n* ability to follow instructions for putting on and operating the CCFES stimulator or a caregiver available to provide assistance\n\nExclusion Criteria:\n\n* metal implant in the head\n* history of seizures as an adult\n* history of alcohol or substance abuse less than 10yrs prior to enrollment\n* intake of anticonvulsants or anti-depressants contraindicated with TMS\n* cardiac pacemaker or other programmable implant","90 Years",{"count":173,"type":23},72,[26],"This study is a necessary and important step in the development of a new therapy for upper limb functional recovery in patients with severe motor impairment. It is the first clinical trial of non-invasive brain stimulation (repetitive transcranial magnetic stimulation or rTMS) delivered to excite the undamaged hemisphere (specifically the contralesional higher motor cortices or cHMC) in stroke. Therefore, this study will determine whether the positive results obtained in our short-term pilot study can be made to last longer and produce functional benefits in severe patients with the application of brain stimulation in combination with long-term rehabilitation therapy. Rehabilitation therapy administered is called contralaterally controlled functional electrical stimulation (CCFES). Determining whether combining rTMS facilitating the cHMC with CCFES produces synergistic gains in functional abilities in severe patients is necessary for acceptance by the clinical community and to move this technology toward commercialization and widespread dissemination. The proposed study will determine whether the combination of rTMS facilitating the cHMC with CCFES produces greater improvements in upper extremity function in severe participants who are ≥6 months from stroke onset than the combination of rTMS facilitating the damaged hemisphere (specifically the ipsilesional primary motor cortex, iM1) and CCFES or the combination of sham rTMS and CCFES. The secondary purposes are to define which patients benefit most from the treatments, which may inform future device and treatment development and clinical translation, and to explore what distinct effects the three treatments have on the brain. To accomplish these purposes, we are conducting a clinical trial that enrolls severe stroke patients.",[30,29,177,178],"Cerebrovascular Accident (CVA)","Hemiparesis",[180,30,181,182,183,184,185,186,187],"Upper limb","CVA","Rehabilitation","Brain Stimulation","CCFES","Motor Cortex","TMS","Motor Recovery","2026-03-20",{"date":190,"type":40},"2026-03-24",{"date":192,"type":40},"2019-05-14",{"date":194,"type":23},"2026-12-31",{"name":196,"class":47},"The Cleveland Clinic",{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":24,"phases":206,"briefSummary":207,"conditions":208,"keywords":215,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":48},"100576220","upper-limb-nerve-cryoneurolysis-is-non-inferior-to-the-usual-care-and-has-therapeutic-add-value-in-dealing-with-shoulder-pain-and-functional-problems-caused-by-spasticity-and-motor-impairment-100576220","NCT06782464","Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment","Ultrasound Guided Cryoneurolysis to Treat Shoulder Pain and Functional Problems Related to Upper Limb Spasticity","spastiCRYO-UL","Inclusion Criteria:\n\n* Be over 18 years old.\n* Have a clinically and functionally stable condition.\n* Present spastic hemiplegia of the upper limb caused by a stroke, traumatic, or hypoxic brain event occurring more than 6 months before the study.\n* The paretic upper limb must present significant spastic plegia at the shoulder adductors and\u002For shoulder internal rotators (≥ 1+ on the Modified Ashworth Scale).\n* Have a Visual Analogue Scale (VAS) pain score \\> 40\u002F100 mm.\n* Have spasticity causing limitations in providing care.\n* Have the cognitive capacity to make informed decisions. A comprehensive explanation of the study will be provided orally and in writing to participants and a trusted relative of their choosing.\n* Maintain any medications on a stable schedule.\n* Accept and have access to an interdisciplinary rehabilitation program and standardized evaluation sessions throughout the study.\n\nExclusion Criteria:\n\n* In the investigator's opinion, the subject will be exposed to unacceptable risk by participation.\n* Previous intervention or condition that altered the target neural anatomy of the upper limb.\n* Any injection (neurolytic, sclerosing, anesthesia, etc.) to the upper limb within the last 4 months.\n* Spasticity invasive treatment such as intrathecal baclofen during the trial.\n* Current enrollment in an investigational drug or device study targeting spasticity management.\n* Pregnancy or lactation.\n* Allergy or intolerance to local anesthesia\u002FBoNT-A.\n* Contraindications to BoNT-A administration, such as:\n\n  * Myasthenia Gravis\n  * Eaton-Lambert syndrome\n  * Possible drug interactions (e.g., aminoglycosides and BoNT-A)\n* Any local skin condition at the treatment site that may adversely affect treatment or outcomes.\n* Chronic medication use (prescription or over-the-counter) that, in the investigator's opinion, would affect study participation or subject safety.\n* Contraindications to cryoneurolysis, including:\n\n  * Diagnosis of cryoglobulinemia\n  * Paroxysmal cold hemoglobinuria\n  * Cold urticaria\n  * Raynaud's disease\n  * Any form of peripheral neuropathy\n  * Open and\u002For infected wounds on the affected limb\n* Diagnosis of concomitant progressive neurological diseases such as Amyotrophic Lateral Sclerosis.\n* Any reason, in the investigator's opinion, that the subject may not be suitable for study participation (e.g., history of noncompliance, drug addiction, or any related upper limb injury).",{"count":146,"type":23},[26],"This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: \"Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add value in dealing with shoulder pain and functional problems caused by spasticity and motor impairment\".\n\nIt is a non-inferiority study on the referred topic, comparing the therapeutic effect (improvement in function and pain) of cryoneurolysis of selected nerves (lateral pectoral nerve and thoracodorsal nerve) with the usual care: intramuscular botulinum neurotoxin type A (BoNT-A) injection of pectoralis major, teres major and subscapularis muscles. The hypothesis is that cryoneurolysis is not inferior to the usual care in terms of magnitude of the therapeutic effect and might have a therapeutic add-value in terms of duration of that effect.\n\nTwo secondary hypotheses are firstly, that cryoneurolysis is a safe procedure that can be deployed in a rehabilitation hospital setting with minimum requirements to perform mini-invasive procedures and secondly that selecting patients who might benefit from this treatment is straightforward.\n\nTo test these hypotheses, the research team will gather, analyse and compare outcome measures data from the endpoints which are the changes along the trial duration in shoulder pain, upper limb function, involved muscles spasticity, shoulder range of motion (abduction and external rotation) level of impairment, and follow-up of potential adverse effects in two independent and equivalent groups of participants who have shoulder pain and functional limitations caused by spasticity and are in a stable phase of their condition. Participants in one group (cryoneurolysis arm) have one session of selected nerves ultrasound and neurostimulation guided cryoneurolysis and participants in the other group (BoNT-A arm) have one session of ultrasound and neurostimulation guided injection of BoNT-A in the pectoralis major, teres major and subscapularis.