[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-myopia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-myopia":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,69,96,116,141,166,188,211,236,259,281,305,323,342],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100563464","artificial-intelligence-for-highly-myopic-cataract-100563464",false,"NCT06616506","Artificial Intelligence for Highly Myopic Cataract","AI-HMC","Inclusion Criteria:\n\nAxial length ≥ 26 mm and patients with high myopia complicated by cataracts who visit our hospital.\n\nPreoperative anterior segment photography and cataract severity assessment, along with fundus OCT examination, have been performed.\n\nIf surgical treatment is conducted, the postoperative follow-up period should be no less than 1 month.\n\nThere are no missing clinical data before and after the surgery.\n\nExclusion Criteria:\n\nPatients who are unable to cooperate with the required examinations for this study.","ALL",{"count":18,"type":19},500000,"ESTIMATED","OBSERVATIONAL","This study aims to establish a multi-center artificial intelligence model for the accurate calculation of intraocular lens and its clinical application in highly myopic cataract, so as to improve the accuracy of the prediction of postoperative diopter in highly myopic cataract patients.",[23,24,25,26,27,28],"Cataract","High Myopia","Myopia","Automatic Judgement","Risk Reduction","Diagnoses Disease",[30,31,32,33],"highly myopic cataract","artificial intelligence","cataract","big data","RECRUITING","2026-05-06",{"date":37,"type":38},"2026-05-11","ACTUAL",{"date":40,"type":38},"2016-01-01",{"date":42,"type":19},"2035-12-31",{"name":44,"class":45},"Shanghai High Myopia Study Group","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":20,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":46},"100290540","shanghai-high-myopia-study-100290540","NCT03062085","Shanghai High Myopia Study","Visual Outcome Evaluation and Genetic Analysis: Shanghai High Myopia Study","Inclusion Criteria:\n\n* Clinical diagnosis of cataract\n* Must be able to cooperate with the ophthalmic examination\n\nExclusion Criteria:\n\n* Clinical diagnosis of mental illness\n* Mentally disabled","20 Years","100 Years",{"count":57,"type":19},60000,"5 Years","The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract and age-related cataract patients. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of high myopic cataract.",[24,23,61,62],"Visual Outcome","Genetic Anticipation",{"date":37,"type":38},{"date":65,"type":38},"2015-01-01",{"date":67,"type":19},"2045-12-31",{"name":44,"class":45},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":46},"100589066","risk-of-posterior-staphyloma-in-highly-myopic-europeans--from-epidemiology-to-anatomy-100589066","NCT06949579","Risk of Posterior Staphyloma in Highly Myopic Europeans : From Epidemiology to Anatomy.","MYOFORTE","Inclusion Criteria:\n\n* Adults with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with and without posterior staphyloma\n\n  * Adults aged 18 years or over\n  * Patient with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with good quality retinal imaging\n  * Patient who has signed a consent form to participate in the study\n  * Patient who is a beneficiary of a social security scheme or who is entitled to it\n\nExclusion Criteria:\n\n* Any systemic or ocular pathologies with an impact on the posterior segment of the eye\n\n  * Patient with a systemic pathology likely to affect the posterior segment of the eye:\n  * Diabetes\n  * Systemic inflammatory disease: sarcoidosis, rheumatoid arthritis, systemic lupus erythematosus, Horton's disease\n  * Patients with retinitis pigmentosa\n  * Patients with syndromic myopia\n  * Patients with myopia associated with a genetic disease such as hereditary vitreoretinopathy\n  * Patients under guardianship, curatorship or legal protection, as well as pregnant or breastfeeding women (article L1121-5 of the CSP).","18 Years",{"count":78,"type":19},200,"INTERVENTIONAL",[81],"NA","In this cross-sectionnal study the aim is to increase the understanding of posterior staphyloma through a unique European consortium. Therefore, all eligible patients that either visit the outpatient clinic at Radboud in Nimegen, the Netherlands, or visit University Hopital Puerta de HierroMajadahonda in Madrid, Spain, or visit University Hospital Cochin in Paris, France, and after consenting, will be included.\n\n600 high myopic European cases are expecting. A standardized protocol in all centers in order to create a uniform dataset.