[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-flow-nasal-cannula\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-flow-nasal-cannula":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,70,94,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100632836","heart-rate-variability-as-a-marker-for-titrating-high-flow-nasal-cannula-therapy-100632836",false,"NCT07518862","Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy","Heart Rate Variability as a Marker for Titrating High Flow Nasal Cannula Therapy in Patients With Respiratory Failure","VARIATION","Inclusion Criteria:\n\n* Age \\> 18\n* Currently receiving High-Flow Nasal Cannula Therapy\n\nExclusion Criteria:\n\n* FiO2 ≥ 90%\n* Pacemaker rhythm or presence of atrial fibrillation\n* Post-cardiac surgery patients\n* Contra-indications to electrical impedance tomography (EIT) and\u002For electrocardiogram (ECG) (active implantable medical device, burns, thoracic wounds limiting electrode placement)\n* Non-English-speaking","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","High-flow nasal cannula is a type of non-invasive respiratory support that helps patients breathe more comfortably. Because the flow is high, it can deliver more oxygen to the lungs and make breathing easier by reducing the effort needed to breathe. However, the best strategy to determine the best oxygen flow rate remains uncertain. Reducing flow rates prematurely can increase work of breathing and prolong ICU stay, while unnecessary prolongation can increase costs. Currently, evidence to guide titration is limited.\n\nHeart rate variability is the natural variation in the time between each heartbeat. Heart rate variability reflects the level of autonomic nervous system activity in response to stress. The autonomic nervous system is the part of the nervous system that automatically controls how heart rate speeds up and slows down. When heart rate variability is higher, it indicates that the system is able to adjust to changes in the body, including stress. However, when heart rate variability is low, it indicates that the system is constrained and in a state of stress.\n\nThe VARIATION study is designed to characterize how heart rate variability goal of this observational study is to learn whether heart rate variability can serve as a marker of the appropriateness of high flow nasal cannula flow support during flow titration in patients with respiratory failure. The main question it aims to answer is:\n\nDoes heart rate variability change before other conventional respiratory signs when there are changes in respiratory function due to inadequate flow rate?\n\nParticipants already on high flow nasal cannula as part of their regular medical care will:\n\n1. Undergo a stepwise decrease in high flow nasal cannula flow rate.\n2. Be recorded continuously with electrocardiogram and electrical impedance tomography.",[25,26,27],"Respiratory Failure","Heart Rate Variability (HRV)","High Flow Nasal Cannula",[29,30],"Electrocardiogram (ECG)","Electrical Impedance Tomography (EIT)","RECRUITING","2026-06-16",{"date":34,"type":35},"2026-06-18","ACTUAL",{"date":37,"type":35},"2026-05-26",{"date":39,"type":21},"2026-12",{"name":41,"class":42},"University Health Network, Toronto","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100605169","high-flow-nasal-cannula-and-mask-oxygenation-in-patients-with-visceral-obesity-undergoing-sedated-gastroscopy-100605169","NCT07159022","High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy","High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* ASA class ≤Ⅲ\n* Visceral obesity（body mass index≥28 and BRI ≥5.46）\n* Patients who will undergo sedated gastroscopy\n\nExclusion Criteria:\n\n* Life-threatening heart disease or acute myocardial infarction within 6 weeks\n* Presence of pneumothorax or pulmonary bullae, pulmonary embolism, pulmonary oedema\n* Upper respiratory tract infection\n* Presence of tracheostomy\n* Nasal or nasopharyngeal diseases\n* Coagulation disorders or a tendency of nose bleeding\n* Pregnancy\n* Recent (within 1 week) thoracic surgery\n* Emergent procedure or surgery\n* Allergy to drugs used during the procedure\n* Unwillingness to participate in the study",true,"80 Years",{"count":54,"type":21},200,"INTERVENTIONAL",[57],"NA","During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance. Patients with obesity, especially visceral fat, have poor lung and chest wall compliance, lower lung capacity and functional residual capacity, and an unbalanced ventilation-to-perfusion ratio. Thus, obese patients are at a high risk of hypoxemia.\n\nIncreasing evidence supports the use of High-flow nasal cannula (HFNC) oxygenation in obese patients during sedated gastrointestinal endoscopy. Obesity, especially visceral obesity, is an established risk factor associated with all-cause mortality. Body roundness index (BRI) is a newer anthropometric measure associated with identification of high-risk individuals. Owing to the limited evidence, we designed this unblinded randomized controlled trial to assess whether HFNC, compared to standard mask oxygenation, improves oxygenation at the end of the procedure (primary endpoint) in patients with visceral obesity.",[27,60],"Body Roundness Index","2025-11-27",{"date":63,"type":35},"2025-12-01",{"date":65,"type":35},"2025-08-31",{"date":67,"type":21},"2026-07-31",{"name":69,"class":42},"Shanghai Zhongshan Hospital",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":51,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":55,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100548777","application-of-hfnc-for-the-prevention-of-hypoxemia-during-perioperative-anesthetic-induced-intubation-in-children-a-randomized-controlled-clinical-trial-100548777","NCT06425406","Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Age 2-10 years old;\n* American Society of Anesthesiologists (ASA) Level I or II;\n* Children with healthy lungs and hearts;\n* Clear headed and able to cooperate with anesthesiologists for treatment.