[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"her2-positive-gastroesophageal-junction-adenocarcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:her2-positive-gastroesophageal-junction-adenocarcinoma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100515571","a-study-of-trastuzumab-deruxtecan-for-patients-with-advanced-her2-positive-gastric-or-gastroesophageal-junction-adenocarcinoma-who-have-received-a-prior-trastuzumab-based-regimen-accompanied-by-a-disease-registry-of-patients-treated-with-conventional-therapies-prosperity-100515571",false,"NCT05993234","A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)","A Prospective Non-interventional Study (NIS) of Trastuzumab DeRuxtecan (T-DXd) for Adult Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction (GEJ) AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen, Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies in a Real-world Setting in Europe (PROSPERITY)","Inclusion Criteria:\n\n* Male or female adult patient (age ≥ 18 years) with HER2 + advanced gastric or GEJ adenocarcinoma who have received a prior trastuzumab based regimen\n* Histological or cytological confirmed diagnosis of advanced HER2 positive gastric cancer or GEJ\n* Documented HER2 + status (archival sample or recent sample prior 2L therapy)\n* Decision to newly initiate monotherapy T-DXd or conventional therapies per SMPC according to the physician's choice\n* Written dated and signed Informed Consent (ICF) to participate in the study\n\nExclusion Criteria:\n\n* Patients who at time of data collection for this study are participating in or have participated in an interventional study that remains blinded\n* Pregnancy or breastfeeding\n\nNo specific exclusion criteria are defined, as patients will be treated according to the proposed indication statements in the SmPC.","ALL","18 Years",{"count":19,"type":20},257,"ESTIMATED","2 Years","OBSERVATIONAL","Trastuzumab deruxtecan (T-DXD) as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.\n\nThis study will assess the effectiveness of T-DXd, patient demographic and clinical characteristics, and treatment patterns in patients with advanced HER2-positive advanced gastric or GEJ adenocarcinoma.",[25,26],"HER2-positive Advanced Gastric Cancer","HER2-positive Gastroesophageal Junction Adenocarcinoma",[25,26,28,29,30],"Trastuzumab Deruxtecan","Conventional therapy","ENHERTU®","RECRUITING","2026-05-05",{"date":34,"type":35},"2026-05-08","ACTUAL",{"date":37,"type":35},"2023-12-05",{"date":39,"type":20},"2027-09-01",{"name":41,"class":42},"Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company","INDUSTRY",76,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100560067","phase-1-disitamab-vedotin-plus-trastuzumab-in-patients-with-her2-positive-gcgej-patiens-100560067","NCT06572319","Disitamab Vedotin Plus Trastuzumab in Patients With HER2 Positive GC\u002FGEJ Patiens","Phase I\u002FII Clinical Study of the Combination of Disitamab Vedotin and Trastuzumab in the Treatment of HER2 Positive Gastric\u002FGastroesophageal Junction Tumors With Previous Systemic Therapy Failure","Inclusion Criteria:\n\n1\\. Sign the informed consent form; 2.18-75 years old (including 18 years old, excluding 75 years old), gender not limited; 3. The pathological histology confirmed by pathology is adenocarcinoma of the gastric\u002Fgastroesophageal junction; 4. HER2 positive tumor criteria (primary tumor or metastatic lesion, HER2 positive is defined as IHC 2+\u002FFISH+(HER2: CEP17 ratio ≥ 2.0) or IHC (3+). Using the criteria for interpreting HER2 in gastric cancer 5. Recurrent or metastatic diseases that cannot be surgically treated, with at least one measurable lesion (RECIST 1.1 criteria) in the subject and an estimated survival time of at least 12 weeks; 6. ECOG score ranges from 0 to 1 points; 7. At least first-line systemic therapy has failed (regardless of whether it includes anti-HER2 monoclonal antibody therapy); 8. Having sufficient bone marrow, liver and kidney function:\n\n* Absolute neutrophil count (ANC) ≥ 1.5 × 109\u002FL, platelets ≥ 90 × 109\u002FL, or\n* hemoglobin ≥ 9g\u002FdL;\n* ALT or AST levels without liver metastasis are less than 2.5 times the upper limit of the normal range; When liver metastasis occurs, ALT or AST is less than 5 times the upper limit of the normal range; Serum bilirubin is 1.5 times lower than the upper limit of the normal reference range;\n* Serum creatinine is lower than 1.5 times the upper limit of the normal reference range or creatinine clearance rate is ≥ 40ml\u002Fmin; 9. Women of childbearing age and their spouses are willing to use effective contraceptive methods within the last 7 months of treatment.\n\nExclusion Criteria:\n\n1. Known to be allergic to the received therapeutic drugs or excipients;\n2. Baseline LVEF\\\u003C50% (measured by echocardiography or MUGA);\n3. Previously received treatment with anti-HER2 ADC drugs;\n4. Individuals who have undergone systemic immunotherapy, biologic therapy, or participated in any clinical drug trials within the past 2 weeks;\n5. Those who have undergone surgery within 3 weeks before the start of the experimental treatment and have not fully recovered;\n6. Patients with uncontrolled central nervous system (CNS) metastases or epilepsy requiring medication treatment;\n7. Serious systemic diseases. Such as infected or uncontrolled diabetes;\n8. Suffering from other malignant tumors within 5 years, except for non melanoma skin cancer and cervical carcinoma in situ;\n9. Clinically symptomatic active coronary heart disease, cardiomyopathy, or congestive heart failure, NYHA III-IV; uncontrolled hypertension (systolic blood pressure\\>180 mmHg or diastolic blood pressure\\>100 mmHg), clinically symptomatic heart valve disease, or high-risk arrhythmia;\n10. Patients receiving long-term or high-dose corticosteroid treatment (inhaled steroids or short-term oral steroids are allowed to resist vomiting or promote appetite)\n11. Individuals without legal capacity, those whose medical or ethical reasons affect the continuation of research;\n12. Pregnant and lactating female patients, or those who wish to become pregnant during treatment;\n13. Uncontrolled pleural and peritoneal effusion;\n14. There is a persistent infection of\\>level 2 (CTC-AE 4.0); Wounds, ulcers, or fractures that cannot heal, or patients with a history of organ transplantation;\n15. There are unresolved toxicity levels\\>1 caused by any previous treatment\u002Fprocedure (CTC-AE 4.0, excluding hair loss, anemia, and hypothyroidism);\n16. After comprehensive assessment of the patient's condition by the researchers, it is deemed that they are not suitable to participate in this study;\n17. Simultaneously participating in another clinical study.","75 Years",{"count":53,"type":20},35,"INTERVENTIONAL",[56,57],"PHASE1","PHASE2","This trial is a single center, single arm, open label clinical study aimed at evaluating the efficacy and safety of the combination therapy of Disitamab Vedotin and trastuzumab in the treatment of advanced HER-2 positive gastric\u002Fgastroesophageal junction tumors",[60,26],"HER2-positive Gastric Cancer",[62,63,64,65],"HER-2","ADC","Disitamab Vedotin","trastuzumab","2024-08-23",{"date":68,"type":35},"2024-08-27",{"date":70,"type":20},"2024-09-01",{"date":72,"type":20},"2026-12-31",{"name":74,"class":75},"Zhejiang Cancer Hospital","OTHER",1]