[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemodynamics-instability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemodynamics-instability":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,78,106,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100635619","correlation-between-capillary-refill-time-and-perfusion-index-in-critically-ill-patients-100635619",false,"NCT07555041","Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients","Correlation Between Capillary Refilling tIme and Perfusion Index in Critically Ill Patients","CRIPI","Inclusion criteria :\n\n* Adult patient.\n* Admission within the previous 24 hours, or within 24 hours of the onset of a hemodynamic instability criterion (requirement for vasopressors or fluid resuscitation).\n* Absence of patient objection.\n\nExclusion criteria :\n\n* Legal guardianship, curatorship, or judicial protection.\n* No social security coverage.\n* Morphological abnormalities preventing CRT and IP measurements.","ALL","18 Years",{"count":20,"type":21},250,"ESTIMATED","OBSERVATIONAL","Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.\n\nCRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.\n\nAlthough CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.\n\nThe perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.\n\nBecause PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.",[25,26,27,28],"Shock State","Hemodynamics Instability","Microcirculation","Monitoring",[30,31,27,32],"Capillary refill time","Perfusion index","Intensive care","RECRUITING","2026-04-30",{"date":36,"type":37},"2026-05-01","ACTUAL",{"date":39,"type":37},"2026-04-29",{"date":41,"type":21},"2027-05-29",{"name":43,"class":44},"Hospices Civils de Lyon","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100583057","low-and-moderete-flow-anaesthesia-on-haemodynamics-100583057","NCT06871371","Low and Moderete Flow Anaesthesia on Haemodynamics","The Comparison of the Effects of Low and Medium Flow Anesthesia on Haemodynamics, Arrhytmia Risk and Cerebral Oxygenation in Laparoscopic Cholecystomy Cases","Inclusion Criteria:\n\n* being ASA1-2 status\n* between the ages of 18-70\n* who are planned for laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Patients who refuse to give informed consent\n* Pregnant and breastfeeding patients\n* Morbidly obese patients (Body mass index over 40)\n* Patients with uncontrolled diabetes mellitus, with serious cardiovascular, pulmonary, renal, hepatic disease, obstructive sleep apnea, with electrolyte imbalance- Those with a history of alcohol or drug abuse, with perioperative hemodynamic instability\n* Patients using drugs known to prolong myocardial repolarization\n* inability to increase SPO2 above 95 despite necessary intervention","17 Years","70 Years",{"count":56,"type":21},76,"INTERVENTIONAL",[59],"NA","The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.",[26,62,63],"Arrhythmias Cardiac","Cerebral Oxygenation",[65],"Low-Medium Flow Anesthesia, Hemodynamics, Oxygenation","NOT_YET_RECRUITING","2025-03-06",{"date":69,"type":37},"2025-03-11",{"date":71,"type":21},"2025-03-15",{"date":73,"type":21},"2025-04-15",{"name":75,"class":76},"Umraniye Education and Research Hospital","OTHER_GOV",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":17,"minAge":86,"maxAge":54,"enrollmentInfo":87,"targetDuration":4,"studyType":57,"phases":89,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":77},"100573025","phase-2-evaluating-perioperative-outcomes-dexmedetomidine-vs-lignocaine-in-laparoscopic-chlolecystectomy-100573025","NCT06740903","Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy","Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n1. Patients of age 20-70 years\n2. Both gender\n3. Laparoscopic cholecystectomy under general Anaesthesia\n4. ASA I-II.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Patients with history of allergic reaction to trial drugs\n* Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record)\n* Anemia\n* Patient on TCA or Beta blocker drugs.