[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemodynamics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemodynamics":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,51,85,113,138,170,195,218,244,273,298,324,352,380,400,425,448,470,494,528,553,578],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100053344","phase-4-comparison-of-low-dose-versus-standard-dose-hyperbaric-bupivacaine-in-spinal-anesthesia-100053344",false,"NCT07684989","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia: Hemodynamic Stability and Recovery Profile in Elderly Patients Undergoing Lower Limb Orthopedic Surgery","Inclusion Criteria:\n\n* Male or female patients aged 65 years and above.\n* Patients scheduled for elective lower limb orthopedic surgery under spinal anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal to participate in the study.\n* Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy, severe hypovolemia, raised intracranial pressure).\n* Known hypersensitivity or allergy to bupivacaine.\n* Severe valvular heart disease.\n* Significant cardiac arrhythmias.\n* Uncontrolled hypertension.\n* Severe hepatic or renal impairment.\n* Pre-existing neurological disorders affecting lower limb motor or sensory function.\n* Severe spinal deformity or previous lumbar spine surgery interfering with spinal anesthesia.\n* Cognitive impairment or inability to provide informed consent.\n* Emergency orthopedic procedures.","ALL","65 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does low-dose hyperbaric bupivacaine reduce the incidence of intraoperative hypotension and bradycardia compared with standard-dose hyperbaric bupivacaine?\n* Does low-dose hyperbaric bupivacaine improve postoperative recovery profile compared with standard-dose hyperbaric bupivacaine?\n\nResearchers will compare elderly patients receiving low-dose hyperbaric bupivacaine with those receiving standard-dose hyperbaric bupivacaine to determine whether a lower intrathecal dose improves cardiovascular stability and recovery without compromising the effectiveness of spinal anesthesia.\n\nParticipants will:\n\n* Provide written informed consent before enrollment.\n* Undergo elective lower limb orthopedic surgery under spinal anesthesia.\n* Be randomly assigned to receive either low-dose or standard-dose hyperbaric bupivacaine.\n* Have their blood pressure, heart rate, and other vital signs monitored throughout the surgical procedure.\n* Be assessed for intraoperative hypotension and bradycardia according to predefined study criteria.\n* Be evaluated for postoperative recovery parameters, including motor recovery and readiness for postoperative recovery and mobilization.\n\nThe information obtained from this study may help identify a safer and more effective spinal anesthetic technique for elderly patients undergoing orthopedic surgery.",[26,27,28,29,30],"Anesthesia, Spinal","Orthopedic Procedures","Postoperative Recovery in Elderly Patients","Hemodynamics","Bupivacaine",[32,33,34,35,36,37],"Low-Dose Hyperbaric Bupivacaine","Standard-Dose Hyperbaric Bupivacaine","Spinal Anesthesia","Geriatric Anesthesia","Lower Limb Orthopedic Surgery","Hemodynamic Stability","NOT_YET_RECRUITING","2026-07-10",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":20},"2026-07-01",{"date":46,"type":20},"2027-06-30",{"name":48,"class":49},"Mayo Hospital Lahore","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":50},"100613000","paired-comparison-of-svv-and-pvi-accuracy-100613000","NCT07260890","Paired Comparison of SVV and PVI Accuracy","Diagnostic Accuracy of Stroke Volume Variation (SVV) vs Pleth Variability Index (PVI) for Predicting Fluid Responsiveness in Laparoscopic Major Abdominal Surgery-A Prospective, Paired, Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* ASA physical status I-III\n* Elective laparoscopic major abdominal surgery under general anesthesia\n* Arterial line in place for clinical care\n* Able to provide informed consent\n* Arterial and plethysmographic waveforms adequate for measurement\n\nExclusion Criteria:\n\n* linically significant arrhythmia (e.g., atrial fibrillation with irregular R-R)\n* Severe valvular heart disease or intracardiac shunt\n* Pregnancy\n* Severe right-heart failure or condition where a fluid bolus is unsafe\n* Ongoing hemodynamic instability requiring rapid vasoactive titration at assessment\n* Persistently unreliable arterial\u002Fpleth signals despite optimization\n* Any situation the anesthesiologist judges that the fluid challenge is unsafe",true,"19 Years",{"count":61,"type":20},300,"OBSERVATIONAL","This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a small fluid bolus will improve the heart's pumping during laparoscopic major abdominal surgery. Adults having elective surgery under general anesthesia will receive two small, timed 250-mL crystalloid infusions as part of routine care (one before and one after creation of the pneumoperitoneum). The research team will record SVV and PVI values just before and three minutes after each infusion while keeping these readings hidden from the clinicians so that usual care is not changed. No experimental drugs or devices are used. The main goal is to learn which index better identifies \"fluid responsiveness,\" so future care can be safer and more consistent. Potential risks are minimal and relate to the small fluid boluses (temporary changes in blood pressure or heart rate); the test stops if the anesthesiologist has any safety concerns. There is no direct benefit to participants, but results may help guide fluid therapy for similar patients in the future. The study is being conducted at a single academic hospital in the Republic of Korea and plans to enroll about 300 adults.",[65,66,67,29,68],"Perioperative Care","Fluid Therapy","Monitoring, Physiologic","Laparoscopy",[70,71,72,73,74,75],"stroke volume variation; SVV","Pleth Variability Index; PVI","fluid responsiveness","goal-directed fluid therapy; GDFT","pneumoperitoneum","diagnostic accuracy; ROC; AUROC","RECRUITING","2026-06-24",{"date":79,"type":42},"2026-06-26",{"date":44,"type":20},{"date":82,"type":20},"2026-08-30",{"name":84,"class":49},"Wonkwang University Hospital",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":108,"leadSponsor":110,"locationsCount":50},"100643852","vnotes-vs-laparoscopy-respiratory-mechanics-and-hemodynamics-100643852","NCT07667907","vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics","Comparison of the Effects of vNOTES and Laparoscopic Gynecological Surgery on Intraoperative Respiratory Mechanics and Hemodynamics: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years\n* Patients scheduled for elective gynecological surgery\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Cardiac arrhythmia\n* ASA physical status IV or above\n* Patients developing intraoperative hemodynamic instability\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","FEMALE","18 Years","75 Years",{"count":96,"type":20},30,"Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics. These conditions increase the risk of ventilator-induced lung injury (VILI) and highlight the importance of lung-protective ventilation strategies.\n\nvNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) is a minimally invasive technique that requires less Trendelenburg tilt and lower insufflation pressures compared to conventional laparoscopic surgery, and may therefore offer a more favorable intraoperative profile.