[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemorrhoidectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemorrhoidectomy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,70,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100634059","minimaly-ivnasive-surgery-for-grade-iii-hemorrhoids-100634059",false,"NCT07534761","Minimaly Ivnasive Surgery for Grade III Hemorrhoids","Prospective Observational Study to Assess the Reproducibility of Minimally Invasive Surgery in Closed Excisional Hemorrhoidectomy: Phase 2A of theI DEAL Framework","Inclusion Criteria:\n\n* Age over 18 years\n* Grade III\u002FIV hemorrhoids\n* Indication for CEH surgery\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Acute hemorrhoidal disease (thrombosis)\n* Previous hemorrhoid surgery\n* Coexistence of anal fissure\n* Coexistence of perianal fistula\n* Coexistence of rectal or anal prolapse\n* Active inflammatory bowel disease\n* Active anal or colorectal cancer\n* Language barrier or difficulty in oral and\u002For written comprehension","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","1 Year","OBSERVATIONAL","Hemorrhoids are vascular-elastic structures of the anal canal that contribute to continence. Their enlargement and descent lead to symptoms such as rectal bleeding and the sensation of anal swelling, known as hemorrhoidal syndrome. In advanced cases (Goligher Grade III-IV), surgery is the only effective treatment. Closed excisional hemorrhoidectomy (CEH), based on the Ferguson technique, is one of the standard procedures. Although effective in the long term, it causes severe postoperative pain. Minimally invasive surgery (MIS) employs enhanced visualization devices to improve surgical precision and reduce tissue damage. While widely used in specialties with small surgical fields, it has not yet been explored in anal surgery. Its advantages include reduced tissue injury and improved healing, although it presents a learning curve and an initially longer surgical time. The IDEAL framework evaluates surgical innovations in five stages: Idea, Development, Exploration, Evaluation, and Long-Term Study. The IDEAL phase 2a is aimed at the optimization and technical definition of surgical innovation with a focus on continuous improvement based on real clinical practice, laying the foundation for broader and more rigorous subsequent studies.\n\nSince no previous studies on the application of MIS in CEH have been found, the investigators propose a study within Stage 2A of the IDEAL model to assess the reproducibility of this technique. The investigators believe its incorporation into closed excisional hemorrhoidectomy could result in less postoperative pain and faster patient recovery.",[25,26],"Hemorrhoidectomy","Minimally Invasive Surgical Technique",[28,25,29,30],"hemorrhoids grade III-IV","IDEAL stage 2A","minimally Invasive Surgical Technique","NOT_YET_RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-21","ACTUAL",{"date":37,"type":20},"2026-06-01",{"date":39,"type":20},"2027-12-01",{"name":41,"class":42},"Hospital Son Llatzer","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100611278","acupuncture-for-post-hemorrhoidectomy-pain-control-100611278","NCT07238504","Acupuncture for Post-hemorrhoidectomy Pain Control","Acupuncture for Post-hemorrhoidectomy Pain Control With Acute Anti-inflammatory Effects: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Symptomatic grade III or IV hemorrhoids undergoing conventional hemorrhoidectomy\n\nExclusion Criteria:\n\n1. Patients scheduled for stapled hemorrhoidopexy\n2. Concomitant surgery other than conventional hemorrhoidectomy\n3. Bleeding tendency, thrombocytopenia (platelet count \\\u003C 100 x 10\\^9\u002FL)\n4. Immunocompromised status or use of chemotherapy\n5. Active dermatitis\n6. Patients with pacemaker or automated implantable cardioverter-defibrillator\n7. Pregnant patients\n8. Known allergy to opioids, local anaesthetic drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDS) including cyclooxygenase-2 inhibitors\n9. History of chronic pain (duration for 3 months or more)\n10. Daily use of strong opioids (e.g. morphine, fentanyl, hydromorphone, methadone, oxycodone, or meperidine)\n11. Alcohol or drug abuse\n12. Psychiatric illness\n13. Impaired renal function (preoperative serum creatinine level \\> 120µmol\u002FL)\n14. Recent acupuncture treatment for other medical conditions","90 Years",{"count":53,"type":20},100,"INTERVENTIONAL",[56],"NA","The goal of this clinical trial is to learn if acupuncture improves pain control after hemorrhoidectomy in patients with symptomatic hemorrhoids. It will also learn about the safety of using acupuncture in surgical patients. The main questions it aims to answer are:\n\nDoes acupuncture lower the maximal pain intensity after hemorrhoidectomy? Does acupuncture reduce analgesics requirement, length of hospital stay and quality of recovery?