[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"high-risk-soft-tissue-sarcoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:high-risk-soft-tissue-sarcoma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100201442","phase-1-dcs-vaccine-combined-with-cytokine-induced-killer-cells-in-patients-with-aml-100201442",false,"NCT01898663","DCs Vaccine Combined With Cytokine-induced Killer Cells in Patients With AML","Safety and Therapeutic Efficacy of DCs Vaccine Combined With Cytokine-induced Killer Cells in Patients With AML: a Phase Ⅰ\u002FⅡ Study","Inclusion Criteria:\n\n* Consistent with the diagnosis of AML\n* Age≥18 years at time of consent\n* KPS(Karnofsky Performance Scale) ≥70\n* Patient's written informed consent\n* No steroid therapy within 4 weeks of first DC vaccination\n* Stable disease, complete response and partial response(WHO, RECIST)\n* Predicted survival≥3 months\n\nExclusion Criteria:\n\n* Serious dysfunction of vital organs(heart, liver or kidney)\n* Received organ transplantation\n* Patients with other malignancies or brain metastases\n* History of autoimmune diseases\n* Pregnant and breast-feeding patient\n* Active or chronic infectious diseases\n* History of allergy or hypersensitivity to study product excipients\n* Currently participating in another clinical trial\n* Received chemotherapy, radiotherapy, immune inhibitor (such as corticosteroid) or other immunotherapy (such as vaccine) during prior 4 weeks\n* Unfit for participating in this clinical trial in investigators' opinions","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","The aim of this Phase Ⅰ\u002FⅡ study is to evaluate the safety and efficacy of dendritic cells (DCs) vaccine combined with cytokine-induced killer (CIK) cells in patients with AML. Experimental recombinant adenovirus-transfected DCs, which engineered to express MUC1 and Survivin are used for DCs-based immunotherapy. Based on the results of our previously performed preclinical study with DCs vaccine combined with CIK cells, the investigators plan to perform the clinical trial.",[27],"High-risk Soft Tissue Sarcoma","RECRUITING","2024-06-28",{"date":31,"type":32},"2024-07-01","ACTUAL",{"date":34,"type":4},"2013-06",{"date":36,"type":20},"2024-12-30",{"name":38,"class":39},"Affiliated Hospital to Academy of Military Medical Sciences","OTHER"]