[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hip-arthroplasty-replacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hip-arthroplasty-replacement":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,74,102,126,154,177],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100640621","phase-4-post-operative-spinal-block-duration-and-pain-relief-after-hip-replacement-surgery-comparing-single-shot-spinal-ropivacaine-and-bupivacaine-100640621",false,"NCT07631091","Post-Operative Spinal Block Duration and Pain Relief After Hip Replacement Surgery: Comparing Single-Shot Spinal Ropivacaine and Bupivacaine","Post-Operative Analgesia and Spinal Block Duration Following Total Hip Arthroplasties: Comparison of Single-Shot Intrathecal Ropivacaine and Bupivacaine in a Randomized Double-Blinded Controlled Study","ROBUTHA","Inclusion Criteria:\n\n* 18 - 80 years of age\n* Scheduled for a primary elective total hip arthroplasty\n* Patient must be a candidate for same day discharge\n* Informed consent understood and signed\n* Patient is 160 - 186 cm tall\n\nExclusion Criteria:\n\n* Scheduled bilateral THA\n* Contraindication to or failed spinal anesthesia\n* Allergy or contraindication to NSAIDs (e.g. chronic kidney disease)\n* Diabetes requiring insulin medication\n* Preoperative chronic use of illegal substances\n* Renal insufficiency (eGFR \\\u003C 60)\n* Unstable psychiatric conditions\n* Severe neurological disorder\n* Cognitive deficiencies preventing informed consent\n* Language barrier preventing completion of study\n* Pregnancy or breastfeeding\n* Chronic pain syndrome","ALL","18 Years","80 Years",{"count":21,"type":22},176,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to determine whether isobaric ropivacaine is more suitable than isobaric bupivacaine for spinal anesthesia in outpatient total hip arthroplasty (THA). The study will evaluate whether ropivacaine allows faster recovery of sensory and motor function while still providing adequate surgical anesthesia and postoperative pain control. Additional aims are to assess the effects of the anesthetic technique on same-day discharge rates, postoperative recovery, urinary retention, opioid consumption, and patient satisfaction after outpatient THA.",[28,29,30],"Hip Osteoarthritis","Hip Arthroplasty Replacement","Postoperative Pain After Ambulatory Surgery","NOT_YET_RECRUITING","2026-06-02",{"date":34,"type":35},"2026-06-05","ACTUAL",{"date":37,"type":22},"2026-06",{"date":39,"type":22},"2028-05",{"name":41,"class":42},"University of Turku","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100601425","characteristics-of-persistent-pain-composition-following-total-hip-or-knee-arthroplasty-a-descriptive-study-100601425","NCT07110324","Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study","PAIN-COMPO","Inclusion Criteria:\n\n* All patients with persistent moderate-severe pain (NRS\\>3) after THA, TKA and UKA\n* Acceptance to be contacted.\n\nExclusion Criteria:\n\n* Re-operation\n* Luxation\n* Do not want to be contacted\n* Post-operative complications such as prosthesis infection, thromboembolism or fracture of the prosthesis.",{"count":51,"type":22},100,"1 Year","OBSERVATIONAL","Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \\> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \\~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS\u002FHOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS\u002FHOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.",[56,29,57,58],"Pain (Visceral, Somatic, or Neuropathic)","Knee Arthroplasty, Total","Survey and Questionnaire",[60,61,62],"Pain","hip arthroplasty","knee arthroplasty","RECRUITING","2026-03-31",{"date":66,"type":35},"2026-04-01",{"date":68,"type":35},"2025-06-26",{"date":70,"type":22},"2026-12-01",{"name":72,"class":42},"Rigshospitalet, Denmark",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100623121","cognitive-and-physical-recovery-after-hip-fracture-in-frail-patients-using-digital-rehabilitation-technology-100623121","NCT07392515","Cognitive and Physical Recovery After Hip Fracture in Frail Patients Using Digital Rehabilitation Technology","Cognitive and Motor Recovery in Frail Patients With Hip Fracture: Effectiveness of Digital Technology-Assisted Rehabilitation and Analysis of Biomolecular Mechanisms","FEWF","Inclusion Criteria:\n\n* Age between 65 and 89 years\n* Patients who have undergone one of the following surgical treatments specifically for proximal femur fracture including Total hip arthroplasty (total hip replacement), Partial hip arthroplasty (hemiarthroplasty), Intramedullary nailing\n* Time since surgery not exceeding 15 days\n* Clinical stability\n* Patients admitted to the rehabilitation wards of the centers involved in the study and therefore eligible for rehabilitative therapy.