[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hering-breuer-reflex\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hering-breuer-reflex":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100614516","the-hering-breuer-reflex-in-bilateral-lung-transplant-patients-100614516",false,"NCT07280611","The Hering-Breuer Reflex in Bilateral Lung Transplant Patients","HB-DLTX","Inclusion Criteria:\n\n* Age \\>18 years;\n* Both sexes;\n* For group 1: patients admitted to the Intensive Care Unit after undergoing bilateral lung transplantation, during respiratory weaning;\n* For group 2: patients admitted to the Intensive Care Unit for support or monitoring after non-thoracic surgery, who will arrive intubated.\n\nExclusion Criteria:\n\nFor group 1, patients meeting at least one of the following criteria will be excluded:\n\n* Re-transplantation or single-lung transplantation;\n* Urgent lung transplantation;\n* Post-transplant respiratory system compliance \\\u003C 30 mL\u002FcmH₂O;\n* Hemodynamic instability (defined as the presence of one or more of the following: plasma lactate \\> 4 mmol\u002FL, need for vasoactive support with norepinephrine and\u002For epinephrine at a dose \\> 0.05 mcg\u002Fkg\u002Fmin, systolic arterial pressure \\\u003C 80 mmHg);\n* Increased risk of bleeding related to the placement of a nasogastric tube due to coagulopathy or severe thrombocytopenia (INR \\> 2 and platelets \\\u003C 70,000);\n* Pregnancy\n\nFor group 2, patients presenting with one or more of the following criteria will be excluded:\n\n* Postoperative respiratory system compliance \\\u003C 30 mL\u002FcmH₂O;\n* Hemodynamic instability (defined as the presence of one or more of the following: plasma lactate \\> 4 mmol\u002FL, need for vasoactive support with norepinephrine and\u002For epinephrine at a dose \\> 0.05 mcg\u002Fkg\u002Fmin, systolic arterial pressure \\\u003C 80 mmHg);\n* Contraindications to nasogastric tube placement (gastroesophageal surgery within the last 3 months, gastroesophageal bleeding in the previous 30 days, esophageal varices, facial trauma);\n* Increased risk of bleeding related to the placement of a nasogastric tube due to coagulopathy or severe thrombocytopenia (INR \\> 2 and platelets \\\u003C 70,000);\n* History of lung transplantation or major thoracic surgery;\n* Pregnancy.","ALL","18 Years",{"count":19,"type":20},22,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial (non-pharmacologic, single-center) is to determine whether the Hering-Breuer inflation reflex is preserved-and how it is modulated by end-expiratory pressure-in adult intensive-care patients who have undergone bilateral lung transplantation.\n\nThe study will enroll men and women ≥ 18 years admitted to the ICU during the early weaning phase and will include a comparison group of intubated ICU patients after major non-thoracic surgery.\n\nThe main questions it aims to answer are:\n\n* Is the Hering-Breuer reflex (measured as the ratio THBR\u002FTSPONT) absent or attenuated in double-lung-transplant recipients?\n* Does changing the level of positive end-expiratory pressure (PEEP 8 vs 12 cmH₂O) influence the reflex?\n\nComparison group: Researchers will compare the transplant arm (post-bilateral lung transplantation) with the control arm (post-operative, non-thoracic surgery patients) to see whether loss or blunting of the reflex-and its response to PEEP-differs between the two cohorts.\n\nParticipants will:\n\n* Have a nasogastric catheter with embedded electrodes positioned to record the electrical activity of the diaphragm (EAdi).\n* Be ventilated in pressure-support mode at two preset PEEP levels (8 cmH₂O and 12 cmH₂O) during the weaning phase.\n* Receive one standardized high-volume insufflation at \\~30 cmH₂O in each PEEP condition to elicit the reflex, while EAdi, airway pressures, inspiratory\u002Fexpiratory times, and tidal volumes are recorded for 10 minutes per level.",[26],"Hering-Breuer Reflex",[28,29],"Hering-Breuer reflex","Bilateral Lung Transplant","RECRUITING","2025-12-01",{"date":33,"type":34},"2025-12-12","ACTUAL",{"date":36,"type":34},"2025-10-07",{"date":38,"type":20},"2026-06",{"name":40,"class":41},"Policlinico Hospital","OTHER"]