\n\nThis prospective, observational, single-center, parallel-group cohort study aims to compare respiratory mechanics parameters (Ppeak, Pplateau, DP, MPtot, MPdyn, Crs) and hemodynamic parameters (MAP, HR, vasopressor requirement) between vNOTES (n=15) and laparoscopic gynecological surgery (n=15) groups at four intraoperative time points.",[99,29],"Respiratory Mechanics",[101,68,99,29,102,103],"vNOTES","Pneumoperitoneum","Trendelenburg","2026-06-19",{"date":106,"type":42},"2026-06-25",{"date":44,"type":20},{"date":109,"type":20},"2027-07-01",{"name":111,"class":112},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":50},"100596075","low-flow-anesthesia-and-open-heart-surgery-100596075","NCT07040735","Low-Flow Anesthesia and Open-Heart Surgery","The Effect of Low-Flow Anesthesia on Hemodynamics in Open-Heart Surgery","Inclusion Criteria:\n\n-≥18 years and scheduled for open-heart surgery patients\n\n-ASA I-II-III-IV physical class\n\nExclusion Criteria:\n\n* Emergency cases\n* Patients under 18 years of age\n* Patients who have had open heart surgery before\n* Patients for whom the use of inhaled anesthetic agents is contraindicated\n* Patients who do not sign a voluntary consent form",{"count":121,"type":20},80,"Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L\u002Fmin. In 1984, Baker and Simionescu classified LFA as 0.5-1 L\u002Fmin and MFA as 0.25-0.5 L\u002Fmin. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.",[124,29,125],"Low-flow Anesthesia","Open-heart Surgery",[127,29,128],"Low-flow anesthesia","Open-heart surgery","2026-05-22",{"date":131,"type":42},"2026-05-27",{"date":133,"type":42},"2025-07-01",{"date":135,"type":20},"2026-09-23",{"name":137,"class":49},"Çağrı Özdemir",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":145,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":148,"conditions":149,"keywords":154,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":50},"100634556","the-impact-of-multiple-antihypertensive-therapy-on-post-induction-hypotension-burden-in-cardiac-surgery-patients-100634556","NCT07541222","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Adult patients aged 40 years and older\n* Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)\n* Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date\n* Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Preoperative shock or requirement for high-dose inotropic\u002Fvasopressor therapy\n* End-stage liver or kidney failure\n* Uncontrolled hypertension\n* Difficult intubation or prolonged induction process\n* Ejection fraction less than 35%","40 Years",{"count":147,"type":20},160,"This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.",[150,151,152,153,29],"Hypotension on Induction","Cardiac Surgery","Antihypertensive Agents","Anesthesia, Intravenous",[155,156,157,158,159,160],"Post-induction hypotension","Cardiac surgery","Antihypertensive drugs","Hypotension burden","Mean arterial pressure","Anesthesia induction","2026-05-05",{"date":163,"type":42},"2026-05-06",{"date":165,"type":42},"2026-05-01",{"date":167,"type":20},"2026-12-01",{"name":169,"class":49},"Konya City Hospital",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":179,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":194},"100507078","phase-4-effect-of-heart-rate-control-with-ivabradine-on-hemodynamic-in-patients-with-sepsis-100507078","NCT05882708","Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis","Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis: a Prospective, Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adult patients aged 18 years or above.\n2. Being treated in an intensive care unit.\n3. Sepsis is diagnosed according to Sepsis-3.0 criteria, which is defined as patients requiring antimicrobial agents due to confirmed or suspected infection, acute increase in the SOFA score at least 2 points.\n4. Mean arterial pressure (MAP) is maintained ≥65 mmHg with adequate volume resuscitation and vasopressor therapy. Volume resuscitation is considered adequate when Central Venous Pressure (CVP) \\> 8mmHg, global end-diastolic volume index (GEDI) \\> 680ml\u002Fm2 and resting inferior vena cava (IVC) diameter \\> 1.5cm.\n5. Patients are in a relatively stable period of hemodynamics, as defined that the targe mean arterial pressure are maintained with the same dosage of vasopressors for at least 2 h.\n6. Sinus rhythm with heart rate ≥ 95bpm maintain for at least 2 hours but less than 72 hours.\n\nExclusion Criteria:\n\n1. Patients who had received ivabradine therapy or known allergy to it prior to randomization.\n2. Patients with severe liver dysfunction (Child-C grade).\n3. Patients with a history of pre-existing chronic renal failure (glomerular filtration rate less than 15 ml\u002Fmin\u002F1.73 m2), except patients treated with continuous renal replacement therapy (CRRT).\n4. Patients with known seizure disorder.\n5. Patients with any contraindication to gastrointestinal drug administration.\n6. Pregnant or lactating patients.\n7. patients requiring the use of potent cytochrome CYP3A4 inhibitors such as antifungals of the azole-type (specifically ketoconazole and itraconazole), macrolide antibiotics (specifically clarithromycin and erythromycin) and HIV protease inhibitors (specifically nelfinavir and ritonavir).\n8. Patients with active bleeding;\n9. Patients with cardiac dysfunction caused by non-septic causes such as recent (\\\u003C 2months) acute myocardial infarction, chronic cardiac dysfunction (NYHA Class Ⅳ), congenital heart disease, pericardial tamponade, severe aortic regurgitation and aortic coarctation before enrollment.\n10. Patients with sinoatrial block, sick sinus syndrome, atrioventricular block or heart rate dependence on pacemaker.\n11. Patients with refractory shock, which may be considered if one of the following conditions still exists in spite of active volume resuscitation, high doses of vasoactive drugs (VIS score \\>120), and other regular therapy: 1) Worsening hypotension (MAP\\\u003C65mmHg); 2) Lactate persistence\\>5mmol\u002FL (two times in a row with an interval of more than 30min), and a progressive upward trend; 3) Mixed venous blood oxygen saturation (SvO2) sustained \\\u003C55% (more than two consecutive times, more than 30min apart), and progressive deterioration. The above conditions lasted for more than 5 hours.\n12. Use of beta blockers within 24 hours before enrollment.\n13. Pheochromocytoma patients.\n14. After cardiopulmonary resuscitation.