\n\nExclusion Criteria:\n\n* Contraindications for HFNC: (1) Complete obstruction of the upper respiratory tract; (2) Skull base fracture or nasal bone fracture; (3) Patients who refuse to use HFNC;\n* The American Society of Anesthesiologists (ASA) rating is greater than Level II;\n* Children with upper respiratory tract infections within 2 weeks;\n* Pulmonary dysfunction, congenital heart disease in children;","2 Years","10 Years",{"count":79,"type":21},48,[57],"Compared with adults, children have higher metabolic needs, and the airway is more likely to collapse. Before tracheal intubation after anesthesia induction, the patient 's spontaneous breathing completely disappears. At this critical stage, the residual oxygen of the lung is consumed, resulting in hypoxemia and atelectasis. Therefore, it is necessary to explore the best oxygenation strategy during intubation. In addition, ultrasound has become a common equipment in the operating room. It has the advantages of portability, repeatability, and no radiation, and can provide strong support for the diagnosis of gastric distension.",[83,84,85],"High-flow Nasal Cannula","Children","Pre-oxygenation","2025-11-24",{"date":63,"type":35},{"date":89,"type":35},"2024-06-15",{"date":91,"type":21},"2025-11-30",{"name":93,"class":42},"Henan Provincial People's Hospital",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":101,"minAge":18,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":55,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":43},"100479711","a-rct-on-the-preventive-effect-of-hfnc-on-postoperative-pulmonary-complications-in-patients-with-gynecologic-neoplasms-100479711","NCT05526534","A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms","A Randomized Controlled Trial on the Preventive Effect of Heated Humidified High Flow Nasal Cannula Oxygen Therapy on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms","Inclusion Criteria:\n\n* Patients with gynecologic Neoplasms, including benign gynecologic tumors and malignant gynecologic tumors, who are 18 to 90 years old and are scheduled for surgical treatment in our center shall receive plain chest CT scan within 1 week before surgery, and the estimated surgical time shall be ≥2 hours, and at least one of the following conditions shall be met:\n\n  1. Assess respiratory risk in surgical patients in Catalonia (ARRSPC) ≥45 points;\n  2. BMI≥30;\n  3. Moderate to severe asthma;\n  4. Moderate to severe chronic obstructive pulmonary disease (COPD);\n  5. Smoking history ≥20 packs\u002Fyear\n\nExclusion Criteria:\n\n1. Patients with lung metastasis of malignant tumor or primary lung malignant tumor;\n2. previous lung surgery or radiotherapy;\n3. the surgery involved segmental bowel resection.","FEMALE","90 Years",{"count":54,"type":21},[57],"Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses conventional nasal cannula oxygen therapy. The primary outcome is the incidence of PPC, including postoperative hypoxemia, atelectasis, pneumonia, etc. Secondary outcomes are the improvement of postoperative oxygenation, antibiotic use, length of hospital stay, adverse events related to oxygen therapy, etc.",[107,83,108],"Gynecologic Surgery","Post-operative Pulmonary Complications","2025-05-20",{"date":111,"type":35},"2025-05-23",{"date":113,"type":35},"2022-11-01",{"date":115,"type":21},"2025-12-31",{"name":117,"class":42},"Sichuan Cancer Hospital and Research Institute",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":55,"phases":127,"briefSummary":128,"conditions":129,"keywords":135,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":43},"100583690","high-flow-nasal-oxygen-for-preoxygenation-in-emergency-surgery-patients-with-full-stomachs-100583690","NCT06879600","High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs","Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs","HFNC","Inclusion Criteria:\n\n* Emergency surgical patients at risk of gastric fullness requiring endotracheal intubation.\n* Patients aged 18 years or older.\n* Health status classified as ASA I or II.\n* Mallampati classification I or II.\n\nExclusion Criteria:\n\n* Patients with a predicted difficult airway, facial deformities, or an inability to achieve a proper mask seal.\n* Patients with respiratory diseases.\n* Pregnant patients.\n* Patients allergic to anesthesia or resuscitation drugs.\n* Patients who do not consent to participate in the study.",{"count":54,"type":21},[57],"Patients with full stomachs face a high risk of regurgitation and aspiration under general anesthesia. To minimize the time between the loss of airway protective reflexes and successful tracheal intubation, rapid sequence induction intubation is commonly used. However, these patients are particularly vulnerable to hypoxemia during anesthesia induction, especially in emergency cases. Pre-oxygenation before induction is crucial for ensuring patient safety during apnea.\n\nHigh-flow nasal oxygen (HFNO) therapy, which consists of an air\u002Foxygen blender, an active humidifier, and a single heated circuit, has recently gained widespread use in intensive care units (ICUs) for managing hypoxemic respiratory failure. HFNC can deliver a constant fraction of inspired oxygen (FiO₂) from 0.21 to 1.0 at high flow rates (up to 60 L\u002Fmin or higher). Its advantages include generating continuous positive airway pressure, reducing anatomical dead space, improving ventilation-perfusion matching, enhancing mucociliary clearance, and decreasing the work of breathing.\n\nGiven these benefits, HFNO has the potential to improve pre-oxygenation before and during anesthesia induction in emergency surgery patients with full stomachs.",[83,130,131,132,133,134],"Oxygenation","General Anesthesia","Induction Anesthesia","Emergency Surgery Patients","Full Stomach",[136,137,138,133,139],"High-flow nasal cannula","oxygenation","Induction anesthesia","full stomach","2025-03-10",{"date":142,"type":35},"2025-03-17",{"date":144,"type":35},"2023-07-19",{"date":146,"type":21},"2026-12-31",{"name":148,"class":42},"Nguyen Dang Thu"]