\n\nThe participants of the two groups follow an upper limb analogous rehabilitation program for 24 weeks after each intervention. Longitudinal follow-up in the trial will take 24 weeks. In a real-world scenario, within 24 weeks the effect of Bont-A intramuscular injection has already waned, and the procedure should be repeated.\n\nSecondary objectives are to compare changes in upper limb sensory function and electroneuromyographic parameters with the intention to understand the cryoneurolysis mechanism of action and the reversibility of this mini-invasive intervention. Changes in quality-of-life dimension of participants is a secondary endpoint as well.",[29,209,210,211,30,212,213,214],"Spasticity","Shoulder Spasticity","Shoulder Stiffness","Multiple Sclerosis","Traumatic Brain Injury","Spinal Cord Injury",[216,217,218,219,220,221],"cryoneurolysis","spasticity","pain","stroke","traumatic brain injury","spinal cord injury","2026-03-17",{"date":224,"type":40},"2026-03-19",{"date":226,"type":40},"2024-12-12",{"date":228,"type":23},"2028-12-12",{"name":230,"class":47},"Centre National de Rééducation Fonctionnelle et de Réadaptation",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":18,"minAge":238,"maxAge":57,"enrollmentInfo":239,"targetDuration":4,"studyType":24,"phases":241,"briefSummary":242,"conditions":243,"keywords":244,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100627924","the-effect-of-blood-flow-restriction-training-combined-with-transcranial-magnetic-stimulation-on-limb-function-in-hemiplegic-patients-after-stroke-100627924","NCT07454954","The Effect of Blood Flow Restriction Training Combined With Transcranial Magnetic Stimulation on Limb Function in Hemiplegic Patients After Stroke","BFR-TMS-Stroke","Inclusion Criteria:\n\n* Diagnosis of stroke (ischemic or hemorrhagic) confirmed by CT or MRI, meeting the diagnostic criteria of the 4th National Cerebrovascular Disease Conference\n* First-ever stroke or recurrent stroke without residual dysfunction from prior events\n* Age 25-70 years, male or female\n* Stable vital signs, conscious, able to understand and follow therapist instructions\n* Brunnstrom stage III or above in both upper and lower limbs\n* Voluntary signed informed consent by patient or legal guardian\n\nExclusion Criteria:\n\n* Presence of cardiac pacemaker or other metal implants\n* Deafness, severe cognitive impairment, history of psychiatric disorders\n* Shoulder subluxation\n* Extensive skin damage on affected limbs\n* Severe cardiac, hepatic, pulmonary, or renal insufficiency\n* Coagulation disorders\n* Post-stroke epilepsy\n* Malignancy\n* Pregnancy or lactation","25 Years",{"count":240,"type":23},69,[26],"This randomized controlled trial aims to evaluate whether combining blood flow restriction training (BFRT) with repetitive transcranial magnetic stimulation (rTMS) improves limb function in stroke patients with hemiplegia. A total of 69 participants will be randomly assigned to three groups: conventional rehabilitation alone (control group), conventional rehabilitation plus rTMS, or conventional rehabilitation plus BFRT combined with rTMS. The intervention period is 4 weeks, with assessments conducted at baseline and at the end of treatment. The primary outcome is the change in upper extremity Fugl-Meyer Assessment (FMA-UE) score, which measures motor function recovery. Secondary outcomes include Wolf Motor Function Test, Modified Barthel Index for daily activities, Berg Balance Scale, and safety parameters such as coagulation markers and adverse events. This study will help determine whether this combined approach offers a more effective rehabilitation strategy for stroke survivors.",[30,29],[30,29,245,246,247,248,249,182,33,250],"Blood Flow Restriction Training","Transcranial Magnetic Stimulation","rTMS","BFR Training","Motor Function","Randomized Controlled Trial","2026-03-05",{"date":253,"type":40},"2026-03-06",{"date":255,"type":23},"2026-03-01",{"date":257,"type":23},"2027-03-31",{"name":259,"class":47},"The First Affiliated Hospital of Zhengzhou University",{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":24,"phases":270,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":48},"100594353","mirror-vs-virtual-reality-therapy-for-upper-extremity-function-in-hemiplegic-patients-100594353","NCT07018336","Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic Patients","Comparison of the Acute Effects of Mirror Therapy and Virtual Reality Therapy on Upper Extremity Function and Performance in Hemiplegic Patients","Inclusion Criteria:\n\n* Hemiplegic patients in need of upper extremity rehabilitation.\n* Having had a stroke 6 to 12 months prior to the study.\n* Being at least Stage 3 for the upper extremity according to the Brunnstrom motor recovery stages.\n* Age range: between 18 and 75 years.\n* Individuals who volunteer to participate in the study.\n* Individuals who are cognitively suitable for mirror therapy and virtual reality applications (a score of at least 24 on the Mini Mental State Examination)\n\nExclusion Criteria:\n\n* Patients with severe spasticity (score ≥ 3 on the Modified Ashworth Scale)\n* Individuals with secondary neurological conditions (e.g., Parkinson's disease, multiple sclerosis).\n* Individuals diagnosed with vestibular dysfunction (as virtual reality equipment may cause issues like nausea or dizziness).\n* Individuals with communication issues, such as hearing or vision loss.","75 Years",{"count":269,"type":23},42,[26],"Upper extremity impairment in hemiplegic patients significantly impacts daily activities and reduces quality of life. Although traditional rehabilitation methods can help, some patients experience limited progress. Recently, modern techniques such as mirror therapy and virtual reality (VR) have emerged, demonstrating promising results in motor skill improvement.\n\nThis study aims to directly compare the acute effects of mirror therapy and VR therapy on upper limb motor function in hemiplegic patients. Forty-two participants aged 18-75 with hemiplegia due to stroke (6-12 months post-stroke) will be randomly assigned to either mirror therapy or VR therapy. The evaluation includes motor function (Fugl-Meyer Assessment), spasticity (Modified Ashworth Scale), activities of daily living (Barthel Index), fine motor skills (Box and Block Test), proprioception, and reaction time.