\n\nBesides the standard of care, blood samples will be collected.\n\nAll data collected will be stored in an onlie Castor database",[24],[85,86],"High myopia","Myopic staphyloma","2026-03-30",{"date":89,"type":38},"2026-03-31",{"date":91,"type":38},"2026-02-02",{"date":93,"type":19},"2027-12",{"name":95,"class":45},"Assistance Publique - Hôpitaux de Paris",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":46},"100625601","ai-empowered-fundus-platform-100625601","NCT07424755","AI-Empowered Fundus Platform","AI-Empowered Fundus Imaging: Building an Intelligent Platform for Diagnosis, Treatment, and Early Warning of Fundus Diseases","Inclusion Criteria:\n\nPatients with a diagnosis of cataract and high myopia and posterior staphyloma, who underwent comprehensive ophthalmic examinations including ultra-widefield fundus photography (Optos), B-scan ultrasonography, and optical coherence tomography (OCT). Baseline data, including demographics, health status, ophthalmic history, and ocular biometric parameters, were completely documented.\n\nExclusion Criteria:\n\nPatients with poor-quality images affecting PSS identification, severe coexisting ocular diseases including glaucoma, diabetic retinopathy that cause media opacities, or severe systemic diseases that could interfere with the study outcomes.",{"count":104,"type":19},1000,"According to estimates by the World Health Organization, approximately half of the global adult population currently suffers from varying degrees of myopia. In urban areas of China, the myopia rate among primary school students has reached about 40%, and can exceed 80% in high school students. The proportion of patients with high myopia (refractive error greater than 600 degrees) is also increasing year by year. This group is more prone to severe visual problems, including an increased risk of complications such as cataracts, glaucoma, and macular degeneration. Pathological myopia is the main risk factor for vision loss caused by high myopia. In such patients, the elongation of the ocular axis leads to local thinning and protrusion of the posterior pole of the eyeball, forming a posterior scleral staphyloma. Posterior scleral staphyloma is the most representative pathological feature of pathological myopia. Local dilation of the choroid leads to thinning and stretching of the retina, which may ultimately cause problems such as macular retinal schisis, seriously affecting vision and even leading to blindness.\n\nThis project aims to develop a multimodal intelligent screening system by combining the excellent imaging technology and advanced artificial intelligence (AI) of the Optos non-mydriatic ultra-wide-angle laser scanning ophthalmoscope, B-scan ultrasonography ophthalmic diagnostic instrument, and optical coherence tomography (OCT). The system is designed to achieve precise identification and assessment of ocular fundus diseases, especially pathological myopia, and particularly the core condition of posterior scleral staphyloma (PSS). Simultaneously, a vision prediction model will be constructed to assist doctors in formulating personalized diagnosis and treatment strategies, predicting the trend of vision deterioration, and enhancing the effectiveness of early intervention. This system is expected to significantly improve the prevention and control of pathological myopia, reduce the risk of blindness, and play a pivotal role in telemedicine services, benefiting people in remote areas and promoting public health equity and service quality.",[24],"2026-02-14",{"date":109,"type":38},"2026-02-20",{"date":111,"type":38},"2024-10-01",{"date":113,"type":19},"2026-12",{"name":115,"class":45},"Shanghai 10th People's Hospital",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":79,"phases":125,"briefSummary":126,"conditions":127,"keywords":128,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100605867","visual-outcomes-of-an-enhanced-monofocal-intraocular-lens-targeted-for-monovision-in-highly-myopic-eyes-a-randomized-controlled-trial-100605867","NCT07168109","Visual Outcomes of an Enhanced Monofocal Intraocular Lens Targeted for Monovision in Highly Myopic Eyes: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 18 and 85 years (inclusive), no gender restrictions;\n2. Scheduled to undergo bilateral phacoemulsification with intraocular lens implantation;\n3. Axial length ≥ 26.0 mm in both eyes;\n4. Desire for postoperative spectacle independence;\n5. Able to understand and cooperate with the trial procedures, voluntarily participate in this clinical trial, and sign an informed consent form.