[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hernia-incisional\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hernia-incisional":226},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,66,99,126,164,193],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100633817","assessment-of-intra-abdominal-pressure-during-the-perioperative-period-of-hernia-repair-100633817",false,"NCT07531615","Assessment of Intra-abdominal Pressure During the Perioperative Period of Hernia Repair","PRESSEVENT","Inclusion Criteria:\n\n* Midline incisional hernias with a hernia defect width between 4 and 10 cm in the transverse axis, corresponding to W2 according to the EHS classification\n* M2, M3, and M4 locations according to the EHS classification (i.e., hernia defects located from 3 cm below the xiphoid process to 3 cm above the upper border of the pubic symphysis)\n* Patients scheduled for elective open midline incisional hernia repair with retromuscular mesh placement\n* Provision of written informed consent\n* Affiliation with a national health insurance system\n\nExclusion Criteria:\n\n* Other types of incisional hernia\n* Minimally invasive surgery (laparoscopic or robotic approach)\n* Patients under legal protection (guardianship or curatorship), or patients unable to participate in a clinical study in accordance with Article L.1121-16 of the French Public Health Code\n* Pregnant or breastfeeding women of childbearing age","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","Thousands of patients worldwide undergo abdominal surgery every day; 2-11% of laparotomies will progress to an incisional hernia, particularly midline laparotomies, which are associated with higher hernia rates, reaching up to 70% in obese patients (1,2). Long-term recurrence after incisional hernia repair is close to 30% after primary repair and may increase to 70% in cases of iterative (redo) surgery (3).\n\nThe main risk factors for incisional hernia formation or recurrence include surgical site infection, surgical technique, respiratory insufficiency (COPD), as well as overweight and obesity, the prevalence of which is rapidly increasing.\n\nMidline incisional hernias are the most frequent and represent a significant public health issue.\n\nIn abdominal wall surgery, some teams perform so-called tension-free repairs, whereas others favor repairs under tension. The tension-free concept may be associated with a lower recurrence rate. However, this intuitive concept has never been mechanically defined, using perioperative pressure measurements or surface tension assessment. Few studies have investigated abdominal pressure and muscle tension measurements in relation to abdominal wall surgery.\n\nThe aim of this study is to evaluate a protocol for measuring abdominal pressures during open repair of midline incisional hernia.",[26],"Hernia Incisional","RECRUITING","2026-07-01",{"date":30,"type":31},"2026-07-02","ACTUAL",{"date":33,"type":20},"2026-07-30",{"date":35,"type":20},"2028-08-01",{"name":37,"class":38},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":48,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100347809","impact-of-core-muscle-training-on-incisional-hernia-and-pain-after-abdominal-surgery-100347809","NCT03808584","Impact of Core Muscle Training on Incisional Hernia and Pain After Abdominal Surgery","Inclusion Criteria:\n\n1. At the University Hospital of Bern, Kantonsspital Solothurn and Olten and BundeswehrZentralkrankenhaus Koblenz:\n\n   * Informed Consent as documented by signature (Appendix Informed Consent Form)\n   * Age \\> 18 years\n   * Capable of judgment\n   * Undergoing elective or emergency abdominal surgery\n   * Laparoscopic or open surgery, midline or transverse incision\n2. At the University Hospital of Lausanne:\n\n   * Informed Consent as documented by signature (Appendix Informed Consent Form)\n   * Age \\> 18 years\n   * Capable of judgment\n   * Undergoing elective open abdominal surgery\n   * Midline or transverse incision\n\nExclusion criteria (in all four participating centres):\n\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders (chronic depression, under antidepressants or neuroleptics), dementia, etc. of the participant\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons\n* Neuromuscular diseases (such as myasthenia gravis or wheelchair-bound patient)\n* Preexisting chronic pain disorder, patients under chronic opioid therapy (WHO II and III) or pain modulating drugs (antidepressive medication or antiepileptic