[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"herniated-disc\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:herniated-disc":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,74,95,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100633807","the-selective-intraperineural-nerve-root-block-study-100633807",false,"NCT07531485","The Selective Intraperineural Nerve Root Block Study","Feasibility, Safety and Diagnostic Accuracy of Selective Intraperineural Nerve Root Block for Identifying Compressed Nerve Root in Lumbosacral Radicular Pain. A Prospective Cohort Study","SINRBS","Inclusion Criteria\n\n* Unilateral sciatica \\>1 month with activity\u002Fdaily life impairment.\n* Suspected L5\u002FS1 root compression at L4-5\u002FL5-S1 with unconfirmed pain correlation, including disc herniation (MSU 1-B\u002F1-A\u002F2-A), lateral recess\u002Fforaminal stenosis (Lee grade 2\u002F3), atypical sciatica, or imaging-exam inconsistency.\n* Candidates for single-segment, single-root lumbar decompression, electing surgery after informed consent.\n\nExclusion Criteria\n\n* No significant pre-SINRB\u002Fsurgery pain, or weakness\u002Fnumbness as primary symptom.\n* Unidentifiable responsible compressed nerve root (RCNR) per surgery.\n* Suspected compression of the same nerve root at more than one segment.\n* Pregnancy, active malignancy, or surgical contraindications.\n* Inability to cooperate with assessment due to comorbidities or dysfunction.","ALL","18 Years","90 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Before lumbosacral decompression surgery for radicular pain, selective nerve root block(SNRB) is a common procedure to identify the responsible compressed nerve root(RCNR) and predict surgical outcomes. However, the diagnostic accuracy of conventional SNRB is unsatisfactory, especially in terms of specificity. The main limitation is the uncontrolled distribution of anesthetics during injection: when anesthetics spread to surrounding soft tissues instead of acting directly on the RCNR, false-negative results may occur with persistent radicular pain; when anesthetics diffuse to two or more nerve roots including the RCNR, false-positive results may occur even if a normal nerve root is punctured, leading to misdiagnosis.\n\nThis study aims to evaluate the diagnostic accuracy of a novel three-dimensional computed tomography multiplanar volume reconstruction (3D-CT MPVR) guided selective intraperineural nerve root block(SINRB) for identifying the RCNR in patients with lumbosacral radicular pain. The investigators hypothesize that this technique will achieve higher diagnostic specificity and overall accuracy than conventional SNRB, by ensuring anesthetics are delivered directly to the target nerve root. This improvement will help clinicians make more accurate surgical plans, achieve better targeted decompression, and ultimately improve postoperative pain relief and functional recovery for patients.\n\nThe main research questions to be addressed in this study are:\n\n* What is the procedural success rate of SINRB?\n* Whether SINRB may cause clinically detectable nerve injury?\n* Whether sciatica is relieved after SINRB when only the responsible compressed nerve root is blocked?\n* Whether sciatica is relieved after SINRB when only a normal unaffected nerve root is blocked?\n\nParticipants will:\n\n* Undergo one or two SINRB procedures and a single-level lumbar decompression surgery\n* Get assessment of pain, mobility disorder and neurological function",[28,29,30,31,32],"Radiculopathy Lumbar","Radiculopathy Sacral","Radiculopathy Multiple Sites","Herniated Disc","Foraminal Stenosis",[34,35,36,37],"intraperineural","3D-CT MPVR","diagnostic selective nerve root block","lumbosacral radiculopathy","NOT_YET_RECRUITING","2026-04-11",{"date":41,"type":42},"2026-04-15","ACTUAL",{"date":44,"type":22},"2026-04-13",{"date":46,"type":22},"2027-01-01",{"name":48,"class":49},"Xi'an Honghui Hospital","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":50},"100570259","conduit-cages-and-fibergraft-bg-putty-100570259","NCT06704919","Conduit Cages and Fibergraft BG Putty","Assess Clinical and Radiographic Outcomes of Conduit Cages and Fibergraft in Cervical and Lumbar Procedures","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Have a radiograph-based diagnosis of degenerative disc disease, ruptured or herniated discs,\n3. Pathology of the cervical or lumbar spine.