\n\nThe goal is to identify the effectiveness of the mirror therapy and VR therapy on motor function, spasticity control, proprioception, daily activity performance, and reaction times, contributing valuable insights to clinical rehabilitation practices.",[29,30,273],"Upper Extremity Dysfunction",[30,209,275,276],"Proprioception","Reaction Time","2026-02-26",{"date":279,"type":40},"2026-03-02",{"date":281,"type":40},"2025-05-30",{"date":283,"type":23},"2026-07",{"name":136,"class":47},{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":114,"enrollmentInfo":291,"targetDuration":4,"studyType":293,"phases":4,"briefSummary":294,"conditions":295,"keywords":299,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":311,"locationsCount":48},"100625957","validity-and-reliability-of-the-hypertonia-assessment-tool-hat-in-stroke-patients-100625957","NCT07429383","Validity and Reliability of the Hypertonia Assessment Tool (HAT) in Stroke Patients","Inclusion Criteria:\n\n* Age 18 years and older\n* Clinically and radiologically confirmed diagnosis of stroke (ischemic or -hemorrhagic)\n* Brunnstrom stage between 2 and 6\n* Presence of post-stroke hypertonia (spasticity, dystonia, or rigidity)\n* Cognitive level sufficient to cooperate with assessments (Mini-Mental State Examination (MMSE) score \\>23 or equivalent clinical evaluation)\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Presence of severe accompanying neurodegenerative diseases (e.g., Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis)\n* Presence of primary musculoskeletal disorders affecting motor performance (e.g., rheumatologic diseases, fractures)\n* Brunnstrom stage of 1\n* Severe aphasia, impaired consciousness, or cognitive deficits preventing effective communication and cooperation\n* Any psychiatric disorder that may interfere with study participation",{"count":292,"type":23},60,"OBSERVATIONAL","In this study, the validity and reliability of the Hypertonia Assessment Tool (HAT), which has previously been validated in the pediatric cerebral palsy (CP) population, will be evaluated in adult individuals who have experienced a stroke. The HAT is a specific clinical instrument designed to differentiate subtypes of hypertonia, including spasticity, dystonia, and rigidity.\n\nAccurate classification of hypertonia subtypes following stroke is crucial for guiding rehabilitation strategies. However, the HAT has not yet been validated in the adult post-stroke population. This study will be conducted at the Physical Medicine and Rehabilitation Clinic of SBU Fatih Sultan Mehmet Training and Research Hospital. The study aims to evaluate the validity and reliability of the HAT for use in adults with stroke.",[30,296,297,298,29],"Hypertonia","Dystonia","Rigidity",[300,301,302,303,304,152,217,219],"hypertonia","dystonia","rigidity","reliability","validity","2026-02-20",{"date":307,"type":40},"2026-02-24",{"date":255,"type":23},{"date":310,"type":23},"2026-10-01",{"name":312,"class":47},"Fatih Sultan Mehmet Training and Research Hospital",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":114,"enrollmentInfo":321,"targetDuration":4,"studyType":24,"phases":323,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":4},"100621363","repetitive-transcranial-magnetic-stimulation-combined-with-motor-rehabilitation-improves-motor-and-functional-outcomes-after-ischemic-stroke-100621363","NCT07369648","Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation Improves Motor and Functional Outcomes After Ischemic Stroke","Effects of Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation on Motor and Functional Outcomes in Patients With Ischemic Stroke: A Randomized Sham-Controlled Trial","rTMS-MOTOR","Inclusion Criteria:\n\n* Aged 18 to 80 years.\n* Diagnosed with a first-ever ischemic stroke, confirmed by neuroimaging.\n* Presence of unilateral hemiparesis attributable to the first-ever ischemic stroke.\n* Time since stroke onset:\n\n  * Acute stage: \\\u003C 1 month after stroke onset\n  * Subacute stage: 1 to 6 months after stroke onset\n  * Chronic stage: \\> 6 months after stroke onset\n* Moderate neurological impairment, defined as a baseline NIHSS score between 5 and 14.\n* Cognitive ability sufficient to understand and follow instructions, indicated by a baseline MMSE score ≥ 20.\n* Medically stable and able to participate in a structured motor rehabilitation program.\n* Provided written informed consent prior to study enrollment.\n* NIHSS and MMSE scores are assessed at baseline only to characterize neurological severity and cognitive status at study entry\n\nExclusion Criteria:\n\n* Motor impairment caused by conditions other than ischemic stroke, such as musculoskeletal disorders, traumatic brain injury, Parkinson's disease, encephalitis, or other neurological conditions.\n* Contraindications to repetitive transcranial magnetic stimulation, including but not limited to intracranial metallic implants, implanted electronic medical devices (e.g., pacemaker), cochlear implants, known bleeding disorders, pregnancy, history of epilepsy or seizure disorders, severe cardiac disease, severe psychiatric or neurological disorders interfering with participation, or active skin conditions at the stimulation site.\n* History of epilepsy or seizure disorders.\n* Recurrent stroke occurring during the intervention period.\n* Refusal to participate, withdrawal of informed consent, or non-adherence to the intervention protocol.",{"count":322,"type":23},66,[26],"Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, particularly in patients with persistent motor impairment.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been used as an adjunct to rehabilitation to modulate cortical excitability and potentially support motor recovery.\n\nThe purpose of this study is to evaluate the effects of low-frequency rTMS combined with conventional motor rehabilitation compared with sham rTMS combined with conventional motor rehabilitation in patients with first-ever ischemic stroke during the acute, subacute, and chronic stages. Motor function, balance, functional mobility, activities of daily living, and stroke-specific quality of life will be assessed at baseline, after the intervention, and at 3-month and 6-month follow-up.",[326,29,327],"Ischemic Stroke","Motor Function Impairment",[329,247,187,96,330,331],"Repetitive Transcranial Magnetic Stimulation","Neurorehabilitation","Motor function","2026-02-06",{"date":334,"type":40},"2026-02-10",{"date":336,"type":23},"2026-02",{"date":338,"type":23},"2028-12",{"name":340,"class":47},"Hanoi Medical University",{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":267,"enrollmentInfo":348,"targetDuration":4,"studyType":24,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":4},"100621035","pelvic-restricted-vs-pelvic-free-robot-assisted-gait-training-in-stroke-patients-100621035","NCT07365384","Pelvic-Restricted vs. Pelvic-Free Robot-Assisted Gait Training in Stroke Patients","Comparison of Pelvic-Free and Pelvic-Restricted Robot-Assisted Gait Training on Walking Pattern, Balance, and Fear of Falling After Stroke","Inclusion Criteria:\n\n* Age 18 years or older\n* History of stroke more than 6 months prior\n* Presence of hemiplegia-related gait disorder\n* Functional Ambulation Category (FAC) score ≥ 2\n* Ability to walk independently prior to stroke\n\nExclusion Criteria:\n\n* Severe cognitive or communication impairment\n* Movement limitations due to joint contracture or deformity\n* Presence of open wounds or pressure ulcers\n* Uncontrolled hypertension or orthostatic hypotension\n* Severe cardiovascular disease, heart failure, cancer, or serious pulmonary disease\n* High risk of fracture due to severe osteoporosis\n* Gait impairment caused by lower extremity musculoskeletal disorders\n* Severe psychosis\u002Fneurosis\n* Modified Ashworth Scale \\> 3 in the lower extremities (severe spasticity)",{"count":349,"type":23},36,[26],"This randomized controlled clinical trial aims to compare the effects of pelvic-free versus pelvic-restricted robot-assisted gait training (RAGT) on gait pattern, balance, and fear of falling in stroke patients. Stroke survivors often experience gait impairments, reduced balance, and fear of falling, which limit independence and quality of life. Conventional physiotherapy requires high intensity and repetition but is restricted by therapist capacity. Robotic gait systems provide intensive, repetitive, and safe training; however, most limit pelvic motion, potentially disrupting natural gait patterns and balance strategies.