[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hernia-umbilical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hernia-umbilical":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100617269","preoptimisation-in-ventral-hernia-surgery-100617269",false,"NCT07316426","Preoptimisation in Ventral Hernia Surgery","Preoptimisation in Ventral Hernia Surgery- a Randomised Trial","PreOpt","Inclusion Criteria:\n\n* Patients with a ventral hernia with a defect width of at least 4 cm.\n* Symptom burden related to the hernia sufficient to justify surgical intervention.\n* Age ≥ 18 years.\n\nExclusion Criteria:\n\n* Expected survival of less than three years.\n* Inability to comprehend oral and written information or to provide informed consent.\n* Acute complication of the hernia requiring emergency surgical intervention.\n* General condition characterised by severe limitations in physical functional capacity.","ALL","18 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.",[27,28,29,30],"Hernia","Hernia, Ventral","Hernia Incisional","Hernia, Umbilical",[32,33],"preoptimisation","prehabilitation","RECRUITING","2025-12-18",{"date":37,"type":38},"2026-01-05","ACTUAL",{"date":40,"type":38},"2025-09-22",{"date":42,"type":21},"2029-09-01",{"name":44,"class":45},"Umeå University","OTHER",5,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100597746","phase-2-clonidine-in-ultrasound-guided-rectus-sheath-block-for-outpatient-umbilical-hernioplasty-100597746","NCT07062497","Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty","Ultrasound-guided Rectus Abdominis Muscle Sheath Block in Outpatient Umbilical Hernioplasties: a Comparative Analysis of the Use of Clonidine as an Adjuvant - Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years;\n* Both male and female participants;\n* ASA physical status I or II (American Society of Anesthesiologists classification);\n* Scheduled for elective ambulatory umbilical hernia repair;\n* Hernial defect size ≤ 4 cm (small to medium).\n\nExclusion Criteria:\n\n* Refusal or inability to provide written informed consent;\n* Cognitive or psychiatric disorders that impair comprehension or adherence to the study protocol;\n* Known allergy or hypersensitivity to local anesthetics, clonidine, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other analgesics;\n* Participation in another clinical trial within the previous 30 days;\n* Missing data or loss to follow-up during postoperative assessments;\n* Contraindications to regional anesthesia or known coagulopathy.","65 Years",{"count":56,"type":21},62,[58,59],"PHASE2","PHASE3","This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery. The procedure, called rectus sheath block (RSB), involves injecting local anesthetic near the abdominal muscles to reduce pain during and after surgery. The study will compare two groups of adult patients: one receiving the nerve block with a medication called clonidine added to the anesthetic solution, and the other receiving the same block without clonidine. Clonidine may help improve pain control and reduce the need for additional pain medications. By analyzing pain scores, recovery quality, and potential side effects, the study seeks to determine whether the use of clonidine in this context is safe, cost-effective, and beneficial for patient recovery. Participants will answer questionnaires about their pain and recovery during the first 48 hours after surgery.",[30,62,63,64,65],"Clonidine","Pain, Postoperative","Ambulatory Surgical Procedures","Regional Anesthesia Block",[67,68,69,62,70,71,72,73,74,75,76],"Rectus Sheath Block","Ultrasound-Guided Regional Anesthesia","Umbilical Hernia Repair","Local Anesthetics","Postoperative Pain Management","Ambulatory Surgery","Quality of Recovery","Alpha-2 Adrenergic Agonists","Pain Measurement","Analgesic Adjuvants","2025-07-10",{"date":79,"type":38},"2025-07-14",{"date":81,"type":38},"2025-01-07",{"date":83,"type":21},"2026-04-30",{"name":85,"class":45},"Universidade Federal do Rio de Janeiro",1]