[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemodynamic-instability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemodynamic-instability":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,47,85,113,146,171,193,219,253,283,309,347,384,405,435,462,487,508,539,565,586,615,641,666,691],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100634317","advanced-vs-standard-hemodynamic-monitoring-during-propofol-sedation-for-ercp-a-prospective-study-100634317",false,"NCT07538115","Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study","Comparison of Advanced Hemodynamic Monitoring With Standard Monitoring During Propofol Sedation for Endoscopic Retrograde Cholangiopancreatography Procedures: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Patients with an ASA physical status score of III or higher scheduled for ERCP\n* Patients maintaining spontaneous respiration\n* Patients who have provided written informed consent\n\nExclusion Criteria:\n\n* Patients requiring general anesthesia\n* Patients requiring mechanical ventilation\n* Patients unsuitable for arterial catheterization due to coagulopathy or local infection\n* Pregnant women\n* Patients who do not sign the informed consent form","ALL","18 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with standard monitoring alone during propofol sedation for ERCP procedures.",[27],"Hemodynamic Instability",[29,30,31,32,33],"Advenced hemodynamic Monitorization","ERCP","Sedation","Propofol","Non-operating room anesthesia","RECRUITING","2026-06-19",{"date":37,"type":38},"2026-06-24","ACTUAL",{"date":40,"type":38},"2026-03-27",{"date":42,"type":21},"2026-07-15",{"name":44,"class":45},"Hitit University","OTHER",1,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100641345","papaverine-and-sublingual-microcirculation-in-septic-shock-100641345","NCT07657741","Papaverine and Sublingual Microcirculation in Septic Shock","Effects of Papaverine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock: A Prospective, Multicenter, Single-arm, Open-label, Pilot Physiological Study","Inclusion Criteria:\n\n* Age 18-85 years.\n* Septic shock according to Sepsis-3 criteria, defined as suspected or documented infection requiring vasopressors to maintain mean arterial pressure ≥65 mmHg and serum lactate \\>2 mmol\u002FL after adequate fluid resuscitation.\n* Enrollment within 24 hours after diagnosis of septic shock in the ICU.\n* Receiving continuous norepinephrine infusion at enrollment.\n* Receiving invasive mechanical ventilation at enrollment, allowing assessment of vascular waterfall-related hemodynamic variables.\n* PiCCO-based hemodynamic monitoring, invasive arterial pressure monitoring, and central venous access available before papaverine administration.\n* Ability to obtain sublingual microcirculatory images of acceptable quality at baseline.\n* Written informed consent obtained from the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Shock primarily caused by non-septic etiologies, including cardiogenic, hypovolemic, obstructive, hemorrhagic, or anaphylactic shock.\n* Expected death or planned withdrawal of life-sustaining treatment within 24 hours.\n* Known allergy or hypersensitivity to papaverine.\n* Severe hemodynamic instability judged unsuitable for papaverine by the treating physician, including refractory hypotension or rapidly escalating vasopressor requirement.\n* Clinically significant arrhythmia, high-grade atrioventricular block, acute coronary syndrome, or active myocardial ischemia before enrollment.\n* Severe hepatic dysfunction judged by the investigator to substantially increase the risk of papaverine-related adverse effects.\n* Conditions preventing reliable sublingual microcirculatory assessment, including major oral or sublingual lesions, active oral bleeding, inability to access the sublingual area, or poor baseline image quality.\n* Pregnancy or lactation.\n* Participation in another interventional clinical trial that may affect study outcomes or safety.","85 Years",{"count":56,"type":21},20,[24],"This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult patients with septic shock.\n\nEligible patients will have septic shock according to Sepsis-3 criteria, require norepinephrine support after adequate fluid resuscitation, and have PiCCO-based hemodynamic monitoring available before papaverine administration. Papaverine will be administered as an intravenous infusion of 30 mg over 10 minutes, followed by a continuous infusion of 2-5 mg\u002Fhour. Sublingual microcirculatory variables, vascular-waterfall-related indices, PiCCO-derived hemodynamic variables, macrocirculatory parameters, tissue perfusion variables, vasopressor dose, and safety outcomes will be assessed before and after papaverine administration.\n\nThe study aims to explore whether papaverine can improve microvascular perfusion and reduce microcirculatory flow impairment in septic shock, and to provide preliminary physiological and safety data for future controlled trials.",[60,61,62,27],"Septic Shock","Microcirculatory Dysfunction","Sublingual Microcirculation",[64,65,66,67,68,69,70,71,72,73],"Septic shock","Papaverine","Sublingual microcirculation","Microcirculatory dysfunction","Vascular waterfall phenomenon","Critical closing pressure","Perfused vessel density","Microvascular flow index","Proportion of perfused vessels","Pilot physiological study","NOT_YET_RECRUITING","2026-06-14",{"date":77,"type":38},"2026-06-18",{"date":79,"type":21},"2026-08-01",{"date":81,"type":21},"2027-12-30",{"name":83,"class":45},"First Affiliated Hospital of Wannan Medical College",2,{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":46},"100453484","respiratory-variation-of-carotid-doppler-peak-velocity-cdpv-for-non-invasive-prediction-of-fluid-responsiveness-100453484","NCT05185141","Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness","Assessing Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness During Abdominal Surgery: a Prospective Observational Trial","Inclusion Criteria:\n\n* Age 18-80 years\n* written informed consent\n* scheduled major abdominal surgery\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>80 years\n* pregnancy\n* SIRS or sepsis\n* any kind of cardiac arrhythmia\n* known valve disease\n* known heart failure\n* any kind of known carotid stenosis\n* carotid doppler peak velocity \\>182 cm\u002Fs before baseline measurement (expected stenosis)\n* missing indication for invasive arterial blood pressure monitoring (IBP) not related to the study\n* peripheral artery disease (PAD)\n* BMI \\> 35 kg\u002Fm2\n* intraabdominal hypertension\n* ASA-PSC of 4\n* severe lung disease (e.g. COPD grade 3, fibrosis)\n* esophageal disease of any kind\n* participation in another clinical study","80 Years",{"count":94,"type":21},84,"OBSERVATIONAL","The purpose of this study is to assess respiratory variation of carotid doppler peak velocity (∆CDPV) for prediction of fluid responsiveness during major abdominal surgery.",[27],[99,100,101,102,103],"Fluid Responsiveness","Hemodynamic Monitoring","Carotid Doppler Peak Velocity","Pulse Pressure Variation","Fluid Challenge","2026-06-09",{"date":106,"type":38},"2026-06-10",{"date":108,"type":38},"2022-01-11",{"date":110,"type":21},"2026-07",{"name":112,"class":45},"Johannes Gutenberg University Mainz",{"id":114,"slug":115,"hasResults":12,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":123,"conditions":124,"keywords":129,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":46},"100640925","peripheral-pulse-assessment-and-arterial-pressure-pulsar-100640925","NCT07609095","Peripheral pULSe Assessment and Arterial pRessure (PULSAR)","Association Between Palpable Peripheral Pulses and Arterial Blood Pressure in Patients With Circulatory Shock: An International Prospective Multicenter Observational Cohort Study","PULSAR","Inclusion Criteria:\n\n* Clinical signs of circulatory shock or impending circulatory failure\n* Availability of non-invasive and\u002For invasive arterial blood pressure monitoring\n* Pulse palpation possible without interfering with emergency care\n\nExclusion Criteria:\n\n* Peripheral vascular conditions preventing reliable pulse palpation\n* Major extremity amputation affecting assessment sites\n* Clinical situations where study procedures interfere with life-saving treatment",{"count":122,"type":21},5000,"This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure. Peripheral pulse palpation is routinely used in emergency medicine, trauma care, critical care, and cardiopulmonary resuscitation as a rapid clinical assessment of circulation. However, the association between palpable pulses and actual arterial blood pressure remains poorly validated.