[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemorrhagic-fever-with-renal-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemorrhagic-fever-with-renal-syndrome":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637454","biomedical-signal-extraction-from-symptom-descriptions-an-observational-registry-using-the-opengenome-platform-100637454",false,"NCT07578610","Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform","Accuracy and Calibration of Evidence-Grounded Biomedical Signal Extraction From Free-Text Symptom Descriptions: A Prospective Observational Registry Using the OpenGenome Automated Research Instrument","OGNOME-REG","* Automated or programmatically generated submissions detected by rate limiting\n* Submissions containing no discernible symptom or health-related content",true,"ALL","18 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio. For each submission, the system retrieves real biomedical literature from PubMed and ClinicalTrials.gov in parallel, applies a constrained reasoning model operating under a strict output schema, and returns a structured biological signal report. The study evaluates the internal consistency of extracted signals, the calibration of confidence scores relative to dataset size and symptom specificity, and the distribution of biological signal categories across a large anonymous population. No intervention is assigned. No participant contact occurs. All data is anonymized at the point of collection.",[26,27,28,29,30,31],"Signs and Symptoms","Fever","Myalgia","Skin Diseases","Hemorrhagic Fever With Renal Syndrome","Zoonoses",[33,34,35],"biomedical signal extraction","symptom analysis","PubMed","RECRUITING","2026-05-16",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":40},"2026-05-05",{"date":44,"type":22},"2028-05-30",{"name":46,"class":47},"OpenGenome","NETWORK",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100387374","hantavirus-registry---hantareg-100387374","NCT04323904","Hantavirus Registry - HantaReg","Hantavirus Registry Gathers Knowledge on Epidemiology, Clinical Course, Prognostic Factors and Molecular Characteristics for Hantavirus Infections and Their Complications (HantaReg)","HantaReg","Inclusion Criteria:\n\n* Serological or molecular evidence of hantavirus infection and clinical evidence of nephropathia epidemica or hemorrhagic fever with renal syndrome (HFRS)\n* Serological or molecular evidence of hantavirus infection and clinical evidence of hantavirus cardiopulmonary syndrome (HCPS)\n\nExclusion Criteria:\n\n\\- Serological or molecular evidence of hantavirus infection without clinical signs of nephropathia epidemica, HFRS or HCPS",{"count":58,"type":22},200,"Hantavirus disease are zoonotic infections and remain a clinical challenge with globally increasing incidence and multiple serious outbreak situations in Europe within the last years. Hantavirus disease encompasses two clinical syndromes, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) caused by Old World and New World hantaviruses, respectively. Depending on the causative Old World hantavirus species, clinical course of HFRS can vary from mild to moderate to severe.\n\nAt present, there is no specific therapy available for hantavirus disease. As the clinical course of hantavirus disease is dependent on the causing viral pathogen and as there worrisome hints that clinical course HFRS and HCPS overlap, further studies with regard to the disease course are mandatory. Furthermore, the examination of attributable mortality and costs of hantavirus disease will need to be studied on a multinational basis and therefore HantaReg will particularly use a matched case control design.",[61,30,62,63],"Hantavirus Infections","Nephropathia Epidemica","Hantavirus Cardiopulmonary Syndrome","2025-12-09",{"date":66,"type":40},"2025-12-17",{"date":68,"type":40},"2020-03-04",{"date":70,"type":22},"2030-12",{"name":72,"class":73},"University of Cologne","OTHER"]