\n* Uncontrolled hypertension (P≥160\u002F100 mmHg)\n* Uncontrolled diabetes mellitus\n* Obesity BMI \\> 35",true,"20 Years",{"count":88,"type":21},140,[90,91],"PHASE2","PHASE3","Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications. To minimize these side effects associated with the use of opioids, various methods have been adopted. Recently, different trials have highlighted the possible role of dexmedetomidine and lignocaine in providing postoperative analgesia and attenuating hemodynamic response. Literature showed conflicting results regarding both these drugs. So, we want to find the evidence for local setting. This Randomized Controlled Trial will be done at Department of Anesthesia, Sahiwal teaching hospital, Sahiwal for 12 months. Sample size of 140 cases; 70 cases in each group will be included through non-probability consecutive sampling. Then patients will be divided in two groups by using computer generated random number table. In group A, patients will be given dexmedetomidine infusion. In group B, patients will be given lignocaine infusion. All anesthesia procedures will be done by researcher. Heart rate and mean arterial pressure will be assessed before induction of anesthesia, after every 10 mins every 30 mins till completion of surgery. Total operative time will be noted. After procedure, patients will be assessed for postoperative pain score. when pain will be ≥4 on visual analogue scale rescue analgesia will be given and time will be noted. Total duration from time of surgery till need for rescue analgesia will be noted. Duration of postoperative analgesia opioid consumption \u002F24 hrs.) will be presented by using mean± SD.",[26,94,95,96],"Post Operative Pain","Gastrointestinal Dysfunction","Cholecystitis","2024-12-14",{"date":99,"type":37},"2024-12-18",{"date":101,"type":37},"2024-08-06",{"date":103,"type":21},"2025-09-06",{"name":105,"class":76},"Sahiwal medical college sahiwal",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":57,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":77},"100465104","non-invasive-goal-directed-therapy-on-circulatory-shock-100465104","NCT05336357","Non-invasive Goal-directed thErapy oN cIrcUlatory Shock","The Effect of Non-invasive Hemodynamic Goal-directed Therapy on the Incidence of Acute Kidney Injury in Circulatory Shock: a Randomized Clinical Trial","GENIUS","Inclusion Criteria\n\n* Age \\> 18 years;\n* Patients admitted to Emergency Units, Intensive Care Units, and Wards within 3 hours of the diagnosis of Septic Shock:\n* Systolic Blood Pressure (SBP) \\\u003C 90 mmHg and\u002For Mean Arterial Pressure (MAP) \\\u003C 65 mmHg (with or without norepinephrine at a dose less than 0.5 mcg\u002Fkg\u002Fmin) + Clinical signs of infection and at least one of the following:\n\n  * Lactate \\> 2 mEq\u002FL;\n  * Oliguria (urine output \\\u003C 0.5 mL\u002Fkg\u002Fh for at least 6 hours);\n  * Neurological changes (mental confusion, decreased level of consciousness, psychomotor agitation, temporal-spatial disorientation);\n  * Capillary refill time \\> 3 s (after digital compression for 10 seconds);\n  * Poor skin perfusion.\n* Signed Informed Consent Form.\n\nExclusion Criteria\n\n* Hospital admission time greater than 24 hours\n* Significant edema in the fingers\n* Severe peripheral vasoconstriction\n* Use of Norepinephrine at a dose greater than or equal to 0.5 mcg\u002Fkg\u002Fmin\n* Presence of significant Aortic Insufficiency\n* Patients undergoing Renal Replacement Therapy\n* Patients with ST-segment elevation Myocardial Infarction\n* Patients requiring Invasive Mechanical Ventilation\n* Patients already participating in another study",{"count":115,"type":21},380,[59],"Circulatory shock occurs when the oxygen supply to the tissues decreases, leading to cellular damage and affecting about one-third of patients admitted to Intensive Care Units (ICUs). Cardiac Output (CO) is defined as the volume of blood ejected by the left ventricle per minute and is a crucial hemodynamic parameter for monitoring patients with signs of circulatory shock. However, this parameter is underutilized in patients treated in Emergency Units because its measurement typically involves invasive methods, which are not commonly available in this setting. Any method capable of measuring CO without the need for pulmonary artery catheter insertion is referred to as minimally invasive CO monitoring. Evaluating these parameters allows for a quicker determination of the etiology of circulatory shock, enabling the early initiation of goal-directed therapy. Goal-directed therapy has been proven effective in reducing morbidity and mortality, ICU length of stay, and mechanical ventilation duration in ICU patients who respond to fluid resuscitation. Currently, there are no data on the impact of a hemodynamic optimization strategy in patients during the early hours of shock.