\n\nExclusion Criteria:\n\n1. Poor-quality preoperative ocular biometry (Axial length, keratometry, anterior chamber depth);\n2. Preoperative corneal astigmatism ≥ 1.5 diopters (D);\n3. Patients with intraoperative or postoperative complications (ie, intraoperative posterior capsular rupture, zonular dehiscence, secondary glaucoma, etc.);\n4. The presence of other ocular diseases (ie, strabismus, severe retinal pathology, uveitis, other relevant ophthalmic diseases that might affect outcomes or trauma, etc.);\n5. A history of intraocular surgery;\n6. Severe chronic systemic diseases, psychiatric disorders, dementia, hearing impairments, or mobility limitations that would interfere with understanding of the monovision design, attendance at follow-up visits, or completion of questionnaires.","85 Years",{"count":124,"type":19},66,[81],"The goal of this clinical trial is to evaluate whether an enhanced monofocal intraocular lens targeted for monovision can improve visual outcomes in patients with cataract and high myopia (axial length ≥ 26 mm).\n\nThe main questions it aims to answer are:\n\nFor people with cataract and high myopia, does an enhanced monofocal intraocular lens targeted for monovision provide greater binocular uncorrected distance visual acuity compared with targeting myopia in both eyes? Does an enhanced monofocal intraocular lens targeted for monovision provide comparable binocular uncorrected intermediate and near visual acuity, contrast sensitivity, reading ability, spectacle independence, stereopsis, and photic phenomena compared with targeting myopia in both eyes?\n\nResearchers will compare an enhanced monofocal intraocular lens targeted for monovision with one targeted for myopia in both eyes to determine whether the monovision strategy is more effective.\n\nParticipants will:\n\nUndergo phacoemulsification with enhanced monofocal intraocular lens implantation. Attend follow-up visits at 1, 3, 6, and 12 months after cataract surgery.",[23,24],[129,32,130],"high myopia","impaired visual acuity","NOT_YET_RECRUITING","2025-09-11",{"date":134,"type":38},"2025-09-18",{"date":136,"type":19},"2025-10-01",{"date":138,"type":19},"2027-07-01",{"name":140,"class":45},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":16,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":79,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":46},"100602225","efficacy-and-safety-of-spectacle-lenses-with-halt-max-technology-on-high-myopia-control-in-children-and-adolescents-100602225","NCT07120737","Efficacy and Safety of Spectacle Lenses With H.A.L.T. MAX Technology on High Myopia Control in Children and Adolescents","Efficacy and Safety of Spectacle Lenses With Maximized Highly Aspherical Lenslets Target Technology (H.A.L.T. MAX) on High Myopia Control in Children and Adolescents: a Randomized Controlled Research","Inclusion Criteria:\n\n* Voluntary, willing to follow the protocol, able to read and understand the information form and give free and informed consent (for parents\u002Fguardian of children subjects) and assent (for subjects aged 7-14 years old);\n* 7-14 years old，regardless of sex;\n* Spherical equivalent refraction (SE) after cyclopegia ≤ -5.00 D and ≥ -9.00D;\n* Anisometropia and Astigmatism ≤2.50D;\n* Best corrected distance visual acuity of at least 0.8 in both eyes;\n* Willing to wear only the spectacles provided by the investigator for all days (\\>10 hours) during the study without additional interventions;\n* Accept randomization;\n* Able to sign the informed consent form with the accompaniment and understanding of parents or guardians.\n\nExclusion Criteria:\n\n* Allergic or intolerant to cycloplegic drugs；\n* Exclude children on high dose atropine (1%) or red light therapy；\n* Any previous history of myopia control treatment in the previous 30 days, like low dose atropine, defocus spectacles, or thokeratology and acupuncture；\n* History or presence of an ocular disease, strabismus or amblyopia or other binocular vision abnormalities, accommodation dysfunction, and cataract.