[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-frequency-oscillatory-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-frequency-oscillatory-ventilation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100342291","high-frequency-oscillation-ventilation-versus-conventional-mechanical-ventilation-in-very-preterm-infants-with-perinatal-acute-respiratory-distress-syndrome-multicenters-randomized-controlled-superiority-trial-100342291",false,"NCT03736707","High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation in Very Preterm Infants With Perinatal Acute Respiratory Distress Syndrome: Multicenters Randomized Controlled, Superiority Trial","HFOV for ARDS","Inclusion criteria\n\n1. GA was between 24+0 and 31+6 weeks.\n2. Preterm neonates were admitted to NICU within 1 hours after birth, diagnosed with perinatal ARDS using Montreux guidelines and stable supported by CMV.\n3. Stabilization for 2 hours before randomization: FiO2 0.40, mean airway pressure (MAP) 10-14 cmH2O, ≤ 40 bpm of respiratory rate, 90%-94% of SpO2, pH \\> 7.20, PaCO2 60 mmHg, tidal volume of 5 ml\u002Fkg and \\> 35% of hematocrit (these may be evaluated by arterial blood gas analysis).\n\nExclusion criteria\n\nNeonates were not included if any of the following criteria were met:\n\n1. Parents or guardians' decision not to participate.\n2. Major congenital anomalies or chromosomal abnormalities\n3. Need for surgery or more than grade 2nd of IVH before randomization.","ALL","1 Minute","1 Hour",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","Bronchopulmonary dysplasia (BPD) is a complex disorder and remains the most common complication in very preterm infants. Its incidence is increased with gestational age from 95.5% among infants born at 22 weeks' gestation to 22.2% among those born at 29 weeks' gestation. BPD is associated with the increased risks of delayed neurodevelopment and pulmonary impairment. High incidences of BPD and morbidities indicate inadequacy of current management guidelines of BPD.3 Caffeine reduces the development of BPD by lowering the duration of intubation.4 How to further reduce the risk of BPD and the duration of invasive ventilation remain the key focus for neonatologists.",[27,28,29,30],"Acute Respiratory Distress Syndrome","High Frequency Oscillatory Ventilation","Preterm","Conventional Mechanical Ventilation","RECRUITING","2025-09-30",{"date":34,"type":35},"2025-10-06","ACTUAL",{"date":37,"type":21},"2025-10-01",{"date":39,"type":21},"2028-12-31",{"name":41,"class":42},"Daping Hospital and the Research Institute of Surgery of the Third Military Medical University","OTHER"]