\n\nExclusion Criteria:\n\n* Age \\> 90 years\n* Age \\\u003C 65 years\n* Refusal to sign the informed consent form\n* Behavioral or cognitive disorders limiting compliance with the rehabilitative treatment\n* Presence of mechanical instability of the implanted surgical device\n* Clinical instability (e.g., sepsis, severe anemia, cardiorespiratory failure) or pre-existing comorbidities affecting ambulation (neurological diseases or chronic pre-existing disabilities)\n* Concomitant presence of other fractures that prevent the possibility of carrying out a rehabilitative treatment\n* Severe visual impairments not correctable with lenses that prevent the patient from performing the treatment using digital tools\n* Pre-existing motor disability prior to the femur fracture due to other systemic diseases (e.g., advanced-stage neurodegenerative diseases, severe heart failure)\n* Conditions contraindicating the use of sensors (pacemaker, epilepsy, skin lesions, open wounds, and severe allergies in areas of contact with the devices).","65 Years","89 Years",{"count":85,"type":22},30,[87],"NA","The aim of this study is to evaluate whether integrating a technology-based rehabilitation approach with conventional therapies in the rehabilitation of patients with proximal femoral fracture may be advantageous compared with conventional therapy alone. Specifically, the objective is to assess whether the addition of technology-assisted rehabilitation can improve cognitive function, in addition to motor function and overall abilities, compared with conventional rehabilitation alone. Furthermore, the study intends to explore the feasibility of implementing technology-assisted rehabilitation as a stable and routine component of everyday clinical practice, also considering the perspective of healthcare professionals.",[90,29,91],"Fracture Femur","Total Hip Arthroplasty (THA)","2026-03-11",{"date":94,"type":35},"2026-03-13",{"date":96,"type":35},"2026-02-09",{"date":98,"type":22},"2026-07-31",{"name":100,"class":42},"C.O.T. Cure Ortopediche Traumatologiche S.p.A.",2,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":19,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":115,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":73},"100608857","comparison-of-wear-between-two-dual-mobility-acetabular-cups-in-patients-undergoing-total-hip-arthroplasty-100608857","NCT07207005","Comparison of Wear Between Two Dual-mobility Acetabular Cups in Patients Undergoing Total Hip Arthroplasty","CUPUSURE","Inclusion Criteria:\n\n* Patient, male or female, aged between 55 and 80.\n* Patient with a life expectancy \\> 5 years at the time of inclusion.\n* Patient scheduled to undergo primary total hip arthroplasty with a dual-mobility cup prosthesis.\n* Patient affiliated with or beneficiary of a social security scheme.\n* Patient who speaks French and has signed an informed consent form.\n\nExclusion Criteria:\n\n* Patients with a contraindication mentioned in the instructions for use of the medical device under investigation\n* Patients with an ASA score of 4\n* Protected patients: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision\n* Patients participating in another clinical study whose objectives could interfere with this study","55 Years",{"count":111,"type":22},96,[87],"In 2022, data from the UK's National Joint Registry (NJR) and the American Joint Replacement Registry (AJRR) indicated that Total Hip Replacement (THR) is the most commonly performed orthopaedic joint surgery.\n\nThe NJR has observed that between 10 and 20% of hip implants require revision within the first 10 years. The main reasons for these revisions include implant fractures, joint incompatibility, aseptic loosening, dislocation and wear of the polyethylene (PE) insert.\n\nTo address this problem, highly cross-linked polyethylene (HXLPE) inserts have been developed. Cross-linking helps to limit wear on polyethylene prostheses in total hip arthroplasty. However, there are concerns about the loss of elasticity of HXLPE and oxidation after implantation.\n\nA new generation of inserts based on highly cross-linked polyethylene (irradiation dose ≥100 Kgy), enriched with vitamin E, has been developed. This PE, called ECIMA, was developed to maintain mechanical properties, minimise PE wear and improve long-term oxidation resistance.\n\nIn the HAS evaluation report on highly cross-linked polyethylene inserts dated 24 January 2023, data from the literature show less wear of highly cross-linked polyethylene compared to conventional polyethylene.\n\nNevertheless, the use of highly cross-linked polyethylene is not yet the gold standard. Furthermore, the data in the literature mainly concern single-mobility cups but not double-mobility cups. Finally, new imaging protocols now make it possible to assess the wear of prosthesis materials more accurately.\n\nIn this context, it seems appropriate to conduct a French study comparing double-mobility cups containing highly cross-linked polyethylene or conventional polyethylene inserts.",[29],[116],"Hip Arthroplasty Insert","2025-09-26",{"date":119,"type":35},"2025-10-03",{"date":121,"type":22},"2025-11-15",{"date":123,"type":22},"2036-08-31",{"name":125,"class":42},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":141,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100601353","comparison-of-pericapsular-nerve-group-peng-block-with-a-combined-femoral-sciatic-lateral-femoral-cutaneous-nerve-block-for-postoperative-analgesia-in-secondary-total-hip-arthroplasty-revpet-100601353","NCT07109388","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty.","REVPET","Inclusion Criteria:\n\n* Male and female patients\n* ASA (American Society of Anaesthesiologists) I-III\n* 18 years of age or older\n* Patients scheduled for elective secundary hip arthroplasty\n* Able to