[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hepatobiliary-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hepatobiliary-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100618701","prediction-model-for-mins-after-major-hepatobiliary-surgery-100618701",false,"NCT07335042","Prediction Model for MINS After Major Hepatobiliary Surgery","Development of an Interpretable Prediction Model for Myocardial Injury After Noncardiac Surgery in Patients Undergoing Major Hepatobiliary Surgery","Inclusion Criteria:\n\nAdults (18-85 yr, ASA physical status II-III) undergoing major hepatobiliary surgery were enrolled. Major surgery was defined as duration ≥ 3 h involving hepatectomy (≥ 3 segments) or biliary reconstruction necessitating ICU admission. Eligibility required paired perioperative high-sensitivity cardiac troponin T (hs-cTnT) data and comprehensive documentation of surgical covariates, including surgical approach (laparoscopic vs. open), resection nature (anatomic vs. non-anatomic), number of resected segments, tumor characteristics (size and location), and presence of cirrhosis.\n\nExclusion Criteria:\n\n(1) preoperative acute myocardial infarction, unstable angina, heart failure, or chronic kidney disease (estimated glomerular filtration rate \\\u003C 60 ml\u002F (min · 1.73 m2); (2) undocumented inflow occlusion strategy; or (3) non-imputable missing covariates.","ALL","18 Years","85 Years",{"count":20,"type":21},1800,"ESTIMATED","OBSERVATIONAL","This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.",[25,26,27,28],"Myocardial Injury After Noncardiac Surgery (MINS)","Postoperative Complications","Liver Neoplasm","Hepatobiliary Diseases",[30,31,32,33,34,35,36],"MINS","Major Hepatobiliary Surgery","Hepatectomy","Hepatic Inflow Occlusion","Pringle Maneuver","Prediction Model","High-sensitivity Cardiac Troponin","RECRUITING","2026-06-12",{"date":40,"type":41},"2026-06-15","ACTUAL",{"date":43,"type":41},"2026-01-14",{"date":45,"type":21},"2027-06-30",{"name":47,"class":48},"Beijing Tsinghua Chang Gung Hospital","OTHER",6,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":60,"conditions":61,"keywords":70,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100635757","outcomes-after-liver-and-biliary-resection-at-a-high-volume-center-100635757","NCT07556835","Outcomes After Liver and Biliary Resection at a High-Volume Center","Ambispective Cohort Study of Clinical and Oncologic Outcomes in Patients Undergoing Liver and Biliary Resection at San Jacopo Hospital, Pistoia","BILIVER","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients undergoing liver resection and\u002For biliary resection at San Jacopo Hospital, Pistoia\n* Diagnosis of benign or malignant hepatobiliary disease\n* Availability of clinical, surgical, and follow-up data\n* For the prospective cohort, provision of written informed consent when required according to local regulations\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnancy\n* No liver or biliary resection performed\n* Biopsy only without resection\n* Refusal or unavailability of consent for the prospective cohort when consent is required",{"count":59,"type":21},1000,"The goal of this observational study is to evaluate clinical and oncologic outcomes in adult patients undergoing liver and\u002For biliary resection for benign and malignant diseases.\n\nThis study evaluates postoperative morbidity and mortality within 90 days after surgery, as well as overall survival and disease-free survival in patients with malignant disease.\n\nParticipants will:\n\n* undergo standard surgical and perioperative management according to routine clinical practice\n* have clinical, surgical, and follow-up data collected from institutional medical records\n* be followed for postoperative outcomes and long-term oncologic outcomes up to 5 years",[62,28,63,64,65,66,67,68,69],"Liver Neoplasms","Cholangiocarcinoma","Hepatocellular Carcinoma","Liver Metastases From Colorectal Cancer","Liver Metastases","Biliary Tract Diseases","Benign Liver Disease","Gallbladder Carcinoma",[71,72,73,32,74,75,76,77,78,79,80,81,82,83,63],"Hepatobiliary surgery","Liver resection","Biliary resection","Postoperative complications","Postoperative mortality","Clavien-Dindo classification","Overall survival","Disease-free survival","Surgical outcomes","Observational study","Ambispective cohort","CRLM","HCC","NOT_YET_RECRUITING","2026-04-22",{"date":87,"type":41},"2026-04-29",{"date":89,"type":21},"2026-04",{"date":91,"type":21},"2036-12",{"name":93,"class":48},"Azienda USL Toscana Centro",1]