[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemodynamic-assessment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemodynamic-assessment":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641384","hemodynamic-effects-of-norepinephrine-reduction-on-critical-closing-pressure-in-distributive-shock-100641384",false,"NCT07653659","Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock","Changes in Critical Closing Pressure and Derived Hemodynamic Parameters Following Norepinephrine Dose Reduction in Distributive Shock Patients: a Prospective Observational Study","Inclusion Criteria:\n\n1. Adult distributive shock patients aged ≥18 years;\n2. Receiving norepinephrine infusion with MAP in the 75-85 mmHg range;\n3. PiCCO catheter in situ;\n4. Under mechanical ventilation;\n5. Clinically indicated norepinephrine dose reduction per attending physician judgment.\n\nExclusion Criteria:\n\n1. Significant cardiac arrhythmia affecting CO measurement reliability;\n2. Contraindication to airway plateau pressure maneuver;\n3. Active titration of other vasoactive agents within 30 minutes prior to measurement;\n4. Hemodynamic instability making it impossible to reduce norepinephrine dose.","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.",[24,25,26],"Distributive Shock","Hemodynamic Assessment","Critical Illness",[28,29,30,31,32],"Critical closing pressure","Tissue perfusion pressure","Vascular waterfall","Norepinephrine dose","Distributive shock","RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-17","ACTUAL",{"date":39,"type":37},"2025-09-01",{"date":41,"type":20},"2027-09-01",{"name":43,"class":44},"Peking Union Medical College Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100638301","assessment-of-lvot-vti-in-healthy-volunteers-100638301","NCT07600931","Assessment of LVOT VTI in Healthy Volunteers","Reproducibility, Intra- and Inter-Observer Variability of Bedside Cardiac Ultrasound Measurements in the Assessment of Hemodynamic Parameters in Healthy Volunteers","Inclusion Criteria:\n\n* Age \\> 18 years,\n* Medical student at Medical University of Warsaw or licensed physician.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years,\n* Prior experience in performing cardiac ultrasound examinations, including acquisition of apical five- and three-chamber views and Doppler measurements of LVOT VTI.",true,{"count":19,"type":20},"Healthy subjects will have transthoracic echocardiography evaluation of Left Ventricular Outflow Tract Velocity-Time Integral (LVOT VTI) performed by operators after brief training.",[25,57,58],"Bedside Ultrasonography","Point of Care Ultrasound (POCUS)",[25,60,57,61,62],"Velocity-Time Integral","Point of care ultrasound","Critical care","2026-05-14",{"date":65,"type":37},"2026-05-22",{"date":67,"type":20},"2026-05-11",{"date":69,"type":20},"2027-01",{"name":71,"class":44},"Medical University of Warsaw"]