[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hepatic-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hepatic-carcinoma":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100542403","an-exosome-based-liquid-biopsy-for-the-differential-diagnosis-of-primary-liver-cancer-100542403",false,"NCT06342414","An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer","ELUCIDATE","Inclusion Criteria:\n\n* A histologically confirmed diagnosis of hepatocellular carcinoma\n* A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma\n* Received standard diagnostic and staging procedures as per local guidelines\n* Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment\n\nExclusion Criteria:\n\n* Lack of or inability to provide informed consent\n* Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma\n* Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma\n* Secondary liver cancer","ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","OBSERVATIONAL","It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.",[24,25,26,27,28,29,30],"Hepatocellular Carcinoma","Intrahepatic Cholangiocarcinoma","Cholangiocarcinoma","Primary Liver Cancer","Primary Liver Carcinoma","Hepatic Cancer","Hepatic Carcinoma",[32,33,34],"Exosome","micro RNA","Differential Diagnosis","RECRUITING","2026-04-01",{"date":38,"type":39},"2026-04-03","ACTUAL",{"date":41,"type":39},"2024-03-15",{"date":43,"type":20},"2026-06-18",{"name":45,"class":46},"City of Hope Medical Center","OTHER",5,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":5},"100620589","laryngopharyngeal-injury-after-endotracheal-intubation-under-general-anesthesia-100620589","NCT07359586","Laryngopharyngeal Injury After Endotracheal Intubation Under General Anesthesia","Incidence,Perioperative Risk Factors and Prognosis Associated With Laryngopharyngea Injury After Endotracheal Intubation Under General Anesthesia：A Retrospective Study","Inclusion Criteria:\n\n* Patients who underwent general anesthesia with tracheal intubation at the First Affiliated Hospital of Zhejiang University School of Medicine between October 2015 and September 2025\n* Patients who required otolaryngological consultation due to laryngopharyngeal complaints (including hoarseness, sore throat, cough, choking on drinking water, etc.) postoperatively\n* The surgical type was non-otolaryngological surgery\n\nExclusion Criteria:\n\n* Patients with a history of laryngopharyngeal lesions (e.g., granuloma, polyp, tumour, vocal cord paralysis\n* Patients with a preexisting tracheotomy\n* Patients requiring postoperative tracheotomy\n* Patients with incomplete medical records\n* Patients who underwent multiple surgeries but for whom the specific surgical episode responsible for the laryngopharyngeal complaints could not be identified",{"count":56,"type":20},1200,"This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025, with a focus on issues related to postoperativelaryngopharyngeal complaints. Patients requiring otolaryngological consultation due to postoperative laryngopharyngeal complaints were identified via the case consultation system. Relevant patient data were collected through the Medison Anesthesia Information Management System and electronic medical record system, and telephone follow-up was conducted to assess patient prognosis. The primary outcome measures were the risk factors of postoperative hoarseness, while the secondary outcome measures included the incidence of postoperative hoarseness, the severity of vocal fold injury and its related risk factors. Additionally, the prognosis of patients and its related risk factors were evaluated. This study aims to reduce the incidence of perioperative laryngopharyngeal injury and provide a reference for the optimization of perioperative anesthetic regimens.",[59,30,60,61,26,62],"Gastric Cancer","Pulmonary Carcinoma","Pancreatic Carcinoma","Thyroid Carcinoma",[64,65,66,67],"hoarseness","Vocal cord injury","Incidence","Prognosis","2026-01-13",{"date":70,"type":39},"2026-01-22",{"date":72,"type":39},"2025-11-01",{"date":74,"type":20},"2026-12-25",{"name":76,"class":46},"Zhejiang University"]