[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hemorrhoids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hemorrhoids":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,59,94,119,146,172,192,213,234,257,280,299,322,353,375,395,417],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100642443","phase-4-oral-nifedipine-versus-placebo-for-pain-and-healing-after-hemorrhoidectomy-100642443",false,"NCT07659665","Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy","The Effect of Oral Nifedipine Versus Placebo on Postoperative Pain and Healing Following Hemorrhoidectomy in Adult Patients: A Randomized Controlled Trial in Sana'a, Yemen","NIFEDIPINE-HD","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective hemorrhoidectomy for grade III or IV hemorrhoids\n* Ability to provide written informed consent\n* Ability to understand and complete study questionnaires\n* Willingness to comply with the study protocol and follow-up visits\n\nExclusion Criteria:\n\n* Known hypersensitivity to nifedipine\n* Severe cardiovascular disease (unstable angina, recent myocardial infarction, severe heart failure)\n* Hypotension (systolic blood pressure \\\u003C 90 mmHg)\n* Severe hepatic or renal impairment\n* Pregnancy or breastfeeding\n* Current use of calcium channel blockers or nitrates\n* Emergency hemorrhoidectomy\n* Concurrent inflammatory bowel disease\n* History of anorectal surgery within the past 6 months","ALL","18 Years","65 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to evaluate whether oral nifedipine reduces postoperative pain and improves wound healing after hemorrhoidectomy in adult patients aged 18-65 years undergoing elective surgery for grade III or IV hemorrhoids in Sana'a, Yemen.\n\nThe main questions it aims to answer are:\n\n* Does oral nifedipine 20 mg twice daily for 14 days reduce postoperative pain compared with placebo?\n* Does oral nifedipine improve wound healing progression and shorten time to complete healing compared with placebo?\n\nResearchers will compare the nifedipine group to the placebo group to see if there is a significant reduction in pain scores, faster wound healing, lower analgesic consumption, and fewer complications.\n\nParticipants will:\n\n* Take either oral nifedipine 20 mg or an identical-looking placebo capsule twice daily for 14 consecutive days, starting 6 hours after surgery.\n* Report pain intensity using a standard 0-10 Visual Analogue Scale at multiple time points during the first 28 days.\n* Attend follow-up visits on postoperative days 7, 14, and 28 for wound healing assessment and safety monitoring.\n* Use rescue analgesia (paracetamol and\u002For diclofenac) as needed for breakthrough pain.",[28,29,30,31],"Hemorrhoids","Postoperative Pain","Wound Healing","Analgesia",[33,34,35,36,37,38,39,40,41,42,43,44,45],"Hemorrhoidectomy","Post-hemorrhoidectomy pain","Internal anal sphincter","Anal sphincter spasm","Nifedipine","Calcium channel blocker","Randomized controlled trial","Yemen","Placebo","Visual Analogue Scale","Pain management","Wound healing","Ecchymosis Discharge Approximation score","NOT_YET_RECRUITING","2026-06-27",{"date":49,"type":50},"2026-07-01","ACTUAL",{"date":52,"type":22},"2026-08-01",{"date":54,"type":22},"2026-12-30",{"name":56,"class":57},"Sana'a University","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":58},"100617351","hemovar-study-on-hemorrhoids-and-varicose-veins-100617351","NCT07317492","HEMOVAR Study on Hemorrhoids and Varicose Veins","Prospective Evaluation of the Association Between Hemorrhoids and Lower Extremity Varicose Veins Using Doppler Ultrasound (HEMOVAR Study)","HEMOVAR","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients presenting to the general surgery proctology outpatient clinic of Aydın Adnan Menderes University Hospital\n* Patients diagnosed with hemorrhoidal disease or other non-hemorrhoidal benign proctologic conditions\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* History of lower extremity varicose vein surgery, endovenous ablation, or sclerotherapy\n* Presence of systemic venous disorders such as portal hypertension or liver cirrhosis\n* Pregnant women\n* Patients with known malignancy or severe comorbid conditions that could interfere with evaluation\n* Refusal or inability to provide written informed consent",{"count":68,"type":22},400,"10 Days","OBSERVATIONAL","The HEMOVAR Study is a prospective observational study designed to evaluate the association between hemorrhoidal disease and lower extremity varicose veins. A total of 400 adult patients presenting to the general surgery proctology outpatient clinic of Aydın Adnan Menderes University Hospital will be included. The study will consist of two groups: 200 patients diagnosed with hemorrhoids and 200 patients with other non-hemorrhoidal benign proctologic conditions serving as controls.