medication)\n* End-stage disease\n* Patients with preexisting abdominal wall mesh, with the exception of inguinal mesh (after inguinal hernia repair)",{"count":47,"type":20},588,[23],"The current practice to avoid incisional hernia, one of the most frequent complications following abdominal surgery, is to minimize core muscle activity in the postoperative phase. However, there is no evidence to support the association of core muscle activity and increased incidence of incisional hernia. On the contrary, it is likely that reduced physical activity could lead to physical deconditioning, chronic postsurgical pain (CPSP), and sarcopenia. The investigators will conduct a prospective multicentric randomized clinical trial to compare standard of care to core muscle exercises targeting the abdominal muscles immediately postsurgery. The principle hypothesis is that neither specific exercises of core muscles before and after surgery nor physical restriction alter the incidence of incisional hernias. Secondly the impact of postoperative rehabilitation on CPSP and sarcopenia will be assessed.",[26,51],"Exercise",[53,54,55],"Core muscle exercise","rehabilitation","Incisional hernia","2026-04-28",{"date":58,"type":31},"2026-05-05",{"date":60,"type":31},"2019-05-20",{"date":62,"type":20},"2030-12-31",{"name":64,"class":38},"Insel Gruppe AG, University Hospital Bern",5,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":76,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100625423","compliance-guided-abdominal-wall-closure-strategy-in-large-ventral-hernia-repair-100625423","NCT07422441","Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair","Impact of a Compliance-Guided Intraoperative Abdominal Wall Closure Decision Strategy on Early Postoperative Respiratory Failure After Large Ventral Hernia Repair Following Preoperative Botulinum Toxin A","CLOSE-STAT","Inclusion Criteria:\n\n* Age 18 years or older\n* Elective repair of a large ventral abdominal wall hernia (including incisional hernia)\n* Preoperative botulinum toxin A preparation performed as part of the local prehabilitation pathway\n* Preoperative abdominal CT available\n* General anesthesia with mechanical ventilation and feasibility of standardized intraoperative respiratory mechanics measurements\n\nExclusion Criteria:\n\n* Severe preoperative respiratory failure judged to preclude standardized intraoperative respiratory mechanics assessment\n* Inability to obtain reliable static respiratory system compliance measurements at predefined timepoints\n* Hemodynamic instability preventing protocolized measurements (as judged by the anesthesiologist)",{"count":75,"type":20},50,[23],"People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed. During closure, pressure inside the abdomen may increase and lung mechanics can worsen. This study will evaluate a structured intraoperative decision approach that uses standard anesthesia measurements of static respiratory system compliance at predefined timepoints to support the choice of abdominal wall closure technique. The main goal is to assess the rate of early postoperative respiratory failure within 72 hours after surgery.",[79,26,80,81],"Hernia, Ventral","Postoperative Complications","Respiratory Insufficiency",[83,84,85,86,87,88,89],"adbominal wall closure","static compliance","respiratory system compliance","intraoperative monitoring","intra-abdominal pressure","complex hernia repair","botulinum toxin a","NOT_YET_RECRUITING","2026-02-12",{"date":93,"type":31},"2026-02-20",{"date":93,"type":20},{"date":96,"type":20},"2026-11-01",{"name":98,"class":38},"Swissmed Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":109,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":65},"100617269","preoptimisation-in-ventral-hernia-surgery-100617269","NCT07316426","Preoptimisation in Ventral Hernia Surgery","Preoptimisation in Ventral Hernia Surgery- a Randomised Trial","PreOpt","Inclusion Criteria:\n\n* Patients with a ventral hernia with a defect width of at least 4 cm.\n* Symptom burden related to the hernia sufficient to justify surgical intervention.\n* Age ≥ 18 years.\n\nExclusion Criteria:\n\n* Expected survival of less than three years.\n* Inability to comprehend oral and written information or to provide informed consent.\n* Acute complication of the hernia requiring emergency surgical intervention.