\n\nResearchers will compare fully active acupuncture to a sham treatment (a look-alike procedure with minimum acupuncture stimulation) to see if active acupuncture works to improve pain control.\n\nParticipants will:\n\nReceive acupuncture treatment for 7 times over first 5 days after surgery. Visit the clinic once 2 weeks after surgery for checkups and tests. Keep a diary of their symptoms and the number of times they take pain-killers.",[25,59,60],"Hemorrhoid Pain","Acupuncture","2025-11-24",{"date":63,"type":35},"2025-12-02",{"date":65,"type":20},"2026-03",{"date":67,"type":20},"2027-04",{"name":69,"class":42},"The University of Hong Kong",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100573508","the-impact-of-methylene-blue-on-the-quality-of-recovery-in-patients-undergoing-hemorrhoidectomy-100573508","NCT06747195","The Impact of Methylene Blue on the Quality of Recovery in Patients Undergoing Hemorrhoidectomy","The Impact of Intradermal Methylene Blue Injection on the Quality of Recovery in Patients Undergoing Hemorrhoidectomy: a Multicenter Prospective Cohort Study","Inclusion Criteria:\n\n* Diagnosed with mixed hemorrhoids, grade III\u002F IV hemorrhoids (Goligher's classification), and underwent hemorrhoidectomy under spinal anesthesia; and\n* Aged between 18 and 65 years; and\n* ASA I or II.\n\nExclusion Criteria:\n\n* Patients who experienced any ill-effects from previous use of MB or other medications in the protocol (ketorolac, ropivacaine); or\n* Patients with diabetes; or\n* Alcohol or other addictive drug dependence; or\n* Illiteracy, combined with mental system or severe mental illness that prevented completion of the assessment; or\n* Patients who are pregnant or breast-feeding; or\n* Aspirin and analgesic drugs taken within 2 weeks before surgery; or\n* Patients taking selective serotonin reuptake inhibitors (SSRIs); or\n* Concurrent additional anorectal diseases (e.g., perianal abscess, anal fistula, fissures, anal incontinence); or\n* Patients who are participating in other clinical trials and have not reached the endpoint.","65 Years",{"count":79,"type":20},290,"Classical hemorrhoidectomy is known to be linked with significant postoperative pain, which can result in patient discomfort, extended hospital stays, and increased costs. The Quality of Recovery (QOR) score serves as an objective measure of patient-centered general health status following surgery and anesthesia. The latest version, QOR-15, is known for its time-efficiency, high rate of response, and completion, and has been validated in patients undergoing a range of surgical procedures.\n\nMethylene blue (MB) is a water-soluble thiazine dye used to treat various conditions and has been found to have a unique analgesic property through the temporary disruption of anal sensory nerve terminals in patients. Studies conducted in Singapore and China have shown that perianal intradermal injection of MB provides temporary pain relief after hemorrhoidectomy and lateral anal sphincterotomy. However, there is limited published information regarding the impact of MB on the quality of recovery in anorectal surgery. This study aims to evaluate the effect of intradermal MB combined with ropivacaine injection on the quality of recovery for patients undergoing hemorrhoidectomy.\n\nStudy population Patients with symptomatic third- and fourth-degree hemorrhoids who are undergoing hemorrhoidectomy under spinal anesthesia and are admitted to the hospitals (145 for each group) will be prospectively enrolled in this study. Before participating, all patients or their caregivers will provide written informed consent. The protocol for this study has been approved by the Ethical Committee of Qilu Hospital of Shandong University with the protocol number Kyll-202405-041-2.\n\nIntervention A standardized spinal anesthesia technique will be utilized, and between 7-9 mg of ropivacaine (Shijiazhuang Siyao Co., Ltd, 10ml:100mg) will be intrathecally injected between the L3 through L5 intervertebral spaces. All patients will undergo hemorrhoidectomy by colorectal surgeons with senior professional titles according to standard techniques. The postoperative analgesia regimen, with or without MB (Jichuan Pharmaceutical Group Co., LTD., 2ml: 20mg), will be determined at the discretion of the colorectal surgeon.