\n\nAll participants will undergo routine clinical evaluation and demographic data collection. Cardiovascular surgeons will voluntarily perform physical examination and Doppler ultrasonography of the lower extremities to assess venous insufficiency and varicose veins. No experimental intervention or treatment will be applied. The study will not require any consumable materials and will not impose any additional financial burden on the hospital, patients, or the national health insurance system. The primary outcome is the prevalence of lower extremity venous insufficiency in patients with hemorrhoids compared with controls.",[73,28],"Varicose Veins of Lower Limb",[28,75,76,77,78,79,80,81,82,83],"Varicose Veins","Venous Insufficiency","Doppler Ultrasound","Venous Reflux","Proctology","Pelvic Congestion Syndrome","Prospective Observational Study","Varicocele","HEMOVAR Study","RECRUITING","2026-04-28",{"date":87,"type":50},"2026-04-29",{"date":89,"type":50},"2025-12-19",{"date":91,"type":22},"2026-12-31",{"name":93,"class":57},"Aydin Adnan Menderes University",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":103,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":58},"100381561","phase-4-ketamine-for-post-operative-analgesia-in-hemorrhoidectomy-100381561","NCT04248205","Ketamine for Post-operative Analgesia in Hemorrhoidectomy","Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial.","Inclusion Criteria:\n\n* Adults aged 18-100\n* Undergoing a hemorrhoidectomy for Grade III or IV hemorrhoids.\n\nExclusion Criteria:\n\n* Inability to undergo general anesthesia\n* Contraindications to hemorrhoidectomy\n* History of schizophrenia or other hallucinatory psychiatric illnesses\n* History of psychosis\n* Chronic narcotic usage defined as either having a pain contract with a pain management specialist and no narcotic usage for one month prior to hemorrhoidectomy.","100 Years",{"count":21,"type":22},[25],"This is a prospective, randomized study of ketamine versus no ketamine in approximately 100 patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. The participants will be blinded to which treatment arm they are assigned, because participants will be under anesthesia when the ketamine is administered. The investigators will know whether the participant receives ketamine or not.",[28],[107,108,109],"hemorrhoidectomy","ketamine","post operative pain","2026-03-26",{"date":112,"type":50},"2026-04-01",{"date":114,"type":50},"2020-06-15",{"date":116,"type":22},"2027-07",{"name":118,"class":57},"University of Oklahoma",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":58},"100619887","pushes-pudendal-block-versus-sacral-esp-hemorrhoidectomy-study-100619887","NCT07350460","PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study)","A Randomized, Double-Blind Trial Comparing Pudendal Block Versus Sacral ESP for Ambulatory Hemorrhoidectomy","PUSHES","Inclusion Criteria:\n\n* Adults (≥18 years old) scheduled for elective excisional hemorrhoidectomy;\n* Ability to understand the nature of the study and provide written informed consent;\n* American Society of Anesthesiologists (ASA) physical status I-III;\n* Ability to comply with study procedures and postoperative evaluations.\n\nExclusion Criteria:\n\n* Pregnancy;\n* Body weight under 50 kg due to the potential risk of local anaesthetic systemic toxicity (LAST);\n* BMI \\> 40; Known allergy or contraindication to local anaesthetics (e.g., ropivacaine, prilocaine);\n* Severe coagulation disorders or current anticoagulant therapy contraindicating spinal or peripheral deep nerve blocks (like pudendal block, because Sacral ESP is considered a superficial block);\n* Infection at the puncture site;\n* Neurological disorders affecting the sacral or pudendal nerve pathways;\n* Severe psychiatric conditions impairing study participation;\n* Language barriers","80 Years",{"count":129,"type":22},64,[131],"NA","The goal of this clinical trial is to learn if the sacral erector spinae plane block can provide equal or better pain control than the pudendal nerve block in adults undergoing hemorrhoid surgery. The main question is: Which block offers more effective analgesia and faster recovery?",[28,134],"Hemorrhoids Third Degree",[28,33,29,136],"Pain Measurement","2026-03-16",{"date":139,"type":50},"2026-03-18",{"date":141,"type":50},"2026-01-05",{"date":143,"type":22},"2027-09-30",{"name":145,"class":57},"Andrea Saporito",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":58},"100623686","phase-2-botulinum-toxin-a-before-hemorrhoidectomy-to-prevent-postoperative-pain-100623686","NCT07399860","Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain","Effect of Internal Anal Sphincter Botulinum Toxin A Injection 7 Days Before Hemorrhoidectomy on Postoperative Pain: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial","BoTo-HEM","Inclusion Criteria:\n\n* Adults ≥18 years, male and female\n* Symptomatic grade III-IV hemorrhoidal disease (Goligher), refractory to conservative treatment\n* Scheduled for open (Milligan-Morgan) or closed (Ferguson) hemorrhoidectomy\n\nExclusion Criteria:\n\n* Known hypersensitivity to botulinum toxin A, human albumin, or local anesthetics.