；\n* History of eye surgery；\n* Ocular or systemic diseases that may be associated with myopia, such as Marfan syndrome, retinopathy of newborns, diabetes, etc；\n* Anatomic or skin factors affecting the wearing of spectacles；\n* Other conditions unsuitable for inclusion (patients with excessive expectations for the effect of the defocus spectacle lenses or desires to try other myopia interventions).","7 Years","14 Years",{"count":151,"type":19},224,[81],"Children aged 7-14 years with high myopia were randomly assigned to a control group or an intervention group at a 1:1 ratio. The intervention group wore H.A.L.T. MAX lenses for at least 10 hours per day for 2 years, and the control group wore ordinary single-vision (SV) spectacles for at least 10 hours per day. At the 1-year follow-up examination (6-month visit), control subjects whose equivalent spherical diopter change (SER) was ≥0.75 D were switched to H.A.L.T. MAX lenses until the end of year 2. After entering year 2, all remaining control (SV) subjects will be replaced with H.A.L.T. MAX defofocus frames for at least 10 hours per day until the end of year 2. And continue to wear it for at least 10 hours per day. To evaluate the efficacy, safety and compliance of H.A.L.T. MAX lenses in delaying myopia progression in children with high myopia, and to provide a scientific basis for the formulation and practice of public health programs for delaying myopia progression and the risk of blindness and visual impairment caused by high myopia.",[25,24],[156,129],"myopia","2025-08-11",{"date":159,"type":38},"2025-08-13",{"date":161,"type":19},"2025-09-01",{"date":163,"type":19},"2028-12-01",{"name":165,"class":45},"Shanghai Eye Disease Prevention and Treatment Center",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":79,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100590377","comparison-of-retinal-damage-in-icl-implantation-using-3d-visualization-system-vs-microscope-100590377","NCT06966622","Comparison of Retinal Damage in ICL Implantation Using 3D Visualization System vs. Microscope","Comparison of Ngenuity and Traditional Microscopy in Assessing Retinal Function Recovery Post-ICL Surgery","Inclusion Criteria:\n\n* Clinical diagnosis of high myopic\n* Aged 18-40 years\n* Desire to improve their refractive status via ICL surgery\n* Relatively stable refractive error (change ≤ 0.50 D per year for two consecutive years)\n* Central anterior chamber depth ≥ 2.8 mm\n* Open angles\n* Corneal endothelial cell density ≥ 2000 cells\u002Fmm2.\n\nExclusion Criteria:\n\n* Cataracts\n* Corneal diseases,\n* Glaucoma,\n* Nystagmus,\n* Strabismus,\n* Lens subluxation,\n* Severe vitreoretinal diseases,\n* Other ocular diseases\n* A history of ocular trauma\n* A history of ocular surgery","40 Years",{"count":175,"type":19},40,[81],"Implantable collamer lens (ICL) implantation is considered one of the most effective surgical treatments for high myopia. The procedure primarily involves adjusting the position of the ICL within the eye. However, precise calculation of the ICL optical power may cause the surgical light source to remain focused on the macular area during this process, potentially leading to iatrogenic light-induced damage. Theoretically, the combination of a 3D visualization surgical system and coaxial illumination technology can reduce the illumination intensity and decrease iatrogenic light damage. This study aims to compare the retinal physiological changes in patients undergoing ICL surgery through 3D visualization surgical system with coaxial illumination versus a traditional microscope with standard illumination.",[24],"2025-08-07",{"date":181,"type":38},"2025-08-08",{"date":183,"type":19},"2025-08-25",{"date":185,"type":19},"2026-05-31",{"name":187,"class":45},"Fuzhou Eye Hospital",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":79,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":4},"100600719","100-high-myopia-patient-reported-outcomes-pro-and-performance-outcomes-perfo-100600719","NCT07101146","100 High Myopia Patient-reported Outcomes (PRO) and Performance Outcomes (PERFO)","Pathological Myopia and Quality of Life: An Exploratory Study of Patient Outcomes and Perceptions","PPO100","Inclusion Criteria:\n\nPatients with pathological myopia and diffuse choroidal atrophy (DCA, Cat. 2 Meta PM)\n\n* Age ≥ 18 years and ≤ 55 years;\n* Patient consenting to be included in the study;\n* Examination and follow-up in at least one of the participating centers;\n* Severe pathological myopia with an axial length ≥ 26.5 mm in both eyes;\n* Presence of diffuse atrophy (category 2 of the Meta-PM classification) in the better eye;\n* Affiliated with or covered by a social security system.\n\nPathological myopic patients with patch choroidal atrophy (PCA,\n\nCat. 3 Meta PM):\n\n* Age ≥ 18 years and ≤ 55 years;\n* Patients who consent to be included in the study;\n* Examination and follow-up at least one of the participating centers;\n* High myopia with an axial length ≥ 26.5 mm in both eyes;\n* Presence of patch atrophy (category 3 of the Meta-PM classification) in the better eye;\n* Affiliated with or beneficiary of a social security system.