\n4. Pathology to be between C2-T1 in the cervical group.\n5. Pathology to be between L2-S1 in the lumbar group.\n6. Patients with 1-2 contiguous levels in both ACDF and Lumbar groups.\n7. Patients receiving the surgery\u002Fdevices as standard of care prescribed by the treating physician.\n\nExclusion Criteria:\n\n1. Patients \\\u003C 18 years\n2. BMI \\> 40 kg\u002Fm2 to be excluded\n3. Patients with a bone density (DEXA) score of \\\u003C2.0 to be excluded\n4. 3 or more levels for ACDF or Lumbar interbody to be excluded\n5. Patients with previous pseudoarthrosis or failed spondylodesis to be excluded\n6. Current smokers and patients who quit smoking within 6 weeks prior to presentation will be excluded",{"count":59,"type":22},100,"OBSERVATIONAL","The Conduit cages are intended to restore the intervertebral height and to facilitate the intervertebral body fusion in the cervical and lumbar spine in skeletally mature patients with degenerative disc disease and instabilities at one or more levels of the spine. The Fibergraft Bioactive Glass (BG) is engineered to mimic the body's natural bone healing process. While previous studies have described the use of conduit cages in interbody fixation procedures, these studies did not specifically study the clinical and radiographic outcomes of patients who have received these implants in addition to Fibergraft. We aim to recruit patients with degenerative disc disease, and instabilities at one to multilevel contiguous levels between C2-T1 and 1-2 contiguous levels between L2-S1 of the spine with accompanying radicular symptoms, ruptured or herniated discs, and pseudarthrosis and spondylodesis. We will then follow these patients for a duration of two years to report their clinical and radiographic outcomes to determine fusion, complication rate, and revision surgeries if any.",[63,31],"Degenerative Disc Disease","RECRUITING","2026-01-20",{"date":67,"type":42},"2026-01-22",{"date":69,"type":42},"2024-11-04",{"date":71,"type":22},"2029-03-30",{"name":73,"class":49},"Nitin Agarwal",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":50},"100595745","comparison-of-interlaminar-ct-guided-epidural-platelet-rich-plasma-versus-steroid-injection-in-patients-with-lumbar-radicular-pain-100595745","NCT07036445","Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain","Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain : a Prospective Study With Long Term Follow up","Inclusion Criteria:\n\n* Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).\n\nExclusion Criteria:\n\n* Patients with infections,\n* Patients who have had previous percutaneous corticosteroid injections,\n* Patients undergoing systemic corticosteroid treatment,\n* Patients with immune deficiencies,\n* Patients who are allergic to the contrast medium used,\n* Pregnant or breastfeeding patients,\n* Patients with a history of allergies to anesthetics or corticosteroids,\n* Anticoagulant treatment or blood disorders, patients on antiplatelet therapy\n* Taking NSAIDs within two weeks prior to the procedure",{"count":82,"type":22},200,[25],"The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications.\n\nThis study aims to compare these two treatments over the long term (2 years).",[31],"2025-09-12",{"date":88,"type":42},"2025-09-18",{"date":90,"type":42},"2025-09-11",{"date":92,"type":22},"2028-12-31",{"name":94,"class":49},"Clinique du Sport, Bordeaux Mérignac",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":50},"100527134","precision-treatment-of-lumbar-spine-surgery-through-advanced-nerve-root-blockade-100527134","NCT06143813","Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade","PLAN","Inclusion Criteria:\n\n* Age \\>18 years old\n* Suspected lumbar radiculopathy persistent ≥ 8 weeks\n* Radiological evidence of lumbar nerve root compression (herniated