\n* General condition characterised by severe limitations in physical functional capacity.",{"count":108,"type":20},130,[23],"The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.",[112,79,26,113],"Hernia","Hernia, Umbilical",[115,116],"preoptimisation","prehabilitation","2025-12-18",{"date":119,"type":31},"2026-01-05",{"date":121,"type":31},"2025-09-22",{"date":123,"type":20},"2029-09-01",{"name":125,"class":38},"Umeå University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":138,"conditions":139,"keywords":145,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":39},"100609884","phase-4-preoperative-botox-injection-for-large-ventral-hernia-repair-100609884","NCT07220382","Preoperative BOTOX® Injection for Large Ventral Hernia Repair","PREoperative Targeted OnabotulinumtoXina Injection for Abdominal Wall Reconstruction: A Randomized, Double-Blind, Placebo-Controlled Trial","PRETOX","Inclusion Criteria:\n\n* Adult (greater than or equal to 18 years of age)\n* Candidate for elective open repair of ventral hernia\n* Preoperative imaging demonstrating either:\n* ventral hernia defect width of at lest 15 cm; AND\u002FOR,\n* Tanaka volume ratio of at least 25%\n* Planned elective hernia repair in an open fashion via a midline laparotomy with posterior component separation and transversus abdominis release\n\nExclusion Criteria:\n\n* Emergent cases\n* Pregnancy and\u002For breastfeeding at time of intramuscular injection\n* Inability to provide informed consent\n* Inability to receive either study intervention (i.e. allergy to local anesthetics utilized for intervention administration, allergy and\u002For contraindication to any botulinum toxin, inability to attend outpatient administration of study intervention, inability to conform to safety check schedule)\n* Known congenital or acquired neuromuscular disorder\n* Presence of stoma\n* Current infection at time of intramuscular injection\n* Flank hernias s defined by EHS L1-L4\n* BMI \\> 45 kg\u002Fm\\^2\n* Diaphragmatic hemiparesis or chronic obstructive pulmonary disease (COPD) with chronic oxygen dependence",{"count":135,"type":20},188,[137],"PHASE4","This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as \"BOTOX®\" (onabotulinumtoxinA) into the side abdominal muscles 3-7 weeks before surgery helps surgeons close the abdominal wall fully at the end of the operation. Closing the muscle and tissue layers (\"primary fascial closure\") is linked to fewer problems after surgery and better quality of life.\n\nParticipants will be randomly assigned (like a coin flip) to receive either the BOTOX® medicine or a saltwater (placebo) injection. Neither patients nor the care team will know which one was given. All participants will still have their planned hernia repair in the standard way that we repair patients who are not part of the study. The study will track whether the abdomen can be closed without leaving a gap, and investigators will also look at recovery, complications, time in the ICU or on a ventilator, length of stay, pain, and quality-of-life scores. Most information will be collected during participants' hospital stay, but the investigators will continue to see how participants are doing up to 2 years after surgery. Short phone check-ins will occur before surgery, and after surgery follow-up happens around 30 days, 90 days, 1 year, and 2 years.\n\nPossible risks from the injection include temporary muscle weakness, trouble swallowing or breathing, pain or infection at the injection site, and (if CT is used for guidance) a small amount of radiation exposure. Surgery itself carries the usual risks (pain, bleeding, wound problems). Benefits are not guaranteed, but the injection may make closure easier and recovery smoother. About 188 people will take part at Cleveland Clinic.",[140,141,142,143,144,112,26],"Hernia Abdominal Wall","Botox Injection","Hernia Incisional Ventral","Hernia Repair With Compartment Syndrome","Hernia Surgery",[146,147,148,149,150,151,152,153,154],"BOTOX","Ventral Hernia","Abdominal Wall Reconstruction","OnabotulinumtoxinA","Preoperative BOTOX","Primary Fascial Closure","Fascial Bridging","Transversus Abdominis Release","Posterior Component Separation","2025-11-18",{"date":157,"type":31},"2025-11-21",{"date":159,"type":31},"2025-11-03",{"date":161,"type":20},"2029-12-15",{"name":163,"class":38},"The Cleveland Clinic",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":39},"100532994","comparing-pp-and-pvdf-meshes-in-midline-laparotomy-closure-for-high-risk-colorectal-surgery-impact-on-incisional-hernia-and-surgical-wound-infection-100532994","NCT06220045","Comparing PP and PVDF Meshes in Midline Laparotomy Closure for High-risk Colorectal Surgery. Impact on Incisional Hernia and Surgical Wound Infection.","Comparison Between the Use of a Polypropylene (PP) Prophylactic Mesh and a Polyvinylidene Fluoride (PVDF) Mesh in the Closure of Midline Laparotomy in Emergency Colorectal Surgery for High-risk Patients of Incisional Hernia. Impact on Surgical Wound Infection.","PROFIMESH","Inclusion Criteria:\n\n* Patients diagnosed with colorectal pathology requiring urgent surgical treatment via midline laparotomy.