[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemodilution\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemodilution":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631629","hypoxia-and-hemodilution-testing-in-healthy-adult-volunteers-100631629",false,"NCT07503171","Hypoxia and Hemodilution Testing in Healthy Adult Volunteers","Inclusion Criteria:\n\n1. In good general health with no evidence of significant medical problems.\n2. Fluent in both written and spoken English.\n\n4\\. Has provided written informed consent and is willing to comply with study procedures.\n\nExclusion Criteria:\n\n1. BMI above 30.\n2. History of heart, lung, kidney, or liver disease.\n3. Diagnosis of asthma, sleep apnea, or use of CPAP.\n4. Diabetes mellitus.\n5. Clotting disorders.\n6. Hemoglobinopathy or history of anemia (ctHb \\\u003C12 g\u002FdL for men, \\\u003C11 g\u002FdL for women, COHb \\>2%).\n7. Any serious systemic illness.\n8. Current smoker.\n9. Injury or abnormality at sensor sites interfering with measurements.\n10. History of fainting or vasovagal response.\n11. Sensitivity to local anesthesia.\n12. Diagnosis of Raynaud's disease.\n13. Unacceptable collateral circulation (Allen's test).\n14. Pregnant, lactating, or attempting to become pregnant.\n15. Unable or unwilling to provide informed consent or comply with study procedures.\n16. Any other condition deemed unsuitable by the investigator.",true,"ALL","18 Years","35 Years",{"count":20,"type":21},7,"ESTIMATED","1 Week","OBSERVATIONAL","This study will collect physiological measurements in healthy adult volunteers under controlled hypoxia and hemodilution conditions.",[26,27],"Hypoxia","Hemodilution",[29,30],"Pulse oximetry","Hb","NOT_YET_RECRUITING","2026-03-25",{"date":34,"type":35},"2026-03-31","ACTUAL",{"date":37,"type":21},"2026-04-02",{"date":39,"type":21},"2028-01-31",{"name":41,"class":42},"Nihon Kohden","INDUSTRY",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100485858","the-impact-of-intra-operative-fluid-infusion-rate-on-microcirculation-100485858","NCT05606536","The Impact of Intra-operative Fluid Infusion Rate on Microcirculation","The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study","Inclusion Criteria:\n\n* elective recumbent and laparoscopic surgery\n* informed consent\n\nExclusion Criteria:\n\n* blood loss over 250 ml\n* hemodynamic instability requiring noradrenaline infusion",{"count":52,"type":21},80,"INTERVENTIONAL",[55],"NA","Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution.\n\nIsovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.",[58,59,27],"Fluid Therapy","Microcirculation","RECRUITING","2025-03-24",{"date":63,"type":35},"2025-03-27",{"date":65,"type":35},"2022-10-01",{"date":67,"type":21},"2025-12-31",{"name":69,"class":70},"University Hospital Hradec Kralove","OTHER",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":43},"100546790","individualized-anh-for-non-cardiac-surgery-100546790","NCT06399536","Individualized ANH for Non-cardiac Surgery","Individualized Acute Normovolemic Hemodilution for Non-cardiac Surgery With Anticipated High-dose Red Cells Transfusion","Inclusion Criteria:\n\n* Patients undergoing elective non-cardiac surgery with an anticipated red blood cells transfusion \\>8 units (or 1600ml)\n* Aged 18\\~75 years\n* Preoperative Hb level \\> 120g\u002FL for men and \\> 110g\u002FL for women.\n\nExclusion Criteria:\n\n* Refusal of blood transfusion\n* Cardiopulmonary insufficiency\n* Cerebrovascular disease\n* Renal impairment\n* Hemoglobinopathies or blood system diseases\n* Other situations not suitable for inclusion in clinical trial.","75 Years",{"count":80,"type":21},40,[55],"In this trial, we proposed an individualized acute normovolemic hemodilution (ANH), and conduct a randomized controlled trial to testify the effect of individualized ANH on red cells requirement for non-cardiac surgeries with anticipating major blood loss in adults.",[84,27],"Transfusion Related Complication",[86,87,88],"acute normovolemic hemodilution","individualized blood transfusion","clinical trial","2024-12-01",{"date":91,"type":35},"2024-12-04",{"date":93,"type":35},"2024-06-01",{"date":95,"type":21},"2026-12-31",{"name":97,"class":70},"West China Hospital"]