[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hie\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hie":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100531096","individual-cerebral-hemodynamic-oxygenation-relationships-ichor-1-100531096",false,"NCT06195345","Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)","ICHOR 1","Inclusion Criteria:\n\n* Individuals who are able to tolerate an MRI.\n* Are patients scheduled for a clinically indicated MRI.\n* Between birth and up to 18 years.\n\nExclusion Criteria:\n\n* Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.\n* Preterm infants less than 25 weeks\n* Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.",true,"ALL","1 Minute","18 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.",[26,27,28,29,30],"HIE","TBI (Traumatic Brain Injury)","TBI","Hemodynamic Instability","Hypoxic-Ischemic Encephalopathy","RECRUITING","2026-04-24",{"date":34,"type":35},"2026-04-29","ACTUAL",{"date":37,"type":35},"2018-11-01",{"date":39,"type":22},"2035-11-01",{"name":41,"class":42},"Children's Hospital Los Angeles","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100624613","phase-1-hydrogen-in-neonatal-encephalopathy-hie-trial-100624613","NCT07411911","Hydrogen In Neonatal Encephalopathy (HIE) Trial","Inclusion Criteria:\n\n1. Infants born ≥36 weeks gestation.\n2. Any one of the following:\n\n   1. sentinel event prior to delivery, such as uterine rupture, profound fetal bradycardia, or cord prolapse\n   2. low Apgar scores (≤ 5 at 10 minutes of life)\n   3. prolonged resuscitation at birth (chest compressions and\u002For intubation and\u002For mask ventilation at 10 minutes)\n   4. severe acidosis (pH \\\u003C 7.0 from cord or neonate blood gas within 60 minutes of birth)\n   5. abnormal base excess (≤ -16 mEq\u002FL from cord gas or neonate blood gas within 60 minutes of birth)\n3. Moderate or severe encephalopathy present in the first 2 hours of life.\n4. Intubated and mechanically ventilated at the time of enrollment.\n\nExclusion Criteria:\n\n1. Enrollment in the opt-out program.\n2. Presence of known cyanotic congenital heart disease.\n3. Presence of known or suspected genetic\u002Fchromosomal syndrome or multiple congenital anomalies.\n4. Presence of known congenital malformation that is expected to require urgent surgical intervention in the neonatal period, including congenital diaphragmatic hernia (CDH), gastroschisis, omphalocele, intestinal atresia, or imperforate anus.\n5. Presence of antenatally diagnosed central nervous system malformation, including hemorrhage, hydrocephalus, or structural anomaly of the brain (eg. polymicrogyria).\n6. Need for high frequency ventilation (HFV) at time of enrollment.\n7. Patients receiving respiratory support via Drager Babylog ventilators.\n8. Study enrollment and randomization after 2 hours of age","2 Hours",{"count":52,"type":22},54,"INTERVENTIONAL",[55],"PHASE1","Despite advances in neonatal care, moderate-to-severe acute perinatal HIE in late preterm and term infants remains a cause of mortality, neurological injury, and long-term neurodevelopmental disability. The current standard of care includes therapeutic hypothermia for 72 hours, but 40-50% of infants will die or suffer significant neurodevelopmental impairment. It has been shown that administration of hydrogen gas (H2) significantly diminishes ischemic injury in swine, and that H2 administration at the dose and duration proposed herein is well-tolerated in healthy adults. The purpose of this project is to test the feasibility and safety of H2 administration as an adjunct to therapeutic hypothermia in infants with HIE. Under exemption from informed consent, infants with severe, acute brain injury at birth will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the ventilator, non-invasive ventilation, or nasal cannula for 72 hours.",[26,30],[30,26,59,60,61],"Hydrogen Gas","Neonates","Brain Injury","NOT_YET_RECRUITING","2026-02-09",{"date":65,"type":35},"2026-02-17",{"date":67,"type":22},"2026-03",{"date":69,"type":22},"2031-03",{"name":71,"class":42},"Boston Children's Hospital"]