\n\nPatients treated in emergency departments, intensive care units, operating rooms, and other acute care settings will undergo routine pulse palpation at predefined anatomical locations including carotid, femoral, and radial arteries. Simultaneously measured non-invasive and\u002For invasive arterial blood pressure values will be recorded from routine clinical monitoring systems. Additional clinical variables relevant to circulatory status will also be collected.\n\nThe study seeks to define blood pressure thresholds associated with pulse palpability and evaluate the agreement between invasive and non-invasive blood pressure measurements in patients with circulatory shock.",[125,27,126,127,128],"Circulatory Shock","Hypotension","Shock","Critical Illness",[125,100,130,131,132,126,133,134,135,27],"Pulse Palpation","Peripheral Pulse","Arterial Blood Pressure","Critical Care","Trauma","Resuscitation","2026-05-19",{"date":138,"type":38},"2026-05-27",{"date":140,"type":21},"2026-06-01",{"date":142,"type":21},"2031-12-31",{"name":144,"class":145},"Region Stockholm","OTHER_GOV",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":12,"sex":154,"minAge":18,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":46},"100598398","proactive-hemodynamic-management-during-cytoreductive-surgery-and-hipec-100598398","NCT07070973","Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC","HEMOdynamic Proactive Management During Cytoreductive Surgery and Intraperitoneal hyPErthermic Chemotherapy for Advanced Ovarian Cancer","HEMOPEC","Inclusion Criteria:\n\n* age \\> 18 years\n* patient scheduled for CRS for ovarian cancer\n\nExclusion Criteria:\n\n* patients' refusal\n* cardiac arrythmia\n* pregnancy.","FEMALE",{"count":156,"type":21},52,[24],"Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex surgical procedure carried out through laparotomic approach. After CRS-HIPEC morbidity and mortality rates go up to 20%-40% and 3% respectively, and acute kidney injury and pulmonary effusion\u002Foedema are the most frequent postoperative complications.\n\nIntraoperative hypotension and risk of fluid overload are common. Efficient and accurate control of arterial pressure and cardiac output is a major concern during CRS-HIPEC.\n\nThe aim of this study is to perform a pilot study describing a hemodynamic management protocol based on artificial intelligence - derived parameters, that allows to implement the standard goal directed therapy (GDT) protocol in term of amount of IOH and stroke volume (SV) optimization.\n\nSpecifically, this study aims to test the hypotheses that a hemodynamic protocol based on HPI-AFM monitoring compared to standard GDT helps clinicians reduce IOH during surgery and improve the time \"in-target\" range of SV index.\n\nThe study cohort will be compared to an historical cohort of 50 patients underwent to CRS-HIPEC between 2022 and 2024, managed with an institutional goal directed therapy protocol.",[160,27,161],"Ovarian Cancer","Fluid Overload","2026-05-06",{"date":164,"type":38},"2026-05-11",{"date":166,"type":38},"2025-09-01",{"date":168,"type":21},"2027-02-01",{"name":170,"class":45},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":179,"targetDuration":181,"studyType":95,"phases":4,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":189,"leadSponsor":191,"locationsCount":46},"100635002","hemodynamic-profiles-and-macro-microcirculatory-coherence-in-liver-transplantation-an-integrative-approach-in-the-immediate-postoperative-period-100635002","NCT07547020","Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: an Integrative Approach in the Immediate Postoperative Period","Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: An Integrative Approach to the Immediate Postoperative Period","COHERENCE-LT","Inclusion Criteria: Consecutive adult patients (≥18 years) admitted to the intensive care unit in the immediate postoperative period following liver transplantation with hemodynamic instability.\n\n\\-\n\nExclusion Criteria: Primary graft failure.\n\n\\-",{"count":180,"type":21},60,"30 Days","Hemodynamic instability is a common and serious condition in patients undergoing liver transplantation and is associated with increased morbidity and mortality if not promptly recognized and treated. It results from multiple interacting factors, including blood loss, changes in vascular tone, cardiac dysfunction, and complications related to the surgical procedure.\n\nTraditional monitoring strategies focus on global hemodynamic variables such as blood pressure and cardiac output. However, these parameters may not accurately reflect tissue perfusion or oxygen delivery at the microcirculatory level. As a result, patients may appear hemodynamically stable while still experiencing inadequate tissue oxygenation.\n\nThis study aims to evaluate hemodynamic instability using an integrative physiological approach based on the interaction between different components of the cardiovascular system. Specifically, the study will assess four key interfaces: the relationship between the heart and the arterial system, the coherence between macrocirculation and microcirculation, the interaction between venous return and the right atrium, and the coupling between the right ventricle and the pulmonary circulation.\n\nThe main objective is to identify distinct hemodynamic profiles in patients during the immediate postoperative period following liver transplantation. In addition, the study will evaluate the incidence of tissue hypoxia within the first 24 hours and its association with clinical outcomes, including 30-day evolution.\n\nThis is a prospective observational study conducted in adult patients admitted to the intensive care unit after liver transplantation who develop hemodynamic instability requiring vasoactive support. During the first 24 hours, multimodal hemodynamic monitoring will be performed, including assessment of cardiac function, vascular tone, venous congestion, pulmonary circulation, and markers of tissue perfusion such as lactate levels and capillary refill time.\n\nBy integrating these variables, patients will be classified into different hemodynamic profiles according to the predominant underlying mechanism. This approach aims to improve the understanding of cardiovascular dysfunction in this setting and to support more individualized and physiologically guided management strategies.",[184,127,27],"Liver Transplantation","2026-04-27",{"date":187,"type":38},"2026-05-01",{"date":187,"type":21},{"date":190,"type":21},"2027-09-01",{"name":192,"class":45},"Hospital El Cruce",{"id":194,"slug":195,"hasResults":12,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":200,"sex":17,"minAge":201,"maxAge":18,"enrollmentInfo":202,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":46},"100531096","individual-cerebral-hemodynamic-oxygenation-relationships-ichor-1-100531096","NCT06195345","Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)","ICHOR 1","Inclusion Criteria:\n\n* Individuals who are able to tolerate an MRI.\n* Are patients scheduled for a clinically indicated MRI.\n* Between birth and up to 18 years.\n\nExclusion Criteria:\n\n* Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.\n* Preterm infants less than 25 weeks\n* Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.",true,"1 Minute",{"count":203,"type":21},1000,"This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.",[206,207,208,27,209],"HIE","TBI (Traumatic Brain Injury)","TBI","Hypoxic-Ischemic Encephalopathy","2026-04-24",{"date":212,"type":38},"2026-04-29",{"date":214,"type":38},"2018-11-01",{"date":216,"type":21},"2035-11-01",{"name":218,"class":45},"Children's Hospital Los Angeles",{"id":220,"slug":221,"hasResults":12,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":17,"minAge":227,"maxAge":92,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":237,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":46},"100611866","non-invasive-blood-pressure-monitoring-in-intracranial-aneurysm-embolization-100611866","NCT07246148","NOn-inVAsive Blood Pressure Monitoring in Intracranial Aneurysm Embolization","A Randomized Controlled Trial on Non-Invasive Continuous Blood Pressure Monitoring as an Alternative to Radial Arterial Catheterization in Patients Undergoing Coil Embolization for Intracranial Aneurysms","NOVA","Inclusion Criteria:\n\n* Adult patients (≥19 and ≤80 years old) scheduled for elective coil embolization of unruptured intracranial aneurysms under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n\nExclusion Criteria:\n\n* Patients who do not provide informed consent.