[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemoglobin-a1c-protein-human\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemoglobin-a1c-protein-human":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100627235","the-association-between-preoperative-hba1c-levels-and-postoperative-acute-kidney-injury-in-isolated-coronary-artery-bypass-surgery-100627235",false,"NCT07445997","The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery","\"The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery: A Prospective Observational Study\"","Inclusion Criteria:\n\n* Patients undergoing isolated elective CABG surgery\n* Patients with available preoperative and postoperative Doppler RRI measurements\n* Patients with available HbA1c data\n\nExclusion Criteria:\n\n* Patients with chronic kidney disease\n* Emergency surgeries\n* Redo\u002Frevision surgeries\n* Patients undergoing concomitant valve surgery\n* Presence of acute infection or sepsis\n* Advanced heart failure (EF \\\u003C30%)\n* Requirement for intra-aortic balloon pump, pacemaker, or mechanical circulatory support\n* History of nephrectomy or single kidney\n* Preoperative serum creatinine \\>2.0 mg\u002FdL\n* Pregnancy\n* Refusal to participate in the study","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","7 Days","OBSERVATIONAL","Renal complications are frequently encountered in cardiac surgery and constitute significant causes of morbidity and mortality. They most commonly present in the form of acute kidney injury (AKI). The etiological factors of AKI include hemodynamic alterations, hemolysis and pigment nephropathy, inflammatory response and cytokine storm, ischemia-reperfusion injury, use of nephrotoxic agents, patient-related risk factors (advanced age, diabetes mellitus, preoperative renal insufficiency, congestive heart failure, hypertension, anemia), duration of surgery, and postoperative complications such as low cardiac output syndrome, sepsis, bleeding and reoperation, hypoalbuminemia, and fluid imbalance.\n\nPrevious studies have demonstrated several mechanisms through which elevated HbA1c levels may contribute to acute renal injury, including glomerular damage and hyperfiltration, endothelial dysfunction and microvascular injury, tubular damage, accumulation of glycation products and advanced glycation end products (AGEs), structural changes in blood vessels, and metabolic and systemic factors.\n\nThe evaluation of acute renal failure relies on fundamental scoring systems, biomarkers, and imaging modalities. Among the scoring systems, the most current and widely used is the KDIGO (Kidney Disease: Improving Global Outcomes) classification. According to the KDIGO definition, the diagnosis of AKI can be established when at least one of the following three criteria is met: an increase in serum creatinine of ≥0.3 mg\u002FdL within 48 hours, an increase in serum creatinine to ≥1.5 times baseline within 7 days, or a urine output of \\\u003C0.5 mL\u002Fkg\u002Fhour for more than 6 hours. AKI staging is performed based on these parameters.\n\nImaging modalities used in the assessment of renal function include renal ultrasonography (US), Doppler ultrasonography with measurement of the renal resistive index (RRI), renal MRI\u002FMR angiography, and renal computed tomography (particularly CT angiography). RRI is a non-invasive, bedside-applicable method that provides direct information about renal vascular resistance by evaluating renal arterial flow patterns.\n\nIn our clinic, the rationale of the present study is to measure preoperative HbA1c and Doppler-derived RRI values in patients undergoing isolated coronary artery bypass surgery, and to evaluate their relationship with postoperative KDIGO classification and Doppler RRI values in order to gain insight into the development of AKI.",[25,26,27,28],"Acute Kidney Injuries","Hemoglobin A1c Protein, Human","Coronary Bypass Graft Surgery","Renal Resistive Index",[30,31,32,33],"acute kidney injuries","hemoglobin A1c protein","coronary bypass graft surgery","renal resistive index","RECRUITING","2026-02-25",{"date":37,"type":38},"2026-03-03","ACTUAL",{"date":40,"type":38},"2026-01-20",{"date":42,"type":20},"2026-08-30",{"name":44,"class":45},"Osman Sila Aydin","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100575087","effectiveness-of-a-lifestyle-intervention-for-pregnant-women-with-abnormal-glucose-metabolism-in-early-pregnancy-eagm-trial-100575087","NCT06767722","Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Trial","Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Randomized Controlled Trial","EAGM","Inclusion Criteria:\n\n* Over 18 years of age.\n* Able to provide informed consent.\n* Confirmed viable pregnancy on a nuchal translucency scan done between 11+0 and 13+6 weeks.\n* Singleton pregnancies.\n* An abnormal glucose metabolism determined by a blood test performed before 14 weeks, defined as FPG 5.1-6.9mmol\u002FL and\u002For HbA1c 5.7-6.4%.\n\nExclusion Criteria:\n\n* Pregestational diabetes (diagnosed as diabetes mellitus before pregnancy, or FPG≥7.0mmol\u002FL, or HbA1c≥6.5% at the first prenatal visit), impaired fasting glucose or impaired glucose tolerance diagnosed before pregnancy.\n* Plan for termination of pregnancy due to fetal anomaly identified at the first trimester scan.\n* Use of medications known to interfere with glucose metabolism (e.g. corticosteroids, antipsychotic drugs) at the time of randomisation.\n* Any other physical (serious medical conditions such as cancer, organ failure, epilepsy, paraplegia, disability) or psychological condition (e.g. learning difficulties, serious mental illness) that is likely to interfere with the conduct of the trial according to evaluation by the trial monitoring group.\n* Women currently with hyperemesis gravidarum leading to dehydration or requiring hospitalization. If persisting vomiting resolves, the patient may be reassessed for inclusion in the trial up to and including 14+6 weeks of gestation, providing all other inclusion and exclusion criteria are met.","FEMALE","55 Years",{"count":58,"type":20},3430,"INTERVENTIONAL",[61],"NA","This is a multicentre, parallel-group, open-label, pragmatic, randomised-control trial of early lifestyle intervention versus routine prenatal care by random allocation (1:1) in women with early abnormal glucose metabolism (EAGM) to compare the incidence of large-gestational age and preterm birth between two groups. The investigators aim to assess the effectiveness of early lifestyle interventions and to provide evidence for the optimal standard management for Chinese women with EAGM.",[64,65,26,66,67],"Early Pregnancy","Fasting Plasma Glucose","Lifestyle Intervention","Adverse Pregnancy Outcomes","2025-06-25",{"date":70,"type":38},"2025-07-01",{"date":72,"type":38},"2025-04-16",{"date":74,"type":20},"2027-06-30",{"name":76,"class":77},"First Affiliated Hospital, Sun Yat-Sen University","OTHER"]