[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemorrhage-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemorrhage-stroke":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100639799","phase-1-investigating-central-contributions-to-fatigue-using-non-invasive-brain-stimulation-100639799",false,"NCT07613970","Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation","Investigating the Causal Contribution of Neural Oscillations to Neuromuscular Fatigue After Stroke Using tACS","Inclusion Criteria:\n\nFirst-ever stroke\n\n≥18 years Subacute phase: 1 week to 6 months post-stroke Quadriceps (hemiplegic side) strength ≤3\u002F5 (Medical Research Council (MRC)) Montreal Cognitive Assessment (MoCA) ≥21\n\nExclusion Criteria:\n\nHistory of a previous stroke Severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps\u002Fhamstrings) Other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility Non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20) Current or former athletes. Athletes are defined as individuals who participated in organized competitive sports and engaged in structured training ≥3 sessions per week for ≥1 year within the 5 years preceding stroke Contraindications for tACS (e.g., presence of a deep brain stimulator, pacemaker, head wound, etc.).",true,"ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The goal of this interventional study is to understand the contribution of the central components to the manifestation of neuromuscular fatigue in stroke survivors. The study will include adults with a first-ever stroke in the subacute phase.\n\nThe main question it aims to answer:\n\n• How does the brain activity contribute to the manifestation of neuromuscular fatigue in stroke survivors?\n\nResearchers will compare stroke participants receiving active vs sham tACS in a single session before the fatiguing contractions to determine whether central changes can influence fatigue onset\u002Fprogression.\n\nParticipants will:\n\n* Perform repeated leg muscle contractions until fatigue while seated in an experimental setup\n* Receive either active or sham tACS for 20 minutes before the fatiguing contractions.\n* Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task\n* Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task",[28,29,30,31],"Stroke","Cerebrovascular Accident (CVA)","Ischemia Stroke","Hemorrhage Stroke",[33,34,35,36,37,38,39],"fatigue","electroencephalography","EEG","electromyography","EMG","transcranial alternating current stimulation","tACS","NOT_YET_RECRUITING","2026-05-21",{"date":43,"type":44},"2026-05-29","ACTUAL",{"date":46,"type":21},"2026-09-01",{"date":48,"type":21},"2029-10-31",{"name":50,"class":51},"Vrije Universiteit Brussel","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":72,"locationsCount":4},"100638548","studying-fatigue-and-movement-after-stroke-100638548","NCT07594938","Studying Fatigue and Movement After Stroke","Exploring Neuromuscular Fatigue in Stroke Survivors: Understanding Central-Peripheral Interaction","Inclusion Criteria:\n\nStroke survivors will be recruited from Brussels University Hospital (Brussels, Belgium). Patients who have a first-ever stroke, ≥18 years, subacute phase: 1 week to 6 months post-stroke, quadriceps (hemiplegic side) strength ≤3\u002F5 (Medical Research Council (MRC)), and Montreal Cognitive Assessment (MoCA) ≥21 will be included.\n\nExclusion Criteria:\n\nExclusion criteria include a history of a previous stroke, severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps\u002Fhamstrings), other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility, non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20), and current or former athletes. Athletes are defined as individuals who participated in organized competitive sports and engaged in structured training ≥3 sessions per week for ≥1 year within the 5 years preceding stroke. Control participants will be excluded if they meet the same exclusion criteria.",{"count":20,"type":21},"1 Day","OBSERVATIONAL","The goal of this observational study is to learn how neuromuscular fatigue develops after stroke and how changes in brain activity, muscle activity, and their interaction contribute to reduced motor performance in stroke survivors compared to healthy individuals. The study will include adults with a first-ever stroke in the subacute phase and age-matched healthy volunteers.\n\nThe main questions it aims to answer are:\n\n* How does neuromuscular fatigue develop during repeated muscle contractions after stroke compared to healthy individuals?\n* How do brain activity, muscle activity, and brain-muscle interaction change during fatigue after stroke?\n\nResearchers will compare stroke participants and healthy control participants to determine whether fatigue-related changes are more strongly associated with altered brain activity, altered muscle activity, or disrupted brain-muscle communication after stroke.\n\nParticipants will:\n\n* Perform repeated leg muscle contractions until fatigue while seated in an experimental setup\n* Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task\n* Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task",[28,64,30,31],"Cerebro-vascular Accident",[33,34,35,36,37,66],"stroke","2026-05-18",{"date":69,"type":44},"2026-05-19",{"date":46,"type":21},{"date":48,"type":21},{"name":50,"class":51},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100636822","hemorrhage-stroke-decision-making-model-based-deep-learning-brainhemoai-system-100636822","NCT07570680","Hemorrhage Stroke Decision Making Model Based Deep Learning (BrainHemoAI System)","Construction of an Integrated Intelligent Model for Spontaneous Intracerebral Hemorrhage Based on Deep Learning","Inclusion Criteria:\n\n1. Age \\>= 8 years old;\n2. Patients diagnosed with spontaneous hemorrhagic stroke based on medical history and auxiliary examinations;\n3. Received non-contrast computed tomography (NCCT) in the outpatient or emergency department;\n4. Treated in accordance with standard clinical guidelines during hospitalization;\n5. Have complete clinical data.\n\nExclusion Criteria:\n\n1. Had undergone surgical treatment in another hospital before admission;\n2. Was in a state of shock upon admission;\n3. Had severe heart, liver, or kidney dysfunction or other life-threatening systemic diseases;\n4. Died during hospitalization;\n5. Had an expected lifespan of less than six months or was unable to complete the study follow-up for other reasons.","8 Years",{"count":82,"type":21},7100,"Although hemorrhagic stroke also has the characteristics of high mortality and disability rates, and constitutes a major public health problem worldwide, there is a relative lack of in-depth research teams for hemorrhagic stroke in China. The current preoperative imaging evaluation of spontaneous cerebral hemorrhage is still limited to the traditional Tada formula, and there are subjective differences in diagnosis among different doctors, making it difficult to achieve homogenization in clinical decision-making. Hemorrhagic stroke is a common and frequently occurring disease in Jiangxi Province. Therefore, establishing a new diagnosis and treatment system focused on hemorrhagic stroke can not only fill the research gap in this field in China, improve the accuracy and homogeneity of hemorrhagic stroke diagnosis and treatment, but also promote related research progress to reduce the mortality and disability rates of this disease and improve the clinical prognosis of patients.",[31],"RECRUITING","2026-04-29",{"date":88,"type":44},"2026-05-06",{"date":90,"type":44},"2022-09-01",{"date":92,"type":21},"2026-12-30",{"name":94,"class":51},"Second Affiliated Hospital of Nanchang University",1]