\n* Patients unable to understand or follow study instructions due to physical or mental limitations.\n* Patients in whom radial arterial catheterization is not feasible (e.g., peripheral vascular disease, skin disorders at the insertion site, absence of radial\u002Fulnar artery, or orthopedic conditions of the upper extremity).\n* Patients with peripheral vascular circulatory disorders.\n* Patients with morbid obesity (BMI ≥ 40 kg\u002Fm²) \\[Eley et al., 2021\\].\n* Patients who are hemodynamically unstable preoperatively or expected to be unstable during the perioperative period.","19 Years",{"count":229,"type":21},50,[24],"The goal of this clinical trial is to evaluate whether non-invasive continuous blood pressure monitoring (NVBP) using the ClearSight system can safely serve as an alternative to radial arterial catheterization for invasive arterial blood pressure monitoring (IABP) in patients undergoing coil embolization for unruptured intracranial aneurysms.\n\nThe main questions it aims to answer are:\n\n* Does NVBP monitoring detect intraoperative hypotension and hypertension events with similar reliability compared to IABP?\n* Does NVBP monitoring reduce the need for invasive arterial catheterization without compromising patient safety or clinical outcomes?\n\nResearchers will compare patients assigned to NVBP monitoring with those receiving conventional IABP monitoring.\n\nParticipants will:\n\n* Be randomly assigned to NVBP monitoring or standard IABP monitoring during coil embolization.\n* Receive continuous monitoring of cerebral oxygenation with near-infrared spectroscopy (rSO₂).\n* Undergo standard anesthesia induction, maintenance, and postoperative intensive care protocols.\n* Have their intraoperative hemodynamic events, vasopressor use, and postoperative outcomes recorded up to 30 days after the procedure.",[233,234,235,27,236],"Cerebral Aneurysms","Intracranial Aneurysms","Coil Embolization","Noninvasive Cardiac Monitoring",[238,239,240,241,242,243],"non-invasive blood pressure monitoring","continuous arterial blood pressure monitoring","coil embolization","neuroanesthesia","cerebral oximetry","radial arterial catheterization","2026-04-06",{"date":246,"type":38},"2026-04-09",{"date":248,"type":38},"2026-01-01",{"date":250,"type":21},"2027-08-31",{"name":252,"class":45},"Korea University Anam Hospital",{"id":254,"slug":255,"hasResults":12,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":260,"enrollmentInfo":261,"targetDuration":263,"studyType":95,"phases":4,"briefSummary":264,"conditions":265,"keywords":269,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100632637","prospective-cohort-study-of-pheochromocytomaparaganglioma-100632637","NCT07516275","Prospective Cohort Study of Pheochromocytoma\u002FParaganglioma","Validation and Extension Study of the Predictive Model for Intraoperative Hemodynamic Instability in Pheochromocytoma\u002FParaganglioma Resection - a Single-center, Prospective, Observational Cohort Study","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Diagnosed with pheochromocytoma\u002Fparaganglioma by imaging and laboratory tests and scheduled for elective resection.\n* Planned intraoperative continuous invasive arterial pressure monitoring.\n* Willing and able to provide written informed consent.\n* Able to comply with preoperative CGM monitoring, AI agent assessment, and postoperative follow-up.\n\nExclusion Criteria:\n\n* Intraoperative hemodynamic data missing ≥20%.\n* Postoperative histopathology excludes PPGL diagnosis.\n* Cardiac paraganglioma or metastatic PPGL.\n* Severe cardiac disease (e.g., severe valvular disease, severe heart failure) that could independently cause intraoperative HDI.\n* Pregnancy or breastfeeding.\n* Mental illness, cognitive impairment, or communication barriers that prevent compliance with study procedures.\n* Refusal to undergo CGM monitoring or AI agent assessment.\n* Major illness (e.g., acute myocardial infarction, stroke, severe infection) within 3 months prior to surgery.\n* Severe hepatic or renal insufficiency (Child-Pugh class C, eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²).","99 Years",{"count":262,"type":21},200,"6 Weeks","The study will enroll patients scheduled for PPGL removal surgery at Peking Union Medical College Hospital. Before surgery, researchers will use a 6-variable model to predict the patient's risk of experiencing severe blood pressure swings during the operation. During surgery, a real-time early warning tool will be tested for its ability to accurately predict blood pressure changes 60 seconds in advance. The study will also explore the value of continuous glucose monitoring (CGM) in understanding blood pressure fluctuations and evaluate the performance of an artificial intelligence (AI) agent for preoperative anesthesia assessment, comparing its accuracy, consistency, and efficiency against that of human anesthesiologists.\n\nParticipation involves no changes to the patient's standard surgical or medical care. It includes collecting clinical data, wearing a CGM sensor from the day before to the day after surgery, and having the preoperative assessment performed by both the AI agent and anesthesiologists.",[266,267,27,268],"Pheochromocytoma","Paraganglioma","Intraoperative Complications",[266,267,27,270,271,272,273],"Predictive Model","Artificial Intelligence","Continuous Glucose Monitoring","Prospective Cohort","2026-04-02",{"date":276,"type":38},"2026-04-07",{"date":278,"type":21},"2026-04",{"date":280,"type":21},"2028-02",{"name":282,"class":45},"Peking Union Medical College Hospital",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":304,"completionDateStruct":305,"leadSponsor":307,"locationsCount":84},"100602451","ai-assisted-blood-pressure-control-during-anesthesia-100602451","NCT07123675","AI-Assisted Blood Pressure Control During Anesthesia","A Dual-Center, Randomized, Controlled, Proof-of-Concept Trial to Evaluate an AI-Based Decision Support System for Intraoperative Blood Pressure Management","RL-PRAIS PoC","Inclusion Criteria:\n\n* Age 18 to 85 years\n* Scheduled for elective non-cardiac surgery\n* Receiving intravenous-inhalation combined general anesthesia with tracheal intubation\n* ASA physical status I to IV\n* Anesthesia maintenance plan includes propofol for continuous sedation, remifentanil for continuous analgesia, and sevoflurane or desflurane for inhalation anesthesia\n* Continuous invasive arterial blood pressure monitoring during surgery\n* Continuous monitoring of heart rate and Bispectral Index (BIS) during surgery\n* Expected surgical duration of at least 2 hours\n\nExclusion Criteria:\n\n* Emergency surgery\n* Continuous infusion of remifentanil or propofol for less than 30 minutes during surgery\n* Receiving continuous intravenous sedatives other than propofol during the maintenance phase\n* Receiving continuous intravenous analgesics other than remifentanil during the maintenance phase\n* Inhaled anesthetic maintenance concentration not equal to 0.5 MAC\n* Known allergy to propofol or remifentanil\n* Severe obesity (BMI \\>= 35 kg\u002Fm2)\n* Severe cardiovascular disease (NYHA class IV heart failure, unstable angina, or recent myocardial infarction within 30 days)\n* Participation in another interventional clinical trial within 30 days",{"count":292,"type":21},40,[24],"This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.\n\nBackground: Intraoperative hypotension is common during general anesthesia and is associated with adverse outcomes including acute kidney injury, myocardial injury, and increased mortality. Current hemodynamic management relies on the individual anesthesiologist's clinical judgment, which can vary in consistency and timeliness. An RL-based system that learns optimal vasoactive agent dosing strategies from clinical data may help standardize and improve real-time hemodynamic decision-making.