[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hernia-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hernia-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100633953","effect-of-anterior-iliac-block-on-postoperative-analgesia-and-patient-satisfaction-in-inguinal-hernia-repair-surgery-100633953",false,"NCT07533383","Effect of Anterior Iliac Block on Postoperative Analgesia and Patient Satisfaction in Inguinal Hernia Repair Surgery","Inclusion Criteria:\n\n* 18-65 years patient\n* American Society of Anesthesiologists(ASA) I-II patient\n\nExclusion Criteria:\n\n* Patients who declined to participate in the study\n* Patients with contraindications to the anterior iliac block\n* Pregnant or breastfeeding patients\n* Patients classified as ASA III, IV, or V","ALL","18 Years","65 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Inguinal hernia repair is one of the most commonly performed surgical procedures worldwide and presents challenges in anesthesia selection and postoperative pain management. Spinal anesthesia is frequently preferred due to its advantages, such as avoiding neuromuscular blockers and endotracheal intubation. Effective postoperative analgesia is essential for improving patient comfort and reducing opioid consumption.\n\nThe anterior iliac block, a recently described technique, has emerged as a potential alternative to conventional regional anesthesia methods, offering wider nerve coverage and possibly improved analgesia. However, evidence regarding its efficacy and safety remains limited.\n\nThis study aims to evaluate the effect of the anterior iliac block on postoperative analgesia duration and patient satisfaction in patients undergoing inguinal hernia surgery.",[26,27,28],"Anterior Ilıac Block","Hernia Surgery","Spinal Anesthesia",[30,31,32,33],"hernia surgery","postoperative pain","numeric rating scale","spinal anesthesia","NOT_YET_RECRUITING","2026-04-09",{"date":37,"type":38},"2026-04-16","ACTUAL",{"date":40,"type":20},"2026-04-30",{"date":42,"type":20},"2027-04-30",{"name":44,"class":45},"Sanliurfa Mehmet Akif Inan Education and Research Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":46},"100609884","phase-4-preoperative-botox-injection-for-large-ventral-hernia-repair-100609884","NCT07220382","Preoperative BOTOX® Injection for Large Ventral Hernia Repair","PREoperative Targeted OnabotulinumtoXina Injection for Abdominal Wall Reconstruction: A Randomized, Double-Blind, Placebo-Controlled Trial","PRETOX","Inclusion Criteria:\n\n* Adult (greater than or equal to 18 years of age)\n* Candidate for elective open repair of ventral hernia\n* Preoperative imaging demonstrating either:\n* ventral hernia defect width of at lest 15 cm; AND\u002FOR,\n* Tanaka volume ratio of at least 25%\n* Planned elective hernia repair in an open fashion via a midline laparotomy with posterior component separation and transversus abdominis release\n\nExclusion Criteria:\n\n* Emergent cases\n* Pregnancy and\u002For breastfeeding at time of intramuscular injection\n* Inability to provide informed consent\n* Inability to receive either study intervention (i.e. allergy to local anesthetics utilized for intervention administration, allergy and\u002For contraindication to any botulinum toxin, inability to attend outpatient administration of study intervention, inability to conform to safety check schedule)\n* Known congenital or acquired neuromuscular disorder\n* Presence of stoma\n* Current infection at time of intramuscular injection\n* Flank hernias s defined by EHS L1-L4\n* BMI \\> 45 kg\u002Fm\\^2\n* Diaphragmatic hemiparesis or chronic obstructive pulmonary disease (COPD) with chronic oxygen dependence",{"count":56,"type":20},188,[58],"PHASE4","This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as \"BOTOX®\" (onabotulinumtoxinA) into the side abdominal muscles 3-7 weeks before surgery helps surgeons close the abdominal wall fully at the end of the operation. Closing the muscle and tissue layers (\"primary fascial closure\") is linked to fewer problems after surgery and better quality of life.