\n* Neuromuscular junction disorders (e.g., myasthenia gravis, Lambert-Eaton syndrome).\n* Use of aminoglycosides or other agents interfering with neuromuscular transmission within 14 days.\n* Coagulopathy or ongoing anticoagulant therapy not suitable for perioperative interruption.\n* Active anorectal infection, fissure, abscess, or inflammatory bowel disease in the active phase.\n* Previous anal sphincter surgery or baseline fecal incontinence.\n* Pregnancy or breastfeeding.\n* ASA ≥ III or significant systemic disease compromising anesthesia or wound healing.\n* Participation in another interventional clinical trial within 30 days.",{"count":155,"type":22},292,[157],"PHASE2","Hemorrhoidectomy is an effective surgical treatment for advanced hemorrhoidal disease but is often associated with significant postoperative pain, which may delay recovery. One of the main contributors to pain after hemorrhoidectomy is spasm and increased tone of the internal anal sphincter.\n\nThis randomized, double-blind, placebo-controlled clinical trial evaluates whether preoperative injection of botulinum toxin type A into the internal anal sphincter, performed seven days before hemorrhoidectomy, can reduce postoperative pain compared with placebo. Adult patients with grade III-IV hemorrhoids scheduled for excisional hemorrhoidectomy will be randomized to receive either botulinum toxin A or saline injection prior to surgery.\n\nPostoperative pain intensity, analgesic consumption, complications, functional outcomes, and patient satisfaction will be assessed during the first 30 days after surgery.",[28,29],[33,161,162,36],"Botulinum toxin","Postoperative pain","2026-03-07",{"date":165,"type":50},"2026-03-10",{"date":167,"type":50},"2026-02-01",{"date":169,"type":22},"2028-01",{"name":171,"class":57},"Lomonosov Moscow State University Medical Research and Educational Center",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":189,"leadSponsor":190,"locationsCount":4},"100608077","comparison-of-the-clinical-effects-of-open-closed-and-semi-close-hemorrhoidectomy-100608077","NCT07196865","Comparison of the Clinical Effects of Open, Closed, and Semi-close Hemorrhoidectomy.","Comparison of the Clinical Effects of Open, Closed, and Semi-close Hemorrhoidectomy: Study Protocol for a Single-center, Prospective, Open-label and Randomized Clinical Trial.","Inclusion Criteria:\n\n1. Patients aged 18 to 75 years.\n2. Clinical diagnosis of mixed hemorrhoids requiring surgical intervention.\n3. Scheduled to undergo hemorrhoidectomy with ligation of internal hemorrhoids and excision of external hemorrhoids.\n4. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n1. History of mental illness or cognitive impairment that may affect the ability to provide informed consent or comply with the study protocol.\n2. Diagnosis of diabetes mellitus.\n3. Planned concomitant procedures (e.g., radiofrequency ablation, sclerotherapy) in addition to hemorrhoidectomy.\n4. Inability or unwillingness to comply with scheduled follow-up visits.\n5. Presence of severe perioperative comorbidities that render the patient unsuitable for the planned surgical protocol or anesthesia (as determined by the attending anesthesiologist or surgeon).","75 Years",{"count":181,"type":22},378,[131],"This study compares three different ways surgeons close the wound after removing hemorrhoids (piles): leaving it completely open, stitching it completely closed, or stitching only half of it closed (semi-closed). The goal is to see which method leads to faster healing, less pain, fewer complications, and better long-term results. Patients undergoing hemorrhoidectomy will be randomly assigned to one of the three groups. All patients will receive standard post-operative care. Researchers will measure healing time, pain levels, need for pain medication, hospital stay, complications, and check if hemorrhoids come back within one year.",[28],"2026-03-02",{"date":187,"type":50},"2026-03-04",{"date":112,"type":22},{"date":54,"type":22},{"name":191,"class":57},"The Affiliated Hospital of Putian University",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":58},"100492854","evaluation-of-superior-rectal-arterial-embolization-in-hemorrhoidal-disease-100492854","NCT05697562","Evaluation of Superior Rectal Arterial Embolization in Hemorrhoidal Disease","A Randomized Comparative Evaluation of Superior Rectal Arterial Embolization in Hemorrhoidal Disease","Inclusion Criteria:\n\n* All patients referred for Hemorrhoidal disease with bleeding are eligible. Significant bleeding is defined as a HBS of ≥ 5.