\n* Patients undergoing urgent laparoscopic surgery but requiring conversion to midline laparotomy.\n* Need for urgent surgical treatment involving the colon and\u002For rectum, even in the presence of other abdominal pathologies.\n* Age over 18 years.\n* Signed informed consent (IC) from both the patient and the investigator\n* Severe chronic obstructive pulmonary disease (COPD) according to the GOLD classification or decompensated COPD.\n* BMI ≥ 35 kg\u002Fm2.\n* Re-laparotomies.\n\nExclusion Criteria:\n\n* Patients with psychiatric illnesses, addictions, or any disorder hindering the understanding of the Informed Consent.\n* Inability to read or comprehend any of the languages in the Informed Consent (Catalan, Spanish).",{"count":173,"type":20},60,[23],"In the latest guidelines for abdominal wall closure in emergency surgery published in the World Journal of Emergency Surgery (WJES) in 2023, no specific recommendations are made in this regard.\n\nCurrent literature does not provide any articles comparing these two types of mesh materials (PP vs PVDF) in emergency colorectal surgery. It is necessary to conduct a study comparing these two types of mesh materials, specifically in high-risk patients for incisional hernia and emergency colorectal surgery. This study aims to contribute to generating evidence regarding differences in wound infection incidence and potential subsequent complications, such as chronic pain.\n\nIt is essential to conduct a study comparing different methods of laparotomy closure, specifically in emergency colorectal surgery, to contribute valuable evidence regarding the incidence of incisional hernia and potential subsequent complications.",[177,178,26],"Colorectal Cancer","Wound Infection",[180,178,26,181,182,183],"Colorectal cancer","Mesh","Polypropylene","PVDF","2024-10-06",{"date":186,"type":31},"2024-10-08",{"date":188,"type":31},"2024-02-01",{"date":190,"type":20},"2025-01-15",{"name":192,"class":38},"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":21,"phases":204,"briefSummary":206,"conditions":207,"keywords":211,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":39},"100511457","phase-3-prophylactic-mesh-placement-during-stoma-closure-after-low-anterior-resection-100511457","NCT05939687","Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection","Prophylactic Mesh Placement During Temporary Stoma Closure: a Prospective Randomized Phase III Clinical Trial","ProMeLAR","Inclusion Criteria:\n\n* Signed informed consent\n* Absence of distant metastases (M0)\n* ECOG (Eastern Cooperative Oncology Group) status 0-2\n* completed course of adjuvant treatment\n* Absence of acute inflammatory parastomal complications\n* Integrity of colorectal anastomosis\n\nExclusion Criteria:\n\n* Inability to obtain consent to participate\n* Synchronous and metachronous malignant neoplasms\n* Clinically significant diseases of the cardiovascular system, liver, kidney, central nervous system\n* Parastomal inflammation and other conditions that increase the risk of postoperative complications\n* Pregnancy\n* HIV infection","85 Years",{"count":203,"type":20},142,[205],"PHASE3","The goal of this clinical trial is to compare the efficacy of using polypropylene mesh for hernia prevention after stoma closure in patients with colorectal cancer and non-mesh repair. The main question it aims to answer is: can mesh help prevent hernia? Participants will be divided into 2 groups: with and without mesh using. They must be followed up for 2 years after enrollment in the study.\n\nResearchers will compare mesh and non-mesh groups to evaluate the benefits and harms of mesh using in hernia prevention.",[208,209,26,210],"Neoplasms Malignant","Rectal Cancer","Surgery",[212,213,214,215,216],"Rectal cancer","mesh","stoma-site hernia","prevention","surgery","2024-08-06",{"date":219,"type":31},"2024-08-07",{"date":221,"type":31},"2023-06-05",{"date":223,"type":20},"2028-12-01",{"name":225,"class":38},"Blokhin's Russian Cancer Research Center","Hernia, Incisional"]