[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hepatitis-b-virus---chronic-active\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hepatitis-b-virus---chronic-active":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100470223","phase-4-efficacy-of-tenofovir-disoproxil-on-mother-to-child-transmission-of-hbv-in-tokombr-cameroon-in-pregnant-women-100470223",false,"NCT05403047","Efficacy of Tenofovir Disoproxil on Mother-to-child Transmission of HBV in Tokombéré, Cameroon in Pregnant Women","Efficacy of Tenofovir Disoproxil on Mother-to-child Transmission of HBV in Tokombéré, Cameroon in Pregnant Women Infected With Hepatitis B Virus (HBeAg Positive or With a High Viral Load) and Whose Newborns Had Been Vaccinated at Birth","TOPCHIB","Inclusion criteria:\n\n* Pregnant women with a term of less than 24 weeks of amenorrhea;\n* HBsAg positive ;\n* HBeAg positive or HBeAg negative with a high viral load ( \\> 200 000 UI\u002Fml) ;\n* 16 years old or more on the inclusion day ;\n* Signature of free and informed consent (for pregnant women aged 16 to 21, the participant's consent as well as the authorization of a parent\u002Fadult husband\u002F legal tutor will be collected) which also includes consent for the children\n\nExclusion criteria :\n\n* HIV co-infection;\n* Women treated for HBV;\n* Creatinine clearance \\\u003C30 ml \u002F min;\n* Suspicion of poor monitoring of children's vaccination schedule for HBV (vaccination at birth + boosters);\n* Disease or treatment contraindicating the taking of TDF.","FEMALE","16 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Pregnant women with HBeAg-positive viral hepatitis b or high viral load will receive Tenofovir disoproxil fumarate (TDF) from the 28th week of amenorrhoea until 6 weeks after delivery. Their newborns will receive the hepatitis B vaccine, starting with one dose at birth and followed by three booster doses, according to the Expanded Programme on Immunisation.\n\nThe investigators hypothesise that a short course of TDF could greatly reduce the risk of HBV MTCT in pregnant women at high risk of MTCT (HBeAg positive or with high viral load).",[27],"Hepatitis B Virus - Chronic Active","RECRUITING","2026-06-25",{"date":31,"type":32},"2026-06-29","ACTUAL",{"date":34,"type":32},"2023-08-22",{"date":36,"type":21},"2028-02",{"name":38,"class":39},"ANRS, Emerging Infectious Diseases","OTHER_GOV"]