\n\nData collection Clinical data, including age, sex, acute complications and total hospitalization cost, will be collected from the enrolled patients. The QOR-15 score will be calculated for all patients. Over a 6-month follow-up period, complications and the Wexner score for postoperative fecal incontinence will be recorded through telephone interviews.\n\nOutcome measures The primary goal of this study is to evaluate the quality of recovery using the QOR-15 questionnaire, a comprehensive measure of recovery after surgery that assesses five dimensions: physical comfort (5 items), physical independence (2 items), emotional state (4 items), psychological support (2 items), and pain (2 items). Each item is rated on an 11-point scale based on its frequency on the questionnaire (higher scores indicate greater frequency for positive items and less frequency for negative items). The total score ranges from 0 (poorest recovery quality) to 150 (best recovery quality). Patients will complete the QOR-15 questionnaire at three time points: the day before surgery, postoperative day 1, and postoperative day 2 (between 4 pm and 6 pm). The postoperative day 1 score is the primary outcome of interest.\n\nAdditional assessments included the following:\n\nThe study will collect data on the Visual Analogue Score of pain at multiple time points (postoperative day 1, postoperative day 2, postoperative day 3, postoperative day 7, postoperative day 14), total hospitalization costs, dosage of analgesics three days and fourteen days after surgery, pain leading to unscheduled hospital returns or stay, and various complications such as urinary retention, fecal incontinence, itch and perianal paresthesia, secondary bleeding, perianal infection, poor wound healing at different postoperative time points (postoperative day 1, postoperative day, 1 month postoperative, 3 months postoperative, 6 months postoperative). Additionally, the Wexner score for postoperative fecal incontinence will be recorded at 1 month and 3 months postoperative.",[25,82],"Postoperative Analgesia",[25,84,85,86,87],"Methylene blue","Quality of recovery","Analgesia","Prospective Cohort Study","RECRUITING","2025-02-13",{"date":91,"type":35},"2025-02-17",{"date":93,"type":35},"2025-01-01",{"date":95,"type":20},"2026-12-31",{"name":97,"class":42},"Qilu Hospital of Shandong University",3,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":108,"targetDuration":4,"studyType":54,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":43},"100557219","postoperative-pain-in-the-surgical-treatment-of-hemorrhoids-conventional-hemorrhoidectomy-with-a-monopolar-electric-scaler-vs-bipolar-energy-with-caiman-aesculap-100557219","NCT06535269","Postoperative Pain in the Surgical Treatment of Hemorrhoids: Conventional Hemorrhoidectomy With a Monopolar Electric Scaler VS Bipolar Energy With Caiman® (Aesculap®)","Prospective Randomized Study on Postoperative Pain in the Surgical Treatment of Hemorrhoids Through Conventional Hemorrhoidectomy With a Monopolar Electric Scalpel or Bipolar Energy With Caiman® (Aesculap®)","TAUHEMOR","Inclusion Criteria:\n\n* All patients with 2 or 3 bundles of grade III-IV hemorrhoids (Goligher classification) clinically symptomatic and subject to outpatient hemorrhoidectomy\n* Voluntary participation.\n* ASA I-II-III.\n\nExclusion Criteria:\n\n* Failure to meet the inclusion criteria.\n* ASA IV.\n* Allergic to Paracetamol, derivatives of morphine.\n* Allergic to NSAIDs.\n* Synchronous colorectal neoplasia.\n* Coagulation disorders.\n* Thrombosed hemorrhoid.\n* Inflammatory bowel disease.\n* Liver cirrhosis and\u002For portal hypertension.\n* Pregnant women.\n* Difficulty following up by phone and\u002For in person.",true,{"count":109,"type":20},27,[56],"To demonstrate that postoperative pain secondary to Milligan and Morgan hemorrhoidectomy with Caiman® (AESCULAP®) and subsequent oral conventional analgesia is at least not greater than that generated after hemorrhoidectomy with monopolar diathermy and intravenous analgesia with care home at discharge.",[59,25],"2024-08-01",{"date":115,"type":35},"2024-08-02",{"date":117,"type":35},"2022-11-02",{"date":119,"type":20},"2025-07",{"name":121,"class":42},"Corporacion Parc Tauli"]