\n\nA total of 36 participants with chronic stroke (≥6 months post-stroke, age ≥18 years, hemiplegic gait disorder, Functional Ambulation Category ≥2) will be randomized into two groups: (1) pelvic-free RAGT plus conventional rehabilitation, or (2) pelvic-restricted RAGT plus conventional rehabilitation. Interventions will consist of 8 RAGT sessions (twice weekly) and 20 conventional rehabilitation sessions (five times weekly) over 4 weeks.\n\nPrimary outcomes include gait analysis parameters (gait speed, step length, cadence, temporal symmetry index) and clinical measures such as the Berg Balance Scale, Functional Ambulation Category, Motricity Index (lower limb), and Falls Efficacy Scale-International. Assessments will be performed at baseline and after 4 weeks of treatment.\n\nThe study hypothesizes that pelvic-free RAGT will improve gait symmetry, balance, and reduce fear of falling more effectively than pelvic-restricted training. Results are expected to provide evidence supporting the integration of pelvic-free robotic gait systems into post-stroke rehabilitation to enhance functional recovery and patient confidence",[30,29,353,354,355],"Gait Disorder, Sensorimotor","Balance Impairment","Fear of Falling","2026-01-23",{"date":358,"type":40},"2026-01-26",{"date":360,"type":23},"2026-01-15",{"date":362,"type":23},"2026-04",{"name":364,"class":47},"Meltem Gunes Akinci",{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":371,"eligibilityCriteria":372,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":24,"phases":375,"briefSummary":376,"conditions":377,"keywords":380,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":386,"leadSponsor":388,"locationsCount":4},"100620097","comparison-of-the-effectiveness-of-tens-and-tens--nmes-treatment-in-stroke-patients-with-shoulder-pain-100620097","NCT07353190","Comparison of the Effectiveness of TENS and TENS + NMES Treatment in Stroke Patients With Shoulder Pain","Comparison of the Effectiveness of TENS and TENS + NMES Treatment in Stroke Patients With Shoulder Pain: Prospective Randomized Controlled Study","TENS","Inclusion Criteria:\n\n* Individuals aged 18 and over\n* Patients with a history of clinically and radiologically confirmed ischemic or hemorrhagic stroke\n* Hemiplegic shoulder pain in the affected shoulder\n* Shoulder pain severity VAS\u002FNRS ≥ 2\n* At least 2 weeks and at most 1 year have passed since the onset of stroke\n* Have a level of cognitive and communicative competence that will not hinder the application of clinical evaluations and scales\n* Must have signed the Informed Volunteer Consent Form to participate in the study.\n* Must have a general medical condition to participate in a conventional rehabilitation program\n\nExclusion Criteria:\n\n\\-",{"count":374,"type":23},40,[26],"In this study, the effects of Transcutaneous Electrical Nerve Stimulation (TENS) and Neuromuscular Electrical Stimulation (TENS + NMES) applied in addition to TENS on pain, shoulder joint range of motion and upper extremity functions will be comparatively evaluated in stroke patients with hemiplegic shoulder pain. In this direction, in the study; The effectiveness of both treatment approaches on the severity of hemiplegic shoulder pain, their contribution to shoulder functionality and daily living activities will be examined; It will be investigated whether NMES application added to TENS provides an additional clinical benefit compared to TENS.",[30,378,29,379],"Shoulder Disease","Hemiplegic Shoulder Pain",[219,381,371,382],"shoulder pain","NMES",{"date":384,"type":40},"2026-01-20",{"date":42,"type":23},{"date":387,"type":23},"2026-06-30",{"name":389,"class":47},"Medical Park Bursa Hospital",{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":24,"phases":399,"briefSummary":400,"conditions":401,"keywords":406,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":420},"100594073","icf-based-effects-of-pnf-and-kinesio-taping-on-hand-function-in-hemiplegic-stroke-100594073","NCT07014696","ICF-Based Effects of PNF and Kinesio Taping on Hand Function in Hemiplegic Stroke","Investigation of the Effects of PNF and Kinesiological Taping on Hand Function in Hemiplegic Stroke Patients Based on the ICF Framework","Inclusion Criteria:Inclusion criteria for the study (Junior et al., 2019; Kim \\& Kim, 2015; Saklecha et al., 2023)\n\n* Stroke diagnosed by MRI or CT, regardless of ischemic or hemorrhagic origin,\n* Hemiplegia caused by stroke alone,\n* At least 6 and at most 24 months have passed since the stroke was diagnosed\n* Being over 18 years of age,\n* Volunteering to participate in the study\n* Scoring 24 or more on the Standardized Mini Mental State Examination (if illiterate, scoring 18 or more is sufficient)\n* Cooperating with evaluation, tests and treatment\n* Understanding and speaking Turkish\n* Being at least stage 4 according to Brunnstrom staging\n\nExclusion Criteria:\n\n* Exclusion Criteria (Junior et al., 2019; Kim \\& Kim, 2015; Saklecha et al., 2023)\n* Individuals with bilateral hemiplegia\n* Individuals with unstable vital signs\n* Individuals with any open wound in the upper extremity\n* Pathological conditions affecting upper extremity sensation (undergoing surgery after fracture, etc.)\n* Individuals with a BMI value greater than 29.9 kg\u002Fm2\n* Individuals with a Standardized Mini Mental Test score below 24 points (18 points)\n* Individuals with major neurological or rheumatological disorders affecting the musculoskeletal system other than stroke (Polyneuropathy, Parkinson's, Multiple Sclerosis, Rheumatoid Arthritis, etc.)\n* Presence of upper extremity amputation\n* Being at less than stage 4 according to Brunnstrom staging",{"count":398,"type":23},54,[26],"This clinical trial aims to compare the effects of kinesio taping and PNF on hemiplegic hand functions. In addition, the effects of these applications on body structure, activity, and participation will be examined. The main questions it aims to answer are:\n\nDo kinesio taping and PNF applications have different effects on hemiplegic hand function? Are kinesio taping and PNF applications effective in body structure, activity, and participation? The researchers will compare the advantages of kinesio taping and PNF applications over each other.\n\nParticipants:\n\nKinesio taping and\u002For PNF applications will be applied 3 days a week for 8 weeks.