[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hernia-abdominal-wall\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hernia-abdominal-wall":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100613507","image-guided-herniorrhaphy-study-100613507",false,"NCT07267494","Image-Guided Herniorrhaphy Study","Image-guided Herniorrhaphy Safety and Efficacy Pilot","Inclusion Criteria:\n\n* English-speaking adult with reducible hernia(s) or diastasis smaller than approximately 8 cm seeking treatment for their hernia but not able or willing to undergo traditional surgery (open, laparoscopic, or robotic)\n* Patient must be willing to undergo a novel 30- to 60-minute image-guided needle-based procedure\n\nExclusion Criteria:\n\n* Children, prisoners, and pregnant women (possibly requiring a pregnancy test on the day of the procedure)\n* Patients with a known reaction to local anesthetic or sedation medications or the suture material to be used\n* Patients with irreducible hernias\n* Patients with herniation not visible by ultrasound or CT\n* Patients that do not fit the diameter of a CT gantry or the weight limit of the procedural CT table\n* Patients without insurance or not willing to pay out-of-pocket for the study procedure","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","This pilot clinical study will evaluate the safety and effectiveness of a new image-guided, needle-based approach for repairing abdominal or groin hernias in adults who are unable or unwilling to undergo traditional open or laparoscopic surgery. The technique uses ultrasound and, when needed, CT imaging to guide a hollow needle preloaded with barbed suture through the skin to close the hernia defect without large incisions or general anesthesia. Each participant will undergo one image-guided procedure and will be followed for eight months to assess complications and changes in hernia-related quality of life. Approximately thirty participants will be enrolled. The study aims to determine whether this minimally invasive approach is safe, feasible, and capable of improving hernia symptoms enough to justify a larger clinical trial",[26,27,28,29,30,31],"Hernia","Hernia Abdominal Wall","Ventral Hernia","Inguinal Hernia","Hiatal Hernia","Diastasis Recti",[33,34,35,36,37],"Image-guided herniorrhaphy","hernia","pilot study","quality of life","safety and feasability","NOT_YET_RECRUITING","2026-06-12",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":44,"type":20},"2026-12-01",{"date":46,"type":20},"2029-05-01",{"name":48,"class":49},"University of California, Davis","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":50},"100609884","phase-4-preoperative-botox-injection-for-large-ventral-hernia-repair-100609884","NCT07220382","Preoperative BOTOX® Injection for Large Ventral Hernia Repair","PREoperative Targeted OnabotulinumtoXina Injection for Abdominal Wall Reconstruction: A Randomized, Double-Blind, Placebo-Controlled Trial","PRETOX","Inclusion Criteria:\n\n* Adult (greater than or equal to 18 years of age)\n* Candidate for elective open repair of ventral hernia\n* Preoperative imaging demonstrating either:\n* ventral hernia defect width of at lest 15 cm; AND\u002FOR,\n* Tanaka volume ratio of at least 25%\n* Planned elective hernia repair in an open fashion via a midline laparotomy with posterior component separation and transversus abdominis release\n\nExclusion Criteria:\n\n* Emergent cases\n* Pregnancy and\u002For breastfeeding at time of intramuscular injection\n* Inability to provide informed consent\n* Inability to receive either study intervention (i.e. allergy to local anesthetics utilized for intervention administration, allergy and\u002For contraindication to any botulinum toxin, inability to attend outpatient administration of study intervention, inability to conform to safety check schedule)\n* Known congenital or acquired neuromuscular disorder\n* Presence of stoma\n* Current infection at time of intramuscular injection\n* Flank hernias s defined by EHS L1-L4\n* BMI \\> 45 kg\u002Fm\\^2\n* Diaphragmatic hemiparesis or chronic obstructive pulmonary disease (COPD) with chronic oxygen dependence",{"count":60,"type":20},188,[62],"PHASE4","This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as \"BOTOX®\" (onabotulinumtoxinA) into the side abdominal muscles 3-7 weeks before surgery helps surgeons close the abdominal wall fully at the end of the operation. Closing the muscle and tissue layers (\"primary fascial closure\") is linked to fewer problems after surgery and better quality of life.