\n\nPurpose: The primary objective is to evaluate whether the RL-based decision support system can learn intraoperative hemodynamic management decisions comparable to those of experienced anesthesiologists, as measured by the mean absolute error (MAE) between RL-recommended and clinician-executed vasoactive agent doses. The secondary objective is to assess whether RL-guided management improves clinical hemodynamic outcomes, including the time-weighted average of hypotension and the percentage of time with mean arterial pressure within the target range.\n\nParticipants: Adult patients (aged 18 to 85 years, ASA I-IV) scheduled for elective non-cardiac surgery under general anesthesia with continuous invasive arterial blood pressure monitoring.\n\nProcedures: Participants will be randomly assigned (1:1) to one of two groups. In the RL-guided group, the anesthesiologist will receive real-time vasoactive agent dosing recommendations from the decision support system displayed on a bedside screen; the anesthesiologist retains full clinical autonomy over all final decisions. In the standard care group, the anesthesiologist will manage hemodynamics according to institutional standard practice without input from the system. The patient and the outcomes assessor will be masked to group assignment. Data collection covers the intraoperative period and 30-day postoperative follow-up.",[296,27],"Intraoperative Hypotension",[298,299,300,271,301],"Reinforcement Learning","Clinical Decision Support System","Depth of Anesthesia","Vasoactive Agent Dosing","2026-04-01",{"date":244,"type":38},{"date":140,"type":21},{"date":306,"type":21},"2027-12-15",{"name":308,"class":45},"Beijing Tsinghua Chang Gung Hospital",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":154,"minAge":18,"maxAge":317,"enrollmentInfo":318,"targetDuration":4,"studyType":22,"phases":320,"briefSummary":321,"conditions":322,"keywords":325,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":340,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":46},"100630998","effect-of-pre-spinal-mindfulness-based-breathing-exercise-on-hemodynamic-response-in-elective-cesarean-section-100630998","NCT07494955","\"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section\"","\"The Effect of a 5-Minute Mindfulness-Based Breathing Exercise Administered Prior to Spinal Anesthesia on Hemodynamic Response in Patients Undergoing Elective Cesarean Section: A Prospective Randomized Controlled Trial\"","BREATHE-CS","Inclusion Criteria:\n\nPregnant women aged 18-45 years Singleton pregnancy Gestational age 37 weeks or greater American Society of Anesthesiologists (ASA) physical status classification II Scheduled for elective cesarean section under spinal anesthesia Body mass index (BMI) 35 kg\u002Fm2 or less Ability to comprehend verbal instructions and perform the breathing exercise Provision of written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, HELLP syndrome) Placenta previa, placental abruption, or active antepartum hemorrhage Multiple pregnancy Contraindications to spinal anesthesia Failed spinal anesthesia requiring conversion to general anesthesia Chronic hypertension or chronic hypotension Known cardiac disease (arrhythmia, valvular disease, cardiomyopathy) Diabetes mellitus with autonomic neuropathy Thyroid dysfunction Chronic pulmonary disease potentially affecting respiratory pattern Body mass index greater than 35 kg\u002Fm2 Regular use of beta-blockers, calcium channel blockers, alpha-agonists, or alpha-antagonists Regular use of anxiolytics, antidepressants, sedatives, or chronic opioids Diagnosed anxiety disorder, panic disorder, major depressive disorder, or other psychiatric illness Regular use of psychiatric medications Cognitive impairment or communication difficulties Attention or compliance problems precluding adequate performance of the breathing exercise Prior regular practice of meditation, yoga, or mindfulness-based training","45 Years",{"count":319,"type":21},150,[24],"Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section. Preoperative anxiety has been shown to potentiate hemodynamic instability through autonomic nervous system activation, thereby increasing susceptibility to spinal hypotension.\n\nThis prospective, randomized, controlled trial aims to evaluate the effect of a standardized 5-minute mindfulness-based breathing exercise administered immediately prior to spinal anesthesia on the hemodynamic response in pregnant women scheduled for elective cesarean section. Eligible participants will be randomized in a 1:1 ratio into two parallel groups: the Mindfulness-Based Breathing Exercise Group and the Control Group receiving standard preoperative care.\n\nThe breathing intervention consists of slow diaphragmatic breathing at a rate of approximately 6 breaths per minute (4-second inhalation through the nose, 6-second exhalation through the mouth), guided by a standardized script delivered by a trained anesthesiologist or nurse. Participants in the intervention group will be instructed to silently repeat the phrase \"My body is relaxing as I exhale\" with each exhalation, incorporating a mindfulness component.\n\nThe primary outcome is the maximum decrease in systolic arterial pressure (SAP) within the first 10 minutes following spinal anesthesia induction. Secondary outcomes include preoperative state anxiety scores (STAI-5), early spinal hypotension incidence, heart rate changes, and vasopressor requirements.\n\nThe study will be conducted at Atatürk University Faculty of Medicine, Department of Anesthesiology and Reanimation, Erzurum, Turkey, in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines.",[126,323,27,324],"Cesarean Section","Anxiety, Anticipatory",[326,126,327,328,329,330,331,332,333,334,335,336,337,338,339],"Spinal anesthesia","Cesarean section","Mindfulness","Breathing exercise","Hemodynamic response","Preoperative anxiety","Autonomic nervous system","Obstetric anesthesia","Vasopressor","Systolic blood pressure","Heart rate variability","Non-pharmacological intervention","Randomized controlled trial","Baroreflex sensitivity",{"date":302,"type":38},{"date":342,"type":38},"2026-03-01",{"date":344,"type":21},"2028-03-01",{"name":346,"class":45},"Aysenur Dostbil",{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":17,"minAge":354,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":357,"briefSummary":358,"conditions":359,"keywords":367,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":382,"locationsCount":46},"100622407","effect-of-electrical-stimulation-and-exercise-on-blood-flow-in-patients-with-resistant-high-blood-pressure-100622407","NCT07383220","Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure","Effect of Combined Transcutaneous Electrical Stimulation and Isometric Exercise on Peripheral Hemodynamic Parameters in Patients With Resistant Hypertension","Inclusion Criteria:\n\n* Age between 50 and 60 years. Both sexes were included Patients had been diagnosed with hypertension for at least 5 years.\n\nPatients had resistant hypertension according to (Whelton et al 2018), defined as:\n\n* Systolic blood pressure (SBP) ≥140 mmHg and\u002For diastolic blood pressure (DBP) ≥90 mmHg despite the use of three or more antihypertensive medications of different classes, including a diuretic,\n* or controlled blood pressure (\\\u003C140\u002F90 mmHg) while on four or more antihypertensive medications.\n\nBody Mass Index (BMI) 25: 34.9 kg\u002Fm²\n\nIncreased waist circumference, defined as:\n\n* Greater than 102 cm for males.\n* Greater than 88 cm for females.\n\nExclusion Criteria:\n\n* Secondary hypertension due to identifiable causes (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma).\n* History of major cardiovascular events in the last 6 months (e.g., myocardial infarction, stroke, or heart failure exacerbation).\n* Severe musculoskeletal or neurological disorders that impair the ability to perform isometric exercise safely (e.g., recent joint replacement, severe osteoarthritis, stroke with residual motor deficit).