\n15. Patients who have been enrolled in another interventional clinical study.",{"count":178,"type":20},172,[23],"Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate volume resuscitation to correct hypovolemia and vasopressor medication to correct hypotension. Recently, relevant studies have shown that sustained tachycardia in sepsis was also related to high mortality, and appropriate control of heart rate could improve prognosis. Ivabradine reduces heart rate directly without a negative inotropic effect through inhibition of the If ionic current，which is absent from the traditional rate control drug (beta-blockers). This is a prospective, multicenter, randomized, open label study designed to compare ivabradine with placebo on the difference of heart rate and haemodynamics in patients with sepsis.",[182,183,29,184],"Sepsis","Ivabradine","Heart Rate Control","2026-04-21",{"date":187,"type":42},"2026-04-24",{"date":189,"type":42},"2023-06-01",{"date":191,"type":20},"2027-05-31",{"name":193,"class":49},"Second Affiliated Hospital of Guangzhou Medical University",3,{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":58,"sex":92,"minAge":93,"maxAge":4,"enrollmentInfo":202,"targetDuration":204,"studyType":62,"phases":4,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":50},"100621899","cardiovascular-research-in-embarazo-and-maternity-emma-study-on-heart-rate-variability-and-hemodynamic-adaptations-during-pregnancy-and-postpartum-100621899","NCT07376616","Cardiovascular Research in EMbarazo and MAternity (EMMA). Study on Heart Rate Variability and Hemodynamic Adaptations During Pregnancy and Postpartum.","EMMA","Inclusion Criteria:\n\n* Over 18 years of age\n* Pregnancy from the third month of gestation\n* No pre-existing cardiovascular disease\n* Good cognitive level\n* Sign informed consent\n\nExclusion Criteria:\n\n* Diabetes mellitus\n* Hyperthyroidism\n* Hypothyroidism\n* Chronic hypertension diagnosed before pregnancy\n* Heart failure\n* Ischemic heart disease or malignant ventricular arrhythmias (ventricular fibrillation, ventricular tachycardia, grade 2 or 3 AV block, atrial fibrillation in patients with Wolff-Parkinson- White syndrome, paroxysmal fibrillation or flutter with rapid ventricular response and hemodynamic deterioration, uncontrolled supraventricular tachycardia)\n* Exercise-induced ischaemia\n* Unstable angina\n* Disease not susceptible to revascularization\n* Associated valvular heart disease\n* Chronic kidney disease\n* Degenerative neurological condition\n* Brain aneurysms\n* Arteriovenous malformations\n* History of transient cerebral infarction (ICTUS)\n* Migraines diagnosed\n* Epilepsy\n* Brain or spinal cord injury\n* Tumors\n* Diseases of the respiratory tract\n* Diseases of lung tissue\n* Diseases of pulmonary circulation",{"count":203,"type":20},242,"21 Months","Heart rate variability (HRV) provides a non-invasive assessment of autonomic control of the nervous system over the heart. During pregnancy, the cardiovascular system adapts significantly, affecting HRV and hemodynamics. Studying the relationship between HRV and hemodynamic changes is critical to understanding and monitoring cardiovascular health during pregnancy and postpartum, and predicting potential complications.",[207,208,29],"Pregnancy Related","Heart Rate Variation (HRV)","2026-02-12",{"date":211,"type":42},"2026-02-17",{"date":213,"type":42},"2025-05-19",{"date":215,"type":20},"2027-12-15",{"name":217,"class":49},"Fundacin Biomedica Galicia Sur",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":92,"minAge":93,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":21,"phases":227,"briefSummary":229,"conditions":230,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":241,"leadSponsor":242,"locationsCount":50},"100619378","virtual-reality-versus-intravenous-dexmedetomidine-on-maternal-anxiety-stress-hemodynamics-and-neonatal-outcomes-during-cesarean-section-100619378","NCT07343843","Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section","Effect of Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section","Inclusion Criteria:\n\n* Age over 18 years old.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for elective cesarean section (CS) delivery under Central Neuraxial Blockade.\n* Provide informed consent and agree to participate in the study.\n\nExclusion Criteria:\n\n* Patient's refusal\n* Patient known have contraindications for Regional Anesthesia as infection at the site of injection, severe coagulopathy or allergy to local anesthetics.\n* Patient with psychiatric disorders.\n* Sensory impairment (blindness, deafness).\n* Any technical problem preventing proper fitting of the glasses to the patient face.\n* Patients with cognitive impairment, epilepsy or with claustrophobia\n* Patients with suspected eye infection\n* Signs of active labor.\n* Pregnancy related-diseases or antepartum hemorrhage.\n* Presence of Fetal distress.",{"count":226,"type":20},52,[228],"NA","This study aims to compare the efficacy of intravenous dexmedetomidine infusion versus virtual reality (VR) in reducing maternal anxiety, stress, and hemodynamic instability during cesarean section and their effects on neonatal outcome as respiration and heart rate.",[231,232,233,234,29,235,236],"Virtual Reality","Dexmedetomidine","Maternal Anxiety","Stress","Neonatal Outcomes","Cesarean Section","2026-01-17",{"date":239,"type":42},"2026-01-21",{"date":237,"type":42},{"date":44,"type":20},{"name":243,"class":49},"Benha University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":58,"sex":16,"minAge":93,"maxAge":251,"enrollmentInfo":252,"targetDuration":254,"studyType":62,"phases":4,"briefSummary":255,"conditions":256,"keywords":259,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":4},"100607911","effect-of-operating-room-noise-on-bis-and-hemodynamics-under-general-anesthesia-100607911","NCT07194707","Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia","The Effect of Operating Room Environmental Noise on BIS and Hemodynamics in Patients Under General Anesthesia: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged 18-70\n* ASA (American Society of Anesthesiologists) physical status score I-II\n* Scheduled for elective surgery\n* To be undergoing general anesthesia\n* Having signed the informed consent form to participate in the study\n\nExclusion Criteria:\n\n* Hearing impairment or ear pathology\n* History of neurological disease (epilepsy, stroke, dementia, etc.)\n* Use of psychiatric medications (anxiolytics, antidepressants, antipsychotics, etc.)\n* Indications for emergency surgery\n* Planned spinal or epidural anesthesia\n* Conditions unsuitable for BIS monitoring\n* Cognitive impairment preventing informed consent","70 Years",{"count":253,"type":20},70,"1 Day","This prospective observational study aims to evaluate the impact of operating room noise on bispectral index (BIS) and hemodynamic parameters in patients undergoing general anesthesia. Environmental noise in operating rooms, often overlooked, may influence anesthesia depth, patient safety, and physiological stability. A total of 70 adult patients (ASA I-II, 18-65 years, elective surgery under general anesthesia) will be enrolled at Başakşehir Çam and Sakura City Hospital. Patients will be categorized into two groups based on intraoperative average noise levels: noisy group (\\>65 dB) and quiet group (\\\u003C55 dB). Noise levels will be measured every 10 minutes using a CEM DT-8850 sound level meter, BIS will be recorded every 10 minutes, and hemodynamic variables (systolic, diastolic, mean arterial pressure, and heart rate) will be recorded every 5 minutes.