\n\nTests will be performed on the first and last day of the study to evaluate hand functions.",[29,402,403,33,404,405],"Hemiplegia Due to Stroke","Hand Functionality","Proprioceptive Neuromuscular Facilitation","Kinesio Taping",[407,152,408,409,410,411,412],"hand functionality","hemiplegia due to stroke","upper extremity","ICF","Proprioceptive neuromuscular facilitation","kinesio taping","2026-01-13",{"date":360,"type":40},{"date":416,"type":40},"2025-06-01",{"date":418,"type":23},"2026-03-30",{"name":136,"class":47},2,{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":428,"targetDuration":4,"studyType":24,"phases":429,"briefSummary":430,"conditions":431,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":4},"100618672","postural-kinesio-taping-in-stroke-rehabilitation-100618672","NCT07334665","Postural Kinesio Taping in Stroke Rehabilitation","Effects of Posture-Oriented Kinesio Taping on Mobility, Balance, Coordination, and Activities of Daily Living in Patients With Stroke: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of ischemic or hemorrhagic stroke confirmed clinically and\u002For radiologically\n* In the subacute or chronic phase of stroke (≥1 month post-stroke) and clinically stable\n* Presence of postural control and\u002For trunk control impairment\n* Ability to participate in a standard neurological rehabilitation program\n* No severe cognitive impairment or communication disorder that would interfere with outcome assessments\n* Intact skin at the kinesio taping application sites\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* Acute stroke phase or clinical instability\n* Severe cognitive impairment, aphasia, or insufficient cooperation that would interfere with reliable outcome assessments\n* Known allergy or hypersensitivity to kinesio tape\n* Active dermatological conditions at taping sites (e.g., open wounds, dermatitis, infection)\n* Severe spasticity (Modified Ashworth Scale ≥3)\n* Presence of other neurological disorders affecting balance or mobility (e.g., Parkinson's disease, multiple sclerosis)\n* Severe orthopedic conditions or cardiopulmonary diseases limiting participation in rehabilitation\n* Receipt of posture-oriented kinesio taping within the previous 3 months\n* Concurrent participation in another interventional clinical study that could influence study outcomes",{"count":292,"type":23},[26],"Stroke often leads to postural asymmetry and impaired trunk control, which negatively affect mobility, balance, coordination, and activities of daily living. These impairments increase the risk of falls and reduce functional independence during the rehabilitation process.\n\nThe purpose of this randomized controlled trial is to investigate the effects of posture-oriented kinesio taping, applied in addition to standard neurological rehabilitation, on functional outcomes in patients with stroke. Participants will be randomly assigned to either an intervention group receiving kinesio taping plus standard rehabilitation or a control group receiving standard rehabilitation alone.\n\nFunctional outcomes including trunk control, postural stability, balance, mobility, and activities of daily living will be assessed using validated clinical scales at baseline and after the intervention period. The findings of this study are expected to provide evidence regarding the clinical effectiveness of posture-oriented kinesio taping as a non-invasive and easily applicable adjunct treatment in stroke rehabilitation.",[30,29,432],"Postural Control","2026-01-10",{"date":413,"type":40},{"date":436,"type":23},"2026-01-30",{"date":438,"type":23},"2027-01-30",{"name":440,"class":441},"Bursa City Hospital","OTHER_GOV",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":293,"phases":4,"briefSummary":451,"conditions":452,"keywords":454,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":464,"locationsCount":48},"100616215","evaluation-of-the-effectiveness-of-pericapsular-nerve-group-block-in-hemiplegic-shoulder-pain-100616215","NCT07302711","Evaluation of the Effectiveness of Pericapsular Nerve Group Block in Hemiplegic Shoulder Pain","Inclusion Criteria:\n\n* Age between 18 and 85 years\n\nStroke onset less than 1 year\n\nPresence of hemiplegic shoulder pain with limited shoulder range of motion confirmed by clinical examination\n\nNumeric Rating Scale (NRS) pain score ≥ 4\n\nExclusion Criteria:\n\n* Severe deformity or pathology of the shoulder region\n\nComplex regional pain syndrome type I\n\nModified Ashworth Scale score ≥ 3\n\nPresence of neglect syndrome\n\nGrade 4 glenohumeral joint degeneration\n\nCoagulopathy or bleeding disorders\n\nFracture on the affected side\n\nSecondary pathology on MRI (malignancy or infection)\n\nPresence of pacemaker\n\nHistory of allergic reaction to local anesthetic agents or dexamethasone\n\nShoulder intervention or injection within the past 3 months\n\nMajor psychiatric illness\n\nRefusal to participate in the study","85 Years",{"count":450,"type":23},15,"Hemiplegic shoulder pain (HSP) is a common and clinically significant complication after stroke that negatively affects rehabilitation outcomes. It is associated with shoulder subluxation, capsular contracture, spasticity, and central pain mechanisms, leading to pain, limited range of motion, and reduced quality of life. The suprascapular nerve (SSN) block has been shown to be effective for shoulder pain management; however, the glenohumeral joint (GHJ) receives innervation from multiple nerves including the axillary, subscapular, and lateral pectoral nerves. The recently described pericapsular\u002Fperiarticular nerve group (PENG) block targets these articular branches and may provide analgesia with minimal motor impairment.\n\nThis study aims to evaluate the effects of adding an ultrasound-guided PENG block to conventional physical therapy in patients with post-stroke hemiplegic shoulder pain, focusing on pain intensity, range of motion, and quality of life outcomes.",[453,29],"Shoulder Pain",[455,456,457],"PENG block","shoulder joint pain","Hemiplegic shoulder","2025-12-11",{"date":460,"type":40},"2025-12-24",{"date":462,"type":23},"2025-12-20",{"date":188,"type":23},{"name":465,"class":47},"Marmara University",{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":472,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":24,"phases":476,"briefSummary":477,"conditions":478,"keywords":481,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":48},"100598573","effects-of-intermitted-theta-burst-stimulation-itbs-on-motor-recovery-of-upper-extremity-in-chronic-stroke-patients-100598573","NCT07073248","Effects of Intermitted Theta Burst Stimulation (iTBS) on Motor Recovery of Upper Extremity in Chronic Stroke Patients","Neuroplastic Changes and Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Upper and Lower Extremity in Chronic Stroke Patients","NIMBLE","Inclusion Criteria:\n\n* Age over 18\n* Chronic stroke (\\>6 months)\n* Residual hemiparesis FM-UE\\>17\n\nExclusion Criteria:\n\n* Metal implants\n* Epilepsy\u002Fseizures\n* Pregnancy\n* Claustrophobia (related to MRIs exams)\n* Severe cognitive impairment\n* Untreated or unstable depression\u002Fanxiety\n* Other disabilities prohibiting intensive physical training",{"count":475,"type":23},48,[26],"This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of upper extremity in the chronic phase after stroke.\n\nIt also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.",[30,29,479,403,480],"Hemiparesis After Stroke","Chronic Stroke Patients",[219,482,186,483,484,485,178,486,487],"iTBS","Motor cortex","chronic stroke patients","hand dexterity","Transcrania Magnetic Stimulation","intermittent Theta Burst Stimulation","2025-11-20",{"date":490,"type":40},"2025-11-21",{"date":492,"type":23},"2025-11",{"date":494,"type":23},"2030-12",{"name":496,"class":47},"Danderyd Hospital",{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":471,"acronym":472,"eligibilityCriteria":502,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":503,"targetDuration":4,"studyType":24,"phases":505,"briefSummary":506,"conditions":507,"keywords":509,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":518,"leadSponsor":519,"locationsCount":48},"100598572","effects-of-intermittent-theta-burst-stimulation-itbs-on-motor-recovery-of-lower-extremity-in-chronic-stroke-patients-100598572","NCT07073235","Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Lower Extremity in Chronic Stroke Patients","Inclusion Criteria:\n\n* Age over 18\n* Chronic stroke (\\>6 months)\n* Residual hemiparesis FAC ≥3\n\nExclusion Criteria:\n\n* Metal implants\n* Epilepsy\u002Fseizures\n* Pregnancy\n* Claustrophobia (related to MRIs exams)\n* Severe cognitive impairment\n* Untreated or unstable depression\u002Fanxiety\n* Other disabilities prohibiting intensive physical training",{"count":504,"type":23},56,[26],"This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of lower extremity in the chronic phase after stroke.