\n\nParticipants will be randomly assigned (like a coin flip) to receive either the BOTOX® medicine or a saltwater (placebo) injection. Neither patients nor the care team will know which one was given. All participants will still have their planned hernia repair in the standard way that we repair patients who are not part of the study. The study will track whether the abdomen can be closed without leaving a gap, and investigators will also look at recovery, complications, time in the ICU or on a ventilator, length of stay, pain, and quality-of-life scores. Most information will be collected during participants' hospital stay, but the investigators will continue to see how participants are doing up to 2 years after surgery. Short phone check-ins will occur before surgery, and after surgery follow-up happens around 30 days, 90 days, 1 year, and 2 years.\n\nPossible risks from the injection include temporary muscle weakness, trouble swallowing or breathing, pain or infection at the injection site, and (if CT is used for guidance) a small amount of radiation exposure. Surgery itself carries the usual risks (pain, bleeding, wound problems). Benefits are not guaranteed, but the injection may make closure easier and recovery smoother. About 188 people will take part at Cleveland Clinic.",[61,62,63,64,27,65,66],"Hernia Abdominal Wall","Botox Injection","Hernia Incisional Ventral","Hernia Repair With Compartment Syndrome","Hernia","Hernia Incisional",[68,69,70,71,72,73,74,75,76],"BOTOX","Ventral Hernia","Abdominal Wall Reconstruction","OnabotulinumtoxinA","Preoperative BOTOX","Primary Fascial Closure","Fascial Bridging","Transversus Abdominis Release","Posterior Component Separation","RECRUITING","2025-11-18",{"date":80,"type":38},"2025-11-21",{"date":82,"type":38},"2025-11-03",{"date":84,"type":20},"2029-12-15",{"name":86,"class":45},"The Cleveland Clinic",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100604951","the-papyrus-study-permanent-vs-absorbable-sutures-in-primary-repair-of-umbilical-hernias-a-multicentre-single-blind-non-inferiority-randomized-controlled-trial-100604951","NCT07156188","The PAPYRUS Study: Permanent vs. Absorbable Sutures in PrimarY Repair of Umbilical HerniaS: A Multicentre, Single-blind, Non-inferiority, Randomized Controlled Trial","PAPYRUS","Inclusion Criteria:\n\n1. Elective surgery for primary umbilical hernia with a defect ≤ 2 cm measured clinically or radiographically\n2. Age 19 years or older\n3. Patient able to give oral and written informed consent\n\nExclusion Criteria:\n\n1. Umbilical hernia defect \\> 2 cm measured clinically, radiologically, or intraoperatively with ruler\n2. Multiple defects\n3. Incisional hernia: prior hernia in area of operation\n4. Recurrent umbilical hernia\n5. Epigastric hernia\n6. Secondary operation performed simultaneously\n7. Pregnancy\n8. Infected wounds\n9. Acute operation (incarcerated or strangulated hernia)\n10. BMI ≥ 35 kg\u002Fm\\^2\n11. Ascites or liver cirrhosis\n12. Peritoneal dialysis\n13. Immunosuppression\n14. Connective tissue disorder\n15. Patient deemed unfit for primary repair at time of surgery based on surgeon discretion at time of operation (e.g. poor tissue quality or unexpected operative finding)\n16. Defect is made in the umbilical skin or skin incision extended beyond paraumbilical incision (e.g. sigma or midline extended incision)",{"count":95,"type":20},914,[23],"Umbilical hernias can be found in over a quarter of the population and comprise of 15% of hernia repairs performed in Canada. While mesh repair is commonly used for larger hernias, smaller hernia defects are often closed with sutures alone. While non-absorbable sutures may have greater tensile strength, the use of absorbable sutures has been found to reduce the risk for wound infection and improve healing. The objective of this multi-centre, nationwide randomized controlled study is to determine whether there is a difference in hernia recurrence when the repair is completed with absorbable polydioxanone suture versus permanent polypropylene suture. The study will also explore post-operative complications and quality of life. Recruitment will take place over 5 years with follow-up at the 30-day, 12-month and 24-month mark following surgery. The results of this trial will be directly applicable to national and international hernia guidelines and will impact the care of thousands of patients.",[27,99],"Umbilical Hernia Repair",[101,102,103],"Umbilical hernia","Hernia repair surgery","Suture use","2025-09-27",{"date":106,"type":38},"2025-09-30",{"date":108,"type":20},"2026-01-01",{"date":110,"type":20},"2030-12-31",{"name":112,"class":45},"University of British Columbia",5]