\n* Age \\> 18 years old;\n* Sexes eligible for study: all\n* Hemorrhoidal disease grade I-III according the Goligher classification with rectal bleeding as predominant symptom\n* History of prior instrumental treatment of HD does not prohibit inclusion\n* Able to understand and read Dutch, French or English\n\nExclusion Criteria:\n\n* Permanent hemorrhoidal prolapse\u002Fgrade IV hemorrhoidal disease\n* Rectal prolapse\n* History of proctological surgery for HD\n* Acute complicated course of HD i.e. acute thrombosis (fluxio hemorrhoidalis or perianal hematoma)\n* Anal stenosis, congenital of acquired\n* Chronic anal fissure\n* Active rectal inflammation, including peri-anal abscess (e.g. Inflammatory Bowel Disease, infectious,…)\n* History of colorectal or anal cancer\n* History of rectal or sigmoidal resection\n* Portal hypertension and liver cirrhosis Child Pugh C\n* Radiation rectitis\n* Neurological disease involving anal sphincter musculature\n* Severe psychiatric disorder\n* Pregnancy\n* Allergy to iodinated contrast agents\n* Colorectal neoplasia as the cause of bleeding (excluded with a (virtual) colonoscopy in the last year)",{"count":200,"type":22},80,[131],"SRAE is a promising treatment of bleeding HD as a minimally invasive approach without sphincter damage nor direct mucosal anorectal trauma. Feasibility, efficacy and safety were studied in several trials. A randomized controlled study should confirm the benefits of this technique and will define its therapeutic role in HD.\n\nEmbolization and DG-HAL are based on the same concept of vascular occlusion of hemorrhoidal branches of the rectal artery. Furthermore, DG-HAL and RBL are equally effective procedures. The assumption is that treatment with SRAE is not inferior in comparison to RBL or DG HAL in respectively patients without or with antiplatelet\u002Fanticoagulation therapy in terms of symptom control and bleeding (non-inferiority study).",[28],"2025-12-11",{"date":206,"type":50},"2025-12-18",{"date":208,"type":50},"2023-06-01",{"date":210,"type":22},"2030-12-31",{"name":212,"class":57},"Universitair Ziekenhuis Brussel",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":219,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":58},"100590581","ultrasound-guided-sacral-erector-spinae-plane-block-as-a-sole-anesthetic-technique-versus-saddle-block-in-hemorrhoidectomy-100590581","NCT06969274","Ultrasound-guided Sacral Erector Spinae Plane Block as a Sole Anesthetic Technique Versus Saddle Block in Hemorrhoidectomy","Inclusion Criteria:\n\n1. Patients with American Society of anesthesiologists' physical status (ASA) I to II.\n2. Aged 18 to 65 years.\n3. Both sexes.\n4. Patients scheduled for perianal surgeries (hemorrhoidectomy).\n\nExclusion Criteria:\n\n* 1- Patients with spinal malformation. 2-Patients with liver impairment. 3- Patients with renal impairment. 4-Patients younger than 18 years or older than 65 years. 5- Patients with hypersensitivity to one of the used drugs. 6- Coagulopathy disorders. 7- Patients who underwent hemorrhoidectomy before.",true,{"count":221,"type":22},50,[131],"Study interventions:\n\nThe patients will be randomized into two equal groups, Group A and Group B.\n\nGroup A: Patients will receive an Ultrasound guided sacral erector spinae plane block (SESPB)\n\nGroup B: Patients will receive Saddle block.\n\nThe surgical procedure will be performed by an experienced surgeon.\n\nThe outcome:\n\nThe primary outcome will be assessment of pain intensity using the NRS ranging from 0 (no pain) to 10 (worst pain) at 0, 2, 4, 6, 12, and 24 hours after the procedure. The secondary outcomes will include the cumulative doses of tramadol (50 mg intramuscular) to be repeated every 8 hours in case NRS score is more than four, the number of patients requiring rescue medication in the postoperative period.",[28],"2025-11-25",{"date":227,"type":50},"2025-12-02",{"date":229,"type":50},"2025-05-29",{"date":231,"type":22},"2025-12",{"name":233,"class":57},"Ain Shams University",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":243,"briefSummary":244,"conditions":245,"keywords":246,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":58},"100607036","comparison-of-clinical-effects-between-routine-and-high-frequency-follow-up-after-hemorrhoids-surgery-100607036","NCT07183332","Comparison of Clinical Effects Between Routine and High-frequency Follow-up After Hemorrhoids Surgery","Comparison of Clinical Effects Between Routine and High-frequency Follow-up After Hemorrhoids Surgery: a Single-center, Prospective, Open-label, Randomized Clinical Trial","Inclusion Criteria:\n\n* 18 years old \\\u003C age \\\u003C 75 years old;\n* Mixed hemorrhoids were diagnosed;\n* Internal hemorrhoids ligation + external hemorrhoidectomy\n* Complete hospital records;⑤voluntary cooperation in the study\n\nExclusion Criteria:\n\n* The patient had mental illness;\n* Serious underlying diseases;\n* pregnant or lactating women;\n* Serious complications and drug allergy occurred during the treatment;\n* Communication difficulties",{"count":242,"type":22},116,[131],"This study aims to investigate whether frequent follow-ups can enhance the quality of life of patients after hemorrhoid surgery and reduce the incidence of complications. A total of 116 eligible patients were randomly and evenly divided into