\n\nIt also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.",[30,479,480,29,508],"Ambulatory Difficulty",[219,482,186,510,511,512,513,514,178,487],"Trancranial Magnetic Stimulation","Cerebellum","Chronic stroke patients","Balance","Walking",{"date":516,"type":40},"2025-11-25",{"date":492,"type":23},{"date":494,"type":23},{"name":496,"class":47},{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":4,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":18,"minAge":527,"maxAge":528,"enrollmentInfo":529,"targetDuration":4,"studyType":24,"phases":531,"briefSummary":532,"conditions":533,"keywords":535,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":545,"locationsCount":48},"100597819","stms-combined-with-cimt-and-tavns-in-infants-with-hemiplegia-100597819","NCT07063446","sTMS Combined With CIMT and taVNS In Infants With Hemiplegia","Integrating Corticospinal Tract Assessment Via sTMS And taVNS-Augmented CIMT In Infants With Hemiplegia","Inclusion Criteria:\n\n* Infants 8-24mo with hemiplegia or asymmetric weakness of one arm, with or without truncal and transitional motor delays\n* Gross Motor function Classification system (GMFCS) I - IV\n* Parents are able to make consecutive appointments for assessments and intervention over 2wks and complete the 3mo follow-up.\n* Parents are willing to fill out developmental questionnaires and provide the study team feedback on tolerability and outcomes.\n\nExclusion Criteria:\n\n* previous CIMT within 3 months\n* GMFCS V or severe motor impairment\u002Fquadriplegia\n* uncorrected blindness\u002Fdeafness, cardiomyopathy\n* poorly controlled seizure disorder","8 Months","24 Months",{"count":530,"type":23},10,[26],"Preterm and term infants with brain injury frequently have delayed motor skills, and one hand and arm may become stronger than the other, which can signal early cerebral palsy. A new treatment, transcutaneous vagus nerve stimulation (taVNS), boosts specific brain circuits and may improve function when paired with intensive motor activities. This study will test taVNS-paired constraint induced movement therapy in infants who have greater weakness on one side and determine if a single pulse of transcranial brain stimulation over the motor area can cause a measurable movement of the hand or thumb, and indicate which infants can benefit from 40h taVNS-paired CIMT.",[29,534],"Perinatal Brain Injury",[536,537,538,539,152],"constraint induced movement therapy","infants","taVNS","sTMS",{"date":541,"type":40},"2025-11-26",{"date":543,"type":40},"2025-11-07",{"date":194,"type":23},{"name":546,"class":47},"Medical University of South Carolina",{"id":548,"slug":549,"hasResults":12,"nctId":550,"briefTitle":551,"officialTitle":552,"acronym":4,"eligibilityCriteria":553,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":267,"enrollmentInfo":554,"targetDuration":4,"studyType":293,"phases":4,"briefSummary":556,"conditions":557,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":48},"100611419","botulinum-toxin-applications-in-hemiplegic-patients-100611419","NCT07240337","Botulinum Toxin Applications in Hemiplegic Patients","Retrospective Evaluation of Muscle Selection, Dosage, and Clinical Outcomes in Botulinum Toxin Applications in Hemiplegic Patients","Inclusion Criteria:\n\n* Aged between 18 and 75 years, clinically diagnosed with hemiplegia\n* Received botulinum toxin injection for upper and\u002For lower extremity spasticity\n* Availability of recorded data for two time points, including the Functional Independence Measure (FIM), Brunnstrom stage, Modified Ashworth Scale (MAS), Global Spasticity Index (GSI)\n* Documentation of injected muscles and total administered botulinum toxin dosage\n\nExclusion Criteria:\n\n* Missing essential data (e.g., absence of FIM, MAS, GSI, or GAS at either visit)\n* Major interventions during the follow-up period such as surgery or initiation of intrathecal baclofen pump therapy\n* Severe concomitant neurological disorders (e.g., progressive neurodegenerative diseases) that interfere with assessment",{"count":555,"type":23},34,"This retrospective study will be conducted by reviewing the medical records of hemiplegic patients who received botulinum toxin treatment between 2017 and 2020 at the Physical Medicine and Rehabilitation outpatient clinic of Istanbul Physical Medicine and Rehabilitation Training and Research Hospital. A total of 35 hemiplegic patients who underwent botulinum toxin injection and had at least two follow-up records (with a 6-month interval) will be included. Sociodemographic and clinical data, stroke-related characteristics, botulinum toxin dosage, injected muscle groups, medications, and comorbidities will be recorded. Functional assessments, including the Functional Independence Measure (FIM) and Brunnstrom stage, as well as spasticity evaluations using the Modified Ashworth Scale and the Global Spasticity Index, will be obtained from patient files.",[29],"2025-11-16",{"date":488,"type":40},{"date":561,"type":40},"2025-10-10",{"date":563,"type":23},"2025-11-10",{"name":565,"class":441},"Istanbul Physical Medicine Rehabilitation Training and Research Hospital",{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":572,"enrollmentInfo":573,"targetDuration":4,"studyType":24,"phases":575,"briefSummary":576,"conditions":577,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":48},"100541430","cuped-an-approach-to-motor-recovery-post-stroke-not-compensation-100541430","NCT06329765","CUped: An Approach to Motor Recovery Post-Stroke, Not Compensation","Inclusion Criteria:\n\n* Single, unilateral stroke in adulthood.\n* Cortical, subcortical stroke. Individuals with cortical lesions affecting sensory and motor structures in the gray matter of the brain will be included. Individuals subcortical white matter lesions affecting the internal capsule and corona radiata will be included.\n* Ischemic, hemorrhagic stroke. Individuals with ischemic and hemorrhagic strokes will be admitted. Because ischemic stroke is more common than hemorrhagic, the investigators expect a smaller proportion of volunteers from the latter group.\n* Chronic stroke. Individuals with chronic stroke, defined as \\>6 months post infarct, will be included.\n* Able to walk 10 m. Stroke survivors capable of walking 10 m overground will be admitted. Canes, walkers, braces, and other devices will be allowed. This study examines the effect of CUped on gait kinematics and kinetics; therefore, the ability to walk is imperative.\n* Unilateral motor impairment consistent with hemiparesis.\n* Learned non-use of the paretic limb. Non-use will be verified by comparing paretic limb work (W) during unilateral and bilateral coupled pedaling. Participants with non-use will be identified as those who produce significantly \\\u003C50% of the total W of bilateral coupled pedaling with their paretic limb but are capable of unilateral pedaling with the paretic limb at a workload equivalent to 50% of the total W of bilateral coupled pedaling. (Significance will be determined using a 1-sample t-test or corresponding non-parametric test in the case of non-normality).