\n\nThe objective is to assess whether goal-directed hemodynamic therapy, through non-invasive hemodynamic monitoring, reduces the time required for hemodynamic resuscitation in patients with septic shock. A multicenter, randomized, open-label study will be conducted in Emergency Units, Intensive Care Units, and Hospital Wards.\n\nPatients over 18 years old admitted with signs of septic shock (defined as systolic blood pressure less than 90 mmHg and\u002For mean arterial pressure less than 65 mmHg, along with at least one of the following criteria: lactate greater than 2 mEq\u002FL, oliguria, neurological alteration, or capillary refill time greater than 3 seconds) will be included Participants will be randomized in a 1:1 ratio into two groups. In the Goal-Directed Therapy Group, patients will be monitored using the HemoSphere HPI™ (Edwards Life Sciences, Irvine, CA, USA), where parameters such as cardiac index (CI), stroke volume (SV), systolic blood pressure (SBP), mean arterial pressure (MAP), and HPI will guide medical management. In the Conventional Therapy Group, patients will be evaluated with the standard hemodynamic monitoring equipment typically found in emergency units..",[26],[120,121,122],"Shock","Sepsis","Early Goal Directed Therapy","2024-08-22",{"date":125,"type":37},"2024-08-26",{"date":127,"type":37},"2024-02-20",{"date":129,"type":21},"2026-10-30",{"name":131,"class":44},"University of Sao Paulo",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":85,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":57,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":77},"100534355","preoperative-sildenafil-administration-for-hepatectomy-100534355","NCT06237751","Preoperative Sildenafil Administration for Hepatectomy","Inclusion Criteria:\n\n* Patients undergoing hepatic resection\n* age from 18-85 years\n* Child-Pugh ≤B\n* ASA II-III\n* willing to join the trial.\n\nExclusion Criteria:\n\n* Pregnancy or Lactation\n* Known Allergy to any Medications used in the Study\n* Hemoglobin (Hb) \\\u003C 90 g\u002FL\n* Body Mass Index (BMI) \\> 35 kg\u002Fm2 or \\\u003C 18 kg\u002Fm2\n* Hypertension \\> 180 mmHg\n* Renal Impairment (Creatinine, Cr 178 µmol\u002FL)\n* Severe Cardiovascular Diseases including Active Coronary Artery Disease, Severe Valve Stenosis and Hypertrophic Obstructive Cardiomyopathy, History of Stroke Within Six Months.","85 Years",{"count":140,"type":21},16,[59],"Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma. The Control Low Central Venous Pressure (CLCVP) technique is currently one of the most important techniques to control intraoperative bleeding. It mainly consists of fluid restriction, position adjustment, and the use of vasodilators. However, these measures focus on decreasing CVP by reducing the volume of return blood, and less attention is paid to factors such as pulmonary vascular resistance and cardiac function. Sildenafil, known as Viagra, is currently used to treat erectile dysfunction and pulmonary hypertension in men. Its action inhibits phosphodiesterase-5 (PDE-5) and increases cGMP levels, leading to smooth muscle relaxation and vasodilation. Its pharmacological properties provide potential value for the treatment of many diseases. However, few studies have been conducted both domestically and internationally on the use of sildenafil citrate in liver resection related to CLCVP. This study aims to investigate the influence of preoperative oral administration of Sildenafil Citrate combined with IPM on IBL and surgical results during open or laparoscopic hepatectomy, as well as its safety and feasibility. It is expected to provide an innovative management optimization plan for reducing the bleeding in hepatectomy and to provide empirical support for the potential value of Sildenafil Citrate or Sildenafil-like drugs in improving the safety and quality of perioperative hepatectomy patients.",[144,145,26,146],"Central Venous Pressure","Hepatectomy","Sildenafil",[148,145,149,150,151],"Sildenafil Citrate","Laparoscopy","Low central venous pressure","Study protocol","2024-06-25",{"date":154,"type":37},"2024-06-27",{"date":156,"type":37},"2024-02-01",{"date":158,"type":21},"2024-12-30",{"name":160,"class":44},"First People's Hospital of Chenzhou"]