\n\nExclusion Criteria:\n\n* Identified genetic syndromic myopia, including Stickler syndromes type 1 and 2 (collagen 2A1 and 11A1), Marfan syndrome (fibrillin), Ehler-Danlos syndrome type 4 (lysyl-protocollagen hydroxylase), and Knobloch syndrome (collagen 18A).\n* Patient unwilling to participate or be followed up at one of the participating centers.\n* Binocular visual acuity ≥ 1 logMar (\\\u003C0.1 on the decimal scale).\n* Media opacities preventing quality imaging, including cataracts.\n* Patients benefiting from legal protection measures.\n* Pregnant or breastfeeding women.\n* Individuals who may not be able to tolerate the driving simulator.","55 Years",{"count":198,"type":19},100,[81],"Prospective, longitudinal, interventional, exploratory, non-randomized, single-center study including patients with pathological myopia .",[24],"2025-08-01",{"date":204,"type":38},"2025-08-03",{"date":206,"type":19},"2025-10",{"date":208,"type":19},"2028-11-30",{"name":210,"class":45},"Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":79,"phases":221,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":46},"100536438","3d-visualization-system-in-highly-myopic-cataract-operation-100536438","NCT06264830","3D Visualization System in Highly Myopic Cataract Operation","Comparing the Effect of Depth of Focus Difference in High Myopic Patients Receiving Cataract Operations Between 3D Visualization System and Traditional Optical Microscope.","3D-HiMCO","Inclusion Criteria:\n\n1. High myopia (axial length of 26 millimeters or more).\n2. Presence of clinically significant age-related nuclear cataract requiring surgery, assessed using the International Classification System for Cataract (Lens Opacities Classification System III, LOC III), with a graded score indicating nuclear cataract (LOC III NC\u002FNO grade 3-5).\n3. Participants must be 20 years of age or older.\n\nExclusion Criteria:\n\n1. The target eye has undergone vitrectomy surgery.\n2. The target eye has undergone corneal refractive surgery.\n3. Presence of corneal diseases such as corneal dystrophy, corneal trauma, corneal scarring, corneal ulcers, or clinically significant corneal softening that significantly affects the clarity of cataract surgery.\n4. Complicated cataracts with features such as extreme hardness, complex composition, zonular laxity, lens dislocation, extensive capsular fibrosis, or those falling under the international cataract classification standards LOCIII NO\u002FNC6 or C4-C5 or P4-P5.\n5. Presence of other non-myopia-related eye diseases significantly affecting the complexity of surgery, such as adhesive uveitis causing adhesions, corneal damage due to trauma or lens dislocation, structural changes and adhesions due to intraocular inflammation, or severe uncorrected strabismus affecting eye alignment.",{"count":220,"type":19},45,[81],"This study aims to investigate the impact of depth of field differences between the use of the 3D imaging system (NGENUITY® 3D Visualization System, Alcon, TX, USA) and conventional optical microscope in cataract surgery for highly myopic patients on intraoperative parameters and outcomes.",[23,24],[23,24,225,226],"Digital 3D System","Depth of Field","2025-07-01",{"date":229,"type":38},"2025-07-02",{"date":231,"type":38},"2024-07-03",{"date":233,"type":19},"2025-12-31",{"name":235,"class":45},"National Taiwan University Hospital",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":79,"phases":245,"briefSummary":246,"conditions":247,"keywords":248,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":46},"100597003","the-role-of-capsular-tension-rings-in-intraocular-lens-stability-in-high-myopia-cataract-patients-a-prospective-self-controlled-study-100597003","NCT07052825","The Role of Capsular Tension Rings in Intraocular Lens Stability in High Myopia Cataract Patients: A Prospective Self-Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Diagnosed with bilateral age-related cataracts and scheduled for phacoemulsification with IOL implantation in both eyes.\n3. High myopia in both eyes, defined as axial length (AL) ≥ 26.0 mm.\n4. No significant difference in axial length between the two eyes (e.g., interocular AL difference \\\u003C 1.0 mm).\n5. Willingness and ability to undergo bilateral surgery within a short interval (e.g., within 1-2 weeks).\n6. Able to provide informed consent and comply with the study protocol and follow-up visits.\n\nExclusion Criteria:\n\n1. History of ocular trauma, surgery, or intraocular inflammation in either eye.