two groups (58 patients in each group): A. The control group: Patients received routine health education services upon discharge and were then followed up by phone at the regular frequency. B. The high-frequency group: Patients received routine health education services upon discharge and were then followed up by phone at a higher frequency. The quality of life of the patients and the incidence of complications were compared to evaluate the clinical effects of different intervention measures. The main hypothesis is that compared to conventional care, frequent follow-ups can significantly improve the quality of life of patients, promote wound healing, and reduce the incidence of complications and disease recurrence.",[28],[28,247,248],"Follow-up","Quality of Life","2025-09-13",{"date":251,"type":50},"2025-09-19",{"date":253,"type":22},"2025-09-15",{"date":255,"type":22},"2026-09-30",{"name":191,"class":57},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":264,"targetDuration":4,"studyType":23,"phases":266,"briefSummary":267,"conditions":268,"keywords":269,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":58},"100529557","trans-radial-superior-rectal-artery-embolisation-for-haemorrhoids-100529557","NCT06175325","Trans-radial Superior Rectal Artery Embolisation for Haemorrhoids","Pilot Study of the Safety and Efficacy of Trans-radial Superior Rectal Artery Embolisation for the Treatment of Haemorrhoids","Inclusion Criteria:\n\nPatients eligible for the study must comply with all of the following prior to enrolment:\n\n* Patients with grade II-IV haemorrhoid disease with re-current or active bleeding\n* Patients with (i) who do not wish to undergo surgery for their symptoms\n* Patients with (i) despite recent surgery\n* Patients willing and able to give fully informed consent\n* Patients aged ≥18 years\n\nExclusion Criteria:\n\n* Patients who are not otherwise fit for surgery\n* Patients with significant ano-rectal comorbidities (cancer, fistula, abscesses)\n* Patient who are unable to sign the informed consent form.\n* Patients who are pregnant (completed as part of standard IRMER protocol)\n* Patients with history of significant colorectal disease or previous colectomy.\n* Patients with history of an allergic reaction to x-ray contrast\n* Patients who are currently involved in research",{"count":265,"type":22},20,[131],"Endovascular embolisation is already a common procedure for bleeding haemorrhoids in the acute setting, where surgical options are not possible or have been exhausted. This pilot study aims to add to the small body of evidence that transarterial embolisation of symptomatic haemorrhoids is also safe and effective in the elective setting, providing a good alternative to conventional surgical management. This is a day case procedure that is performed under local anaesthetic. For selected patients, this presents a less invasive management option with reduced potential morbidity. For a health care system under significant financial stress, this provides a potential means of cost improvement, the extent of which this study will try and quantify. A series of 20 selected patients will be recruited to undergo this procedure and then followed up for 24 months. The long-term goal of this pilot study is to form the basis of a national registry of such procedures.",[28],[270],"Embolisation","2025-08-26",{"date":273,"type":50},"2025-09-03",{"date":275,"type":50},"2025-07-17",{"date":277,"type":22},"2026-12",{"name":279,"class":57},"University Hospitals of North Midlands NHS Trust",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":290,"conditions":291,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":298,"locationsCount":58},"100602298","effect-of-red-and-blue-light-irradiation-on-wound-healing-after-hemorrhoid-surgery-100602298","NCT07121686","Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery","Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery: A Single - Center Prospective Open - Label Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged 18-75 years\n* Diagnosed with Grade III-IV hemorrhoids according to Goligher classification\n* Scheduled to undergo rubber band ligation of internal hemorrhoids + external hemorrhoidectomy\n* Willing and able to provide written informed consent\n* Able to comply with postoperative follow-up and treatment protocol\n\nExclusion Criteria:\n\n* Psychiatric disorders or cognitive impairment\n* Uncontrolled chronic diseases:\n* Diabetes (HbA1c \\>7.5%)\n* Hypertension (BP \\>160\u002F100 mmHg)\n* Coronary artery disease (NYHA Class III-IV heart failure)\n* Concurrent other hemorrhoid treatments (e.g., radiofrequency ablation\u002Fsclerotherapy)\n* Inability to complete follow-up (e.g., living too far away, no stable contact)\n* Concurrent anal disorders:\n* Perianal abscess\n* Anal fissure\n* Anal fistula\n* Hypertrophied anal papilla\n* Pregnancy or lactation (for female patients)\n* History of phototherapy allergy\n* Participation in other clinical