\n* No contraindications for exercise. Contraindications to exercise include but may not be limited to recent electrocardiogram changes or recent myocardial infarction, uncontrolled arrhythmia, unstable angina, third degree heart block, acute progressive heart failure, uncontrolled hypertension, and orthopedic conditions (e.g., severe muscle contracture, arthritis, acute limb injury) that may interfere with pedaling.\n* Age ≥18. All participants must be at least 18 years of age. The investigators are studying adult not childhood stroke. Recovery mechanisms are different between adult and childhood stroke survivors.\n* Able to commit to 27 visits to the lab (pre-, mid-, post-test, plus 24 training sessions).\n\nExclusion Criteria:\n\n* More than 1 stroke. Individuals with more than one clinically apparent stroke, as evidenced by residual impairments and\u002For medical imaging, will be excluded. Individuals with history of transient ischemic attack (TIA) resulting in no residual impairments or brain damage will NOT be excluded.\n* Stroke in the cerebellum or basal ganglia. Individuals with stroke affecting primarily the cerebellum or basal ganglia will be excluded. The cerebellum has an important role in motor learning. Given that CUped depends on motor learning, people with cerebellar strokes may not benefit. Basal ganglia strokes can cause tremor, which is not the target of CUped. However, individuals with predominantly internal capsule lesions that also affect the basal ganglia will be included.\n* Dementia or other cognitive impairment that interferes with learning and\u002For the ability to consent.\n* Communication impairments, such as receptive aphasia, that prevent safe participation. Expressive aphasia is not an exclusion criterion. Participants will be included as long as they have a method to communicate willingness to participate, discomfort, and\u002For the desire to start or stop a study activity.\n* Orthopedic impairments that interfere with pedaling.\n* Cardiovascular contraindications to exercise.\n* Inability to walk 10 m overground. Participants will be excluded in they are not able to walk 10 m overground our cannot do so safely.\n* Neurological disorder other than stroke. Individuals with history or signs of any neurologic disease or injury other than stroke will be excluded. Such conditions may include head trauma, cerebral palsy, epilepsy, brain tumor, diabetic neuropathy, dementia, multiple sclerosis, Parkinson's disease, or Alzheimer's disease.\n* Other conditions that interfere with safe participation or data integrity. Participants will be excluded if, at any point in the recruitment or enrollment process, the investigators become aware of a condition that increases risk beyond that indicated in our IRB protocols. Exclusion will also occur if the investigators become aware of a condition that introduces an experimental variable that could confound the results of the study.\n* Failure to meet any inclusion criteria listed above.","100 Years",{"count":574,"type":23},12,[26],"The goal of lower limb rehabilitation after stroke is recovery of independent walking at home and in the community. Few stroke survivors achieve this goal. Suboptimal outcomes are due to the serious and intransigent nature of movement impairments caused by stroke and the scarcity of feasible and effective therapies that restore movement lost to stroke. Our team has developed a novel exercise intervention called CUped (pronounced cupid, like the Roman god) to address barriers to recovery and improve walking after stroke. CUped is so called because it compels use of the paretic limb during a movement that resembles pedaling. This project will examine safety, acceptability, and tolerance to CUped, characterize its therapeutic effects, and identify dose-response relationships. Results will provide preliminary data for an R01 to support a randomized controlled trial (RCT). CUped is designed to help stroke survivors recover lower limb movement lost to stroke, thereby improving walking. It is intended to be used as an adjunct to gait training. CUped uses a robotic technology that eliminates compensatory movements that interfere with recovery, compels use of the paretic lower limb, and targets 3 key movement impairments caused by stroke: decreased muscle output from the paretic limb, inappropriate paretic muscle timing, and abnormal interlimb coordination. Exercise is done in sitting which enables high repetition practice. Like walking, CUped requires continuous, reciprocal use of both lower limbs; effects are likely to transfer to walking. The risk-reward profile of this proposal is ideal for an R21, which is an NIH funding opportunity intended to encourage exploratory\u002Fdevelopmental research by providing support for the early and conceptual stages of project development. CUped is a novel therapy grounded in a physiologic premise and based on prior observations from our laboratory. The investigators have pilot data suggesting that CUped fulfills its design specifications, and this study will be the first to test its therapeutic effects. In this Stage 1 rehabilitation trial, The investigators will support or quickly refute the hypothesis that CUped is safe, acceptable, and capable of eliciting a therapeutic response in stroke survivors. The investigators will also examine tolerance to CUped and dose-response effects. If our hypotheses are supported, the investigators will be poised to run an RCT to isolate the effects of CUped and compare them to standard care. Future work will investigate physiologic mechanisms underlying the effects of CUped.",[30,29],"2025-09-25",{"date":580,"type":40},"2025-09-30",{"date":582,"type":40},"2023-08-07",{"date":584,"type":23},"2027-04-04",{"name":586,"class":47},"Marquette University",{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":18,"minAge":594,"maxAge":171,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":597,"briefSummary":598,"conditions":599,"keywords":601,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":48},"100505793","tdcs--ccfes-mediated-functional-task-practice-for-post-stroke-upper-extremity-hemiplegia-100505793","NCT05866003","tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia","tDCS During Contralaterally Controlled FES for Upper Extremity Hemiplegia","Inclusion Criteria:\n\n1. Age ≥ 21 and ≤ 90\n2. ≥ 6 and ≤ 24 months since first clinical hemorrhagic or nonhemorrhagic stroke\n3. Able to follow 3-stage command\n4. Able to remember 2 of 3 items after 30 minutes\n5. Full volitional elbow extension\u002Fflexion and hand opening\u002Fclosing of unaffected limb\n6. Adequate active movement of shoulder and elbow to position the paretic hand in the workspace for table-top task practice\n7. Patient must be able to sit unassisted in an armless straight-back chair for the duration of the screening portion of the eligibility assessment\n8. Medically stable\n9. ≥ 10° finger and wrist extension\n10. Skin intact on hemiparetic arm, hand and scalp\n11. Muscle contraction can be elicited with Transcranial Magnetic Stimulation\n12. Unilateral upper limb hemiparesis with finger extensor strength of ≤ grade 4\u002F5 on the Medical Research Council (MRC) scale\n13. Score of ≥1\u002F14 and ≤ 11\u002F14 on the hand section of the upper extremity Fugl-Meyer Assessment\n14. While relaxed, surface NMES of finger extensors and thumb extensors and\u002For abductors produces a functional degree of hand opening without pain.