\n\nPrimary outcome is the correlation between mean intraoperative noise levels (LAeq) and BIS values during the maintenance phase of anesthesia. Secondary outcomes include the relationship between noise characteristics (e.g., device-related, human-related, alarms, media) and hemodynamic stability, as well as surgical branch-related noise classifications (high, moderate, low). The study is non-interventional, with no additional risk to participants beyond standard clinical monitoring. Findings are expected to provide evidence on the role of environmental noise in anesthesia quality, inform operating room organization, and contribute to patient safety improvements.",[257,29,258],"General Anesthesia","Noise Exposure",[260,261,262,29,263,258],"Anesthesia, General","Operating Rooms","Monitoring, Intraoperative","Bispectral Index (BIS)","2026-01-03",{"date":266,"type":42},"2026-01-06",{"date":268,"type":20},"2026-02-01",{"date":270,"type":20},"2026-06-01",{"name":272,"class":112},"Başakşehir Çam & Sakura City Hospital",{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":280,"targetDuration":282,"studyType":62,"phases":4,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":4},"100617285","correlation-between-postoperative-blood-pressure-variability-perfusion-index-and-perioperative-adverse-events-in-cardiac-surgery-100617285","NCT07316634","Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery","Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery: A Single-Center Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age at surgery ≥ 18 years\n\n  * Patients admitted to the ICU for the first time after undergoing their first cardiac surgical procedure during the current hospitalization ③ Expected to receive continuous invasive blood pressure monitoring and noninvasive pulse oximetry monitoring for at least 12 hours postoperatively in the ICU ④ Written or verbal informed consent obtained from the patient or their family members\n\nExclusion Criteria:\n\n* Patients with severe peripheral vascular disease in the arm used for noninvasive pulse oximetry monitoring\n\n  * Patients not undergoing invasive hemodynamic monitoring ③ Patients requiring preoperative or intraoperative support with IABP or ECMO\n\n    * Patients expected to have incomplete postoperative monitoring data or a monitoring duration of less than 12 hours\n\n      * Postoperative patients who are not admitted to the ICU for the first time during the current hospitalization ⑥ Patients admitted to the ICU prior to undergoing cardiac surgery ⑦ Patients with critically insufficient baseline preoperative data",{"count":281,"type":20},1200,"30 Days","In patients after cardiac surgery, disturbances in macrocirculatory fluctuations and tissue perfusion commonly coexist. The stress state induced by factors such as surgical manipulation, cardiopulmonary bypass, anesthetic agents, pain, and ischemia-reperfusion injury, along with the use of vasoactive drugs postoperatively, often leads to increased blood pressure fluctuations in the early postoperative period. Additionally, dysregulation of organ blood flow autoregulation post-surgery contributes to peripheral circulatory impairment, rendering perfusion pressure an unreliable indicator of actual organ perfusion. We aim to assess postoperative blood pressure fluctuation using blood pressure variability and evaluate peripheral circulatory status via the perfusion index. In this prospective cohort study, we will examine the correlation between these two parameters and perioperative adverse events.",[285,29],"Cardiac Surgery Intensive Care Treatment",[287,288,151],"Blood Pressure Variability","Perfusion Index","2025-12-19",{"date":291,"type":42},"2026-01-05",{"date":293,"type":20},"2026-01-01",{"date":295,"type":20},"2026-08-01",{"name":297,"class":49},"Beijing Anzhen Hospital",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":17,"enrollmentInfo":305,"targetDuration":4,"studyType":21,"phases":307,"briefSummary":308,"conditions":309,"keywords":310,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":50},"100615276","gradual-versus-intermittent-release-of-tourniquet-effect-on-map-in-hypertensive-patients-undergoing-upper-limb-orthopedic-surgeries-100615276","NCT07290504","Gradual Versus Intermittent Release of Tourniquet Effect on MAP in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries","The Effect of Gradual Versus Intermittent Release of Tourniquet on Mean Arterial Blood Pressure in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries: A Blinded Randomized Controlled Study","Inclusion Criteria:\n\n* Hypertensive patients (controlled on medical treatment more than three months)\n* Patients scheduled for upper limb orthopedic surgeries using a tourniquet for at least 30 min.\n* BMI from 18.5 to 29.9\n\nExclusion Criteria:\n\n* Patient refusal\n* ASA physical status \\> II\n* Multiple orthopedic surgeries\n* Emergency surgeries\n* Patient with relative contraindications for tourniquet use",{"count":306,"type":20},68,[228],"In this clinical trial, the authors will compare two tourniquet deflation techniques and their clinical implications on hemodynamics and acid base parameters in hypertensive orthopedic patients undergoing upper limb surgeries under general anesthesia.",[29],[159,311,312,313,314],"Acid base","Tourniquet","Orthopedics","Hypertension","2025-12-17",{"date":317,"type":42},"2025-12-18",{"date":319,"type":42},"2025-12-13",{"date":321,"type":20},"2026-05",{"name":323,"class":49},"Kasr El Aini Hospital",{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":21,"phases":335,"briefSummary":336,"conditions":337,"keywords":340,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":50},"100613842","phase-4-nalbuphine-timing-effects-on-hemodynamics-and-analgesia-in-elderly-patients-100613842","NCT07271849","Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients","Effects of Different Administration Timings of Nalbuphine on Hemodynamics and Postoperative Analgesia in Elderly Patients Undergoing Total Knee Arthroplasty","TKA","Inclusion Criteria:\n\n* All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial's purpose and significance\n* Participants underwent unilateral total knee arthroplasty under general anesthesia\n* Elderly participants (age ≥ 65 years), regardless of gender\n* Body mass index (BMI) ranging from 18 kg\u002Fm² to 30 kg\u002Fm²\n* Absence of psychiatric disorders, normal consciousness, and ability to communicate effectively\n* American Society of Anesthesiologists (ASA) physical status classification I-III;\n* No contraindications to the study medications\n\nExclusion Criteria:\n\n* Study participants with uncontrolled or untreated hypertension (resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Individuals with severe respiratory diseases\n* Subjects with abnormal liver or renal function (ALT and\u002For AST \\>2.5 times the upper limit of normal, total bilirubin \\>1.5 times the upper limit of normal, serum creatinine \\>1.5 times the upper limit of normal)\n* Individuals with a history of drug abuse, illicit drug use, or alcohol abuse, where alcohol abuse is defined as an average daily alcohol intake exceeding 2 units (1 unit = 360 mL of beer, 45 mL of 40% alcohol by volume spirits, or 150 mL of wine)","90 Years",{"count":334,"type":20},162,[23],"In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and cerebral damage in patients. Consequently, maintaining hemodynamic stability, ensuring adequate cerebral perfusion, and achieving controlled blood pressure during the perioperative period are critical factors influencing patient outcomes. Postoperatively, patients typically experience moderate to severe pain. Severe postoperative pain can result in prolonged hospital stays, increased readmission rates, elevated opioid consumption, and associated nausea and vomiting. Therefore, exploring effective multimodal postoperative pain management strategies is essential. Nalbuphine, an opioid analgesic acting as a full kappa-receptor agonist and a partial mu-receptor antagonist, is considered to provide analgesic efficacy equivalent to morphine while potentially offering advantages in maintaining hemodynamic stability. This study aims to investigate the effects of administering equivalent doses of nalbuphine at different perioperative time points on analgesia and