trials within 3 months\n\nFor registration, simply copy this structured list directly into the PRS system's eligibility section. The clear formatting will facilitate efficient review.",{"count":288,"type":22},315,[131],"The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The haemorrhoidectomy patients were randomly divided into routine group, red light group and red and blue light group, and were given different ways of trauma care, and the number of cases in each group was 105 , with a total of 305 cases. Observe the difference between red and blue light irradiation and routine care on the healing time of postoperative trauma and postoperative complications after haemorrhoidectomy, and evaluate the patients' quality of life and satisfaction with treatment under both red light irradiation and routine care.",[28],"2025-08-10",{"date":294,"type":50},"2025-08-13",{"date":296,"type":22},"2025-08-15",{"date":52,"type":22},{"name":191,"class":57},{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":23,"phases":308,"briefSummary":309,"conditions":310,"keywords":311,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":58},"100594156","evaluation-of-the-analgesic-efficacy-of-an-ultrasound-guided-transperineal-pudendal-block-in-outpatient-hemorrhoidal-surgery-100594156","NCT07015775","Evaluation of the Analgesic Efficacy of an Ultrasound-guided Transperineal Pudendal Block in Outpatient Hemorrhoidal Surgery","BACH","Inclusion Criteria:\n\n* Adult male or female patient\n* Patient who has signed informed consent to participate in the study\n* Patient scheduled for outpatient hemorrhoidal surgery under general anesthesia\n\nExclusion Criteria:\n\n* History of hemorrhoidal surgery\n* Allergy or contraindication to any of the medications used in the study\n* Patient undergoing surgery under spinal anesthesia\n* History of chronic pain requiring opioid use, unrelated to hemorrhoids\n* Mental impairment or any other condition that could hinder understanding or strict adherence to the protocol\n* Patient not affiliated with the French national health insurance system\n* Patient under legal protection (e.g., guardianship, trusteeship, or court protection)\n* Pregnant woman or woman at risk of being pregnant (i.e., of childbearing age without effective contraception and without an HCG test)\n* Patient already enrolled in another therapeutic clinical trial or within the exclusion period of another clinical trial",{"count":307,"type":22},202,[131],"In a population of patients undergoing hemorrhoidal surgery under general anesthesia and divided into two equal groups based on the method used for intraoperative pudendal nerve block and its branches in the ischioanal fossa:\n\nGroup 1: Pudendal block guided by neurostimulation Group 2: Pudendal block guided by ultrasound\n\nThe primary objective of this study is to compare the maximum immediate postoperative pain score between the two groups (pain reported by the patients in the recovery room on a simple numeric scale before morphine titration).",[28],[312],"hemorroidal surgery","2025-06-03",{"date":315,"type":50},"2025-06-11",{"date":317,"type":22},"2025-08-01",{"date":319,"type":22},"2026-08-08",{"name":321,"class":57},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":330,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":333,"briefSummary":334,"conditions":335,"keywords":340,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":352},"100499342","sci-pex-study---safety-and-performance-of-pexyeazy-a-device-for-treatment-of-hemorrhoids-100499342","NCT05782010","SCI-Pex Study - Safety and Performance of PexyEazy®, a Device for Treatment of Hemorrhoids","SCI-Pex, a Multi-center, Prospective, Non-controlled Investigation to Evaluate the Safety and Performance of PexyEazy®, a Device for Treatment of Hemorrhoids","SCI-Pex","Inclusion Criteria:\n\n* Adult\n* Hemorrhoidal disease grade II and III\n* American Society of Anesthesiologists (ASA) classification I-III.\n\nExclusion Criteria:\n\n* Previous surgical treatment for hemorrhoids by all methods except rubber band ligation or sclerosing injection therapy within the last 3 years.\n* Previous surgical treatment with rubber band ligation or injection therapy within the last 2 months.\n* More than three surgical treatments with rubber band ligation or sclerosing injection therapy within the last 3 years.\n* Under medication with immunosuppressive drugs and\u002For anticoagulant drugs (not including 75mg acetylsalicylic acid) and not able to interrupt the anticoagulant drug medication or replace it with low molecular weight heparin for 5 days.\n* Have ulcerative colitis, Crohn's disease or other intestinal inflammatory disease or presence of inflamed or thickened mucosa of the rectum.\n* Presence of anal fissure, anal stenosis, stricture, fistulas or ulcers in the rectal area.\n* The rectum has not been prepared prior to the investigation with rectal enema and is contaminated with feces that cannot easily be removed.