\n\nParticipants will be randomly assigned (like a coin flip) to receive either the BOTOX® medicine or a saltwater (placebo) injection. Neither patients nor the care team will know which one was given. All participants will still have their planned hernia repair in the standard way that we repair patients who are not part of the study. The study will track whether the abdomen can be closed without leaving a gap, and investigators will also look at recovery, complications, time in the ICU or on a ventilator, length of stay, pain, and quality-of-life scores. Most information will be collected during participants' hospital stay, but the investigators will continue to see how participants are doing up to 2 years after surgery. Short phone check-ins will occur before surgery, and after surgery follow-up happens around 30 days, 90 days, 1 year, and 2 years.\n\nPossible risks from the injection include temporary muscle weakness, trouble swallowing or breathing, pain or infection at the injection site, and (if CT is used for guidance) a small amount of radiation exposure. Surgery itself carries the usual risks (pain, bleeding, wound problems). Benefits are not guaranteed, but the injection may make closure easier and recovery smoother. About 188 people will take part at Cleveland Clinic.",[27,65,66,67,68,26,69],"Botox Injection","Hernia Incisional Ventral","Hernia Repair With Compartment Syndrome","Hernia Surgery","Hernia Incisional",[71,28,72,73,74,75,76,77,78],"BOTOX","Abdominal Wall Reconstruction","OnabotulinumtoxinA","Preoperative BOTOX","Primary Fascial Closure","Fascial Bridging","Transversus Abdominis Release","Posterior Component Separation","RECRUITING","2025-11-18",{"date":82,"type":42},"2025-11-21",{"date":84,"type":42},"2025-11-03",{"date":86,"type":20},"2029-12-15",{"name":88,"class":49},"The Cleveland Clinic",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":50},"100495670","optimization-of-surgical-treatment-of-patients-with-incisional-ventral-hernias-100495670","NCT05734222","Optimization of Surgical Treatment of Patients With Incisional Ventral Hernias","Optimization of Surgical Treatment of Patients With Postoperative Median and Median-lateral Ventral Hernias","Inclusion Criteria:\n\n* The study will include patients with postoperative ventral hernias of median and lateral localization and an average hernial gate width from 4.1 to 15 cm (W2-W3 according to the EHS classification).. The size of the hernial gate is determined by CT.\n\nExclusion Criteria:\n\n* Patients without postoperative ventral hernias median and lateral localization","25 Years","88 Years",{"count":99,"type":20},110,[23],"The goal of our work of optimization of the treatment of postoperative hernias is to improve the results of treatment of patients with median and median-lateral postoperative hernias of medium (W2) and large (W3) sizes by developing new surgical techniques. The main questions it aims to answer are:\n\n1. To study the topographic and variant anatomy of vessels and nerves in the retromuscular, preperitoneal, postperitoneal and pre-abdominal cell spaces of the anterior abdominal wall. To determine the most probable sources of blood flow and lymph from the anatomical formations forming the bed of the endoprosthesis.\n2. To develop technical, surgical techniques that allow to form an implant bed with minimal traumatization of blood vessels and nerves and reduce the risk of postoperative complications.\n3. To develop a technique for plasty of the anterior abdominal wall in mid-lateral postoperative hernias with a combination of retromuscular and subaponeurotic spaces.\n\nThe researchers will compare an experimental group in which a new method of preparing the implant place will be used and a control group in which standard methods of treating postoperative ventral hernias were used to see whether the new method affects the improvement of the postoperative period and the reduction of complications.",[103,104,27],"Hernia, Ventral","Hernias Intestinal",[26,106,107,108,109],"median","median-lateral","median-lateral Incisional hernia","Incisional","2024-12-31",{"date":112,"type":42},"2025-01-01",{"date":114,"type":42},"2022-09-29",{"date":116,"type":20},"2025-05-23",{"name":118,"class":49},"Samara State Medical University"]