hemodynamics in elderly patients undergoing knee arthroplasty.",[338,29,339],"Postoperative Pain, Acute","Total Knee Arthroplasty (TKA)",[339,341,342,29],"Postoperative Pain","Nalbuphine","2025-12-06",{"date":345,"type":42},"2025-12-09",{"date":347,"type":42},"2025-10-28",{"date":349,"type":20},"2026-10-31",{"name":351,"class":49},"Qianfoshan Hospital",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":16,"minAge":359,"maxAge":332,"enrollmentInfo":360,"targetDuration":4,"studyType":21,"phases":362,"briefSummary":363,"conditions":364,"keywords":369,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":50},"100341763","restoring-flow-by-revascularization-with-submaximal-angioplasty-in-hemodynamic-intracranial-atherosclerotic-stenosis-100341763","NCT03729817","REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis","VERiTAS-2 REFRESH ICAS (REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis)","Inclusion:\n\n* Non-severe recent stroke (within 30 days) attributed to 70-99% stenosis of intracranial artery (internal carotid, middle cerebral, vertebral, basilar); must be confirmed by CTA (or DSA if already available) for enrollment into the trial.\n* Hemodynamic compromise based on borderzone infarct pattern\\* for the anterior circulation (internal carotid and middle cerebral artery stenosis) and by low flow state on QMRA\\*\\* for the posterior circulation (vertebral and basilar artery stenosis).\n* Target vessel with minimal nominal diameter of 2mm\n* Target length of stenosis \\\u003C18mm\n* Symptoms within 30 days of enrollment\n* Age ≥30 and ≤90 years old#\n* Able to provide informed consent\n\n  * \\*Sole or predominant borderzone infarct pattern of qualifying event, as defined by SAMMPRIS cohort analysis \\*\\*Low flow state as determined by optimized flow algorithm as defined by the VERiTAS Study\n  * #Those 30-49 years of age must also have the presence of established atherosclerotic disease in another vascular bed (coronary, extracranial carotid, peripheral) or the presence of 2 or more risk factors (hypertension, diabetes mellitus, hyperlipidemia, tobacco abuse within the last 2 years).\n\nExclusion:\n\n* Major disabling stroke mRS \\>3; progressive or fluctuating deficit within 24 hours\n* Hemorrhagic infarction (based on CT) within 14 days of enrollment\n* Any large stroke (\\>5cm) to be at risk for hemorrhagic conversion\n* Any neurological disease which would confound follow-up assessment\n* Any co-morbid disease condition with \\\u003C12 month life expectancy\n* Known cardiac disease associated with elevated cardioembolic risk, specifically, atrial fibrillation, prosthetic valve, endocarditis, left atrial\u002Fventricular thrombus, cardiomyopathy with EF\\\u003C25%, cardiac myxoma\n* Blood dyscrasias, specifically polycythemia vera, essential thrombocytosis, sickle cell disease\n* Active bleeding diathesis, h\u002Fo major systemic hemorrhage within 30 days, active PUD, platelets\\\u003C100K (severe liver impairment (AST or ALT\\>3 x normal, cirrhosis)\n* Non-atherosclerotic stenosis including dissection, fibromuscular dysplasia, vasculitis, radiation induced vasculopathy, suspected recanalized embolus, suspected vasospastic process\n* Mori C classification of stenosis (i.e. diffuse lesion, extremely angulated \\>90⁰, excessive proximal tortuosity) Previous treatment of target lesion with stent, angioplasty or other mechanical device\n* Extracranial vertebral artery or carotid artery tortuosity, stenosis or occlusion prohibiting access to the target lesion (not exclusionary if does not prohibit access to target lesion)\n* Unable or unwilling to undergo MRI\n* Unable to undergo cerebral angiography\n* Pregnancy\n* Concurrent participation in another study which would conflict with the current study\n* Allergy or contraindication to aspirin or Plavix\n* Indication for warfarin or NOAC beyond enrollment (e.g. venous thrombo-embolism, atrial fibrillation)\n* Thrombolytic therapy within 24 hours","30 Years",{"count":361,"type":20},159,[228],"By assessing the safety and durability of an endovascular intervention, this study will justify and inform the design of a subsequent seamless feasibility\u002Fpivotal trial aimed at the treatment of intracranial atherosclerotic stenosis (ICAS), an entity which carries a high risk of stroke despite existing medical therapies, and has no other treatment options. Given the global burden of ICAS as a leading cause of stroke, there is a high potential for public health impact not just in the U.S., but world-wide.",[365,366,367,29,368],"Intracranial Atherosclerotic Disease","Stroke","Angioplasty, Balloon","Device Safety",[370,366,367,29,368],"Intracranial atherosclerotic disease","2025-11-03",{"date":373,"type":42},"2025-11-04",{"date":375,"type":20},"2027-10",{"date":377,"type":20},"2032-10-31",{"name":379,"class":49},"Case Western Reserve University",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":17,"enrollmentInfo":386,"targetDuration":4,"studyType":21,"phases":388,"briefSummary":389,"conditions":390,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":50},"100599798","the-effect-site-concentration-of-remifentanil-blunting-endotracheal-intubation-responses-during-anesthesia-induction-with-lidocaine-or-sufentanil-combined-with-etomidate-a-randomized-controlled-study-100599798","NCT07089173","The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective surgery under general anesthesia with endotracheal intubation;\n* Classified as ASA physical status I-II.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>65 years;\n* Body mass index (BMI) \\>30 kg\u002Fm² or \\\u003C18.5 kg\u002Fm²;\n* Diagnosis of hypertension or severe cardiovascular diseases (including myocardial infarction, heart failure, atrial fibrillation, atrioventricular block, moderate-to-severe valvular diseases) or respiratory diseases (including acute exacerbation of chronic obstructive pulmonary disease, acute respiratory distress syndrome, acute asthma attack, moderate-to-severe pulmonary hypertension, severe pneumonia);\n* Diagnosis of obstructive sleep apnea syndrome or history of difficult intubation or preoperatively anticipated difficult airway;\n* Renal, hepatic or hematologic diseases;\n* High risk of aspiration or reflux;\n* Current use of analgesics for chronic pain or β-blockers for cardiovascular diseases;\n* Current use of psychotropic medications;\n* Contraindications to remifentanil or sufentanil, including: known hypersensitivity to any component of these drugs or other fentanyl analogues, current use of monoamine oxidase inhibitors, myasthenia gravis or conditions predisposing to respiratory depression, bronchial asthma or related disorders;\n* Contraindications to lidocaine, including: known allergy to local anesthetics, concurrent Adams-Stokes syndrome, Wolff-Parkinson-White syndrome, or severe cardiac conduction block.",{"count":387,"type":20},99,[228],"The aim of this study was to compare the effect-site target concentration (including EC₅₀ and EC₉₀) of remifentanil required to suppress cardiovascular responses to tracheal intubation during anesthesia induction with etomidate combined with either lidocaine or sufentanil.",[29],"2025-09-17",{"date":393,"type":42},"2025-09-22",{"date":395,"type":42},"2025-08-01",{"date":397,"type":20},"2026-07-30",{"name":399,"class":49},"Peking University Shenzhen Hospital",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":407,"enrollmentInfo":408,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":409,"conditions":410,"keywords":415,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":423,"locationsCount":50},"100593092","correlation-study-between-sma-blood-flow-reactivity-and-acute-gastrointestinal-injury-in-critically-ill-patients-100593092","NCT07001943","Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients","Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Functional Injury in Critically Ill Patients","Inclusion Criteria:\n\n* Adults aged ≥18 years and ≤80 years.