\n* Have schizophrenia, untreated depression or other mental illness or conditions that may affect judgment, sensation of pain or inability to complete the follow-up.\n* Under medication of morphine or other strong painkillers, not including paracetamol.\n* Fecal incontinence (not including soiling due to hemorrhoidal disease), or conditions with impaired sensation in the rectal area or impaired function of the anal sphincter.\n* Previous rectal radiation.\n* Rectal cancer or previous surgery due to rectal cancer.\n* Pregnancy\n* Hypercoagulability disorders or diseases that result in increased risk of bleeding.\n* Impaired immune system or condition that increases the risk of infection.","84 Years",{"count":332,"type":22},35,[131],"The SCI-Pex study is a multicenter, prospective, non-controlled investigation on PexyEazy®, a new device for treatment of hemorrhoids based on the mucopexy method. Mucopexy is a well established method where sutures are applied above the hemorrhoids. When knots are tied, the hemorrhoids are lifted inwards to their normal position, which makes them swell down and symptoms disappears. PexyEazy® perform a mukopexy in a semiautomatic, faster and easier way on awake patient in less than 10 minutes. The SCI-Pex study will evaluate the safety and performance of PexyEazy on 35 patients with hemorrhoids grade II and III with a follow-up after 1 week, 3 months and 1 years. Adverse events, pain and other complications will be recorded, quality of life and hemorrhoid symptom questionnaires and clinical examination after 3 months and 1 year will be monitored to evaluate the result after a PexyEazy® procedure.",[28,336,337,338,339],"Hemorrhoids, Internal","Suture; Complications, Infection or Inflammation","Rectal Diseases","Gastrointestinal Diseases",[341],"PexyEazy","2025-03-04",{"date":344,"type":50},"2025-03-07",{"date":346,"type":50},"2023-06-15",{"date":348,"type":22},"2026-05-30",{"name":350,"class":351},"Developeration AB","INDUSTRY",3,{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":4},"100566023","comparison-of-the-clinical-efficacy-and-safety-of-endoscopic-superior-rectal-mucosal-ligation-and-hemorrhoids-ligation-100566023","NCT06649786","Comparison of the Clinical Efficacy and Safety of Endoscopic Superior Rectal Mucosal Ligation and Hemorrhoids Ligation","Comparison of the Efficacy and Safety of Endoscopic Hemorrhoids Ligation: a Single-center Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. According to the Goligher classification in the Chinese guidelines for the diagnosis and treatment of hemorrhoids (2020) , patients who are diagnosed with grade II-III internal hemorrhoids .\n2. Patients who voluntarily participate and sign the informed consent form.\n\nExclusion Criteria:\n\n1. patients who had severe heart, liver, and kidney disease.\n2. patients who had severe immune deficiency.\n3. patient\\'s general condition is too poor to tolerate endoscopic therapy.\n4. patients had a history of pelvic chemoradiotherapy.\n5. patients had severe infection or inflammatory lesion in the rectum or anal canal,or the rectum or anal canal had undergone surgery.\n6. patient is a pregnant woman.\n7. patients who disagree with endoscopic treatment and are concerned about the possible risks refused to sign the informed consent form.\n8. the follow-up time is insufficient and the clinical data were incomplete.","90 Years",{"count":362,"type":22},96,[131],"Endoscopic superior rectal mucosal ligation and hemorrhoids ligation are two types of endoscopic ligation, The aim of this study is to compare the clinical efficacy and safety of these two approaches.If you accept this study,you need to provide case information before the operation, complete the endoscopic treatment according to the routine colonoscopy procedure, and follow-up survey after the operation.",[28],"2024-10-17",{"date":368,"type":50},"2024-10-21",{"date":370,"type":22},"2024-11-01",{"date":372,"type":22},"2026-04-30",{"name":374,"class":57},"The Affiliated Hospital of Qingdao University",{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":219,"sex":17,"minAge":18,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":393,"locationsCount":4},"100561300","hemorrhoidectomy-only-versus-hemorrhoidectomy-with-lateral-internal-sphincterotomy-100561300","NCT06588374","Hemorrhoidectomy Only Versus Hemorrhoidectomy With Lateral Internal Sphincterotomy","The Effect of Lateral Internal Sphincterotomy During Hemorrhoidectomy ,a Randomized Clinical Trial.","Inclusion Criteria:\n\n1. Surgically fit according to ASA.\n2. Cases with hemorrhoids Grade ll\\& III \\& IV.\n3. Age between (18-60).\n\nExclusion Criteria:\n\n1. Age less than 18 years old.\n2. Complete rectal prolapse.