\n2. Presence of other ocular diseases that may affect visual outcomes, such as glaucoma, diabetic retinopathy, macular degeneration, or corneal opacity.\n3. Evidence of zonular weakness, pseudoexfoliation, or significant phacodonesis preoperatively.\n4. Severe dry eye or poor fixation that may interfere with postoperative imaging.\n5. Systemic diseases affecting visual function (e.g., uncontrolled diabetes, neurologic disorders).\n6. Participation in other clinical trials that may affect the study outcomes.","90 Years",{"count":244,"type":19},120,[81],"Study Purpose:\n\nThis prospective, self-controlled clinical study aims to evaluate the impact of capsular tension rings (CTR) on intraocular lens (IOL) stability in high myopia patients undergoing bilateral cataract surgery. Each patient will receive CTR implantation in one eye, with the fellow eye serving as control. Postoperative outcomes, including visual acuity, refraction, IOL positioning, and visual quality, will be compared between eyes to assess the effectiveness of CTR.\n\nStudy Methods:\n\nEligible participants (axial length ≥ 26.0 mm) will undergo femtosecond-assisted phacoemulsification with identical IOLs implanted in both eyes. One eye will be randomly assigned to receive a CTR. All surgeries will be performed by the same surgeon. Follow-up will be conducted at 1 day, 1 week, 1 month, 3 months, and 6 months postoperatively. Assessments will include UCVA, BCVA, refractive error, anterior segment OCT, IOL decentration and tilt, and visual quality (iTrace).\n\nSample Size and Population:\n\nA total of 60 patients (120 eyes) will be enrolled. Inclusion criteria include age ≥ 18 years and bilateral cataracts with high myopia. Exclusion criteria include other ocular diseases, history of severe ocular trauma, or poor visual potential. Patients will be stratified by axial length into three groups: ≤28 mm, 28-30 mm, and \\>30 mm.\n\nStudy Procedure:\n\nAfter informed consent and baseline examinations (including ocular biometry and imaging), patients will undergo surgery and be followed at specified intervals. All data will be managed securely. Comparative analysis between CTR and non-CTR eyes will be performed to evaluate the effect of CTR on IOL stability and visual outcomes in highly myopic cataract patients.",[24,23],[249],"Capsular Tension Ring（CTR）, High Myopia, Intraocular lens, Tilt, Decentration, Visual Quality","2025-06-29",{"date":252,"type":38},"2025-07-07",{"date":254,"type":38},"2025-01-01",{"date":256,"type":19},"2030-12-31",{"name":258,"class":45},"Jin Yang",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":266,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":278,"locationsCount":280},"100572880","anterior-segment-and-corneal-parameters-in-keratoconus-and-high-myopic-astigmatism-using-schiempflug-imaging-100572880","NCT06739018","Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging","Comparison of Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging","Inclusion Criteria:\n\n* keratoconus patient\n* virgin clear cornea with high myopic astigmatism\n* normal cornea with high myopic astigmatism\n\nExclusion Criteria:\n\n* patients had previous ocular surgery\n* ocular diseases rather than keratoconus\n* contact lens wearer\n* corneal opacity and corneal dystrophy","15 Years","50 Years",{"count":124,"type":19},"The purpose of this study was to compare Scheimpflug corneal tomography findings in keratoconus and high myopic astigmatic eyes, as well as to establish the parameters distinguishing keratoconus from high myopic astigmatism.",[271,24],"Keratoconus","2024-12-16",{"date":274,"type":38},"2024-12-18",{"date":276,"type":19},"2024-12",{"date":206,"type":19},{"name":279,"class":45},"Assiut University",2,{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":287,"sex":16,"minAge":76,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":290,"conditions":291,"keywords":292,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":46},"100370954","clinical-results-of-small-incision-lenticule-extraction-smile-for-the-correction-of-high-myopia-100370954","NCT04110067","Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia","Inclusion Criteria:\n\n* adults\n* myopia more than -7.75 D\n* refractive stability more than 1 year\n\nExclusion Criteria:\n\n* corneal irregular astigmatism\n* ectatic conditions",true,{"count":289,"type":19},5000,"Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.\n\nIt involves the creation of a corneal tissue disk called lenticule and its extraction through a minimally invasive incision, utilizing only a femtosecond laser. This enables rapid visual recovery with very little discomfort to the patient.