\n* Admitted to the study with a expected stay of more than 72 hours.\n* Require initiation of enteral nutrition support.\n\nExclusion Criteria:\n\n* Pre-existing severe gastrointestinal diseases.\n* Patients with gastrointestinal bleeding.\n* Patients with bowel obstruction.\n* Pregnant or lactating women.\n* Patients with contraindications to bedside Doppler ultrasound.","80 Years",{"count":121,"type":20},"This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.",[411,412,413,29,414],"Intestinal Ischemia","Critical Illness","Enteral Nutrition Feeding","Ultrasonography, Doppler",[416,412,411,29],"Enteral Nutrition","2025-08-28",{"date":419,"type":42},"2025-09-05",{"date":421,"type":42},"2025-06-01",{"date":44,"type":20},{"name":424,"class":49},"Peking Union Medical College Hospital",{"id":426,"slug":427,"hasResults":11,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":21,"phases":433,"briefSummary":434,"conditions":435,"keywords":438,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":446,"locationsCount":50},"100597062","clinical-study-on-laparoscopic-resection-of-splenic-artery-aneurysm-with-preservation-of-spleen-100597062","NCT07053605","Clinical Study on Laparoscopic Resection of Splenic Artery Aneurysm With Preservation of Spleen","Inclusion Criteria:\n\n* Asymptomatic splenic artery aneurysms with a diameter\\>2 cm,ruptured splenic artery aneurysms,and splenic artery aneurysms with a diameter increase\\>0.5 cm\u002Fyear.\n\nAneurysm located in the main trunk of the splenic artery. Informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with malignancies Hepatic cirrhosis with portal hypertension peptic ulcer disease Recent peptic ulcer disease History of Hemorrhagic stroke Pregnancy hematological diseases Uncontrolled Hypertension Human immunodeficiency virus (HIV) infection",{"count":432,"type":20},10,[228],"In this study, researchers examined the changes in related indicators such as immune function, splenic vein,proper hepatic artery, and portal venous hemodynamics following laparoscopic resection of a splenic artery aneurysm. We determined the changes in these patient-related indicators after surgical treatment and whether these changes could improve patient outcomes.",[436,437,29],"Splenic Artery Aneurysm","Immune Function",[68,439,440,29],"resection of splenic artery aneurysm","Immune function",{"date":442,"type":42},"2025-07-08",{"date":444,"type":42},"2025-06-23",{"date":46,"type":20},{"name":447,"class":49},"Northern Jiangsu People's Hospital",{"id":449,"slug":450,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":21,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":50},"100596949","non-invasive-blood-pressure-monitoring-in-icu-patients-using-the-dare-device-100596949","NCT07052123","Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device","Inclusion Criteria:\n\n* Adult patients (male or female), aged 18 years or older\n* Admitted to intensive care unit (ICU) or critical care with an expected hospital stay longer than 2 days\n* Equipped with an arterial catheter for invasive blood pressure monitoring\n* Equipped with a urinary catheter for invasive core body temperature monitoring\n\nExclusion Criteria:\n\n* Patients under 18 years old (minors)\n* Known skin allergy to adhesives or silicone, or skin condition preventing adhesive use\n* History of extensive skin pathology (e.g., Lyell syndrome)\n* Patients with therapeutic limitations\n* Patients with active implanted medical devices (e.g., pacemaker, defibrillator)\n* Pregnant or breastfeeding women\n* Patients not affiliated with the French social security system\n* Patients or their legal representatives refusing consent, or unable to understand information and give informed consent\n* Patients under legal guardianship, curatorship, or deprived of liberty",{"count":455,"type":20},2,[228],"This study tests a new non-invasive device called DARE to monitor blood pressure in patients in intensive care. It compares the device's readings to standard invasive methods and also looks at how well it measures other vital signs like temperature, oxygen levels, and heart rhythm. The goal is to improve patient safety and comfort while helping doctors detect problems earlier.",[29,459,460,412,67],"Blood Pressure Monitoring","Intensive Care Units","2025-06-26",{"date":463,"type":42},"2025-07-04",{"date":465,"type":42},"2025-03-24",{"date":467,"type":20},"2028-03-24",{"name":469,"class":49},"Centre Hospitalier de Saint-Denis",{"id":471,"slug":472,"hasResults":11,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":476,"eligibilityCriteria":477,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":478,"targetDuration":4,"studyType":21,"phases":480,"briefSummary":481,"conditions":482,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":492,"locationsCount":50},"100522456","evaluation-of-the-hemodynamic-effect-of-dexmedetomidine-in-scheduled-outpatient-surgery-100522456","NCT06082856","Evaluation of the Hemodynamic Effect of Dexmedetomidine in Scheduled Outpatient Surgery","Evaluation of the Hemodynamic Effect of Dexmedetomidine in Scheduled Outpatient Surgery: Single-center Prospective Randomized Double-blind Non-inferiority Study.","DEXCOEUR","Inclusion Criteria:\n\n* Patient with scheduled surgery under general anesthesia for one of the following: oral, orthopedic, urological, digestive and gynecological surgeries.\n* The patient must have given their free and informed consent and signed the consent form\n* The patient must be a member or beneficiary of a health insurance plan\n\nExclusion Criteria:\n\n* The subject is in a period of exclusion determined by a previous study\n* The subject is unable to give consent\n* It is impossible to give the subject informed information\n* The patient is under safeguard of justice or state guardianship\n* Patient with a known allergy to dexmedetomidine or other drugs.\n* Patient with a contraindication to general anesthesia or outpatient management.\n* Patient treated with beta-blocker, ACE inhibitor or ARB2\n* Patient with an ASA4 score.\n* Patient with HR \\\u003C 50 bpm.\n* Patient with the following cardiovascular comorbidities: coronary insufficiency, obstructive cardiomyopathy, severe hypertension, ventricular rhythm or conduction disorder.\n* Patient with hepatic (prothrombin rate \\\u003C 70%, liver enzyme\u002FBilirubin X 3) and\u002For renal (clearance \\\u003C 50 ml.min) insufficiency.\n* Pregnant, parturient or nursing patient",{"count":479,"type":20},594,[228],"Ambulatory surgery is increasingly used in anesthesia. In case of general anesthesia, it is recommended to use anesthesia molecules with a short half-life and low doses of opiates to ensure a rapid awakening and to prevent nausea and vomiting by systematic administration of anti-emetics during the operation.