\n\nExclusion Criteria:\n\n1. Co-existing neurological condition other than prior stroke involving the hemiparetic upper limb (e.g., peripheral nerve injury, PD, SCI, TBI, MS).\n2. Uncontrolled seizure disorder\n3. Use of seizure lowering threshold medications and the discretion of the study physician\n4. Cardiac pacemaker or other implanted electronic device\n5. Pregnant\n6. IM Botox injections in any UE muscle in the last 3 months\n7. Insensate arm, forearm, or hand\n8. Deficits in communication that interfere with reasonable study participation\n9. Severely impaired cognition and communication\n10. Uncompensated hemi-neglect (extinguishing to double simultaneous stimulation)\n11. Severe shoulder or hand pain (unable to position hand in the workspace without pain)","21 Years",{"count":596,"type":23},63,[26],"After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement.\n\nThe purpose of this study is to compare 3 non-invasive brain stimulation protocols combined with therapy to see if they result in different amounts of recovery of hand movement after a stroke.",[30,600,29],"Upper Extremity Paresis",[30,182,602,603,604,605,184,185,186,187,606,181,607],"Therapy","Electrical Stimulation","Brain stimulation","Hand","Central Nervous System","Upper Limb","2025-09-23",{"date":610,"type":40},"2025-09-29",{"date":612,"type":40},"2023-07-01",{"date":614,"type":23},"2028-04",{"name":616,"class":47},"MetroHealth Medical Center",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":624,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":625,"targetDuration":4,"studyType":24,"phases":626,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":636,"locationsCount":48},"100570590","robotic-rehabilitation-and-dual-task-exercises-in-hemiplegic-patients-100570590","NCT06709222","Robotic Rehabilitation and Dual-Task Exercises in Hemiplegic Patients","Investigation of the Effectiveness of Dual-Task Exercises Applied in Addition to Robotic Rehabilitation in Hemiplegic Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of post-stroke hemiplegia (hemiplegia onset must be between 3 months and 1 year).\n* Age range: 30-60 years.\n* Voluntariness to participate in rehabilitation.\n* Patients with a motor function loss of 30-70% according to Fugl-Meyer Motor Assessment results.\n* Literacy\n\nExclusion Criteria:\n\n* History of active psychiatric disease.\n* Severe joint deformities or other neurological diseases.\n* Having had a recent stroke during rehabilitation.",true,{"count":374,"type":23},[26],"The aim of this study was to investigate the effectiveness of dual-task exercises combined with robotic rehabilitation applied to post-stroke hemiplegia patients.",[629,29],"Cognitive Coping","2025-07-16",{"date":632,"type":40},"2025-07-20",{"date":634,"type":23},"2025-12-13",{"date":418,"type":23},{"name":637,"class":47},"Uskudar University",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":4,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":18,"minAge":645,"maxAge":646,"enrollmentInfo":647,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":659,"locationsCount":48},"100560582","a-novel-program-using-ride-on-toys-to-improve-upper-extremity-function-in-children-with-hemiplegia-100560582","NCT06579027","A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia","A Novel, Child-friendly, Home-based Navigation Training Program Using Joystick-operated Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia: A Pilot Study","Inclusion Criteria:\n\n* Boys and girls between the ages of 3 - 8 years\n* Diagnosed with hemiplegia by a medical doctor with clear asymmetry in upper extremity strength and control (i.e., one upper limb is clearly weaker than the other)\n* Can maintain a supported sitting position for at least 15 minutes\n\nExclusion Criteria:\n\n* Only lower limb involvement\n* Recent history (within past 6 months) of trauma or surgery or Botox\n* Uncorrected blindness\u002Fprofound visual impairment\n* Fixed deformities at wrist or hand\n* No active control in affected UE\n* Inability to follow 2-step directions\n* Weight \\> 150 lbs.","3 Years","8 Years",{"count":22,"type":23},[26],"The purpose of this study is to assess the feasibility and utility of 2 types of play-based training programs co-delivered by researchers and caregivers within home\u002Fcommunity settings to promote arm function among 3-to-8-year-old children with hemiplegia. Specifically, investigators will assess the feasibility of implementation and acceptance\u002Fsatisfaction associated with a researcher-caregiver co-delivered community-based training program involving either joystick-operated powered ride-on toys (SPEED training) or creative upper extremity training (CRAFT training).\n\nThe investigators will also compare the effects of these 2 types of training programs on children's arm motor function and spontaneous use of their affected arm during daily activities.",[29,651,652],"Cerebral Palsy","Children, Only","2025-06-04",{"date":655,"type":40},"2025-06-05",{"date":657,"type":40},"2024-09-26",{"date":71,"type":23},{"name":660,"class":47},"University of Connecticut",{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":293,"phases":4,"briefSummary":670,"conditions":671,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":676,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":683,"locationsCount":48},"100588798","the-effect-of-upper-extremity-motor-function-trunk-control-and-motor-imagery-ability-on-turkish-language-skills-in-individuals-with-stroke-100588798","NCT06946082","The Effect of Upper Extremity Motor Function, Trunk Control and Motor Imagery Ability on Turkish Language Skills in Individuals With Stroke","It is to Examine the Relationship Between Upper Extremity Motor Function, Trunk Control, Motor Imagery.","Inclusion Criteria:\n\n* 18 years of age or older\n* Stroke onset more than 1 week\n* Not having practiced imagery before\n* Being a native speaker of Turkish\n* Standardized Mini Mental Test (SMMT) Score of 24 and above\n* History of cerebrovascular events\n* Not having any neurological disorder other than stroke\n* The ability to grasp and hold a 2.5 cm cube\n\nExclusion Criteria:\n\n* No consent from the family or person\n* Having had a stroke before\n* Severe hearing or vision loss\n* Individuals are excluded if they have other primary medical conditions that may affect language and motor functions (e.g. brain tumor, Parkinson's disease, severe post-stroke depression, Alzheimer's disease) or have undergone surgery.",{"count":669,"type":23},101,"A large number of people have a stroke each year and it is a major cause of disability worldwide. Upper limb motor impairments, aphasia, body control problems and decreased motor imagery ability are common after stroke. Although there are studies showing that these impairments may be related to each other, there is no comprehensive study examining the relationship between Turkish language skills and these motor functions. The aim of this study was to evaluate the relationship between Turkish language skills and upper extremity motor function, trunk control and motor imagery ability in stroke patients.",[29,672,30,673,674,675],"Aphasia","Trunk","Upper Limbs","Motor Imagery","2025-04-19",{"date":678,"type":40},"2025-04-27",{"date":680,"type":40},"2024-12-10",{"date":682,"type":23},"2025-12-10",{"name":684,"class":47},"Izmir Bakircay University"]