\n\nThis observational case series monitors visual and refractive outcomes of myopic correction for more than -7.75 D.\n\nIt is to\n\n* gather long-term results and refractive stability\n* detect rare complications or side-effects\n* evaluate the efficacy in a large number of patients",[25,24],[25,293,294,295],"Refractive Surgery","Small Incision Lenticule Extraction","SMILE","2024-11-26",{"date":298,"type":38},"2024-11-29",{"date":300,"type":38},"2016-01",{"date":302,"type":19},"2029-11",{"name":304,"class":45},"Suphi Taneri",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":16,"minAge":266,"maxAge":4,"enrollmentInfo":311,"targetDuration":4,"studyType":79,"phases":313,"briefSummary":314,"conditions":315,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":320,"leadSponsor":321,"locationsCount":46},"100561918","evaluation-of-retinal-vascular-density-in-high-myopia-without-pathological-myopic-maculopathy-using-octa--100561918","NCT06596408","Evaluation of Retinal Vascular Density in High Myopia Without Pathological Myopic Maculopathy Using OCTA .","Inclusion Criteria wil include :\n\n* All myopic patients with axial high myopia (-6 spherical refractive error or more) of different age groups .\n\nExclusion Criteria will include :\n\n* -History of other any ocular diseases , systemic diseases that may affect the ocular circulation .\n* Previous intraocular surgery or ocular injury .\n* Any patient with pathological myopic maculopathy as epiretinal membrane, foveoschisis, macular holes, lamellar holes, Lacquers cracks, choroidal neovascularization and retinal atrophy .",{"count":312,"type":19},50,[81],"Study aiming to evaluate Macular Vascular Density in High Myopes without pathological myopic maculopathy in outpatient clinic in Sohag teaching hospital using OCTA .",[24],"2024-09-11",{"date":318,"type":38},"2024-09-19",{"date":316,"type":19},{"date":206,"type":19},{"name":322,"class":45},"Sohag University",{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":242,"enrollmentInfo":329,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":331,"conditions":332,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":46},"100223182","evaluation-of-cataract-surgery-outcome-100223182","NCT02182921","Evaluation of Cataract Surgery Outcome","Evaluation of Surgical Outcomes of Cataract Surgery",{"count":330,"type":19},20000,"The purpose of this study is to evaluate the visual outcome of the cataract surgery, including best uncorrected and corrected visual acuity, spherical equivalent, wavefront aberration and other measurements.",[23,24],"2024-08-27",{"date":335,"type":38},"2024-08-28",{"date":337,"type":4},"2013-08",{"date":339,"type":19},"2030-12",{"name":341,"class":45},"Evidence Based Cataract Study Group",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":348,"eligibilityCriteria":349,"healthyVolunteers":287,"sex":16,"minAge":76,"maxAge":350,"enrollmentInfo":351,"targetDuration":352,"studyType":20,"phases":4,"briefSummary":353,"conditions":354,"keywords":355,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":46},"100528550","wuhan-high-myopia-study-100528550","NCT06162234","Wuhan High Myopia Study","Long Term Observation of Ocular Structure and Visual Function in Eyes With High Myopia：Wuhan High Myopia Study","LOVE-WH","Inclusion Criteria:\n\n* Voluntarily sign informed consent;\n* Commit to follow the research procedures and cooperate with the whole process of the study;\n* Age ≥18 years old;\n* Best corrected visual acuity ≥0.1;\n* Spherical Equivalent Refraction≤-6.00D or axial length ≥26mm in high myopia group；\n\nExclusion Criteria:\n\n* Unable or unwilling to sign informed consent;\n* Unable to cooperate with the examination;\n* Astigmatism ≤-1.5D；\n* Patients with refractive interstitial opacity so that fundus images cannot be collected；\n* Patients with fundus diseases such as diabetic retinopathy, hypertensive retinopathy, age-related macular degeneration, retinal vein obstruction, retinal artery obstruction, etc","65 Years",{"count":104,"type":19},"4 Years","The study aims to observe the long-term changes of ocular（especially fundus） structure and visual function in patients with high myopia, so as to provide evidence for the prevention, diagnosis and prognosis of high myopia.",[24],[356,357],"ocular biometric parameters","Refractive Errors","2023-12-19",{"date":360,"type":38},"2023-12-27",{"date":362,"type":19},"2023-12-25",{"date":364,"type":19},"2027-09-01",{"name":366,"class":45},"Renmin Hospital of Wuhan University"]