\n\nOpiates (including sufentanil) have recently been called into question because of the nausea and vomiting and the delay in waking up induced by these molecules. To combat these side effects, the authors have proposed either to reduce the doses or to substitute them with dexmedetomidine, a sedative antihypertensive drug. Recent studies have demonstrated that opiates used in general anesthesia can be replaced by dexmedetomidine. However, literature data are controversial concerning the hemodynamic impact. No study has compared the hemodynamic profile of opioid-free anesthesia with dexmedetomidine versus conventional anesthesia with opioids.\n\nThe ambulatory context lends itself to the use of dexmedetomidine because it is aimed at a population without strong cardiac pathology, concerns non-major interventions, with the need to optimize pain and side effects.\n\nThe study authors therefore wish to compare the effects of induction of general anesthesia with low-dose Dexmedetomidine versus sufentanil, on post-induction hemodynamic stability in scheduled outpatient surgeries. The investigators hypothesize that hemodynamic stability at induction of general anesthesia with low-dose dexmedetomidine is not inferior to that obtained with sufentanil in scheduled ambulatory surgeries.",[483,232,29,484],"Anesthesia","Ambulatory Care","2025-06-04",{"date":487,"type":42},"2025-06-06",{"date":489,"type":42},"2023-10-19",{"date":491,"type":20},"2026-02",{"name":493,"class":49},"Centre Hospitalier Universitaire de Nīmes",{"id":495,"slug":496,"hasResults":11,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":500,"eligibilityCriteria":501,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":332,"enrollmentInfo":502,"targetDuration":4,"studyType":21,"phases":504,"briefSummary":505,"conditions":506,"keywords":513,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":50},"100591559","importance-of-arterial-measurement-sites-ipams-on-intraoperative-hemodynamic-management-100591559","NCT06982001","ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management","Importance of Arterial Measurement Sites on Intraoperative Hemodynamic Management of Major Abdominal Surgeries and Artificial Intelligence-based Prediction of Arterial Gradient Using Peripheral Radial Pressure Waveform Analysis","IPAMS","Inclusion Criteria:\n\n* Patients between 18 and 90 years of age;\n* Major abdominal surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia;\n* Expected anesthesia time of more than 120 minutes.\n\nExclusion Criteria:\n\n* Known peripheral severe vascular disease with subclavian artery stenosis,\n* Significant arterial gradient between arms with preoperative non-invasive bloop pressure measurements (\\>25 mm Hg of systolic blood pressure or 10 mm Hg of mean arterial pressure);\n* Inability or contraindications to insert arterial line on either arm (arteriovenous fistula, surgical sterility);\n* Known allergies, intolerance, other medical conditions that precludes the use of prescribed general anesthesia protocol for this trial;\n* Inability to communicate in French or English.",{"count":503,"type":20},204,[228],"The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those obtained from brachial artery catheterization (a more accurate reflection of central arterial pressure). At the end of the study, we are looking to answer the following questions:\n\n1. Does arterial pressure measurement sites influence the amount of vasopressors that is administered during major abdominal surgeries?\n2. What are the instances where there is a difference between peripheral (radial catheter) and central (brachial catheter) monitoring and what are the risk factors leading to the appearance of this radial-brachial pressure gradient?\n3. With the data collected, can artificial intelligence based analysis help predict the reliability of a radial monitoring and help guide clinicians on choosing a peripheral versus central arterial pressure monitoring site? All adult participants who are scheduled for elective major abdominal surgeries and meeting our inclusion criteria will be approached and included if they consent. Participants will be randomized 1:1 in the intervention group and the standard of care group. In the intervention group, the brachial arterial line will be used intraoperatively to guide vasopressor and fluid administration. A radial line will also be installed to measure the radial arterial pressure simultaneously, but will not be used to guide hemodynamic management. In the standard of care group, both lines will be installed just like in the intervention group, however, it is the radial arterial line that will guide fluid and vasopressor administration. In both groups, the anesthesia protocol will be standardized and the anesthesiologist will be blinded to the arterial pressure measurement site.",[65,29,507,508,483,509,510,511,512],"Monitoring Blood Pressure","Arterial Lines","Vasopressor","Fluid Management","Artificial Intelligence in Operating Room","Artificial Intelligence (AI)",[514,515,516,517,518],"Comparison of arterial catheterization sites on hemodynamic monitoring","Incidence of radial-brachial pressure gradient","Risk factors of radial-brachial pressure gradient","Effect of arterial catheterization sites on hemodynamic management","Effect of peripheral vs central arterial pressure measurements in intraoperative hemodynamic management","2025-05-13",{"date":521,"type":42},"2025-05-21",{"date":523,"type":20},"2025-09",{"date":525,"type":20},"2028-12",{"name":527,"class":49},"Ciusss de L'Est de l'Île de Montréal",{"id":529,"slug":530,"hasResults":11,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":535,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":537,"conditions":538,"keywords":541,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":50},"100586964","hipec-surgery-and-hemodynamics-100586964","NCT06922227","HIPEC Surgery and Hemodynamics","Perioperative Hemodynamic and Respiratory Changes During Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Combined With Cytoreductive Surgery","Inclusion Criteria:\n\n* ≥18 years old Patients planned to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy\n* ASA II-III-IV physical class\n\nExclusion Criteria:\n\n* \\\u003C18 years\n* Emergency cases",{"count":536,"type":20},15,"Hyperthermic Intraperitoneal Chemotherapy (HIPEC) involves the intraoperative administration of heated chemotherapeutic agents into the abdominal cavity following cytoreductive surgery (CRS). The increasing use of CRS combined with HIPEC has introduced certain procedural and physiological considerations that distinguish it from other surgical interventions, posing unique challenges for researchers and clinicians alike.\n\nDespite advancements in surgical and anesthetic techniques, this combined approach is frequently associated with significant hemodynamic instability, coagulation abnormalities, respiratory complications, and nutritional imbalances.\n\nThe study aims to contribute to the existing body of knowledge by examining the physiological alterations induced by HIPEC, thereby offering practical insights and guidance for investigators involved in the management and study of this complex therapeutic modality.",[29,539,540],"Cytoreductive Surgery","Hyperthermic Intraperitoneal Chemotherapy (HIPEC)",[542,543,29],"HİPEC","cytoreductive surgery","2025-04-10",{"date":546,"type":42},"2025-04-13",{"date":548,"type":20},"2025-04-01",{"date":550,"type":20},"2025-07-15",{"name":552,"class":112},"Miray Gözde Özdemir",{"id":554,"slug":555,"hasResults":11,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":559,"eligibilityCriteria":560,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":561,"enrollmentInfo":562,"targetDuration":4,"studyType":21,"phases":564,"briefSummary":565,"conditions":566,"keywords":567,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":574,"leadSponsor":576,"locationsCount":50},"100568743","observation-on-administration-of-propofol-at-different-titration-endpoints-100568743","NCT06685198","Observation on Administration of Propofol at Different Titration Endpoints","The Impact of Different Titration Endpoints of Propofol on Hemodynamics and Stress During the Induction Phase of General Anesthesia","OAPDTE","Inclusion Criteria:\n\n1. Age 18-60 years.