\n* Contraindications to the use of Transcutaneous Electrical Nerve Stimulation (TENS):\n\nImplanted electronic devices: pacemakers, cardioverter defibrillators. Uncontrolled arrhythmias. Sever skin condition: open wounds, rashes, burns, eczema. Peripheral neuropathy or sensory loss.\n\n-Known cognitive impairment or psychiatric conditions that would limit the ability to follow instructions or provide informed consent.","50 Years","60 Years",{"count":229,"type":21},[24],"The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered from resistant hypertension which is a type of hypertension where blood pressure remains above your target goal despite the use of three or more different classes of antihypertensive medications at their maximum tolerated doses. The main question to answer is:\n\nIs there a significant effect on the combined use of TENS and IE on peripheral hemodynamic parameters in patients with resistant hypertension? Total sample will be 50 patients from both sexes\n\nI will compare between two groups:\n\nExperimental group (15 men, 10 women) will take: medication plus IE and TENS Control group (15 men, 10 women) will take: medication plus Conventional Physical Therapy Program",[360,27,361,362,363,364,365,366],"Resistant Hypertension","Essential (Primary) Hypertension","Abdominal Obesity","Metabolic Syndrome","Hypertension (HTN)","Vascular Resistance","High Blood Pressure",[368,369,370,371,372,373,374,375],"Mean Arterial Pressure","Peripheral Hemodynamics","Physical Therapy","Long Term Hypertension","Resistant HTN","Systolic Blood Pressure (SBP)","Diastolic Blood Pressure (DBP)","Heart Rate Variability (HRV)","2026-01-28",{"date":378,"type":38},"2026-02-03",{"date":380,"type":21},"2026-01-15",{"date":106,"type":21},{"name":383,"class":45},"Mohamed Mohamed Ali Morgan",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":200,"sex":17,"minAge":391,"maxAge":317,"enrollmentInfo":392,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":46},"100331210","hemodynamics-monitoring-during-lower-body-negative-pressure-lbnp-induced-controlled-hypovolemia-100331210","NCT03592290","Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia","LBPN","Inclusion Criteria:\n\n\\* Healthy volunteers aged 20-45 with\n\nExclusion Criteria:\n\n* Pregnant women\n* Under 20 years of age\n* Subjects with coronary artery disease, diabetes, epilepsy and hypertension","20 Years",{"count":393,"type":21},120,"To monitor the changes in central and peripheral monitors\u002Fwaveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.",[396,27],"Hypovolemia",{"date":398,"type":38},"2026-01-20",{"date":400,"type":38},"2017-11-15",{"date":402,"type":21},"2027-01",{"name":404,"class":45},"Yale University",{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":411,"eligibilityCriteria":412,"healthyVolunteers":200,"sex":154,"minAge":413,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":22,"phases":417,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":46},"100620587","lidocaine-vs-magnesium-sulfate-for-hemodynamic-stability-during-emergence-in-infertility-related-laparoscopic-surgery-100620587","NCT07359560","Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery\"","Intravenous Lidocaine Versus Magnesium Sulfate for Hemodynamic Stability During Emergence From General Anesthesia in Infertility-related Laparoscopic Gynecologic Surgeries","LidoMagGyna","Inclusion Criteria:\n\nFemale patients aged 21 to 40 years\n\nBody mass index (BMI) between 18.5 and 29 kg\u002Fm²\n\nAmerican Society of Anesthesiologists (ASA) physical status I or II\n\nScheduled for elective infertility-related laparoscopic gynecologic surgery (e.g., diagnostic laparoscopy, ovarian cystectomy, adhesiolysis) under general anesthesia\n\nExpected duration of anesthesia less than 2 hours\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nKnown allergy or contraindication to lidocaine or magnesium sulfate\n\nHistory of significant cardiac, renal, or hepatic disease\n\nChronic use of analgesics or history of drug dependence\n\nHistory of myasthenia gravis\n\nPregnancy or positive serum β-hCG test\n\n\\-","21 Years","40 Years",{"count":416,"type":21},69,[24],"This study is being conducted to compare two medications, intravenous lidocaine and intravenous magnesium sulfate, and their ability to keep blood pressure and heart rate stable during the period of waking up from general anesthesia in infertility-related laparoscopic gynecologic surgeries.\n\nLaparoscopic gynecologic procedures can cause changes in heart rate and blood pressure, especially during emergence from anesthesia, and these changes may affect patient safety.\n\nIn this randomized, double-blind clinical trial, women scheduled for elective infertility-related laparoscopic surgery will be assigned to one of three groups: lidocaine, magnesium sulfate, or a control group. The study will evaluate mean arterial pressure (primary outcome), heart rate, pain scores, sedation level, nausea and vomiting, and any side effects during and after surgery.\n\nThe goal is to determine which medication provides better hemodynamic stability and improves recovery in the early postoperative period.",[420,27],"Infertility Female",[422,423,424,425],"lidocaine magnisium","hemodynamic instability","infertility female","laparoscopic surgery","2026-01-13",{"date":428,"type":38},"2026-01-22",{"date":430,"type":21},"2026-01-02",{"date":432,"type":21},"2026-07-02",{"name":434,"class":145},"Zagazig University",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":443,"targetDuration":444,"studyType":95,"phases":4,"briefSummary":445,"conditions":446,"keywords":450,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":460,"locationsCount":46},"100437150","resuscitative-tee-collaborative-registry-100437150","NCT04972526","Resuscitative TEE Collaborative Registry","Evaluation of the Clinical Impact and Safety of Focused Transesophageal Echocardiography During Resuscitation of Critically Ill Patients in the Emergency Department and Intensive Care Settings","rTEECoRe","Inclusion Criteria:\n\n* Adult critically-ill patients who as part of their routine clinical care receive focused TEE in the emergency department of intensive care setting.\n\nExclusion Criteria:\n\n* Children (age under 18 years)\n* Vulnerable populations",{"count":203,"type":21},"1 Month","The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused TEE.\n\nThe primary objective of this study is to determine the clinical impact and safety of TEE performed during the evaluation of critically-ill patients in the emergency department and intensive care settings.\n\nThe secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.",[447,448,449,127,27],"Cardiac Arrest","Cardiac Arrest Circulatory","Cardiac Arrest, Out-Of-Hospital",[451,135,447,452,453],"Transesophageal Echocardiography","Point-of-care Ultrasound","Focused Cardiac Ultrasound","2026-01-12",{"date":456,"type":38},"2026-01-14",{"date":458,"type":38},"2020-12-01",{"date":306,"type":21},{"name":461,"class":45},"University of Pennsylvania",{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":469,"targetDuration":471,"studyType":95,"phases":4,"briefSummary":472,"conditions":473,"keywords":474,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":483,"leadSponsor":485,"locationsCount":46},"100616365","comparison-of-ppv-and-lvot-vti-during-passive-leg-raising-to-predict-fluid-responsiveness-100616365","NCT07304661","Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness","Comparison of Pulse Pressure Variation and LVOT VTI-Based Cardiac Output Changes During Passive Leg Raising Maneuver in Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Patients: A Prospective Observational Study","Inclusion Criteria:\n\n1. Adult patients aged ≥18 years\n2. Patients admitted to the intensive care unit receiving mechanical ventilation\n3. Presence of suspected intravascular fluid deficit (hypotension, negative fluid balance, or clinical signs of peripheral hypoperfusion)\n4. Patients in sinus rhythm\n5. Presence of invasive arterial blood pressure monitoring\n6. Adequate echocardiographic window allowing transthoracic echocardiographic measurement of LVOT VTI\n7. Patients ventilated with tidal volume ≥8 mL\u002Fkg (ideal body weight)\n8. Hemodynamically stable enough to allow measurement\n\nExclusion Criteria:\n\n1. Patients under 18 years of age\n2. Presence of atrial fibrillation or significant arrhythmias such as frequent