disc, recess stenosis, foraminal stenosis)\n\nExclusion Criteria:\n\n* Prior lumbar spine surgery\n* Mental illness\n* Language barrier in Danish\n* Severe physical co-morbidity\n* Known allergies to medicine used in the study\n* Pregnant\n* Plans to move abroad during the next 12-months",{"count":103,"type":22},180,[25],"The overall purpose of the study is to investigate whether selective spinal nerve root blocks can improve diagnostics of radiculopathy due to lumbar disc herniation (LDH), foraminal stenosis (FS), and recess stenosis (RS), and hence identify the patients that will benefit from surgical intervention.",[28,29,31,32,107],"Stenosis, Spinal","2024-04-29",{"date":110,"type":42},"2024-05-02",{"date":112,"type":42},"2023-11-09",{"date":114,"type":22},"2027-11-01",{"name":116,"class":49},"University of Aarhus",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":140,"locationsCount":5},"100410947","lisa-post-market-clinical-follow-up-study-documentation-of-clinical-outcomes-after-surgery-with-lisa-implant-100410947","NCT04631133","LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant","LISA Post Market Clinical Follow-Up Study:Post Marketing Prospective Documentation of Clinical Outcomes (Post-operative, Safety and Performance) After Lumbar Dynamic Stabilization Surgery With LISA Implant","LISA-PMCF","Inclusion Criteria:\n\n* Skeletally mature patients Patient ≥18 years of age\n* Patients with low-back pain caused by degenerative lesions of grade II, III and IV (Pfirrmann MRI classification)\n* Failed conservative treatment for low back pain conducted for at least 6 months\n\nExclusion Criteria:\n\n* Stage V degenerative disk lesions in Pfirrmann's MRI classification\n* Spondylolisthesis\n* Osteoporosis\n* Non-specific back pain\n* Modic 2 and Modic 3 changes\n* L5\u002FS1 segments affected\n* Local or general infections that may compromise the surgical goals\n* Major local inflammatory phenomena\n* Pregnant and lactating Women\n* Immunosuppressive diseases\n* Bone immaturity\n* Severe mental illnesses\n* Bone metabolism diseases that may compromise the mechanical support expected from this type of implant\n* Patient with worker's compensation, under litigation or on disability benefits\n* Excessive physical activities\n* Patients deprived of their liberty in accordance with respective national regulations\n* Protected patients or patients not in a position to declare his or her consent in accordance with respective national regulations",{"count":126,"type":22},136,"The study is a post-market surveillance study of the Lumbar Implant for Stiffness Augmentation (LISA), a medical device, which is used to treat low-back pain that accompanies degenerative lesions of grades II, III, and IV (Pfirrmann MRI classification). \"Post-market\" means the device (i.e. the LISA implant) being used in this study has already obtained CE certification and is commercially available for use in the European market.\n\nThe LISA device consists of 3 components: A PEEK interspinous spacer, a polyester band, and a titanium blocker. The spacer is positioned between two adjacent spinous processes, the band is belted around the spinous processes and through the spacer, and the blocker is used to lock the band inside the spacer.\n\nMedical Device manufacturers conduct \"post-market\" clinical studies in order to continuously evaluate the product scientifically and to comply with legal and ethical obligations. With these studies, the long-term safety as well as performance of their medical devices are assessed.\n\nThis study, which is initiated and sponsored by BACKBONE (LISA designer, developer, manufacturer and marketer), aims to evaluate the long-term safety and performance of the LISA implant for the treatment of lumbar degenerative disease and to evaluate the treatment.",[129,31,63,130],"Chronic Low-back Pain","Lumbar Canal Stenosis",[129,31,63,130,132,133],"Dynamic Stabilization Implants","Post-Market Clinical Follow-Up Study","2022-07-19",{"date":136,"type":42},"2022-07-21",{"date":138,"type":42},"2019-04-17",{"date":92,"type":22},{"name":141,"class":142},"BACKBONE","INDUSTRY"]