[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hepatic-resection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hepatic-resection":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100643118","erector-spinae-plane-block-versus-thoracic-epidural-analgesia-for-open-liver-resection-100643118",false,"NCT07642336","Erector Spinae Plane Block Versus Thoracic Epidural Analgesia for Open Liver Resection","Comparison of Postoperative Analgesic Efficacy Between Erector Spinae Plane Block and Thoracic Epidural Analgesia in Open Hepatectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* \\* Patients aged between 18 and 80 years old.\n\n  * American Society of Anesthesiologists (ASA) physical status classification I to III.\n  * Scheduled to undergo elective open liver resection (open hepatectomy).\n  * Patient provides written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Severe coagulation profile derangement prior to surgery (defined as International Normalized Ratio \\[INR\\] \\> 1.5 or 2.0, or Platelet count \\[PLT\\] \\\u003C 50 G\u002FL or 100 G\u002FL).\n\n  * Severe hepatic impairment (Child-Pugh Class C).\n  * Severe chronic obstructive pulmonary disease (COPD GOLD stage III-IV).\n  * Severe cardiac dysfunction with an ejection fraction (EF) \\\u003C 35%.\n  * Severe obesity with a Body Mass Index (BMI) \\> 40 kg\u002Fm².\n  * Localized infection at the planned puncture\u002Fneedle insertion site.\n  * Known allergy or hypersensitivity to local anesthetics (e.g., Ropivacaine) or opioids (e.g., Morphine).\n  * Pregnancy or current lactation.","ALL","18 Years","80 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Open liver resection is associated with severe postoperative pain. While thoracic epidural analgesia (TEA) is considered the gold standard for pain control, its clinical application is often limited by postoperative coagulation profile derangement, which increases the risk of epidural hematoma. Continuous erector spinae plane block (ESPB) has emerged as a promising, safer alternative with a lower risk of bleeding complications. Objective: This study aims to compare the postoperative analgesic efficacy, safety profiles, and impacts on respiratory function between ultrasound-guided continuous ESPB and TEA in patients undergoing elective open liver resection. Hypothesis: The investigators hypothesize that continuous ESPB using a programmed intermittent bolus (PIB) regimen is non-inferior to TEA regarding 72-hour postoperative pain scores at rest, while offering superior hemodynamic stability and fewer technique-related risks.",[27,28,29],"Liver Neoplasms","Hepatic Resection","Liver Cancer",[31,32,28],"Postoperative Pain","Acute Pain","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-25","ACTUAL",{"date":39,"type":37},"2026-06-15",{"date":41,"type":21},"2026-08-20",{"name":43,"class":44},"Nguyen Toan Thang","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":45},"100571277","immunohistochemical-algorithm-for-the-diagnosis-and-classification-of-hepatocellular-carcinomas-with-tert-tp53-and-ctnnb1-mutation-100571277","NCT06718153","Immunohistochemical Algorithm for the Diagnosis and Classification of Hepatocellular Carcinomas With TERT, TP53 and CTNNB1 Mutation","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients resected for HCC\n* Availability of NGS data\n* Availability of paraffin material for immunohistochemistry investigations\n\nExclusion Criteria:\n\n* None",{"count":53,"type":21},100,[24],"The presence of certain mutations in HCC, such as TERT and TP53, have a suspected or proven prognostic role in resected patients, but lack a morphological or immunophenotypic counterpart, which would allow us to define which tumours are rationally candidate for molecular biology analysis. The identification of a histological and immunohistochemical algorithm to determine which HCCs to take to NGS for prognostic purposes will save time and economic costs in the laboratory by rationalising available resources. In the future, the application of the immunohistochemical and molecular algorithm on biopsy could allow better prognosis and predictivity even before surgery\u002Ftherapy.",[57,28],"Hepatic Cancer",[59,60],"Molecular diagnostics","Immunohistochemistry","2024-12-04",{"date":63,"type":37},"2024-12-05",{"date":65,"type":37},"2024-10-23",{"date":67,"type":21},"2025-06",{"name":69,"class":44},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":45},"100427703","phase-4-erector-spinae-plane-block-catheters-and-intrathecal-morphine-for-hepatic-resection-100427703","NCT04849455","Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection","Erector Spinae Plane Block Catheters: The Role in Acute Postoperative Pain After Hepatic Resection With Intrathecal Morphine","Inclusion Criteria:\n\n* undergoing hepatic resection\n* Admitting service requests APS consult\n* \\>18 years old and able to provide consent\n\nExclusion criteria:\n\n* pregnancy\n* incarceration\n* inability to communicate with the investigators and hospital staff\n* severe hepatic disease\n* chronic high-dose opioid use (defined as daily use for more than 4 weeks prior to surgery of at least the equivalent of 20 mg oxycodone);\n* BMI \\> 40 kg\u002Fm2\n* allergy to study medications (lidocaine, ropivacaine)",{"count":78,"type":21},70,[80],"PHASE4","To determine whether the addition of erector spinae plane (ESP) catheters to existing multimodal analgesic regimen with intrathecal morphine provides superior postoperative analgesia in patients undergoing hepatic resection compared with patients not receiving ESP catheters.",[28,32,83,84],"Anesthesia","Anesthesia, Local",[86,87,88],"acute postoperative pain","erector spinae plane block","liver resection","2022-06-06",{"date":91,"type":37},"2022-06-07",{"date":93,"type":37},"2021-05-24",{"date":95,"type":21},"2023-05-01",{"name":97,"class":44},"University of California, San Diego"]