ventricular or atrial ectopy\n3. Severe right ventricular dysfunction or significant tricuspid regurgitation\n4. Advanced aortic valve disease (severe stenosis or severe regurgitation)\n5. Patients with significant spontaneous breathing effort\n6. Patients receiving lung-protective low tidal volume ventilation strategy (\\\u003C8 mL\u002Fkg) due to ARDS\n7. Inadequate echocardiographic window for LVOT VTI assessment\n8. Severe hemodynamic instability during measurement (sudden vasopressor escalation or need for resuscitation)\n9. Patients who refuse to participate or from whom written informed consent cannot be obtained from themselves or a first-degree relative",{"count":470,"type":21},48,"1 Day","Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit. Although fluid administration is often preferred as an initial intervention, inaccurate estimation of fluid requirements carries significant risks. Inadequate resuscitation may lead to tissue hypoperfusion and organ dysfunction, whereas excessive fluid loading is associated with pulmonary edema, increased intra-abdominal pressure, multi-organ dysfunction, and increased mortality. Consequently, reliable prediction of fluid responsiveness is considered a critical determinant in modern intensive care management.\n\nThe limited reliability of static parameters in predicting fluid responsiveness and the fact that PPV retains its validity only under specific clinical conditions highlight the need for more effective methods. In recent years, hemodynamic changes assessed during the passive leg raising (PLR) maneuver have gained prominence; particularly, left ventricular outflow tract velocity time integral (LVOT VTI)-based cardiac output measurements have been identified as a strong parameter for predicting fluid responsiveness . Moreover, changes in pulse pressure variation (PPV) during PLR have also been reported as a potential predictor; however, the number of studies prospectively comparing PPV variation and LVOT VTI-based cardiac output change within the same patient population remains limited . Therefore, the proposed study aims to fill this gap in the literature and contribute to fluid management in the intensive care setting.\n\nThe aim of this study is to compare the performance of PPV variation and LVOT VTI-based cardiac output change after the PLR maneuver in predicting fluid responsiveness among mechanically ventilated critically ill patients, and to determine the diagnostic value of both methods. The findings of the present study are expected to support more reliable decision-making in fluid therapy and provide clinical evidence toward the individualization of fluid management in intensive care practice.",[27,396,128,102],[99,475,102,476,477,478],"Passive Leg Raising","LVOT VTI","Cardiac Output","Echocardiography","2025-12-13",{"date":481,"type":38},"2025-12-26",{"date":248,"type":21},{"date":484,"type":21},"2027-06-01",{"name":486,"class":45},"Izmir Katip Celebi University",{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":496,"conditions":497,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":46},"100604346","hemosphere-alta-study-100604346","NCT07148323","HemoSphere Alta Study","HemoSphere Alta Clinical Development Study","Inclusion Criteria:\n\n1. Signed informed consent\n2. Age ≥ 18 years\n3. Planned monitoring with a pulmonary artery catheter\n4. Patient scheduled to undergo cardiac or liver transplant surgery lasting \\> 2 hours\n5. Additional criteria for Sub-Cohort A (RVF)\n\n   1. Possible Right Ventricular Dysfunction\u002FFailure based on pre-operative assessment of previous Transthoracic Echocardiogram (TTE)\n   2. Planned Transesophageal Echocardiogram (TEE) assessment during the operative procedure\n6. Additional criteria for Sub-Cohort B (CAI)\n\n   1. Age ≥ 45 years\n   2. Planned cardiac surgery with Cardiopulmonary Bypass (CPB)\n   3. Ability to place ForeSight IQ and Acumen IQ sensors during the operative monitoring period\n   4. High risk for cerebral vascular disease, defined as: a history of hypertension, pulse pressure \\> 60 mmHg, diabetes, stroke, transient ischemic attack, carotid bruit, tobacco smoking, or peripheral vascular disease\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. Pregnancy as confirmed per EMR\n3. Patients deemed not suitable for the study at the discretion of the Investigator\n4. Participation in another study that clinically interferes with the current study\n5. Additional exclusion criteria for Sub-Cohort A\n\n   1. Presence of left bundle branch block\n   2. Presence of current\u002Frecurrent sepsis\n   3. Presence of hypercoagulability, as identified in the patient's past medical history and preoperative evaluation\n   4. Structural abnormality, including congenital heart defects, of the right ventricle\n6. Additional exclusion criteria for Sub-Cohort B a. Surgery for congenital heart defect",{"count":495,"type":21},100,"A prospective, non-randomized single arm study using the HemoSphere Alta Advanced Monitoring Platform and associated devices in adult subjects. Data collected from enrolled study subjects will be used for continual device development purposes.",[27],"2025-11-06",{"date":500,"type":38},"2025-11-10",{"date":502,"type":38},"2025-10-14",{"date":504,"type":21},"2026-12",{"name":506,"class":507},"Edwards Lifesciences","INDUSTRY",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":512,"acronym":513,"eligibilityCriteria":514,"healthyVolunteers":200,"sex":17,"minAge":18,"maxAge":515,"enrollmentInfo":516,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":518,"conditions":519,"keywords":521,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":46},"100497375","consortium-for-optimized-integration-of-bio-artificial-blood-components-for-adaptive-resuscitation-therapy-100497375","NCT05756426","Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy","CONCERT","Inclusion Criteria:\n\n* Subject \\>\u002F= 18 years of age\n* Subject weighs \\>40kg (88lbs)\n* Subject must be generally healthy\n\nExclusion Criteria:\n\n* Suspected or diagnosed with ongoing (chronic) or acute infection\n* Subject is pregnant\n* Subject is non-english speaking","88 Years",{"count":517,"type":21},250,"There is need for a whole blood analog for use when banked blood is unavailable or undesirable.\n\nIn civilian trauma, hemorrhage accounts for \\~ 35% of pre-hospital deaths; moreover, \\~ 20% of military casualties are in hemorrhagic shock on arrival to field hospitals and an additional 5% require urgent transfusion. A recent review concluded that hemorrhage accounted for \\~ 90% of potentially survivable battlefield deaths - lives that could be saved with better hemorrhage control capabilities and improved, field-ready blood, blood components, or blood substitutes. While study of ideal composition for resuscitative fluids is ongoing, it is evident that for those in hemorrhagic shock, volume replenishment alone (without O2 carrying capacity) is insufficient. Alternatively, with massive blood loss or with ongoing bleeding from non-compressible injuries, resuscitation with an O2 carrier alone may be complicated by acquired coagulopathy (either dilutional or trauma-induced).\n\nDevelopment of a balanced resuscitation fluid that treats both shock and coagulopathy (comprising a field-deployable O2 carrier with lyophilized humoral hemostatic components and platelets) is essential to allow on-scene treatment during the critical 'golden-hours' after injury. As such, the whole blood analog described herein could be this product, thus transforming care in both civilian and military settings.The scientific purpose of this study is to develop a combined whole blood substitute from individual artificial prototypes that have been separately developed for each blood component (i.e., combining an artificial oxygen carrier, with an artificial plasma analogue and an artificial platelet analogue). Together, these combined components will recapitulate the composition and performance of natural whole blood.