\n2. Elective surgery with planned endotracheal intubation under general anesthesia.\n3. ASA classification of I or II,with heart function classified as 1 or 2.\n4. Body Mass Index (BMI) 18-30 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Severe cardiac, pulmonary, hepatic, or renal diseases (heart function classification greater than 3 \u002F respiratory failure \u002F liver failure \u002F renal failure).\n2. Malignant arrhythmias: atrial flutter, atrial fibrillation, atrioventricular block, frequent ventricular premature beats, multifocal ventricular premature beats, ventricular premature beats R on T, ventricular flutter, and ventricular fibrillation.\n3. Expected difficulty with intubation, hypoalbuminemia, hypertension, or diabetes mellitus.\n4. Patients with a high risk of aspiration due to a full stomach, gastrointestinal obstruction, or pregnancy.\n5. Patients with schizophrenia, epilepsy, Parkinson's disease, intellectual disabilities, etc.\n6. Alcohol abusers or those who have been using sedatives or analgesics long-term.\n7. Allergic to propofol or its emulsion.\n8. Currently participating in a clinical trial that conflicts with this study.","60 Years",{"count":563,"type":20},258,[228],"Propofol has a rapid onset and short duration of action, making it widely used for induction of general anesthesia. However, its prominent drawback is circulatory depression. Our research team previously proposed an individualized dosing method for the titration of propofol. We then compared the effects of different titration rates of propofol on hemodynamics and stress during general anesthesia induction. It was found that the incidence of hypotension during the induction period was lower in the 0.5 mg\u002Fkg\u002Fmin group, with lower stress levels and faster postoperative recovery. However, this group still had a 25.3% incidence of hypotension. Therefore, we plan to further study the differences in hemodynamics, depth of anesthesia, stress response, and postoperative recovery in three groups of patients induced with a constant infusion rate of propofol at 0.5 mg\u002Fkg\u002Fmin titrated to an OAA\u002FS score of 1, an OAA\u002FS score of 2, and BIS ≤ 60, combined with remifentanil 2 μg\u002Fkg. This study aims to explore the appropriate propofol titration endpoint during general anesthesia induction to maintain stable perioperative haemodynamics and achieve rapid postoperative recovery.",[260,29],[568],"titration of propofol","2024-12-01",{"date":571,"type":42},"2024-12-04",{"date":573,"type":20},"2025-02-20",{"date":575,"type":20},"2025-08-20",{"name":577,"class":49},"SanQing Jin",{"id":579,"slug":580,"hasResults":11,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":4,"eligibilityCriteria":584,"healthyVolunteers":58,"sex":585,"minAge":93,"maxAge":17,"enrollmentInfo":586,"targetDuration":254,"studyType":62,"phases":4,"briefSummary":588,"conditions":589,"keywords":594,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":598,"lastUpdatePostDateStruct":599,"startDateStruct":601,"completionDateStruct":603,"leadSponsor":605,"locationsCount":4},"100563837","hemonirs-a-paradigm-shift-in-the-process-of-musculoskeletal-rehabilitation-of-acl-injuries-in-cyclic-sports-athletes-100563837","NCT06621355","HemoNIRS: a Paradigm Shift in the Process of Musculoskeletal Rehabilitation of ACL Injuries in Cyclic Sports Athletes.","HemoNIRS: Un Cambio De Paradigma En El Proceso De Rehabilitación Musculoesquelética De Lesiones De Ligamento Cruzado Anterior Mediante Dispositivos NIRS En Deportistas Que Realizan Deportes Cíclicos","General inclusion criteria\n\n* Men aged 18 to 65\n* An adipose layer of \\<2 cm in areas of NIRS placement, assessed with a plicometer\n* Understand written, read and spoken Spanish, English or Catalan.\n\nGeneral exclusion criteria\n\n* Having any cardio-metabolic, hormonal, neurological or other comorbidities that could affect participation in the study (e.g. severe mental illness, end-stage disease).\n\nEligibility criteria (LCA1 group)\n\n* Regular athlete with training and\u002For competition \\>3 days\u002Fwk prior to injury.\n* ACL injury \\<6 months after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (LCA2 group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* ACL injury \\>2 years after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (CON group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* Never suffered an ACL injury in any knee - Able to perform incremental intervallic test on cycleergometer or treadmill.\n\nAll the groups exclusion criteria\n\n\\- Incapacitating pain that prevents assessment","MALE",{"count":587,"type":20},129,"Muscle haemodynamics has so far been assessed using at most 2-3 near-infrared spectroscopy devices on isolated muscles and without correlating variables. At the same time, research on musculoskeletal pathologies is limited, and there are no studies that analyse the haemodynamic changes that occur when the anterior cruciate ligament (ACL) is injured and whether these changes last over time. The aim of the study is to monitor and evaluate the physiological changes produced by ACL injury on muscle performance using non-invasive near-infrared spectroscopy (NIRS) devices in trained athletes. This descriptive cross-sectional observational multicentre multicentre study, with Balearic Islands ethics committee IB 5585\u002F24PI, will include males aged 18-65 years who have undergone ACL surgery, divided into 3 groups that: have an evolution of less than 6 months (ACL1), more than 2 years since the surgical intervention and are already practising normal physical-sports activities (ACL2) and the control group (CON) that has never suffered an ACL affectation to date. The 3 groups will perform an incremental intervallic test (4:1) on a cycloergometer or treadmill (according to the specificity of their sport), where different muscular haemodynamic variables will be assessed using 12-24 NIRS devices. The main study variables will be the muscular haemodynamic values of each muscle analysed and their correlation between them: muscular oxygen saturation, absolute capillary haemoglobin, loaded and unloaded with oxygen and relative muscular haemoglobin blood flow, loaded and unloaded with oxygen. Secondary variables will be heart rate, socio-demographic variables (age, toxic habits, injury and sports history) and subjective perception of effort (RPE-20).",[590,591,29,592,593],"ACL - Anterior Cruciate Ligament Rupture","ACL Injury","Oxygen Consumption Based Assessment of Hemodynamics","Exercise",[595,29,593,596,597],"Spectroscopy, Near-Infrared","Vascular resistance","Oxygen consumption","2024-09-27",{"date":600,"type":42},"2024-10-01",{"date":602,"type":20},"2024-12-02",{"date":604,"type":20},"2026-12-02",{"name":606,"class":49},"Universitat de Lleida"]