\n3. Grade I hemorrhoids.","60 Years",{"count":265,"type":22},[131],"The aim of this study was to access the comparison of pain and complications after hemorrhoidectomy with or without lateral sphincterotomy.",[28],"2024-09-04",{"date":389,"type":50},"2024-09-19",{"date":391,"type":22},"2024-08-31",{"date":317,"type":22},{"name":394,"class":57},"Assiut University",{"id":396,"slug":397,"hasResults":11,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":403,"targetDuration":4,"studyType":23,"phases":404,"briefSummary":405,"conditions":406,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":416},"100431298","efficacy-and-safety-of-radiofrequency-versus-hal--rar-doppler-in-hemorrhoidal-pathology-100431298","NCT04896268","Efficacy and Safety of RAdiofrequency Versus HAL- RAR DOppler in Hemorrhoidal Pathology","Prospective, Multicentric, Randomized, Open-label Study Comparing the Efficacy, in Terms of Quality of Life, and Safety of RAdiofrequency Versus HAL- RAR DOppler in Hemorrhoidal Pathology","RADO","Inclusion Criteria:\n\n* Male or Female consulting for hemorrhoidal pathology (grade II or III) after failure of medico-instrumental treatments.\n* Age ≥ 18 years and \\\u003C 75 years\n* Mandatory affiliation to a health insurance system.\n* Patient having been informed of the study and having given informed consent\n\nExclusion Criteria:\n\n* Patients with chronic inflammatory bowel disease\n* Patients with suspected gastro-colic pathology\n* Haematological diseases\n* Anal fistulas\n* Patients unable to discontinue anti-vitamin K or oral anticoagulants\n* Associated anal fissure\n* External haemorrhoidal disease\n* Pregnant or breastfeeding women\n* Patients under legal protection",{"count":21,"type":22},[131],"Haemorrhoids are composed of tissue rich in blood vessels and are present in all individuals inside the anus (internal haemorrhoids) or under the skin of the anus (external haemorrhoids). Haemorrhoidal disease (HD) occurs when haemorrhoids become troublesome and cause symptoms such as pain, bleeding, prolapse or oozing. In case of failure of medical treatment, instrumental procedures or extensive disease, surgical treatment can be considered. There are two classic surgical techniques. The first is the pedicle haemorrhoidectomy of the Milligan and Morgan type. The second classic surgical technique is the Longo stapled anopexy. Recently, less invasive surgical techniques such as arterial ligation (HAL, with or without Doppler) followed by recto-anal repair (RAR for \"Recto Anal Repair\") and sometimes associated with mucopexy, which allows the excess mucosa to be ligated and the muco-haemorrhoidal tissue to be fixed to the rectal wall, have developed. The use of radiofrequency current (Rafaelo technique) in the treatment of haemorrhoidal disease is an innovative technique of haemorrhoidal thermocoagulation. It is a mini-invasive technique, which can be performed under sedation or short general anaesthesia (GA), with little pain, allowing a rapid return to normal life and a short time off work. Although this technique is already used in other European countries: Poland, Germany, Belgium, Great Britain (UK), there is now a Polish, German, Spanish and English study in the process of publication. There have been no studies in France to evaluate this new technique and assess its good tolerance, the duration of work stoppage, the improvement in quality of life and the evaluation of its effectiveness.",[28],"2024-06-17",{"date":409,"type":50},"2024-06-18",{"date":411,"type":50},"2023-01-03",{"date":413,"type":22},"2025-08",{"name":415,"class":57},"Elsan",2,{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":424,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":426,"conditions":427,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":58},"100360424","samples-procurement-for-colorectal-cancer-gastric-cancer-and-non-malignant-disease-100360424","NCT03972956","Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease","Samples Procurement for Patients With Colorectal Cancer, Gastric Cancer, and Non-malignant Disease Undergoing Surgery","Inclusion Criteria:\n\n* Any patient diagnosed with colorectal cancer, gastric cancer, non-malignant disease that requires undergoing surgery.\n* Must be willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Subjects whose comorbidities would preclude diagnostic or therapeutic intervention.",{"count":425,"type":22},1000,"The purposes of this study are to collect and store samples including blood, normal and tumor tissue from patients with colorectal cancer or gastric cancer, to collect and store samples including blood and\u002For normal gastrointestinal tissue (if available) from patients with non-malignant disease (including, but not limited to, inflammatory bowel disease (IBD), gastric ulcer, hemorrhoids or hernia), and to create a database for the collected samples and allow access to relevant clinical information for current and future protocols.",[428,429,430,431,28,432],"Colorectal Cancer","Gastric Cancer","Inflammatory Bowel Diseases","Gastric Ulcer","Hernia","2022-04-28",{"date":435,"type":50},"2022-04-29",{"date":437,"type":50},"2020-12-23",{"date":439,"type":22},"2026-12-23",{"name":441,"class":57},"Renmin Hospital of Wuhan University"]