\n\nBlending and combination experiments of the individual artificial prototypes will be performed to test compatibility and optimize efficacy. State of the art in vitro (bench top) assays will be performed to assess physicochemical and functional performance (hemodynamics, oxygen delivery, hemostasis), with data being compared to experiments performed on fresh and stored whole blood.",[520,27],"Hemorrhage",[522,523,524,525,526,527,528,529],"Hemostasis","Vasoactivity","Oxygen affinity","Red Blood Cell","Whole blood analogue","Perfusion","Nitric Oxide","Methemoglobin","2025-10-01",{"date":532,"type":38},"2025-10-07",{"date":534,"type":38},"2023-04-13",{"date":536,"type":21},"2029-01-30",{"name":538,"class":45},"University of Maryland, Baltimore",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":17,"minAge":547,"maxAge":548,"enrollmentInfo":549,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":550,"conditions":551,"keywords":553,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":46},"100536303","hemodynamic-monitoring-during-craniosynostosis-surgery-comparing-traditional-and-newer-technology-monitors-crasy-pram-100536303","NCT06263075","Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)","Evaluation of the Hemodynamic Variability During Craniosynostosis Surgery: a Comparison Between Traditional Hemodynamic Monitoring and Pressure Recording Analytic Method (CRASY-PRAM)","CRASY-PRAM","Inclusion Criteria:\n\n* Infants with craniosynostosis undergoing corrective surgery\n* Ages between 3 and 8 months\n* Physical status classification of the American Society of Anesthesiologists (ASA) \\\u003C\u002F= 2\n* Consent obtained from the patients' parents\u002Flegal guardians\n\nExclusion Criteria:\n\n* Congenital or acquired cardiac disease\n* Preoperative cardiac dysfunction\n* Metabolic diseases\n* Gestational age at birth \\\u003C30 weeks\n* Body weight less than 3 kg\n* Dislocation or malfunction of the arterial catheter\n* Malfunctioning of monitoring devices","3 Months","8 Months",{"count":5,"type":21},"Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic conduction and promptly detect changes in blood pressure, cardiac output, blood volume, and organ perfusion. In this context, advanced hemodynamic monitoring, continuous measuring, and estimating various parameters can allow a more specific hemodynamic profile and help identify the causal mechanisms of its variability. Moreover, the reference ranges of hemodynamic values in different pediatric ages and how to best monitor hemodynamic status in pediatrics are still debated.\n\nSurgical treatment of craniosynostosis is usually performed at an early age, between 3 and 8 months of age. The operation is burdened by a high risk of hemodynamic instability related mainly, but not only, to potential substantial hemorrhagic losses.\n\nThis study aims to characterize the hemodynamic events occurring during corrective craniosynostosis surgery, recorded simultaneously with standard monitoring and Pressure Recording Analytic Method (PRAM), and to analyze the paired measurements.",[552,396,520,27],"Craniosynostoses",[554,555],"Monitoring Physiologic","Monitoring Intraoperative","2025-09-30",{"date":558,"type":38},"2025-10-03",{"date":560,"type":38},"2023-12-13",{"date":562,"type":21},"2026-06",{"name":564,"class":45},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":573,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":575,"conditions":576,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":46},"100601225","o2-consumption-and-co2-production-after-hemodynamic-optimization-in-shock-100601225","NCT07107724","O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock","Oxygen Consumption And Carbon Dioxide Production Following Hemodynamic Optimization In Shock: The OxyCarDio Study","OxyCarDio","Inclusion Criteria:\n\nHypotension (MAP\\\u003C 65mmHg or sudden drop in MAP \\> 15 mmHg) and one of the following conditions:\n\n* Heart rate \\> 120 bpm\n* Urinary output \\\u003C 0.5 ml\u002Fkg\u002Fh for at least two hours\n* Lactate \\> 2 mmol\u002FL\n\nExclusion Criteria:\n\n* Urgent need for surgery\n* Urgent need for veno-arterial ECMO or severe hemodynamic instability\n* Consistent risk of imminent death\n* Severe ARDS or severe respiratory failure (p\u002FF \\\u003C 100 mmHg) and\u002For FiO2\\>0.8\n* Severe heart failure (NYHA 4 and\u002For EF\\\u003C25%)\n* Need for intermittent or continuous renal replacement therapy (IRRT or CRRT)\n* Anemia defined as Hb\\\u003C8 g\u002FdL\n* VO2 variability \\\u003C 5% throughout ten minutes of stabilization before procedure start\n* Intraabdominal hypertension, defined as intraabdominal pressure \\> 18 mmHg\n* Pregnancy\n* Withdrawal or refuse of informed consent\n* Terminal disease\n* Do-not-resuscitate order.",{"count":574,"type":21},36,"The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.\n\nThe main questions it aims to answer are:\n\n1. Do common maneuvers for hemodynamic optimization (fluid bolus and\u002For vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator?\n2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas?\n\nParticipants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.",[27,577],"Oxygen Consumption (V̇O2)","2025-07-30",{"date":580,"type":38},"2025-08-06",{"date":582,"type":38},"2025-07-29",{"date":584,"type":21},"2027-12",{"name":170,"class":45},{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":593,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":595,"conditions":596,"keywords":601,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":613,"locationsCount":46},"100594658","urine-output-response-to-fluid-and-diuretic-therapy-in-cardiac-icu-patients-monitored-with-fize-kuo-100594658","NCT07022314","Urine Output Response to Fluid and Diuretic Therapy in Cardiac ICU Patients Monitored With FIZE kUO®","FIZE kUO® Real-Time Measurement of Urine Output Response to Fluid Therapy and Diuretics in Cardiovascular Surgery Patients: A Prospective Post-Market Study","Inclusion Criteria:\n\n1. Adults aged 18 years and older scheduled for CABG or valve surgery and expected postoperative admission to CTICU\n2. Ability to provide informed consent\n\nExclusion Criteria:\n\n1. Pregnancy\n2. Preoperative dialysis (chronic or acute)\n3. Enrollment in other interventional trials assessing urine output or AKI",{"count":594,"type":21},45,"This prospective observational study evaluates the real-time urine output response to fluid therapy and diuretics in cardiothoracic intensive care unit (CTICU) patients monitored with the FIZE kUO® device. The study aims to assess how continuous urine output monitoring can inform fluid management and improve patient outcomes post-cardiac surgery.",[597,598,599,27,600],"AKI - Acute Kidney Injury","Cardiac Surgery","Fluid Therapy","Postoperative Complications",[602,603,604,605,606],"FIZE kUO","Urine Output","Fluid Management","Diuretics","Cardiothoracic Surgery","2025-06-12",{"date":609,"type":38},"2025-06-15",{"date":611,"type":21},"2025-07",{"date":562,"type":21},{"name":614,"class":507},"FIZE Medical ltd",{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":12,"sex":17,"minAge":622,"maxAge":623,"enrollmentInfo":624,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":626,"conditions":627,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":46},"100530453","fetal-assessment-of-the-myocardium-and-evaluation-of-the-neonate-100530453","NCT06186973","Fetal Assessment of the Myocardium and Evaluation of the Neonate","FAME-n","Inclusion Criteria:\n\nWomen admitted for labor and newborn infants will be included after written consent from both parents (if applicable). The final inclusion criterion is that CTG with STAN is used for fetal surveillance at clinician's discretion.\n\nExclusion Criteria:\n\nPerinatal asphyxia fulfilling the criteria for therapeutic hypothermia, major malformations and stillbirth, known chromosomal anomalies or congenital heart defects other than a patent ductus arteriosus.","0 Hours","1 Hour",{"count":625,"type":21},220,"FAME-n aims to improve perinatal care by introducing new approaches to fetal and neonatal heart assessment. Better identification of high-risk deliveries requiring intervention will reduce perinatal asphyxia-related illness and death. Neonatal hemodynamics may be improved by early detection of instability of the heart and circulation. Innovative use of technology enables characterization of normal and abnormal cardiovascular transition in a significantly larger number of fetuses and newborn infants than what was previously possible. The methods used may have broad generalizability and applicability in perinatal, neonatal and pediatric medicine.