[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hereditary-angioedema-with-c1-esterase-inhibitor-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hereditary-angioedema-with-c1-esterase-inhibitor-deficiency":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100627403","real-life-ecological-momentary-assessment-of-lived-burden-in-hereditary-angioedema-100627403",false,"NCT07448181","Real-life Ecological Momentary Assessment of Lived Burden in Hereditary AngioEdema","REAL-HAE","Inclusion Criteria:\n\n* Confirmed diagnosis of Type 1 or Type 2 hereditary angioedema;\n* Age ≥ 18 years;\n* Ability to understand instructions and provide informed consent;\n* Ownership and proficiency in using a personal smartphone compatible with the m-Path application (Android or iOS);\n* Willingness to participate in the study for the entire duration of the observation period (8 weeks).\n\nExclusion Criteria:\n\n* Diagnosis of acquired angioedema or other forms of angioedema unrelated to C1-inhibitor deficiency;\n* Severe cognitive or psychiatric disorders that compromise the ability to complete the questionnaires independently;\n* Age \\\u003C 18 years;","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","The aim of this study is to conduct an in-depth analysis of the Burden of Disease (BoD) perceived by patients with Hereditary Angioedema (HAE), through daily prospective observations based on Ecological Momentary Assessment (EMA) via digital surveys and standardised questionnaires.\n\nParticipants will answer online survey questions about their perceived burden of disease for 8 consecutive weeks. The main hypothesis is that daily prospective observation (EMA) will reveal a higher and more fluctuating burden of disease compared to traditional retrospective scales, providing a more accurate representation of the impact of HAE on patients' daily lives.",[24,25,26],"Hereditary Angioedema With C1 Esterase Inhibitor Deficiency","Hereditary Angioedema - Type 1","Hereditary Angioedema - Type 2",[28,29,30,31],"Hereditary Angioedema","Burden of disease","Ecological Momentary Assessment","Quality of Life","RECRUITING","2026-03-03",{"date":35,"type":36},"2026-03-04","ACTUAL",{"date":38,"type":36},"2026-02-23",{"date":40,"type":20},"2027-02-28",{"name":42,"class":43},"Istituti Clinici Scientifici Maugeri SpA","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":5},"100503312","identification-and-characterization-of-genetic-variants-in-hereditary-angioedema-100503312","NCT05833620","Identification and Characterization of Genetic Variants in Hereditary Angioedema","Identification and Functional Characterization of Genetic Variants Associated With Specific Clinical Phenotypes in Hereditary Angioedema Due to C1 Inhibitor Deficiency: An Unbiased Approach","GENOMAEH_01","Inclusion Criteria:\n\n* Adult patients (≥ 18 years old) with HAE-C1INH diagnosis (confirmed by mutation in SERPING1 gen or immunochemical study showing a decrease in C1INH function \\\u003C50% in two determinations together with a family history (symptomatic patients' group)\n* Patients ≥ 22 years old with C1INH hereditary deficiency (confirmed by mutation of SERPING1 gene or immunochemical study showing a decrease in C1INH function \\\u003C50% in two determinations together with a family history) and who have not developed symptoms consistent with HAE-C1INH\n* Signed informed consent.\n\nExclusion Criteria:\n\n* No confirmed C1INH deficiency.\n* Inability to sign the informed consent.\n* Presence of recurrent angioedema with histaminergic characteristics (response to treatment with antihistamines, glucocorticoids and\u002For epinephrine)",{"count":54,"type":20},200,"This project aims to analyse in an unbiased way the existence of genetic variants that contribute to explaining and predicting the differences in clinical expression between patients with HAE.",[24],"NOT_YET_RECRUITING","2023-04-17",{"date":60,"type":36},"2023-04-27",{"date":62,"type":20},"2023-05",{"date":64,"type":20},"2027-03-31",{"name":66,"class":43},"Hospital Universitari Vall d'Hebron Research Institute"]