give written conformed consent autonomously\n\nExclusion Criteria:\n\n* Refusal or inability to give consent\n* Allergy to any of: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone\n* Bleeding diathesis\n* Neurological deficit of the operative side\n* Existing preoperative opioid use\n* Renal insufficiency (GFR\\\u003C30ml\u002Fmin according to the Cockroft-Gault formula)\n* Hepatic insufficiency\n* Morbid Obésity III",{"count":135,"type":22},50,[87],"The aim of this clinical trial is to compare the analgesic effect of a pericapsular nerve group (PENG) block with a combined femoral, sciatic, lateral femoral cutaneous nerve block for postoperative analgesia in patients scheduled for secondary total hip arthroplasty. The primary objective of this study is to compare postoperative pain management between the PENG block and the combined block (femoral, sciatic, lateral femoral cutaneous) by measuring postoperative morphine consumption in each of the two groups.\n\nParticipants will be randomized into two groups. Patients assigned to the PENG group will receive a PENG block with ropivacaine, followed by a sham (sciatic) block, and spinal anesthesia with isobaric bupivacaine. Patients assigned to the combined block group will receive femoral, sciatic, lateral femoral cutaneous nerve blocks with ropivacaine, followed by spinal anesthesia with isobaric bupivacaine.",[29,139,140],"Post Operative Analgesia","Post Operative Pain, Acute",[142,143,144],"nerve block","postoperative pain","hip arthroplasty replacement","2025-09-16",{"date":147,"type":35},"2025-09-22",{"date":149,"type":22},"2025-09-30",{"date":151,"type":22},"2027-09-01",{"name":153,"class":42},"Centre Hospitalier Universitaire Vaudois",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":163,"conditions":164,"keywords":165,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":73},"100584405","changes-in-perioperative-blood-volume-and-fluid-distribution-in-patients-undergoing-primary-total-hip-replacement-100584405","NCT06888908","Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.","Perioperative Change in Blood Volume and Fluid Distribution in Total Hip Arthroplasty","Inclusion Criteria:\n\n* Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting.\n* Capable of participating in CO-rebreathing measurement\n* Age ≥ 18 years\n* Able to speak and understand Danish\n* Has provided written informed consent.\n\nExclusion Criteria:\n\n* Intraoperative blood loss exceeding 750 mL.\n* Perioperative need for a blood transfusion.\n* Confirmed or suspected coagulopathies.\n* Factors that make CO-rebreathing measurement impossible.\n* Known orthostatic intolerance.\n* American Society of Anesthesiologists physical status (ASA) classification ≥ 4.",{"count":162,"type":22},25,"Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume.\n\nThe purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.",[29],[166,167],"Blood loss","Blood volume","2025-03-17",{"date":170,"type":35},"2025-03-21",{"date":172,"type":22},"2025-03",{"date":174,"type":22},"2026-09",{"name":176,"class":42},"Copenhagen University Hospital, Hvidovre",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":73},"100583226","cephalic-femoral-heads-follow-up-100583226","NCT06873568","Cephalic Femoral Heads Follow Up","A Post-market Study Evaluating Clinical and Safety Outcomes of Unipolar Hemiarthroplasty Using Cephalic Femoral Heads in Subjects with Hip Fracture","Inclusion Criteria:\n\n* Displaced intracapsular hip fracture (Garden III-IV).\n* Subjects underwent a Unipolar Hemiarthroplasty with a Cephalic femoral head as per their Indication For Use from January 1st, 2023, onwards.\n* No concurrent joint disease at the time of the surgery.\n* Absence of severe cognitive dysfunction demonstrated by 3 or more correct answers on the Pfeiffer test.\n* Ability to ambulate independently with or without walking aids before surgery.\n* Subject willingness to participate.\n\nExclusion Criteria:\n\n* Undisplaced or minimally displaced intracapsular hip fracture (Garden I-II).\n* Any Cephalic femoral head contraindication for use as reported in the current Instruction For Use.\n* Pathological fracture secondary to malignant disease.\n* Subjects with rheumatoid arthritis or symptomatic osteoarthritis.\n* Previous treatment to the same hip for a fracture at the time of the surgery.\n* Subjects who were deemed unsuitable for the surgical procedures by the anesthesiologist.\n* Severe cognitive dysfunction or cognitive impairment demonstrated by 2 or less correct answers on the Pfeiffer test.\n* Unable to walk before surgery (e.g., wheelchair or bed-ridden subjects).",{"count":185,"type":22},47,"Study design: monocentric, retrospective, observational and post-market clinical study.\n\nPurpose: To demonstrate the safety and performance of cephalic femoral heads. The eligible study population is represented by the entire population that underwent a hip replacement with cephalic femoral heads from 1st January 2023 onwards at the site in accordance with the indication for use of the product.",[29,188],"Femoral Fractures",[190,191],"femoral head","Partial hip arthroplasty","2025-03-13",{"date":194,"type":35},"2025-03-18",{"date":196,"type":22},"2025-10",{"date":198,"type":22},"2027-12",{"name":200,"class":201},"Limacorporate S.p.a","INDUSTRY"]