\n\nIn September 2023, the project was expanded with an obstetric arm called Epidural analgesia: Fetal Oxygenation and Maternal Oxygenation (Epi-FOMO). In Epi-FOMO, the relationship between maternal breathing and arterial blood gases during labour, and umbilical cord blood gases and neonatal outcomes (as specified in FAME-n) will be investigated.",[628,27,629,630,631],"Newborn Asphyxia","Myocardium; Ischemic","Fetal Distress","Labor Pain","2025-03-17",{"date":634,"type":38},"2025-03-18",{"date":636,"type":38},"2022-11-14",{"date":638,"type":21},"2035-12-31",{"name":640,"class":45},"Oslo University Hospital",{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":649,"targetDuration":4,"studyType":22,"phases":651,"briefSummary":652,"conditions":653,"keywords":654,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":46},"100294479","patient-management-during-major-abdominal-surgery-an-oxygen-consumption-protocol-compared-to-standard-approach-100294479","NCT03113435","Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach","Patient Management During Major Abdominal Surgery: the Impact of a Hemodynamic Approach Oriented to Oxygen Consumption Optimization Compared to Standard Approach Targeting Preload-dependency and a Clinically-guided Strategy","HEART-CORE","Inclusion Criteria:\n\n* patients aged \\> 18 years\n* acquisition of written informed consent\n* Major abdominal surgery (major gastrointestinal surgery: DCP, gastrectomy, Miles, emicolectomy; gynecologic surgery: oncologic surgery) Surgery times ≥ 3 hours\n\nExclusion Criteria:\n\n* Absolute contraindication to CVC placement\n* pregnant women\n* hepatic surgery\n* laparoscopic surgery\n* Major vascular surgery\n* Dialysis treatment and kidney transplant surgery\n* Severe heart failure (EF ≤ 35%)\n* Emergency surgery",{"count":650,"type":21},76,[24],"This study compares the actual standard of care with a new protocol to guide hemodynamic optimization during major abdominal surgery, which is more tailored on patient real needs. During general anesthesia metabolic needs of the body are markedly reduced and increase in CO may not be necessary. In addition, excessive fluid administration has been related to worse post-operative outcomes. We divide patients into three groups: the standard treatment group, the NICE protocol group and the intervention group. In this group we use the v-aCO2\u002FCaO2-CvO2 as marker of tissue ability to increase their oxygen consumption in response to increased O2 delivery, and based on this index the administration of fluid. The principal aim is to optimize functional hemodynamics in order to reduce the fluid balance at the end of the surgery.",[27],[655,656,657],"CO2 gap","oxygen consumption","Stroke volume optimization","2025-03-10",{"date":660,"type":38},"2025-03-11",{"date":662,"type":38},"2018-06-01",{"date":664,"type":21},"2026-12-31",{"name":170,"class":45},{"id":667,"slug":668,"hasResults":12,"nctId":669,"briefTitle":670,"officialTitle":671,"acronym":4,"eligibilityCriteria":672,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":673,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":674,"conditions":675,"keywords":677,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":682,"lastUpdatePostDateStruct":683,"startDateStruct":685,"completionDateStruct":687,"leadSponsor":689,"locationsCount":46},"100456577","hemodynamic-measurements-of-macrocirculatory-and-perfusion-parameters-in-icu-100456577","NCT05225402","Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU","Effects of Norepinephrine on Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU Patients with Septic Shock","Inclusion Criteria:\n\n* Suspected or documented infection\n* Need for vasopressors to maintain mean arterial blood pressure (MAP) ≥65 mmHg\n* Serum lactate levels \\>2 mmol\u002FL\n* Norepinephrine infusion of \\> 0.2 mcg\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Absolute contraindication for esophageal doppler or urinary catheter insertion as noted in the patients' charts.\n* Severe valvular pathology and cardiac arrhythmias resulting in severe hemodynamic instability.\n* Lithium treatment\n* Treatment with other vasopressor or inotropic drugs.",{"count":594,"type":21},"In septic shock there is growing evidence of a state of hemodynamic \"disconnection\" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand. Norepinephrine (NE) is recommended as first choice vasoactive agent for the treatment of septic shock. However, the dynamic effects of NE on macro- and microcirculation and perfusion parameters has not been described in detail in the context of septic shock, precluding rational individualized titration of NE and fluids, as recommended recently. In the present prospective observational multicenter study in adult septic shock patients, we intend to explore the effects of NE on preload dependency and tissue perfusion by evaluating the correlation and potential discrepancies between macro- and microcirculation both during titration of NE and after fluid resuscitation. The conclusions drawn from our study will contribute to the physiological knowledge necessary for establishing individualized evidence-based bedside management of hemodynamics in the setting of septic shock.",[60,27,676],"Vasoconstriction",[60,678,679,680,681],"Norepinephrine","Hemodynamic","Microcirculation","Intensive Care","2025-03-05",{"date":684,"type":38},"2025-03-07",{"date":686,"type":38},"2022-03-08",{"date":688,"type":21},"2025-12-30",{"name":690,"class":45},"Copenhagen University Hospital, Hvidovre",{"id":692,"slug":693,"hasResults":12,"nctId":694,"briefTitle":695,"officialTitle":695,"acronym":4,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":697,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":699,"conditions":700,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":701,"lastUpdatePostDateStruct":702,"startDateStruct":704,"completionDateStruct":706,"leadSponsor":708,"locationsCount":46},"100579767","evaluation-of-the-success-of-artificial-intelligence-models-in-interpreting-arterial-waveform-analysis-data-100579767","NCT06828575","Evaluation of the Success of Artificial Intelligence Models in Interpreting Arterial Waveform Analysis Data","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Undergoing elective surgery with arterial waveform monitoring as part of standard perioperative care\n* Hemodynamic data successfully recorded using the MostCare hemodynamic monitoring system\n* Able to provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Incomplete or corrupted hemodynamic data (e.g., signal artifacts preventing reliable analysis)\n* Emergency surgery cases\n* Patients with severe arrhythmias or hemodynamic instability that might interfere with arterial waveform interpretation\n* Refusal to participate or withdrawal of consent\n* Patients with contraindications to arterial catheterization (e.g., coagulopathy, severe peripheral vascular disease)",{"count":698,"type":21},145,"The goal of this observational study is to evaluate the ability of artificial intelligence (AI) models to interpret arterial waveform analysis data obtained from a hemodynamic monitoring system in adult patients undergoing elective surgery. The main questions it aims to answer are:\n\nCan AI models (ChatGPT-4 and Gemini 2.0) accurately detect hemodynamic abnormalities in arterial waveform data? How well do AI-generated diagnoses align with expert anesthesiologist assessments? Are AI-generated treatment recommendations clinically appropriate?\n\nParticipants will:\n\nUndergo standard hemodynamic monitoring with an arterial waveform analysis device (MostCare).\n\nHave their anonymized hemodynamic data analyzed by AI models for abnormality detection, diagnosis suggestions, and treatment recommendations.\n\nHave AI-generated results reviewed and validated by experienced anesthesiologists.\n\nThis study aims to assess whether AI models can serve as decision-support tools in perioperative and critical care settings by improving the interpretation of complex hemodynamic data, potentially enhancing patient safety, diagnostic accuracy, and clinical efficiency.",[27],"2025-03-03",{"date":703,"type":38},"2025-03-04",{"date":705,"type":38},"2025-02-15",{"date":707,"type":21},"2025-08-16",{"name":709,"class":45},"Kanuni Sultan Suleyman Training and Research Hospital"]