[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-altitude\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-altitude":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100527821","evaluation-of-membrane-lung-function-in-high-altitude-regions-100527821",false,"NCT06152744","Evaluation of Membrane Lung Function in High-altitude Regions","Evaluation of Membrane Lung Function for Patients Receiving Venovenous Extracorporeal Membrane Oxygenation in High-altitude Regions","Inclusion Criteria:\n\n* Receiving ECMO support\n\nExclusion Criteria:\n\n* Unable to obtain post-membrane blood gas\n* Pregnancy\n* Patients cannot receive anticoagulation\n* Refusal to participate in the trial","ALL","18 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","Over the last 20 years, extracorporeal membrane oxygenation (ECMO) has been used to support adult patients with respiratory or cardiac failure who are unlikely to survive conventional treatment methods. ECMO circuit, pump, and oxygenator technology improvements permit safer perfusion for extended periods. The prolonged use of an ECMO circuit increases the risk of membrane lung (ML) dysfunction. The ML is responsible for taking in oxygen and removing carbon dioxide. The non-biologic surface of the ML triggers inflammatory and coagulation pathways, resulting in the formation of blood clots, breakdown of fibrin, and activation of white blood cells, which ultimately leads to ML dysfunction. Coagulation and fibrinolysis activation can cause systemic coagulopathy or hemolysis, and the deposition of blood clots can block blood flow. Moreover, the accumulation of moisture in the gas phase and the buildup of protein and cellular debris in the blood phase may contribute to shunt and dead-space physiology, respectively, impairing the exchange of gases. These three categories-hematologic abnormalities, mechanical obstruction, and inadequate gas exchange-account for most ML exchanges. Worsening oxygenation during ECMO should prompt quantification of oxygen transfer. ML exchange is indicated when the ML can no longer meet the patient's oxygen demand. The partial pressure of Post-ML arterial oxygen less than 200 mmHg is the most important consideration in this decision. In some high-altitude regions of China, ECMO treatment is also routinely conducted. The experiences above are derived from low-altitude areas, and whether they apply in high-altitude regions is still being determined. This study aimed to explore the significantly lower membrane lung oxygen uptake in high-altitude regions compared to low-altitude areas.",[25,26,27],"Extracorporeal Membrane Oxygenation","Membrane Lung Function","High Altitude","RECRUITING","2025-06-13",{"date":31,"type":32},"2025-06-17","ACTUAL",{"date":34,"type":32},"2023-12-05",{"date":36,"type":21},"2025-12-31",{"name":38,"class":39},"Beijing Chao Yang Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100594342","the-study-of-personalized-health-check-up-programs-and-standards-for-high-altitude-migrant-populations-100594342","NCT07018193","The Study of Personalized Health Check-up Programs and Standards for High-altitude Migrant Populations","Inclusion Criteria:\n\n* Men and women aged ≥18;\n* Those living in plains and preparing to move to the plateau for a short-term or medium-term period;\n* Can understand the research requirements and be willing to sign a written informed consent form (ICF).\n\nExclusion Criteria:\n\n* Past history of contraindicated plateau travel: such as advanced COPD (FEV₁\\\u003C30% of the expected value or requires continuous oxygen therapy), advanced cystic fibrosis (FEV₁\\\u003C30% of the expected value or requires continuous oxygen therapy), advanced restricted pulmonary disease (FEV₁\\\u003C50% of the expected value or requires continuous oxygen therapy), decompensated heart failure, high-risk pregnancy, myocardial infarction or stroke occurred within 90 days, poorly controlled epilepsy, pulmonary hypertension (PASP\\>90mmHg), sickle cell anemia, unstable angina pectoris, high-risk cerebrovascular abnormalities that have not been treated, etc.",true,{"count":49,"type":21},300,"By using wearable devices to monitor and record the physiological data changes and health outcomes (incidence and severity of high-altitude illnesses) of high-altitude migrants at different stages (pre-entry, acute\u002Fchronic high-altitude phases, and de-acclimatization phase), and referencing previous cohort studies on high-altitude populations, the study aims to provide a basis for developing personalized health assessment protocols for high-altitude migrants. The formulated assessment protocols and standards will then be validated.",[27],"NOT_YET_RECRUITING","2025-06-04",{"date":55,"type":32},"2025-06-12",{"date":57,"type":21},"2025-06-30",{"date":59,"type":21},"2028-12-31",{"name":61,"class":39},"Capital Medical University",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":4},"100565167","postoperative-complications-of-orthopedic-surgery-in-patients-from-high-altitude-regions-100565167","NCT06638658","Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions","Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions: a Cohort Study.","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. ASA classification I-III;\n3. Patients who have lived at an altitude above 2500 meters for more than 6 months ;\n4. Patients scheduled for elective orthopedic surgery.\n\nExclusion Criteria:\n\n1. Urgent or emergent surgery;\n2. Expected hospital stay \\\u003C 48 hours;\n3. Inability to provide informed consent；\n4. Patients who have been out of high-altitude regions for over three months.",{"count":70,"type":21},400,"This study will focus on orthopedic surgery patients from high-altitude regions, utilizing smart wearables and monitoring tools to gather perioperative data, including heart rate, oxygen saturation, sleep quality, stress levels, and other relevant metrics. Regular follow-ups will assess recovery and complications, in addition to collecting medical records, lab results, imaging data, and other pertinent records. The ultimate goal is to establish a comprehensive follow-up cohort of orthopedic surgery patients from high-altitude areas.",[73,74,27],"Orthopedic Surgery","Postoperative Complications",[76,77,78],"High-altitude population","Perioperative cohort","Orthopedic surgery","2024-10-10",{"date":81,"type":32},"2024-10-15",{"date":83,"type":21},"2024-11-15",{"date":85,"type":21},"2029-10-31",{"name":87,"class":39},"West China Hospital"]